EcoR1 Capital, LLC Activity Q4 2014-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
APLS	Buy	APELLIS PHARMACEUTICALS INC	$414,630,636	-16.5%	10,899,859	+99.9%	13.99%	+14.9%
MRTX	New	MIRATI THERAPEUTICS INC	$250,400,260	–	5,748,399	–	8.45%	–
RVMD	Sell	REVOLUTION MEDICINES INC	$154,395,248	-19.8%	5,577,863	-22.5%	5.21%	+10.4%
ARVN	Buy	ARVINAS INC	$107,373,117	+7.7%	5,467,063	+36.1%	3.62%	+48.3%
	Buy	TANGO THERAPEUTICS INC	$98,205,621	+630.9%	8,721,636	+115.5%	3.31%	+907.0%
CRNX	Buy	CRINETICS PHARMACEUTICALS IN	$45,510,022	+89.9%	1,530,263	+15.0%	1.54%	+161.5%
MORF	Sell	MORPHIC HLDG INC	$33,911,153	-84.6%	1,480,190	-61.5%	1.14%	-78.8%
	New	NEUMORA THERAPEUTICS INC.	$29,228,160	–	2,071,450	–	0.99%	–
APLS	New	APELLIS PHARMACEUTICALS INCcall	$27,864,300	–	732,500	–	0.94%	–
NUVB	Buy	NUVATION BIO INC	$25,740,922	+2.9%	19,209,643	+38.2%	0.87%	+41.6%
MRSN	New	MERSANA THERAPEUTICS INC	$24,593,154	–	19,364,688	–	0.83%	–
	Buy	THIRD HARMONIC BIO INC	$19,057,817	+89.7%	2,982,444	+42.8%	0.64%	+161.4%
	New	ACELYRIN INC	$14,260,384	–	1,402,201	–	0.48%	–
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$12,630,960	–	993,000	–	0.43%	–
GOSS	New	GOSSAMER BIO INC	$7,657,932	–	9,195,404	–	0.26%	–
	New	AEGLEA BIOTHERAPEUTICS INC	$2,449,951	–	199,996	–	0.08%	–
RVMD	New	REVOLUTION MEDICINES INCcall	$866,384	–	31,300	–	0.03%	–
TPST	Sell	TEMPEST THERAPEUTICS INC	$283,676	-80.1%	931,000	-17.1%	0.01%	-71.4%
KRON	Exit	KRONOS BIO INC	$0	–	-326,780	–	-0.01%	–
PSTX	Exit	POSEIDA THERAPEUTICS INC	$0	–	-676,296	–	-0.03%	–
FDMT	Exit	4D MOLECULAR THERAPEUTICS IN	$0	–	-66,978	–	-0.03%	–
AGLE	Exit	AEGLEA BIOTHERAPEUTICS INC	$0	–	-5,000,000	–	-0.06%	–
KURA	Exit	KURA ONCOLOGY INCcall	$0	–	-500,000	–	-0.13%	–
JANX	Exit	JANUX THERAPEUTICS INC	$0	–	-452,590	–	-0.13%	–
ZNTL	Exit	ZENTALIS PHARMACEUTICALS INC	$0	–	-300,000	–	-0.21%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-798,701	–	-0.22%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-1,798,300	–	-2.78%	–
JNJ	Exit	JOHNSON & JOHNSONcall	$0	–	-1,700,000	–	-6.89%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-3,660,798	–	-10.27%	–

Q2 2023

			Value		Shares		↓ Weighting
PRTA	New	PROTHENA CORP PLC	$790,974,638	–	11,584,280	–	19.38%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$496,645,042	–	5,451,647	–	12.17%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$419,234,587	–	3,660,798	–	10.27%	–
JNJ	New	JOHNSON & JOHNSONcall	$281,384,000	–	1,700,000	–	6.89%	–
GLPG	New	GALAPAGOS NVspon adr	$234,049,857	–	5,756,268	–	5.73%	–
MORF	New	MORPHIC HLDG INC	$220,546,446	–	3,846,964	–	5.40%	–
RVMD	New	REVOLUTION MEDICINES INC	$192,565,225	–	7,198,700	–	4.72%	–
ANAB	New	ANAPTYSBIO INC	$152,977,628	–	7,521,024	–	3.75%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$143,495,922	–	5,991,479	–	3.52%	–
XNCR	New	XENCOR INC	$131,904,425	–	5,282,516	–	3.23%	–
	New	ZYMEWORKS INC	$116,099,767	–	13,437,473	–	2.84%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$113,652,560	–	1,798,300	–	2.78%	–
ARVN	New	ARVINAS INC	$99,721,498	–	4,017,788	–	2.44%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$90,726,654	–	3,460,208	–	2.22%	–
KURA	New	KURA ONCOLOGY INC	$61,436,695	–	5,806,871	–	1.50%	–
RLAY	New	RELAY THERAPEUTICS INC	$52,297,629	–	4,163,824	–	1.28%	–
JAZZ	New	JAZZ PHARMACEUTICALS PLC	$45,671,912	–	368,411	–	1.12%	–
VYGR	New	VOYAGER THERAPEUTICS INC	$44,099,755	–	3,851,507	–	1.08%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$34,780,242	–	5,618,779	–	0.85%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$27,072,254	–	3,493,194	–	0.66%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$26,524,208	–	3,418,068	–	0.65%	–
AVIR	New	ATEA PHARMACEUTICALS INC	$26,164,520	–	6,995,861	–	0.64%	–
NUVB	New	NUVATION BIO INC	$25,013,777	–	13,896,543	–	0.61%	–
ALEC	New	ALECTOR INC	$24,379,853	–	4,056,548	–	0.60%	–
CRNX	New	CRINETICS PHARMACEUTICALS IN	$23,971,339	–	1,330,263	–	0.59%	–
ALLO	New	ALLOGENE THERAPEUTICS INC	$22,306,354	–	4,488,200	–	0.55%	–
GRPH	New	GRAPHITE BIO INC	$22,199,960	–	8,538,446	–	0.54%	–
OVID	New	OVID THERAPEUTICS INC	$20,065,072	–	6,117,400	–	0.49%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$16,667,992	–	6,435,518	–	0.41%	–
	New	TANGO THERAPEUTICS INC	$13,436,418	–	4,047,114	–	0.33%	–
	New	TSCAN THERAPEUTICS INC	$12,500,000	–	5,000,000	–	0.31%	–
GBIO	New	GENERATION BIO CO	$11,257,769	–	2,046,867	–	0.28%	–
PHAT	New	PHATHOM PHARMACEUTICALS INC	$10,024,000	–	700,000	–	0.25%	–
	New	THIRD HARMONIC BIO INC	$10,047,032	–	2,088,780	–	0.25%	–
DYN	New	DYNE THERAPEUTICS INC	$8,985,386	–	798,701	–	0.22%	–
	New	PRIME MEDICINE INC	$8,790,000	–	600,000	–	0.22%	–
ZNTL	New	ZENTALIS PHARMACEUTICALS INC	$8,463,000	–	300,000	–	0.21%	–
JANX	New	JANUX THERAPEUTICS INC	$5,372,243	–	452,590	–	0.13%	–
KURA	New	KURA ONCOLOGY INCcall	$5,290,000	–	500,000	–	0.13%	–
PRLD	New	PRELUDE THERAPEUTICS INC	$5,208,534	–	1,157,452	–	0.13%	–
PRQR	New	PROQR THRAPEUTICS N V	$4,827,626	–	2,980,016	–	0.12%	–
HOOK	New	HOOKIPA PHARMA INC	$4,043,621	–	4,595,024	–	0.10%	–
ALGS	New	ALIGOS THERAPEUTICS INC	$3,833,858	–	3,948,360	–	0.09%	–
ALLK	New	ALLAKOS INC	$3,265,204	–	748,900	–	0.08%	–
AGLE	New	AEGLEA BIOTHERAPEUTICS INC	$2,252,500	–	5,000,000	–	0.06%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/202	$1,733,999	–	963,333	–	0.04%	–
TPST	New	TEMPEST THERAPEUTICS INC	$1,426,761	–	1,123,434	–	0.04%	–
FDMT	New	4D MOLECULAR THERAPEUTICS IN	$1,210,292	–	66,978	–	0.03%	–
PSTX	New	POSEIDA THERAPEUTICS INC	$1,190,281	–	676,296	–	0.03%	–
	New	NEWAMSTERDAM PHARMA COMPANY*w exp 11/22/202	$792,647	–	66,665	–	0.02%	–
KRON	New	KRONOS BIO INC	$562,062	–	326,780	–	0.01%	–
CMAXW	New	CAREMAX INC*w exp 06/08/202	$311,000	–	100,000	–	0.01%	–
	New	SURROZEN INC*w exp 08/01/203	$36,666	–	66,665	–	0.00%	–

