| Hillsdale Investment Management Inc. | 146,100 | $4,330,404 | 0.40% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 36,500 | $1,081,130 | 0.36% |
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| RTW INVESTMENTS, LP | 500,887 | $14,846,291 | 0.31% |
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| Ghisallo Capital Management LLC | 100,000 | $2,964,000 | 0.30% |
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| SEVEN EIGHT CAPITAL, LP | 85,809 | $2,543,379 | 0.30% |
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| Granite Investment Partners, LLC | 232,378 | $6,887,684 | 0.29% |
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| Alpha DNA Investment Management LLC | 21,566 | $639,217 | 0.26% |
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| IMA Wealth, Inc. | 31,102 | $921,864 | 0.24% |
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| Mach-1 Financial Group, LLC | 19,076 | $565,413 | 0.23% |
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| Green Alpha Advisors, LLC | 10,110 | $299,660 | 0.23% |
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| Nebula Research & Development LLC | 14,375 | $426,075 | 0.22% |
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| Parkwood LLC | 2,800,000 | $1,932 | 0.21% |
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| Triatomic Management LP | 10,000 | $296,400 | 0.20% |
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| Trexquant Investment LP | 227,744 | $6,750,332 | 0.17% |
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| Hudson Value Partners, LLC | 9,340 | $276,838 | 0.14% |
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| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 947,932 | $28,096,704 | 0.14% |
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| Bayesian Capital Management, LP | 38,700 | $1,147,068 | 0.13% |
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| ARK Investment Management | 573,323 | $16,993,288 | 0.13% |
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| PURA VIDA INVESTMENTS, LLC | 22,943 | $680,031 | 0.13% |
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| Railway Pension Investments Ltd | 379,078 | $11,235,872 | 0.12% |
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