| Atlas Venture Life Science Advisors, LLC | 2,745,335 | $128,975,838 | 19.98% |
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| Foresite Capital Management V, LLC | 243,513 | $11,440,241 | 18.25% |
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| Bain Capital Life Sciences Investors, LLC | 1,332,545 | $62,602,964 | 7.00% |
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| Trustees of Columbia University in the City of New York | 78,682 | $3,696,480 | 6.80% |
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| 5AM Venture Management, LLC | 438,442 | $20,598,005 | 5.93% |
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| ACUTA CAPITAL PARTNERS, LLC | 138,198 | $6,492,542 | 4.35% |
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| Paradigm Biocapital Advisors LP | 1,272,279 | $59,771,667 | 4.06% |
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| Novo Holdings A/S | 1,090,772 | $51,244,485 | 3.79% |
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| Orbimed Advisors | 2,269,637 | $106,627,546 | 2.26% |
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| Frazier Life Sciences Management, L.P. | 655,000 | $30,771,900 | 2.04% |
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| Perceptive Advisors | 895,641 | $42,077,214 | 1.40% |
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| SPHERA FUNDS MANAGEMENT LTD. | 111,398 | $5,233,478 | 0.95% |
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| Ikarian Capital, LLC | 1,526 | $7,169,148 | 0.86% |
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| Ikarian Capital, LLC | 142,766 | $6,707,146 | 0.81% |
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| Cormorant Asset Management, LP | 225,000 | $10,570,500 | 0.62% |
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| CHI Advisors LLC | 25,000 | $1,174,500 | 0.47% |
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| EAM Investors, LLC | 51,111 | $2,401,195 | 0.46% |
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| Rock Springs Capital Management LP | 363,468 | $17,075,727 | 0.46% |
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| Parkman Healthcare Partners LLC | 52,058 | $2,445,685 | 0.45% |
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| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 430,000 | $20,201,400 | 0.44% |
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