Q4 2022

			Value		Shares		↓ Weighting
	Exit	SURROZEN INC*w exp 08/01/203	$0	–	-66,665	–	-0.00%	–
TMPMW	Exit	TURMERIC ACQUISITION CORP*w exp 10/08/202	$0	–	-33,333	–	-0.01%	–
OMEG	Exit	OMEGA ALPHA SPACcl a	$0	–	-50,000	–	-0.02%	–
EUCRW	Exit	EUCRATES BIOMEDICAL ACQU COR*w exp 10/23/202	$0	–	-66,666	–	-0.02%	–
FLACW	Exit	FRAZIER LIFESCIENCES ACQU CO*w exp 11/30/202	$0	–	-66,665	–	-0.02%	–
CMAXW	Exit	CAREMAX INC*w exp 06/08/202	$0	–	-100,000	–	-0.02%	–
	Exit	NUVALENT INC	$0	–	-40,970	–	-0.02%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-40,480	–	-0.02%	–
RETA	Exit	REATA PHARMACEUTICALS INCcl a	$0	–	-38,467	–	-0.03%	–
TMPM	Exit	TURMERIC ACQUISITION CORPcl a	$0	–	-100,000	–	-0.03%	–
DSGN	Exit	DESIGN THERAPEUTICS INCcall	$0	–	-63,400	–	-0.03%	–
KRON	Exit	KRONOS BIO INC	$0	–	-326,780	–	-0.03%	–
ARYD	Exit	ARYA SCIENCES ACQU CORP IVcl a	$0	–	-150,000	–	-0.04%	–
TPST	Exit	TEMPEST THERAPEUTICS INC	$0	–	-1,031,268	–	-0.05%	–
EUCR	Exit	EUCRATES BIOMEDICAL ACQU COR	$0	–	-200,000	–	-0.06%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-200,000	–	-0.06%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-200,000	–	-0.06%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-175,000	–	-0.06%	–
NUVBWS	Exit	NUVATION BIO INC*w exp 07/07/202	$0	–	-963,333	–	-0.06%	–
ASND	Exit	ASCENDIS PHARMA A/Ssponsored adr	$0	–	-27,208	–	-0.08%	–
MGNX	Exit	MACROGENICS INC	$0	–	-930,955	–	-0.10%	–
PRAX	Exit	PRAXIS PRECISION MEDICINES I	$0	–	-1,496,324	–	-0.10%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-400,000	–	-0.12%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-3,924,713	–	-0.12%	–
ALGS	Exit	ALIGOS THERAPEUTICS INC	$0	–	-3,948,360	–	-0.13%	–
FLAC	Exit	FRAZIER LIFESCIENCES ACQU CO	$0	–	-487,615	–	-0.14%	–
JYAC	Exit	JIYA ACQUISITION CORP	$0	–	-500,000	–	-0.15%	–
GRPH	Exit	GRAPHITE BIO INC	$0	–	-1,582,135	–	-0.15%	–
	Exit	ERASCA INC	$0	–	-678,441	–	-0.16%	–
AVEO	Exit	AVEO PHARMACEUTICALS INC	$0	–	-650,489	–	-0.16%	–
GERN	Exit	GERON CORP	$0	–	-2,301,980	–	-0.16%	–
SELB	Exit	SELECTA BIOSCIENCES INC	$0	–	-3,500,000	–	-0.17%	–
GRCL	Exit	GRACELL BIOTECHNOLOGIES INCsponsored ads	$0	–	-1,921,310	–	-0.18%	–
ARGX	Exit	ARGENX SEsponsored adr	$0	–	-17,527	–	-0.18%	–
DTIL	Exit	PRECISION BIOSCIENCES INC	$0	–	-5,035,971	–	-0.19%	–
HOOK	Exit	HOOKIPA PHARMA INC	$0	–	-5,000,000	–	-0.20%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-541,108	–	-0.21%	–
ARQT	Exit	ARCUTIS BIOTHERAPEUTICS INC	$0	–	-415,322	–	-0.23%	–
PSTX	Exit	POSEIDA THERAPEUTICS INC	$0	–	-2,650,000	–	-0.28%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-3,418,068	–	-0.32%	–
OVID	Exit	OVID THERAPEUTICS INC	$0	–	-6,117,400	–	-0.33%	–
CNTA	Exit	CENTESSA PHARMACEUTICALS PLCsponsored ads	$0	–	-3,236,352	–	-0.38%	–
AKUS	Exit	AKOUOS INC	$0	–	-1,975,984	–	-0.39%	–
KDNY	Exit	CHINOOK THERAPEUTICS INC	$0	–	-690,000	–	-0.40%	–
	Exit	VENTYX BIOSCIENCES INC	$0	–	-400,000	–	-0.41%	–
CGEM	Exit	CULLINAN ONCOLOGY INC	$0	–	-1,143,218	–	-0.43%	–
	Exit	TANGO THERAPEUTICS INC	$0	–	-4,201,414	–	-0.45%	–
KYMR	Exit	KYMERA THERAPEUTICS INC	$0	–	-796,093	–	-0.51%	–
JANX	Exit	JANUX THERAPEUTICS INC	$0	–	-1,421,319	–	-0.57%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS IN	$0	–	-1,330,263	–	-0.77%	–
VYGR	Exit	VOYAGER THERAPEUTICS INC	$0	–	-4,753,907	–	-0.83%	–
NUVB	Exit	NUVATION BIO INC	$0	–	-13,896,543	–	-0.92%	–
	Exit	2SEVENTY BIO INC	$0	–	-2,341,313	–	-1.00%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-3,493,194	–	-1.02%	–
AVIR	Exit	ATEA PHARMACEUTICALS INC	$0	–	-6,184,861	–	-1.04%	–
RVMD	Exit	REVOLUTION MEDICINES INC	$0	–	-1,801,847	–	-1.05%	–
ALEC	Exit	ALECTOR INC	$0	–	-4,056,548	–	-1.13%	–
SGEN	Exit	SEAGEN INC	$0	–	-285,793	–	-1.15%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-2,519,268	–	-1.24%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,899,285	–	-1.40%	–
ALLO	Exit	ALLOGENE THERAPEUTICS INC	$0	–	-4,488,200	–	-1.43%	–
GOSS	Exit	GOSSAMER BIO INC	$0	–	-4,160,887	–	-1.47%	–
ZLAB	Exit	ZAI LAB LTDadr	$0	–	-2,030,252	–	-2.05%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-1,015,572	–	-2.09%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-6,638,371	–	-2.68%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-4,163,824	–	-2.75%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-5,991,479	–	-2.89%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-3,460,208	–	-2.91%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-3,951,566	–	-3.30%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-3,197,500	–	-4.02%	–
XNCR	Exit	XENCOR INC	$0	–	-5,282,516	–	-4.05%	–
ARVN	Exit	ARVINAS INC	$0	–	-3,123,300	–	-4.10%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-7,521,024	–	-5.66%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-2,999,453	–	-9.79%	–
APLS	Exit	APELLIS PHARMACEUTICALS INC	$0	–	-5,183,431	–	-10.45%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-11,584,280	–	-20.73%	–

Q3 2022

			Value		Shares		↓ Weighting
SRPT	Buy	SAREPTA THERAPEUTICS INC	$331,560,000	+54.2%	2,999,453	+4.6%	9.79%	+31.9%
XNCR	Buy	XENCOR INC	$137,240,000	-5.1%	5,282,516	+0.0%	4.05%	-18.8%
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$98,720,000	–	3,460,208	–	2.91%	–
RLAY	Buy	RELAY THERAPEUTICS INC	$93,145,000	+49.3%	4,163,824	+11.8%	2.75%	+27.7%
MRTX	New	MIRATI THERAPEUTICS INC	$70,928,000	–	1,015,572	–	2.09%	–
ZLAB	Sell	ZAI LAB LTDadr	$69,435,000	-17.7%	2,030,252	-16.5%	2.05%	-29.6%
GOSS	New	GOSSAMER BIO INC	$49,847,000	–	4,160,887	–	1.47%	–
RNA	Buy	AVIDITY BIOSCIENCES INC	$47,345,000	+18.1%	2,899,285	+5.1%	1.40%	+0.9%
DSGN	Sell	DESIGN THERAPEUTICS INC	$42,122,000	+14.2%	2,519,268	-4.4%	1.24%	-2.4%
SGEN	Sell	SEAGEN INC	$39,105,000	-78.1%	285,793	-71.7%	1.15%	-81.3%
RVMD	Sell	REVOLUTION MEDICINES INC	$35,532,000	-57.4%	1,801,847	-57.9%	1.05%	-63.6%
AVIR	Sell	ATEA PHARMACEUTICALS INC	$35,192,000	-21.8%	6,184,861	-2.5%	1.04%	-33.1%
EWTX	Buy	EDGEWISE THERAPEUTICS INC	$34,373,000	+83.0%	3,493,194	+48.0%	1.02%	+56.6%
	Sell	2SEVENTY BIO INC	$34,066,000	-26.2%	2,341,313	-33.0%	1.00%	-36.9%
KYMR	New	KYMERA THERAPEUTICS INC	$17,331,000	–	796,093	–	0.51%	–
	Buy	TANGO THERAPEUTICS INC	$15,209,000	+45.8%	4,201,414	+82.5%	0.45%	+24.7%
CGEM	Sell	CULLINAN ONCOLOGY INC	$14,656,000	-2.3%	1,143,218	-2.3%	0.43%	-16.4%
	Sell	VENTYX BIOSCIENCES INC	$13,964,000	-12.2%	400,000	-69.2%	0.41%	-25.0%
CNTA	Buy	CENTESSA PHARMACEUTICALS PLCsponsored ads	$13,010,000	+813.6%	3,236,352	+1007.1%	0.38%	+683.7%
PSTX	New	POSEIDA THERAPEUTICS INC	$9,355,000	–	2,650,000	–	0.28%	–
ARQT	Sell	ARCUTIS BIOTHERAPEUTICS INC	$7,937,000	-58.4%	415,322	-53.6%	0.23%	-64.5%
ARGX	Sell	ARGENX SEsponsored adr	$6,188,000	-86.9%	17,527	-86.0%	0.18%	-88.8%
GERN	Sell	GERON CORP	$5,387,000	-75.5%	2,301,980	-83.8%	0.16%	-79.0%
AVEO	Buy	AVEO PHARMACEUTICALS INC	$5,354,000	+26.0%	650,489	+0.5%	0.16%	+7.5%
GRPH	Buy	GRAPHITE BIO INC	$5,015,000	+56.9%	1,582,135	+36.1%	0.15%	+34.5%
FLAC	Sell	FRAZIER LIFESCIENCES ACQU CO	$4,862,000	-16.2%	487,615	-17.0%	0.14%	-28.0%
SURF	Sell	SURFACE ONCOLOGY INC	$4,082,000	-46.5%	3,924,713	-15.7%	0.12%	-54.4%
PRAX	Buy	PRAXIS PRECISION MEDICINES I	$3,397,000	+559.6%	1,496,324	+612.2%	0.10%	+455.6%
MGNX	New	MACROGENICS INC	$3,221,000	–	930,955	–	0.10%	–
ASND	New	ASCENDIS PHARMA A/Ssponsored adr	$2,809,000	–	27,208	–	0.08%	–
DSGN	New	DESIGN THERAPEUTICS INCcall	$1,060,000	–	63,400	–	0.03%	–
RETA	Sell	REATA PHARMACEUTICALS INCcl a	$967,000	-98.4%	38,467	-98.1%	0.03%	-98.6%
	New	NUVALENT INC	$796,000	–	40,970	–	0.02%	–
ITOS	Sell	ITEOS THERAPEUTICS INC	$771,000	-86.6%	40,480	-85.5%	0.02%	-88.4%
BOLT	Exit	BOLT BIOTHERAPEUTICS INC	$0	–	-150,000	–	-0.01%	–
EVLO	Exit	EVELO BIOSCIENCES INC	$0	–	-200,417	–	-0.02%	–
	Exit	PARDES BIOSCIENCES INC	$0	–	-200,000	–	-0.02%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-1,046,700	–	-0.04%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-310,960	–	-0.05%	–
OLMA	Exit	OLEMA PHARMACEUTICALS INC	$0	–	-353,701	–	-0.05%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-215,000	–	-0.05%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-98,593	–	-0.05%	–
SBTX	Exit	SILVERBACK THERAPEUTICS INC	$0	–	-575,359	–	-0.08%	–
CLDX	Exit	CELLDEX THERAPEUTICS INC NEWput	$0	–	-115,200	–	-0.11%	–
INCY	Exit	INCYTE CORP	$0	–	-182,783	–	-0.48%	–
EXEL	Exit	EXELIXIS INCcall	$0	–	-760,000	–	-0.55%	–
CERE	Exit	CEREVEL THERAPEUTICS HLDNG I	$0	–	-1,646,260	–	-1.50%	–

