| RA Capital Management | 11,225,357 | $1,001,863,112 | 18.92% |
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| Q Global Advisors, LLC | 195,000 | $17,404 | 12.55% |
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| Sofinnova Investments, Inc. | 754,032 | $67,297,356 | 4.41% |
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| Avoro Capital Advisors LLC | 3,580,555 | $319,564,534 | 4.34% |
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| Finepoint Capital LP | 139,772 | $12,474,651 | 4.32% |
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| Spyglass Capital Management LLC | 657,853 | $58,713,380 | 4.24% |
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| Saturn V Capital Management LP | 78,442 | $7,000,948 | 3.88% |
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| DAFNA Capital Management LLC | 135,212 | $12,067,671 | 3.30% |
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| ARS Investment Partners, LLC | 289,860 | $25,870,005 | 3.02% |
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| Ghost Tree Capital, LLC | 100,000 | $8,925,000 | 2.95% |
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| Resolute Capital Asset Partners LLC | 37,500 | $3,347 | 2.38% |
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| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,631,712 | $324,130,268 | 2.06% |
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| Evolutionary Tree Capital Management, LLC | 16,947 | $1,512,520 | 1.82% |
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| Affinity Asset Advisors, LLC | 57,760 | $5,155,080 | 1.80% |
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| Matisse Capital | 31,950 | $2,851,538 | 1.77% |
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| Nicholas Investment Partners, LP | 170,609 | $15,226,853 | 1.04% |
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| TimesSquare Capital Management, LLC | 767,427 | $68,493 | 0.98% |
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| Henry James International Management Inc. | 24,495 | $2,186,179 | 0.95% |
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| Rock Springs Capital Management LP | 425,500 | $37,975,875 | 0.90% |
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| Artisan Partners Limited Partnership | 6,222,451 | $555,353,752 | 0.89% |
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