| Eventide Asset Management | 575,438 | $53,884,014 | 0.97% |
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| Artisan Partners Limited Partnership | 5,995,408 | $561,410,005 | 0.95% |
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| BERYLSON CAPITAL PARTNERS, LLC | 2,600 | $243,464 | 0.62% |
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| Values First Advisors, Inc. | 10,235 | $958,412 | 0.62% |
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| Boxer Capital, LLC | 95,000 | $8,895,800 | 0.47% |
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| HARBOR CAPITAL ADVISORS, INC. | 14,135 | $1,323,601 | 0.28% |
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| T. Rowe Price Investment Management, Inc. | 3,984,503 | $373,109 | 0.26% |
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| HighVista Strategies LLC | 5,898 | $552,289 | 0.26% |
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| JANUS HENDERSON GROUP PLC | 3,854,533 | $360,951,709 | 0.24% |
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| Virtus ETF Advisers LLC | 3,368 | $315,380 | 0.19% |
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| Parkwood LLC | 18,097 | $1,695 | 0.18% |
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| FRED ALGER MANAGEMENT, LLC | 270,005 | $25,283,268 | 0.14% |
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| JGP Global Gestao de Recursos Ltda. | 2,305 | $215,840 | 0.14% |
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| TANG CAPITAL MANAGEMENT LLC | 10,000 | $936,400 | 0.13% |
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| DUALITY ADVISERS, LP | 10,683 | $1,000,356 | 0.12% |
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| ADAGE CAPITAL PARTNERS GP, L.L.C. | 526,371 | $49,289,380 | 0.11% |
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| CenterBook Partners LP | 9,524 | $891,827 | 0.11% |
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| PUTNAM INVESTMENTS LLC | 772,362 | $72,323,978 | 0.11% |
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| Verition Fund Management LLC | 87,112 | $8,157,168 | 0.10% |
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| Candriam S.C.A. | 139,375 | $13,051,075 | 0.09% |
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