Q2 2022

			Value		Shares		↓ Weighting
PRTA	New	PROTHENA CORP PLC	$314,513,000	–	11,584,280	–	10.86%	–
APLS	New	APELLIS PHARMACEUTICALS INC	$234,395,000	–	5,183,431	–	8.09%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$214,996,000	–	2,868,145	–	7.42%	–
SGEN	New	SEAGEN INC	$178,467,000	–	1,008,628	–	6.16%	–
GLPG	New	GALAPAGOS NVspon adr	$178,420,000	–	3,197,500	–	6.16%	–
ANAB	New	ANAPTYSBIO INC	$152,677,000	–	7,521,024	–	5.27%	–
XNCR	New	XENCOR INC	$144,580,000	–	5,282,416	–	4.99%	–
ARVN	New	ARVINAS INC	$131,460,000	–	3,123,300	–	4.54%	–
KURA	New	KURA ONCOLOGY INC	$121,681,000	–	6,638,371	–	4.20%	–
MORF	New	MORPHIC HLDG INC	$85,749,000	–	3,951,566	–	2.96%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$84,420,000	–	5,991,479	–	2.91%	–
ZLAB	New	ZAI LAB LTadr	$84,338,000	–	2,431,885	–	2.91%	–
RVMD	New	REVOLUTION MEDICINES INC	$83,380,000	–	4,278,069	–	2.88%	–
RLAY	New	RELAY THERAPEUTICS INC	$62,369,000	–	3,723,541	–	2.15%	–
RETA	New	REATA PHARMACEUTICALS INCcl a	$60,039,000	–	1,975,611	–	2.07%	–
ALLO	New	ALLOGENE THERAPEUTICS INC	$51,165,000	–	4,488,200	–	1.77%	–
ARGX	New	ARGENX SEsponsored adr	$47,360,000	–	125,000	–	1.64%	–
	New	2SEVENTY BIO INC	$46,146,000	–	3,495,943	–	1.59%	–
AVIR	New	ATEA PHARMACEUTICALS INC	$45,019,000	–	6,340,639	–	1.55%	–
NUVB	New	NUVATION BIO INC	$45,025,000	–	13,896,543	–	1.55%	–
CERE	New	CEREVEL THERAPEUTICS HLDNG I	$43,527,000	–	1,646,260	–	1.50%	–
ALEC	New	ALECTOR INC	$41,215,000	–	4,056,548	–	1.42%	–
RNA	New	AVIDITY BIOSCIENCES INC	$40,096,000	–	2,759,505	–	1.38%	–
DSGN	New	DESIGN THERAPEUTICS INC	$36,878,000	–	2,634,178	–	1.27%	–
VYGR	New	VOYAGER THERAPEUTICS INC	$28,096,000	–	4,753,907	–	0.97%	–
CRNX	New	CRINETICS PHARMACEUTICALS IN	$24,809,000	–	1,330,263	–	0.86%	–
GERN	New	GERON CORP	$21,962,000	–	14,168,988	–	0.76%	–
ARQT	New	ARCUTIS BIOTHERAPEUTICS INC	$19,083,000	–	895,503	–	0.66%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$18,784,000	–	2,359,808	–	0.65%	–
JANX	New	JANUX THERAPEUTICS INC	$17,354,000	–	1,421,319	–	0.60%	–
	New	VENTYX BIOSCIENCES INC	$15,899,000	–	1,300,000	–	0.55%	–
EXEL	New	EXELIXIS INCcall	$15,823,000	–	760,000	–	0.55%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$15,313,000	–	3,418,068	–	0.53%	–
CGEM	New	CULLINAN ONCOLOGY INC	$14,998,000	–	1,169,889	–	0.52%	–
INCY	New	INCYTE CORP	$13,886,000	–	182,783	–	0.48%	–
OVID	New	OVID THERAPEUTICS INC	$13,152,000	–	6,117,400	–	0.45%	–
KDNY	New	CHINOOK THERAPEUTICS INC	$12,068,000	–	690,000	–	0.42%	–
GRCL	New	GRACELL BIOTECHNOLOGIES INCsponsored ads	$10,567,000	–	1,921,310	–	0.36%	–
	New	TANGO THERAPEUTICS INC	$10,428,000	–	2,302,065	–	0.36%	–
AKUS	New	AKOUOS INC	$9,267,000	–	1,975,984	–	0.32%	–
HOOK	New	HOOKIPA PHARMA INC	$8,150,000	–	5,000,000	–	0.28%	–
DTIL	New	PRECISION BIOSCIENCES INC	$8,058,000	–	5,035,971	–	0.28%	–
SURF	New	SURFACE ONCOLOGY INC	$7,631,000	–	4,653,000	–	0.26%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$6,937,000	–	541,108	–	0.24%	–
FLAC	New	FRAZIER LIFESCIENCES ACQU CO	$5,800,000	–	587,615	–	0.20%	–
ITOS	New	ITEOS THERAPEUTICS INC	$5,768,000	–	279,999	–	0.20%	–
JYAC	New	JIYA ACQUISITION CORP	$4,940,000	–	500,000	–	0.17%	–
ALGS	New	ALIGOS THERAPEUTICS INC	$4,778,000	–	3,948,360	–	0.16%	–
SELB	New	SELECTA BIOSCIENCES INC	$4,585,000	–	3,500,000	–	0.16%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$4,248,000	–	647,489	–	0.15%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$3,984,000	–	400,000	–	0.14%	–
	New	ERASCA INC	$3,779,000	–	678,441	–	0.13%	–
GRPH	New	GRAPHITE BIO INC	$3,196,000	–	1,162,179	–	0.11%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/202	$3,121,000	–	963,333	–	0.11%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEWput	$3,106,000	–	115,200	–	0.11%	–
SBTX	New	SILVERBACK THERAPEUTICS INC	$2,440,000	–	575,359	–	0.08%	–
TPST	New	TEMPEST THERAPEUTICS INC	$2,217,000	–	1,031,268	–	0.08%	–
KNTE	New	KINNATE BIOPHARMA INC	$2,207,000	–	175,000	–	0.08%	–
BLSA	New	BCLS ACQUISITION CORP	$1,980,000	–	200,000	–	0.07%	–
EUCR	New	EUCRATES BIOMEDICAL ACQU COR	$1,980,000	–	200,000	–	0.07%	–
FVAM	New	5 01 ACQUISITION CORP	$1,980,000	–	200,000	–	0.07%	–
VERV	New	VERVE THERAPEUTICS INC	$1,507,000	–	98,593	–	0.05%	–
ARYD	New	ARYA SCIENCES ACQU CORP IVcl a	$1,472,000	–	150,000	–	0.05%	–
DYN	New	DYNE THERAPEUTICS INC	$1,477,000	–	215,000	–	0.05%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,437,000	–	310,960	–	0.05%	–
OLMA	New	OLEMA PHARMACEUTICALS INC	$1,440,000	–	353,701	–	0.05%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$1,424,000	–	292,320	–	0.05%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$1,256,000	–	1,046,700	–	0.04%	–
KRON	New	KRONOS BIO INC	$1,189,000	–	326,780	–	0.04%	–
TMPM	New	TURMERIC ACQUISITION CORPcl a	$993,000	–	100,000	–	0.03%	–
EUCRW	New	EUCRATES BIOMEDICAL ACQU COR*w exp 10/23/202	$660,000	–	66,666	–	0.02%	–
FLACW	New	FRAZIER LIFESCIENCES ACQU CO*w exp 11/30/202	$658,000	–	66,665	–	0.02%	–
	New	PARDES BIOSCIENCES INC	$614,000	–	200,000	–	0.02%	–
PRAX	New	PRAXIS PRECISION MEDICINES I	$515,000	–	210,100	–	0.02%	–
OMEG	New	OMEGA ALPHA SPACcl a	$493,000	–	50,000	–	0.02%	–
EVLO	New	EVELO BIOSCIENCES INC	$423,000	–	200,417	–	0.02%	–
CMAXW	New	CAREMAX INC*w exp 06/08/202	$363,000	–	100,000	–	0.01%	–
BOLT	New	BOLT BIOTHERAPEUTICS INC	$306,000	–	150,000	–	0.01%	–
TMPMW	New	TURMERIC ACQUISITION CORP*w exp 10/08/202	$331,000	–	33,333	–	0.01%	–
	New	SURROZEN INC*w exp 08/01/203	$200,000	–	66,665	–	0.01%	–

