| Tao Capital Management LP | 568,981 | $11,716,000 | 8.11% |
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| Iron Triangle Partners LP | 850,000 | $17,502,000 | 2.27% |
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| Sands Capital Ventures, LLC | 326,427 | $6,721,000 | 1.85% |
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| Opaleye Management Inc. | 166,406 | $3,426,000 | 1.54% |
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| Parkman Healthcare Partners LLC | 149,315 | $3,074,000 | 1.13% |
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| Nicholas Investment Partners, LP | 551,895 | $11,364,000 | 1.07% |
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| Altium Capital Management LP | 125,000 | $2,574,000 | 1.03% |
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| Eversept Partners, LP | 470,444 | $9,686,442 | 0.69% |
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| Eventide Asset Management | 1,498,101 | $30,846,000 | 0.66% |
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| Granahan Investment Management | 900,255 | $18,536,000 | 0.63% |
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| SECTORAL ASSET MANAGEMENT INC | 131,757 | $2,713,000 | 0.55% |
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| PLATINUM INVESTMENT MANAGEMENT LTD | 570,157 | $11,740,000 | 0.44% |
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| PURA VIDA INVESTMENTS, LLC | 296,288 | $6,101,000 | 0.35% |
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| EMERALD ADVISERS, LLC | 320,442 | $6,598,000 | 0.34% |
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| EMERALD MUTUAL FUND ADVISERS TRUST | 250,605 | $5,160,000 | 0.30% |
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| ARK Investment Management | 3,628,220 | $50,505,000 | 0.30% |
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| RTW INVESTMENTS, LP | 512,957 | $10,562,000 | 0.27% |
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| Decheng Capital Management III (Cayman), LLC | 20,000 | $412,000 | 0.16% |
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| FRED ALGER MANAGEMENT, LLC | 1,070,259 | $22,037,000 | 0.10% |
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| Nikko Asset Management Americas, Inc. | 538,392 | $6,999,000 | 0.09% |
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