| Palo Alto Investors LP | 5,270,209 | $169,753,432 | 14.06% |
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| Essex Woodlands Management, Inc. | 457,085 | $14,722,708 | 8.52% |
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| Evolutionary Tree Capital Management, LLC | 66,825 | $2,152,433 | 2.98% |
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| Ghost Tree Capital, LLC | 250,000 | $8,053,000 | 2.38% |
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| Jericho Capital Asset Management L.P. | 1,438,669 | $46,339,528 | 1.92% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 183,000 | $5,888,940 | 1.64% |
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| Integral Health Asset Management, LLC | 250,000 | $8,052,500 | 1.62% |
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| RICE HALL JAMES & ASSOCIATES, LLC | 809,176 | $26,063,559 | 1.48% |
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| Waypoint Capital Advisors, LLC | 90,989 | $2,929,846 | 0.95% |
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| Polar Capital Holdings Plc | 4,167,842 | $134,246,191 | 0.87% |
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| Rhenman & Partners Asset Management AB | 230,000 | $7,159,900 | 0.79% |
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| RF&L WEALTH MANAGEMENT, LLC | 20,000 | $644,200 | 0.62% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 108,613 | $3,498,425 | 0.51% |
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| EAM Investors, LLC | 79,905 | $2,573,740 | 0.51% |
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| HAP Trading, LLC | 253,400 | $2,724 | 0.43% |
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| Jackson Creek Investment Advisors LLC | 28,214 | $909 | 0.38% |
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| Caption Management, LLC | 585,700 | $18,865,397 | 0.36% |
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| Alpha DNA Investment Management LLC | 33,552 | $1,080,709 | 0.32% |
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| Kamunting Street Capital Management, L.P. | 7,736 | $249,177 | 0.32% |
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| Kula Investments, LLC | 31,545 | $1,016,064 | 0.25% |
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