Q4 2021

			Value		Shares		↓ Weighting
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-7,001	–	-0.00%	–
SRRK	Exit	SCHOLAR ROCK HLDG CORP	$0	–	-8,208	–	-0.01%	–
TMPMW	Exit	TURMERIC ACQUISITION CORP*w exp 10/08/202	$0	–	-33,333	–	-0.01%	–
	Exit	SURROZEN INC*w exp 10/28/2025	$0	–	-66,665	–	-0.02%	–
OMEG	Exit	OMEGA ALPHA SPACcl a	$0	–	-50,000	–	-0.02%	–
EUCRW	Exit	EUCRATES BIOMEDICAL ACQU COR*w exp 10/23/202	$0	–	-66,666	–	-0.02%	–
FLACW	Exit	FRAZIER LIFESCIENCES ACQU CO*w exp 11/30/202	$0	–	-66,665	–	-0.02%	–
CMAXW	Exit	CAREMAX INC*w exp 06/08/202	$0	–	-100,000	–	-0.03%	–
TMPM	Exit	TURMERIC ACQUISITION CORPcl a	$0	–	-100,000	–	-0.03%	–
VYGR	Exit	VOYAGER THERAPEUTICS INC	$0	–	-445,992	–	-0.04%	–
MGTX	Exit	MEIRAGTX HLDGS PLC	$0	–	-94,819	–	-0.04%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-50,000	–	-0.04%	–
BCAB	Exit	BIOATLA INC	$0	–	-50,000	–	-0.05%	–
ARYD	Exit	ARYA SCIENCES ACQU CORP IVcl a	$0	–	-150,000	–	-0.05%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-50,000	–	-0.05%	–
	Exit	CARIBOU BIOSCIENCES INC	$0	–	-75,000	–	-0.06%	–
BOLT	Exit	BOLT BIOTHERAPEUTICS INC	$0	–	-150,000	–	-0.06%	–
FVAM	Exit	5 01 ACQUISITION CORP	$0	–	-200,000	–	-0.07%	–
EUCR	Exit	EUCRATES BIOMEDICAL ACQU COR	$0	–	-200,000	–	-0.07%	–
BLSA	Exit	BCLS ACQUISITION CORP	$0	–	-200,000	–	-0.07%	–
HLXA	Exit	HELIX ACQUISITION CORP	$0	–	-200,000	–	-0.07%	–
FMTX	Exit	FORMA THERAPEUTICS HLDGS INC	$0	–	-90,141	–	-0.07%	–
IGMS	Exit	IGM BIOSCIENCES INC	$0	–	-38,030	–	-0.09%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-215,000	–	-0.12%	–
FSII	Exit	FS DEVELOPMENT CORP II	$0	–	-371,014	–	-0.13%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2 ORD	$0	–	-400,000	–	-0.14%	–
KNTE	Exit	KINNATE BIOPHARMA INC	$0	–	-175,000	–	-0.14%	–
VERV	Exit	VERVE THERAPEUTICS INC	$0	–	-100,000	–	-0.16%	–
JYAC	Exit	JIYA ACQUISITION CORP	$0	–	-500,000	–	-0.17%	–
CYCN	Exit	CYCLERION THERAPEUTICS INC	$0	–	-1,606,276	–	-0.17%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INCcall	$0	–	-245,000	–	-0.17%	–
ACIU	Exit	AC IMMUNE SA	$0	–	-751,251	–	-0.18%	–
FLAC	Exit	FRAZIER LIFESCIENCES ACQU CO	$0	–	-587,615	–	-0.20%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS INC	$0	–	-860,619	–	-0.22%	–
KRON	Exit	KRONOS BIO INC	$0	–	-387,357	–	-0.28%	–
CCCC	Exit	C4 THERAPEUTICS INC	$0	–	-200,000	–	-0.31%	–
NUVBWS	Exit	NUVATION BIO INC*w exp 07/07/202	$0	–	-963,333	–	-0.33%	–
IMVT	Exit	IMMUNOVANT INC	$0	–	-1,140,819	–	-0.34%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-2,081,077	–	-0.35%	–
ODT	Exit	ODONATE THERAPEUTICS INC	$0	–	-3,727,261	–	-0.38%	–
SBTX	Exit	SILVERBACK THERAPEUTICS INC	$0	–	-1,184,710	–	-0.41%	–
CNTA	Exit	CENTESSA PHARMACEUTICALS PLCsponsored ads	$0	–	-754,545	–	-0.44%	–
	Exit	ERASCA INC	$0	–	-700,000	–	-0.52%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-802,507	–	-0.53%	–
	Exit	TANGO THERAPEUTICS INC	$0	–	-1,300,000	–	-0.58%	–
OVID	Exit	OVID THERAPEUTICS INC	$0	–	-6,082,200	–	-0.71%	–
EWTX	Exit	EDGEWISE THERAPEUTICS INC	$0	–	-1,279,175	–	-0.74%	–
SLDB	Exit	SOLID BIOSCIENCES INC	$0	–	-9,202,702	–	-0.76%	–
AKUS	Exit	AKOUOS INC	$0	–	-1,975,984	–	-0.80%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-1,249,812	–	-0.88%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-1,443,800	–	-0.89%	–
BPMC	Exit	BLUEPRINT MEDICINES CORPcall	$0	–	-250,000	–	-0.90%	–
DSGN	Exit	DESIGN THERAPEUTICS INC	$0	–	-1,863,098	–	-0.95%	–
JANX	Exit	JANUX THERAPEUTICS INC	$0	–	-1,411,975	–	-1.06%	–
NRIX	Exit	NURIX THERAPEUTICS INC	$0	–	-1,126,640	–	-1.17%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-1,303,157	–	-1.22%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-1,385,276	–	-1.52%	–
GRTS	Exit	GRITSTONE BIO INC	$0	–	-5,560,748	–	-2.09%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,759,505	–	-2.36%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-3,724,437	–	-2.43%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-3,468,944	–	-2.52%	–
STTK	Exit	SHATTUCK LABS INC	$0	–	-3,709,072	–	-2.63%	–
GLPG	Exit	GALAPAGOS NVspon adr	$0	–	-1,558,749	–	-2.85%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-464,298	–	-2.86%	–
ALEC	Exit	ALECTOR INC	$0	–	-4,994,970	–	-3.96%	–
NUVB	Exit	NUVATION BIO INC	$0	–	-13,711,517	–	-4.74%	–
XNCR	Exit	XENCOR INC	$0	–	-4,906,106	–	-5.57%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-5,122,359	–	-6.21%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-7,521,024	–	-7.10%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-3,951,566	–	-7.79%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-11,284,280	–	-27.96%	–

Q3 2021

			Value		Shares		↓ Weighting
RCUS	Buy	ARCUS BIOSCIENCES INC	$178,617,000	+95.0%	5,122,359	+53.6%	6.21%	+81.5%
ALEC	Buy	ALECTOR INC	$113,985,000	+29.0%	4,994,970	+17.7%	3.96%	+20.0%
GLPG	New	GALAPAGOS NVspon adr	$82,006,000	–	1,558,749	–	2.85%	–
STTK	Buy	SHATTUCK LABS INC	$75,591,000	-21.4%	3,709,072	+11.8%	2.63%	-26.8%
ORIC	Buy	ORIC PHARMACEUTICALS INC	$72,536,000	+32.6%	3,468,944	+12.2%	2.52%	+23.4%
RNA	Buy	AVIDITY BIOSCIENCES INC	$67,967,000	+30.7%	2,759,505	+31.2%	2.36%	+21.7%
GRTS	Buy	GRITSTONE BIO INC	$60,056,000	+92.3%	5,560,748	+62.5%	2.09%	+79.0%
RLAY	Sell	RELAY THERAPEUTICS INC	$43,678,000	-73.4%	1,385,276	-69.1%	1.52%	-75.2%
ITOS	Buy	ITEOS THERAPEUTICS INC	$35,185,000	+32.4%	1,303,157	+25.8%	1.22%	+23.3%
NRIX	Sell	NURIX THERAPEUTICS INC	$33,754,000	-35.3%	1,126,640	-42.8%	1.17%	-39.8%
DSGN	Buy	DESIGN THERAPEUTICS INC	$27,369,000	+9.2%	1,863,098	+47.9%	0.95%	+1.6%
BPMC	New	BLUEPRINT MEDICINES CORPcall	$25,933,000	–	250,000	–	0.90%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$25,584,000	–	1,443,800	–	0.89%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$25,196,000	–	1,249,812	–	0.88%	–
EWTX	Buy	EDGEWISE THERAPEUTICS INC	$21,234,000	-18.7%	1,279,175	+4.5%	0.74%	-24.3%
	New	TANGO THERAPEUTICS INC	$16,809,000	–	1,300,000	–	0.58%	–
BLUE	New	BLUEBIRD BIO INC	$15,336,000	–	802,507	–	0.53%	–
	New	ERASCA INC	$14,854,000	–	700,000	–	0.52%	–
SBTX	Sell	SILVERBACK THERAPEUTICS INC	$11,823,000	-85.4%	1,184,710	-54.7%	0.41%	-86.4%
ODT	Buy	ODONATE THERAPEUTICS INC	$10,846,000	+273.9%	3,727,261	+348.4%	0.38%	+249.1%
CRVS	Sell	CORVUS PHARMACEUTICALS INC	$10,072,000	+5.4%	2,081,077	-41.9%	0.35%	-2.0%
IMVT	New	IMMUNOVANT INC	$9,914,000	–	1,140,819	–	0.34%	–
NLTX	Sell	NEOLEUKIN THERAPEUTICS INC	$6,222,000	-71.4%	860,619	-63.5%	0.22%	-73.5%
FLAC	Buy	FRAZIER LIFESCIENCES ACQU CO	$5,770,000	+194.8%	587,615	+193.1%	0.20%	+175.3%
ACIU	Sell	AC IMMUNE SA	$5,041,000	-76.0%	751,251	-71.6%	0.18%	-77.7%
NGM	New	NGM BIOPHARMACEUTICALS INCcall	$5,000,000	–	245,000	–	0.17%	–
KNTE	Buy	KINNATE BIOPHARMA INC	$4,029,000	+592.3%	175,000	+600.0%	0.14%	+536.4%
FSII	Buy	FS DEVELOPMENT CORP II	$3,692,000	+146.6%	371,014	+147.3%	0.13%	+128.6%
FMTX	Sell	FORMA THERAPEUTICS HLDGS INC	$2,090,000	-20.5%	90,141	-14.7%	0.07%	-25.5%
	New	CARIBOU BIOSCIENCES INC	$1,790,000	–	75,000	–	0.06%	–
VYGR	New	VOYAGER THERAPEUTICS INC	$1,173,000	–	445,992	–	0.04%	–
	New	SURROZEN INC*w exp 10/28/2025	$471,000	–	66,665	–	0.02%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$271,000	–	8,208	–	0.01%	–
ALPN	Sell	ALPINE IMMUNE SCIENCES INC	$75,000	-98.4%	7,001	-98.7%	0.00%	-98.3%
FSTX	Exit	F-STAR THERAPEUTICS INC	$0	–	-46,000	–	-0.02%	–
CHFWWS	Exit	CONSONANCE HFW ACQUISITION C*w exp 10/28/202	$0	–	-66,665	–	-0.02%	–
CHFW	Exit	CONSONANCE HFW ACQUISITION C	$0	–	-200,000	–	-0.07%	–
NGM	Exit	NGM BIOPHARMACEUTICALS INC	$0	–	-143,567	–	-0.11%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-366,867	–	-0.13%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-1,000,000	–	-0.20%	–
ALVR	Exit	ALLOVIR INC	$0	–	-447,012	–	-0.33%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-800,000	–	-0.34%	–
ZNTL	Exit	ZENTALIS PHARMACEUTICALS INC	$0	–	-200,000	–	-0.40%	–
KDNY	Exit	CHINOOK THERAPEUTICS INC	$0	–	-931,650	–	-0.49%	–
BCEL	Exit	ATRECA INC	$0	–	-2,426,685	–	-0.77%	–
ARVN	Exit	ARVINAS INC	$0	–	-321,724	–	-0.93%	–
KYMR	Exit	KYMERA THERAPEUTICS INC	$0	–	-519,416	–	-0.94%	–
TBIO	Exit	TRANSLATE BIO INC	$0	–	-1,048,976	–	-1.08%	–

