| Darwin Global Management, Ltd. | 273,343 | $106,529,967 | 17.42% |
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| Kynam Capital Management, LP | 184,300 | $71,827,239 | 9.88% |
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| Ikarian Capital, LLC | 132,100 | $51,483,333 | 8.20% |
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| Avoro Capital Advisors LLC | 1,263,500 | $492,423,855 | 6.68% |
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| Artia Global Partners LP | 46,438 | $18,098,282 | 6.24% |
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| DCF Advisers, LLC | 25,700 | $10,016,061 | 5.29% |
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| Bellevue Group AG | 923,284 | $359,831,473 | 5.13% |
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| Eagle Health Investments LP | 64,400 | $25,098,612 | 4.69% |
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| Paradigm Biocapital Advisors LP | 150,000 | $58,459,500 | 4.52% |
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| Paradigm Biocapital Advisors LP | 142,259 | $55,442,600 | 4.28% |
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| Fairmount Funds Management LLC | 73,526 | $28,655,288 | 4.04% |
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| RTW INVESTMENTS, LP | 482,195 | $187,925,857 | 3.58% |
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| Aquilo Capital Management, LLC | 16,315 | $6,358,445 | 3.52% |
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| Decheng Capital Management III (Cayman), LLC | 27,429 | $10,689,904 | 3.35% |
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| ACUTA CAPITAL PARTNERS, LLC | 12,568 | $4,898,127 | 3.32% |
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| Rock Springs Capital Management LP | 350,000 | $136,405,500 | 3.24% |
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| Nicholas Investment Partners, LP | 95,414 | $37,185,698 | 2.54% |
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| Avidity Partners Management LP | 184,300 | $71,827,239 | 2.51% |
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| AWM Investment Company, Inc. | 45,000 | $17,537,850 | 2.38% |
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| Ikarian Capital, LLC | 38,000 | $14,809,740 | 2.36% |
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