| Tao Capital Management LP | 568,981 | $10,817,000 | 3.94% |
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| Iron Triangle Partners LP | 713,105 | $13,556,000 | 1.61% |
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| Sands Capital Ventures, LLC | 326,427 | $6,205,000 | 1.30% |
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| Opaleye Management Inc. | 166,406 | $3,163,000 | 0.98% |
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| Parkman Healthcare Partners LLC | 175,000 | $3,327,000 | 0.97% |
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| Meridian Financial Partners LLC | 34,124 | $649,000 | 0.97% |
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| Nicholas Investment Partners, LP | 552,801 | $10,509,000 | 0.75% |
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| SECTORAL ASSET MANAGEMENT INC | 134,872 | $2,564,000 | 0.46% |
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| Eventide Asset Management | 1,410,000 | $26,804,000 | 0.42% |
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| Granahan Investment Management | 852,712 | $16,210,000 | 0.40% |
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| PLATINUM INVESTMENT MANAGEMENT LTD | 626,366 | $11,907,000 | 0.37% |
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| Eversept Partners, LP | 217,149 | $4,128,002 | 0.32% |
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| ARK Investment Management | 3,482,926 | $66,210,000 | 0.28% |
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| EMERALD ADVISERS, LLC | 329,442 | $6,263,000 | 0.24% |
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| EMERALD MUTUAL FUND ADVISERS TRUST | 268,186 | $5,098,000 | 0.22% |
|---|
| PURA VIDA INVESTMENTS, LLC | 296,288 | $5,632,000 | 0.18% |
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| Decheng Capital Management III (Cayman), LLC | 20,000 | $380,000 | 0.12% |
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| TimesSquare Capital Management, LLC | 393,230 | $7,475,000 | 0.08% |
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| Nikko Asset Management Americas, Inc. | 567,650 | $10,218,000 | 0.08% |
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| FRED ALGER MANAGEMENT, LLC | 727,172 | $13,824,000 | 0.04% |
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