Q2 2021

			Value		Shares		↓ Weighting
PRTA	New	PROTHENA CORP PLC	$580,125,000	–	11,284,280	–	21.68%	–
MORF	New	MORPHIC HLDG INC	$226,780,000	–	3,951,566	–	8.48%	–
ANAB	New	ANAPTYSBIO INC	$195,020,000	–	7,521,024	–	7.29%	–
XNCR	New	XENCOR INC	$169,212,000	–	4,906,106	–	6.32%	–
RLAY	New	RELAY THERAPEUTICS INC	$164,208,000	–	4,487,776	–	6.14%	–
NUVB	New	NUVATION BIO INC	$127,654,000	–	13,711,517	–	4.77%	–
STTK	New	SHATTUCK LABS INC	$96,201,000	–	3,318,410	–	3.60%	–
RCUS	New	ARCUS BIOSCIENCES INC	$91,586,000	–	3,335,247	–	3.42%	–
ALEC	New	ALECTOR INC	$88,374,000	–	4,242,634	–	3.30%	–
SBTX	New	SILVERBACK THERAPEUTICS INC	$80,871,000	–	2,618,036	–	3.02%	–
KURA	New	KURA ONCOLOGY INC	$77,655,000	–	3,724,437	–	2.90%	–
MRTX	New	MIRATI THERAPEUTICS INC	$74,998,000	–	464,298	–	2.80%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$54,701,000	–	3,092,218	–	2.04%	–
NRIX	New	NURIX THERAPEUTICS INC	$52,210,000	–	1,967,950	–	1.95%	–
RNA	New	AVIDITY BIOSCIENCES INC	$51,989,000	–	2,103,950	–	1.94%	–
JANX	New	JANUX THERAPEUTICS INC	$35,229,000	–	1,411,975	–	1.32%	–
SLDB	New	SOLID BIOSCIENCES INC	$33,682,000	–	9,202,702	–	1.26%	–
GRTS	New	GRITSTONE BIO INC	$31,236,000	–	3,421,287	–	1.17%	–
TBIO	New	TRANSLATE BIO INC	$28,889,000	–	1,048,976	–	1.08%	–
ITOS	New	ITEOS THERAPEUTICS INC	$26,570,000	–	1,035,864	–	0.99%	–
EWTX	New	EDGEWISE THERAPEUTICS INC	$26,112,000	–	1,224,175	–	0.98%	–
KYMR	New	KYMERA THERAPEUTICS INC	$25,192,000	–	519,416	–	0.94%	–
DSGN	New	DESIGN THERAPEUTICS INC	$25,062,000	–	1,260,019	–	0.94%	–
AKUS	New	AKOUOS INC	$24,799,000	–	1,975,984	–	0.93%	–
ARVN	New	ARVINAS INC	$24,773,000	–	321,724	–	0.93%	–
OVID	New	OVID THERAPEUTICS INC	$23,781,000	–	6,082,200	–	0.89%	–
NLTX	New	NEOLEUKIN THERAPEUTICS INC	$21,772,000	–	2,358,804	–	0.81%	–
ACIU	New	AC IMMUNE SA	$21,000,000	–	2,648,163	–	0.78%	–
BCEL	New	ATRECA INC	$20,675,000	–	2,426,685	–	0.77%	–
CNTA	New	CENTESSA PHARMACEUTICALS PLCsponsored ads	$16,758,000	–	754,545	–	0.63%	–
KDNY	New	CHINOOK THERAPEUTICS INC	$13,155,000	–	931,650	–	0.49%	–
ZNTL	New	ZENTALIS PHARMACEUTICALS INC	$10,640,000	–	200,000	–	0.40%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$9,557,000	–	3,579,377	–	0.36%	–
KRON	New	KRONOS BIO INC	$9,277,000	–	387,357	–	0.35%	–
BCTG	New	BCTG ACQUISITION CORP	$9,104,000	–	800,000	–	0.34%	–
NUVBWS	New	NUVATION BIO INC*w exp 07/07/202	$8,969,000	–	963,333	–	0.34%	–
ALVR	New	ALLOVIR INC	$8,824,000	–	447,012	–	0.33%	–
CCCC	New	C4 THERAPEUTICS INC	$7,568,000	–	200,000	–	0.28%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$6,264,000	–	1,606,276	–	0.23%	–
VERV	New	VERVE THERAPEUTICS INC	$6,025,000	–	100,000	–	0.22%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$5,450,000	–	1,000,000	–	0.20%	–
JYAC	New	JIYA ACQUISITION CORP	$4,970,000	–	500,000	–	0.19%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$4,704,000	–	522,635	–	0.18%	–
DYN	New	DYNE THERAPEUTICS INC	$4,524,000	–	215,000	–	0.17%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$4,080,000	–	400,000	–	0.15%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$3,588,000	–	366,867	–	0.13%	–
IGMS	New	IGM BIOSCIENCES INC	$3,164,000	–	38,030	–	0.12%	–
ODT	New	ODONATE THERAPEUTICS INC	$2,901,000	–	831,200	–	0.11%	–
NGM	New	NGM BIOPHARMACEUTICALS INC	$2,831,000	–	143,567	–	0.11%	–
FMTX	New	FORMA THERAPEUTICS HLDGS INC	$2,629,000	–	105,638	–	0.10%	–
BOLT	New	BOLT BIOTHERAPEUTICS INC	$2,319,000	–	150,000	–	0.09%	–
BLSA	New	BCLS ACQUISITION CORP	$2,106,000	–	200,000	–	0.08%	–
BCAB	New	BIOATLA INC	$2,119,000	–	50,000	–	0.08%	–
HLXA	New	HELIX ACQUISITION CORP	$2,070,000	–	200,000	–	0.08%	–
FVAM	New	5 01 ACQUISITION CORP	$1,994,000	–	200,000	–	0.08%	–
CHFW	New	CONSONANCE HFW ACQUISITION C	$1,987,000	–	200,000	–	0.07%	–
EUCR	New	EUCRATES BIOMEDICAL ACQU COR	$1,969,000	–	200,000	–	0.07%	–
FLAC	New	FRAZIER LIFESCIENCES ACQU CO	$1,957,000	–	200,495	–	0.07%	–
PMVP	New	PMV PHARMACEUTICALS INC	$1,708,000	–	50,000	–	0.06%	–
ARYD	New	ARYA SCIENCES ACQU CORP IVcl a	$1,608,000	–	150,000	–	0.06%	–
RPTX	New	REPARE THERAPEUTICS INC	$1,559,000	–	50,000	–	0.06%	–
FSII	New	FS DEVELOPMENT CORP II	$1,497,000	–	150,000	–	0.06%	–
MGTX	New	MEIRAGTX HLDGS PLC	$1,470,000	–	94,819	–	0.06%	–
CMAXW	New	CAREMAX INC*w exp 06/08/202	$1,290,000	–	100,000	–	0.05%	–
TMPM	New	TURMERIC ACQUISITION CORPcl a	$989,000	–	100,000	–	0.04%	–
EUCRW	New	EUCRATES BIOMEDICAL ACQU COR*w exp 10/23/202	$656,000	–	66,666	–	0.02%	–
CHFWWS	New	CONSONANCE HFW ACQUISITION C*w exp 10/28/202	$662,000	–	66,665	–	0.02%	–
FLACW	New	FRAZIER LIFESCIENCES ACQU CO*w exp 11/30/202	$651,000	–	66,665	–	0.02%	–
KNTE	New	KINNATE BIOPHARMA INC	$582,000	–	25,000	–	0.02%	–
OMEG	New	OMEGA ALPHA SPACcl a	$498,000	–	50,000	–	0.02%	–
FSTX	New	F-STAR THERAPEUTICS INC	$395,000	–	46,000	–	0.02%	–
TMPMW	New	TURMERIC ACQUISITION CORP*w exp 10/08/202	$330,000	–	33,333	–	0.01%	–

Q4 2020

			Value		Shares		↓ Weighting
SVRA	Exit	SAVARA INC	$0	–	-56,500	–	-0.00%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INCcall	$0	–	-17,800	–	-0.02%	–
XOMA	Exit	XOMA CORP DEL	$0	–	-50,809	–	-0.07%	–
UBX	Exit	UNITY BIOTECHNOLOGY INC	$0	–	-296,000	–	-0.07%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS INcall	$0	–	-25,300	–	-0.08%	–
MGTX	Exit	MEIRAGTX HLDGS PLC	$0	–	-94,819	–	-0.09%	–
RPTX	Exit	REPARE THERAPEUTICS INC	$0	–	-50,000	–	-0.11%	–
XCUR	Exit	EXICURE INC	$0	–	-1,017,801	–	-0.13%	–
PMVP	Exit	PMV PHARMACEUTICALS INC	$0	–	-50,000	–	-0.13%	–
FPRX	Exit	FIVE PRIME THERAPEUTICS INC	$0	–	-379,945	–	-0.13%	–
RPRX	Exit	ROYALTY PHARMA PLC	$0	–	-50,000	–	-0.15%	–
GLYC	Exit	GLYCOMIMETICS INCcall	$0	–	-850,000	–	-0.19%	–
KYMR	Exit	KYMERA THERAPEUTICS INC	$0	–	-100,000	–	-0.23%	–
MTCR	Exit	METACRINE INC	$0	–	-333,332	–	-0.24%	–
FSDC	Exit	FS DEV CORP	$0	–	-350,000	–	-0.28%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-1,531,312	–	-0.28%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-215,000	–	-0.31%	–
HSAQ	Exit	HEALTH SCIENCES ACQ CORP 2	$0	–	-400,000	–	-0.31%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INCcall	$0	–	-500,000	–	-0.32%	–
PANAU	Exit	PANACEA ACQUISITION CORPunit 99/99/9999	$0	–	-390,000	–	-0.33%	–
DFHTU	Exit	DEERFIELD HEALTHCARE TECH ACunit 07/16/2025	$0	–	-500,000	–	-0.38%	–
ITOS	Exit	ITEOS THERAPEUTICS INC	$0	–	-260,000	–	-0.46%	–
ALPN	Exit	ALPINE IMMUNE SCIENCES INC	$0	–	-741,290	–	-0.46%	–
LSAC	Exit	LIFESCI ACQUISITION CORP*w exp 02/14/202	$0	–	-630,505	–	-0.56%	–
CNST	Exit	CONSTELLATION PHARMCETICLS Icall	$0	–	-400,000	–	-0.58%	–
BCTG	Exit	BCTG ACQUISITION CORP	$0	–	-800,000	–	-0.59%	–
GLYC	Exit	GLYCOMIMETICS INC	$0	–	-3,725,150	–	-0.82%	–
ALVR	Exit	ALLOVIR INC	$0	–	-447,012	–	-0.88%	–
CYCN	Exit	CYCLERION THERAPEUTICS INC	$0	–	-2,742,276	–	-1.19%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-3,333,177	–	-1.64%	–
	Exit	GOSSAMER BIO INCnote	$0	–	-30,000,000	–	-2.21%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-1,810,000	–	-2.21%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-3,113,617	–	-2.23%	–
GERN	Exit	GERON CORP	$0	–	-19,230,769	–	-2.39%	–
BCEL	Exit	ATRECA INC	$0	–	-2,426,685	–	-2.42%	–
AMTI	Exit	APPLIED MOLECULAR TRANS INC	$0	–	-1,150,000	–	-2.61%	–
NRIX	Exit	NURIX THERAPEUTICS INC	$0	–	-1,192,156	–	-2.97%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-2,548,382	–	-2.99%	–
AKUS	Exit	AKOUOS INC	$0	–	-1,975,984	–	-3.22%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS INC	$0	–	-3,862,931	–	-3.30%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-3,223,324	–	-3.39%	–
RNA	Exit	AVIDITY BIOSCIENCES INC	$0	–	-2,103,950	–	-4.22%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-2,642,218	–	-4.71%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-464,298	–	-5.50%	–
MORF	Exit	MORPHIC HLDG INC	$0	–	-2,839,884	–	-5.54%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-9,426,640	–	-6.72%	–
RLAY	Exit	RELAY THERAPEUTICS INC	$0	–	-3,200,649	–	-9.72%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-4,608,529	–	-10.07%	–
XNCR	Exit	XENCOR INC	$0	–	-4,547,072	–	-12.58%	–

