| PFM Health Sciences, LP | 104,732 | $51,489,393 | 2.43% |
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| Sofinnova Investments, Inc. | 78,186 | $38,438,583 | 2.42% |
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| Artisan Partners Limited Partnership | 2,828,299 | $1,390,476,637 | 2.36% |
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| Tri Locum Partners LP | 14,346 | $7,052,924 | 2.26% |
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| Boxer Capital, LLC | 85,000 | $41,788,550 | 2.22% |
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| AWM Investment Company, Inc. | 30,000 | $14,748,900 | 2.18% |
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| Evolutionary Tree Capital Management, LLC | 3,393 | $1,668,101 | 2.15% |
|---|
| Saturn V Capital Management LP | 10,074 | $4,952,681 | 2.07% |
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| Aquilo Capital Management, LLC | 3,715 | $1,826,405 | 1.66% |
|---|
| Avidity Partners Management LP | 80,600 | $39,625,378 | 1.60% |
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| Atika Capital Management LLC | 24,695 | $12,140,803 | 1.59% |
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| Monashee Investment Management LLC | 7,500 | $3,687,225 | 1.54% |
|---|
| ARMISTICE CAPITAL, LLC | 200,000 | $98,326,000 | 1.51% |
|---|
| Privium Fund Management B.V. | 8,208 | $4,035,299 | 1.20% |
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| EFG Asset Management (North America) Corp. | 10,115 | $4,972,888 | 1.18% |
|---|
| Samson Rock Capital LLP | 7,000 | $3,441,410 | 1.11% |
|---|
| ARMISTICE CAPITAL, LLC | 140,000 | $68,828,200 | 1.05% |
|---|
| O'Neil Global Advisors, Inc. | 2,332 | $1,146 | 1.04% |
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| Values First Advisors, Inc. | 3,059 | $1,504,116 | 0.97% |
|---|
| Caption Management, LLC | 124,500 | $61,207,935 | 0.94% |
|---|