Q3 2020

			Value		Shares		↓ Weighting
RLAY	New	RELAY THERAPEUTICS INC	$136,316,000	–	3,200,649	–	9.72%	–
MORF	Buy	MORPHIC HLDG INC	$77,642,000	+1.1%	2,839,884	+0.1%	5.54%	-2.3%
MRTX	Buy	MIRATI THERAPEUTICS INC	$77,097,000	+88.7%	464,298	+29.7%	5.50%	+82.2%
ANAB	Buy	ANAPTYSBIO INC	$47,544,000	-30.8%	3,223,324	+4.8%	3.39%	-33.2%
NLTX	Buy	NEOLEUKIN THERAPEUTICS INC	$46,355,000	-21.0%	3,862,931	+9.2%	3.30%	-23.8%
ASMB	Sell	ASSEMBLY BIOSCIENCES INC	$41,895,000	-43.0%	2,548,382	-19.2%	2.99%	-45.0%
NRIX	New	NURIX THERAPEUTICS INC	$41,618,000	–	1,192,156	–	2.97%	–
BCEL	Buy	ATRECA INC	$33,901,000	+7.0%	2,426,685	+63.0%	2.42%	+3.3%
STRO	Buy	SUTRO BIOPHARMA INC	$31,292,000	+120.5%	3,113,617	+70.3%	2.23%	+112.9%
	New	GOSSAMER BIO INCnote	$31,008,000	–	30,000,000	–	2.21%	–
SURF	Sell	SURFACE ONCOLOGY INC	$22,999,000	-30.4%	3,333,177	-33.8%	1.64%	-32.8%
ALVR	New	ALLOVIR INC	$12,293,000	–	447,012	–	0.88%	–
GLYC	Buy	GLYCOMIMETICS INC	$11,436,000	+61.0%	3,725,150	+97.2%	0.82%	+55.2%
BCTG	New	BCTG ACQUISITION CORP	$8,288,000	–	800,000	–	0.59%	–
LSAC	New	LIFESCI ACQUISITION CORP*w exp 02/14/202	$7,818,000	–	630,505	–	0.56%	–
ALPN	New	ALPINE IMMUNE SCIENCES INC	$6,516,000	–	741,290	–	0.46%	–
ITOS	New	ITEOS THERAPEUTICS INC	$6,414,000	–	260,000	–	0.46%	–
DFHTU	New	DEERFIELD HEALTHCARE TECH ACunit 07/16/2025	$5,315,000	–	500,000	–	0.38%	–
PANAU	New	PANACEA ACQUISITION CORPunit 99/99/9999	$4,680,000	–	390,000	–	0.33%	–
HSAQ	New	HEALTH SCIENCES ACQ CORP 2	$4,400,000	–	400,000	–	0.31%	–
DYN	New	DYNE THERAPEUTICS INC	$4,341,000	–	215,000	–	0.31%	–
FSDC	New	FS DEV CORP	$3,919,000	–	350,000	–	0.28%	–
MTCR	New	METACRINE INC	$3,403,000	–	333,332	–	0.24%	–
KYMR	New	KYMERA THERAPEUTICS INC	$3,231,000	–	100,000	–	0.23%	–
GLYC	New	GLYCOMIMETICS INCcall	$2,610,000	–	850,000	–	0.19%	–
PMVP	New	PMV PHARMACEUTICALS INC	$1,775,000	–	50,000	–	0.13%	–
XCUR	Sell	EXICURE INC	$1,781,000	-56.4%	1,017,801	-39.2%	0.13%	-57.9%
UBX	New	UNITY BIOTECHNOLOGY INC	$1,024,000	–	296,000	–	0.07%	–
ASMB	New	ASSEMBLY BIOSCIENCES INCcall	$293,000	–	17,800	–	0.02%	–
SVRA	Sell	SAVARA INC	$62,000	-98.3%	56,500	-96.1%	0.00%	-98.5%
PLRX	Exit	PLIANT THERAPEUTICS INC	$0	–	-1,300	–	-0.00%	–
EQ	Exit	EQUILLIUM INC	$0	–	-59,014	–	-0.01%	–
KLDO	Exit	KALEIDO BIOSCIENCES INC	$0	–	-31,374	–	-0.02%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-737,612	–	-0.15%	–
LSACU	Exit	LIFESCI ACQUISITION CORPunit 03/31/2025	$0	–	-300,000	–	-0.24%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-450,000	–	-0.25%	–
PRVL	Exit	PREVAIL THERAPEUTICS INC	$0	–	-367,218	–	-0.40%	–
EVLO	Exit	EVELO BIOSCIENCES INC	$0	–	-1,250,000	–	-0.45%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-135,413	–	-0.48%	–
KROS	Exit	KEROS THERAPEUTICS INC	$0	–	-220,216	–	-0.61%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-200,000	–	-0.66%	–
CRNX	Exit	CRINETICS PHARMACEUTICALS IN	$0	–	-859,802	–	-1.11%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-882,353	–	-1.19%	–
BMYRT	Exit	BRISTOL-MYERS SQUIBB COright 99/99/9999	$0	–	-4,748,300	–	-1.26%	–
DNLI	Exit	DENALI THERAPEUTICS INC	$0	–	-733,561	–	-1.31%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-619,855	–	-1.57%	–
CNST	Exit	CONSTELLATION PHARMCETICLS I	$0	–	-837,885	–	-1.86%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-519,119	–	-3.00%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-2,721,993	–	-5.11%	–

Q2 2020

			Value		Shares		↓ Weighting
XNCR	New	XENCOR INC	$147,280,000	–	4,547,072	–	10.88%	–
PRTA	New	PROTHENA CORP PLC	$98,603,000	–	9,426,640	–	7.28%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$89,122,000	–	2,642,218	–	6.58%	–
MORF	New	MORPHIC HLDG INC	$76,767,000	–	2,837,973	–	5.67%	–
KURA	New	KURA ONCOLOGY INC	$75,119,000	–	4,608,529	–	5.55%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$73,547,000	–	3,153,797	–	5.43%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$69,139,000	–	2,721,993	–	5.11%	–
ANAB	New	ANAPTYSBIO INC	$68,696,000	–	3,075,014	–	5.07%	–
RNA	New	AVIDITY BIOSCIENCES INC	$59,458,000	–	2,103,950	–	4.39%	–
NLTX	New	NEOLEUKIN THERAPEUTICS INC	$58,709,000	–	3,536,684	–	4.34%	–
RCUS	New	ARCUS BIOSCIENCES INC	$44,779,000	–	1,810,000	–	3.31%	–
AKUS	New	AKOUOS INC	$44,460,000	–	1,975,984	–	3.28%	–
GERN	New	GERON CORP	$41,923,000	–	19,230,769	–	3.10%	–
MRTX	New	MIRATI THERAPEUTICS INC	$40,856,000	–	357,849	–	3.02%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$40,605,000	–	519,119	–	3.00%	–
SURF	New	SURFACE ONCOLOGY INC	$33,022,000	–	5,033,861	–	2.44%	–
BCEL	New	ATRECA INC	$31,690,000	–	1,489,185	–	2.34%	–
AMTI	New	APPLIED MOLECULAR TRANS INC	$28,911,000	–	1,150,000	–	2.14%	–
CNST	New	CONSTELLATION PHARMCETICLS I	$25,178,000	–	837,885	–	1.86%	–
FATE	New	FATE THERAPEUTICS INC	$21,267,000	–	619,855	–	1.57%	–
DNLI	New	DENALI THERAPEUTICS INC	$17,738,000	–	733,561	–	1.31%	–
BMYRT	New	BRISTOL-MYERS SQUIBB COright 99/99/9999	$16,999,000	–	4,748,300	–	1.26%	–
CYCN	New	CYCLERION THERAPEUTICS INC	$16,207,000	–	2,742,276	–	1.20%	–
FULC	New	FULCRUM THERAPEUTICS INC	$16,138,000	–	882,353	–	1.19%	–
CRNX	New	CRINETICS PHARMACEUTICALS IN	$15,064,000	–	859,802	–	1.11%	–
STRO	New	SUTRO BIOPHARMA INC	$14,189,000	–	1,828,492	–	1.05%	–
CNST	New	CONSTELLATION PHARMCETICLS Icall	$12,020,000	–	400,000	–	0.89%	–
RLMD	New	RELMADA THERAPEUTICS INC	$8,950,000	–	200,000	–	0.66%	–
KROS	New	KEROS THERAPEUTICS INC	$8,260,000	–	220,216	–	0.61%	–
GLYC	New	GLYCOMIMETICS INC	$7,103,000	–	1,889,000	–	0.52%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$6,563,000	–	135,413	–	0.48%	–
EVLO	New	EVELO BIOSCIENCES INC	$6,125,000	–	1,250,000	–	0.45%	–
PRVL	New	PREVAIL THERAPEUTICS INC	$5,472,000	–	367,218	–	0.40%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INCcall	$5,160,000	–	500,000	–	0.38%	–
XCUR	New	EXICURE INC	$4,083,000	–	1,673,301	–	0.30%	–
SVRA	New	SAVARA INC	$3,567,000	–	1,432,664	–	0.26%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$3,380,000	–	450,000	–	0.25%	–
LSACU	New	LIFESCI ACQUISITION CORPunit 03/31/2025	$3,300,000	–	300,000	–	0.24%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$2,481,000	–	1,531,312	–	0.18%	–
RPRX	New	ROYALTY PHARMA PLC	$2,428,000	–	50,000	–	0.18%	–
FPRX	New	FIVE PRIME THERAPEUTICS INC	$2,318,000	–	379,945	–	0.17%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$2,006,000	–	737,612	–	0.15%	–
RPTX	New	REPARE THERAPEUTICS INC	$1,551,000	–	50,000	–	0.12%	–
ICPT	New	INTERCEPT PHARMACEUTICALS INcall	$1,212,000	–	25,300	–	0.09%	–
MGTX	New	MEIRAGTX HLDGS PLC	$1,187,000	–	94,819	–	0.09%	–
XOMA	New	XOMA CORP DEL	$1,004,000	–	50,809	–	0.07%	–
KLDO	New	KALEIDO BIOSCIENCES INC	$233,000	–	31,374	–	0.02%	–
EQ	New	EQUILLIUM INC	$174,000	–	59,014	–	0.01%	–
PLRX	New	PLIANT THERAPEUTICS INC	$42,000	–	1,300	–	0.00%	–

Q4 2019

			Value		Shares		↓ Weighting
UBX	Exit	UNITY BIOTECHNOLOGY ORD	$0	–	-51,400	–	-0.04%	–
RGLS	Exit	REGULUS THERAPEUTICS ORD	$0	–	-1,049,088	–	-0.10%	–
AUTL	Exit	AUTOLUS THERAPEUTICS ADRsponsored adr	$0	–	-69,155	–	-0.11%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES ORD	$0	–	-96,600	–	-0.12%	–
CRTX	Exit	CORTEXYME ORD	$0	–	-49,993	–	-0.16%	–
ZFGN	Exit	ZAFGEN ORD	$0	–	-1,944,500	–	-0.18%	–
IGMS	Exit	IGM BIOSCIENCES ORD	$0	–	-100,000	–	-0.22%	–
VCEL	Exit	VERICEL ORD	$0	–	-131,001	–	-0.25%	–
RUBY	Exit	RUBIUS THERAPEUTICS ORD	$0	–	-260,152	–	-0.26%	–
SURF	Exit	SURFACE ONCOLOGY ORD	$0	–	-1,548,888	–	-0.28%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL ORD	$0	–	-61,554	–	-0.33%	–
MRUS	Exit	MERUS ORD	$0	–	-165,600	–	-0.37%	–
MRTX	Exit	MIRATI THERAPEUTICS ORD	$0	–	-44,221	–	-0.44%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES ORDcall	$0	–	-498,300	–	-0.62%	–
NLTX	Exit	NEOLEUKIN THERAPEUTICS ORD	$0	–	-2,265,880	–	-0.82%	–
CRIS	Exit	CURIS ORD	$0	–	-2,982,208	–	-0.84%	–
RCUS	Exit	ARCUS BIOSCIENCES ORD	$0	–	-754,505	–	-0.87%	–
NXTC	Exit	NEXTCURE ORD	$0	–	-250,500	–	-0.98%	–
CYCN	Exit	CYCLERION THERAPEUTICS ORD	$0	–	-776,206	–	-1.19%	–
EIGR	Exit	EIGER BIOPHARMACEUTICAL ORD	$0	–	-1,060,043	–	-1.37%	–
GOSS	Exit	GOSSAMER BIO INC ORDcall	$0	–	-800,000	–	-1.70%	–
XCUR	Exit	EXICURE ORD	$0	–	-5,515,225	–	-1.76%	–
SRPT	Exit	SAREPTA THERAPEUTICS ORD	$0	–	-189,745	–	-1.80%	–
CHMA	Exit	CHIASMA ORD	$0	–	-3,043,827	–	-1.90%	–
BCEL	Exit	ATRECA CL A ORD	$0	–	-1,481,411	–	-2.29%	–
HARP	Exit	HARPOON THERAPEUTICS ORD	$0	–	-1,463,423	–	-2.52%	–
FGEN	Exit	FIBROGEN ORDcall	$0	–	-652,500	–	-3.05%	–
PRVL	Exit	PREVAIL THERAPEUTICS ORD	$0	–	-2,392,556	–	-3.71%	–
SLDB	Exit	SOLID BIOSCIENCES ORD	$0	–	-3,342,691	–	-4.36%	–
MORF	Exit	MORPHIC HOLDING ORD	$0	–	-2,161,520	–	-4.94%	–
IRWD	Exit	IRONWOOD PHARMA CL A ORD	$0	–	-4,671,408	–	-5.06%	–
FGEN	Exit	FIBROGEN ORD	$0	–	-1,293,807	–	-6.04%	–
DRNA	Exit	DICERNA PHARMACEUTICALS ORD	$0	–	-3,962,978	–	-7.19%	–
ARGX	Exit	ARGENX ADR REP ORDsponsored adr	$0	–	-531,165	–	-7.64%	–
KURA	Exit	KURA ONCOLOGY ORD	$0	–	-4,041,953	–	-7.74%	–
ONCE	Exit	SPARK THERAPEUTICS ORD	$0	–	-714,789	–	-8.75%	–
PRTA	Exit	PROTHENA ORD	$0	–	-9,426,640	–	-9.33%	–
XNCR	Exit	XENCOR ORD	$0	–	-2,501,557	–	-10.66%	–

Q3 2019

			Value		Shares		↓ Weighting
XNCR	Buy	XENCOR ORD	$84,378,000	-11.8%	2,501,557	+7.1%	10.66%	+10.3%
PRTA	Buy	PROTHENA ORD	$73,905,000	+866.7%	9,426,640	+1203.3%	9.33%	+1107.4%
ONCE	Buy	SPARK THERAPEUTICS ORD	$69,320,000	+10.3%	714,789	+16.4%	8.75%	+37.8%
KURA	Sell	KURA ONCOLOGY ORD	$61,316,000	-41.0%	4,041,953	-23.4%	7.74%	-26.3%
ARGX	Sell	ARGENX ADR REP ORDsponsored adr	$60,532,000	-26.4%	531,165	-8.6%	7.64%	-8.1%
DRNA	Buy	DICERNA PHARMACEUTICALS ORD	$56,908,000	+9.0%	3,962,978	+19.5%	7.19%	+36.2%
FGEN	Sell	FIBROGEN ORD	$47,845,000	-30.0%	1,293,807	-14.4%	6.04%	-12.5%
MORF	Sell	MORPHIC HOLDING ORD	$39,145,000	-12.9%	2,161,520	-4.6%	4.94%	+8.9%
SLDB	Buy	SOLID BIOSCIENCES ORD	$34,563,000	+626.9%	3,342,691	+304.2%	4.36%	+809.4%
FGEN	Buy	FIBROGEN ORDcall	$24,130,000	+92.5%	652,500	+135.1%	3.05%	+140.5%
HARP	Buy	HARPOON THERAPEUTICS ORD	$19,990,000	+14.0%	1,463,423	+8.5%	2.52%	+42.5%
BCEL	Sell	ATRECA CL A ORD	$18,132,000	-35.3%	1,481,411	-0.4%	2.29%	-19.1%
SRPT	New	SAREPTA THERAPEUTICS ORD	$14,292,000	–	189,745	–	1.80%	–
XCUR	New	EXICURE ORD	$13,954,000	–	5,515,225	–	1.76%	–
GOSS	New	GOSSAMER BIO INC ORDcall	$13,432,000	–	800,000	–	1.70%	–
EIGR	Sell	EIGER BIOPHARMACEUTICAL ORD	$10,865,000	-9.8%	1,060,043	-6.7%	1.37%	+12.7%
NXTC	New	NEXTCURE ORD	$7,728,000	–	250,500	–	0.98%	–
RCUS	Sell	ARCUS BIOSCIENCES ORD	$6,866,000	-41.7%	754,505	-49.3%	0.87%	-27.2%
NLTX	New	NEOLEUKIN THERAPEUTICS ORD	$6,458,000	–	2,265,880	–	0.82%	–
MRTX	Sell	MIRATI THERAPEUTICS ORD	$3,445,000	-94.4%	44,221	-92.6%	0.44%	-93.0%
MRUS	New	MERUS ORD	$2,951,000	–	165,600	–	0.37%	–
RARE	Sell	ULTRAGENYX PHARMACEUTICAL ORD	$2,633,000	-91.7%	61,554	-87.6%	0.33%	-89.6%
SURF	Sell	SURFACE ONCOLOGY ORD	$2,199,000	-66.3%	1,548,888	-33.0%	0.28%	-57.8%
RUBY	Sell	RUBIUS THERAPEUTICS ORD	$2,042,000	-72.0%	260,152	-43.8%	0.26%	-64.9%
IGMS	New	IGM BIOSCIENCES ORD	$1,775,000	–	100,000	–	0.22%	–
ZFGN	New	ZAFGEN ORD	$1,437,000	–	1,944,500	–	0.18%	–
CRTX	New	CORTEXYME ORD	$1,246,000	–	49,993	–	0.16%	–
ASMB	New	ASSEMBLY BIOSCIENCES ORD	$950,000	–	96,600	–	0.12%	–
AUTL	New	AUTOLUS THERAPEUTICS ADRsponsored adr	$859,000	–	69,155	–	0.11%	–
RGLS	Sell	REGULUS THERAPEUTICS ORD	$755,000	-45.6%	1,049,088	-5.6%	0.10%	-32.1%
UBX	Sell	UNITY BIOTECHNOLOGY ORD	$314,000	-96.8%	51,400	-95.1%	0.04%	-96.0%
TCRR	Exit	TCR2 THERAPEUTICS ORD	$0	–	-16,114	–	-0.02%	–
GMDA	Exit	GAMIDA CELL ORD	$0	–	-52,120	–	-0.03%	–
SYRS	Exit	SYROS PHARMACEUTICALS ORD	$0	–	-248,480	–	-0.23%	–
ADRO	Exit	ADURO BIOTECH ORD	$0	–	-1,761,421	–	-0.27%	–
KZR	Exit	KEZAR LIFE SCIENCES ORD	$0	–	-583,293	–	-0.45%	–
NGM	Exit	NGM BIOPHARMACEUTICALS ORD	$0	–	-316,900	–	-0.47%	–
RYTM	Exit	RHYTHM PHARMACEUTICALS ORD	$0	–	-223,167	–	-0.50%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS ORD	$0	–	-2,265,880	–	-0.54%	–
MRSN	Exit	MERSANA THERAPEUTICS ORD	$0	–	-1,392,231	–	-0.57%	–
ARQL	Exit	ARQULE ORD	$0	–	-1,300,000	–	-1.45%	–
GOSS	Exit	GOSSAMER BIO INC ORD	$0	–	-772,096	–	-1.73%	–
CRSP	Exit	CRISPR THERAPEUTICS ORD	$0	–	-1,610,250	–	-7.66%	–

Q2 2019

			Value		Shares		↓ Weighting
KURA	New	KURA ONCOLOGY ORD	$103,899,000	–	5,276,753	–	10.50%	–
XNCR	New	XENCOR ORD	$95,635,000	–	2,336,557	–	9.66%	–
ARGX	New	ARGENX ADR REP ORDsponsored adr	$82,281,000	–	581,165	–	8.31%	–
CRSP	New	CRISPR THERAPEUTICS ORD	$75,843,000	–	1,610,250	–	7.66%	–
FGEN	New	FIBROGEN ORD	$68,302,000	–	1,511,785	–	6.90%	–
ONCE	New	SPARK THERAPEUTICS ORD	$62,874,000	–	614,128	–	6.35%	–
MRTX	New	MIRATI THERAPEUTICS ORD	$61,564,000	–	597,711	–	6.22%	–
DRNA	New	DICERNA PHARMACEUTICALS ORD	$52,233,000	–	3,316,407	–	5.28%	–
IRWD	New	IRONWOOD PHARMA CL A ORD	$51,105,000	–	4,671,408	–	5.16%	–
MORF	New	MORPHIC HOLDING ORD	$44,928,000	–	2,266,804	–	4.54%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL ORD	$31,617,000	–	497,899	–	3.20%	–
PRVL	New	PREVAIL THERAPEUTICS ORD	$31,582,000	–	2,392,556	–	3.19%	–
BCEL	New	ATRECA CL A ORD	$28,015,000	–	1,486,979	–	2.83%	–
CHMA	New	CHIASMA ORD	$22,737,000	–	3,043,827	–	2.30%	–
HARP	New	HARPOON THERAPEUTICS ORD	$17,529,000	–	1,348,423	–	1.77%	–
GOSS	New	GOSSAMER BIO INC ORD	$17,125,000	–	772,096	–	1.73%	–
ARQL	New	ARQULE ORD	$14,313,000	–	1,300,000	–	1.45%	–
FGEN	New	FIBROGEN ORDcall	$12,537,000	–	277,500	–	1.27%	–
EIGR	New	EIGER BIOPHARMACEUTICAL ORD	$12,042,000	–	1,136,043	–	1.22%	–
RCUS	New	ARCUS BIOSCIENCES ORD	$11,787,000	–	1,488,205	–	1.19%	–
UBX	New	UNITY BIOTECHNOLOGY ORD	$9,923,000	–	1,044,500	–	1.00%	–
CYCN	New	CYCLERION THERAPEUTICS ORD	$8,888,000	–	776,206	–	0.90%	–
PRTA	New	PROTHENA ORD	$7,645,000	–	723,300	–	0.77%	–
RUBY	New	RUBIUS THERAPEUTICS ORD	$7,285,000	–	463,152	–	0.74%	–
ASMB	New	ASSEMBLY BIOSCIENCES ORDcall	$6,723,000	–	498,300	–	0.68%	–
SURF	New	SURFACE ONCOLOGY ORD	$6,522,000	–	2,312,688	–	0.66%	–
MRSN	New	MERSANA THERAPEUTICS ORD	$5,639,000	–	1,392,231	–	0.57%	–
CRIS	New	CURIS ORD	$5,547,000	–	2,982,208	–	0.56%	–
AQXP	New	AQUINOX PHARMACEUTICALS ORD	$5,347,000	–	2,265,880	–	0.54%	–
RYTM	New	RHYTHM PHARMACEUTICALS ORD	$4,910,000	–	223,167	–	0.50%	–
SLDB	New	SOLID BIOSCIENCES ORD	$4,755,000	–	827,000	–	0.48%	–
NGM	New	NGM BIOPHARMACEUTICALS ORD	$4,639,000	–	316,900	–	0.47%	–
KZR	New	KEZAR LIFE SCIENCES ORD	$4,497,000	–	583,293	–	0.45%	–
ADRO	New	ADURO BIOTECH ORD	$2,713,000	–	1,761,421	–	0.27%	–
VCEL	New	VERICEL ORD	$2,475,000	–	131,001	–	0.25%	–
SYRS	New	SYROS PHARMACEUTICALS ORD	$2,301,000	–	248,480	–	0.23%	–
RGLS	New	REGULUS THERAPEUTICS	$1,389,000	–	1,111,110	–	0.14%	–
GMDA	New	GAMIDA CELL ORD	$265,000	–	52,120	–	0.03%	–
TCRR	New	TCR2 THERAPEUTICS ORD	$231,000	–	16,114	–	0.02%	–

Q4 2018

			Value		Shares		↓ Weighting
ERYP	Exit	ERYTECH PHARMAsponsored adr	$0	–	-69,569	–	-0.05%	–
ARVN	Exit	ARVINAS INC	$0	–	-50,000	–	-0.08%	–
APTX	Exit	APTINYX INC	$0	–	-41,037	–	-0.11%	–
INFI	Exit	INFINITY PHARMACEUTICALS INC	$0	–	-462,068	–	-0.11%	–
CHMA	Exit	CHIASMA INC	$0	–	-379,753	–	-0.12%	–
FTSV	Exit	FORTY SEVEN INC	$0	–	-99,000	–	-0.13%	–
CNST	Exit	CONSTELLATION PHARMACEUTICALS INC	$0	–	-280,000	–	-0.17%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-44,841	–	-0.20%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-351,401	–	-0.27%	–
	Exit	JOUNCE THERAPEUTICS INCcall	$0	–	-497,400	–	-0.29%	–
AVRO	Exit	AVROBIO INC	$0	–	-68,646	–	-0.32%	–
ONTX	Exit	ONCONOVA THERAPEUTICS INC	$0	–	-500,000	–	-0.33%	–
IONS	Exit	IONIS PHARMACEUTICALS INC	$0	–	-72,326	–	-0.34%	–
KDMN	Exit	KADMON HOLDINGS INC	$0	–	-1,480,870	–	-0.45%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-495,618	–	-0.45%	–
	Exit	ASSEMBLY BIOSCIENCES INCcall	$0	–	-148,100	–	-0.50%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS	$0	–	-1,564,080	–	-0.52%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-343,231	–	-0.52%	–
ELAN	Exit	ELANCO ANIMAL HEALTH INC	$0	–	-190,000	–	-0.60%	–
AQXP	Exit	AQUINOX PHARMACEUTICALS INC	$0	–	-2,265,880	–	-0.60%	–
ZLAB	Exit	ZAI LAB LTDsponsored adr	$0	–	-350,000	–	-0.61%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-2,241,900	–	-0.70%	–
SPRO	Exit	SPERO THERAPEUTICS INC	$0	–	-892,741	–	-0.84%	–
	Exit	IRONWOOD PHARMACEUTICALS INCcall	$0	–	-567,600	–	-0.94%	–
ABUS	Exit	ARBUTUS BIOPHARMA CORP	$0	–	-1,231,800	–	-1.05%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-1,039,500	–	-1.12%	–
RUBY	Exit	RUBIUS THERAPEUTICS INC	$0	–	-592,128	–	-1.28%	–
SURF	Exit	SURFACE ONCOLOGY INC	$0	–	-1,363,479	–	-1.34%	–
UBX	Exit	UNITY BIOTECHNOLOGY INC.	$0	–	-967,114	–	-1.42%	–
	Exit	CELGENE CORPORATIONcall	$0	–	-200,000	–	-1.61%	–
	Exit	ASCENDIS PHARMA A Scall	$0	–	-257,000	–	-1.64%	–
MGTA	Exit	MAGENTA THERAPEUTICS INC	$0	–	-1,538,088	–	-1.66%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL INC	$0	–	-254,000	–	-1.75%	–
	Exit	NEKTAR THERAPEUTICScall	$0	–	-325,000	–	-1.78%	–
	Exit	FIBROGEN INCcall	$0	–	-350,000	–	-1.92%	–
CRSP	Exit	CRISPR THERAPEUTICS AG	$0	–	-500,000	–	-2.00%	–
	Exit	GILEAD SCIENCES INCcall	$0	–	-292,600	–	-2.04%	–
	Exit	ULTRAGENYX PHARMACEUTICALcall	$0	–	-325,000	–	-2.24%	–
AKCA	Exit	AKCEA THERAPEUTICS INC	$0	–	-755,120	–	-2.38%	–
KZR	Exit	KEZAR LIFE SCIENCES INC	$0	–	-1,288,198	–	-2.48%	–
RCUS	Exit	ARCUS BIOSCIENCES INC	$0	–	-2,236,387	–	-2.81%	–
MGNX	Exit	MACROGENICS INC	$0	–	-1,481,086	–	-2.86%	–
ONCE	Exit	SPARK THERAPEUTICS INC	$0	–	-837,048	–	-4.11%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-3,802,327	–	-5.23%	–
SRRK	Exit	SCHOLAR ROCK HOLDING CORP	$0	–	-2,367,378	–	-5.49%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-3,902,975	–	-6.15%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-1,087,257	–	-6.94%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-5,141,624	–	-8.55%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-2,943,164	–	-9.85%	–
FGEN	Exit	FIBROGEN INC	$0	–	-2,017,250	–	-11.04%	–

Q3 2018

			Value		Shares		↓ Weighting
IRWD	Sell	IRONWOOD PHARMACEUTICALS INC	$94,914,000	-20.6%	5,141,624	-17.7%	8.55%	-24.8%
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$77,043,000	-20.9%	1,087,257	-25.7%	6.94%	-25.1%
KURA	Sell	KURA ONCOLOGY INC	$68,302,000	-3.9%	3,902,975	-0.0%	6.15%	-9.1%
SRRK	Sell	SCHOLAR ROCK HOLDING CORP	$60,960,000	+46.3%	2,367,378	-11.4%	5.49%	+38.4%
DRNA	Buy	DICERNA PHARMACEUTICALS INC	$58,024,000	+60.0%	3,802,327	+28.4%	5.23%	+51.4%
ONCE	New	SPARK THERAPEUTICS INC	$45,661,000	–	837,048	–	4.11%	–
MGNX	Buy	MACROGENICS INC	$31,754,000	+6.0%	1,481,086	+2.1%	2.86%	+0.3%
KZR	Buy	KEZAR LIFE SCIENCES INC	$27,580,000	+25.3%	1,288,198	+1.3%	2.48%	+18.6%
AKCA	New	AKCEA THERAPEUTICS INC	$26,444,000	–	755,120	–	2.38%	–
	New	ULTRAGENYX PHARMACEUTICALcall	$24,811,000	–	325,000	–	2.24%	–
CRSP	New	CRISPR THERAPEUTICS AG	$22,175,000	–	500,000	–	2.00%	–
	New	NEKTAR THERAPEUTICScall	$19,812,000	–	325,000	–	1.78%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL INC	$19,390,000	–	254,000	–	1.75%	–
	Sell	ASCENDIS PHARMA A Scall	$18,211,000	-38.8%	257,000	-42.5%	1.64%	-42.0%
	Sell	CELGENE CORPORATIONcall	$17,898,000	-61.5%	200,000	-65.8%	1.61%	-63.6%
UBX	Sell	UNITY BIOTECHNOLOGY INC.	$15,754,000	-37.8%	967,114	-42.5%	1.42%	-41.1%
SURF	Buy	SURFACE ONCOLOGY INC	$14,916,000	+2.7%	1,363,479	+53.1%	1.34%	-2.8%
RUBY	New	RUBIUS THERAPEUTICS INC	$14,211,000	–	592,128	–	1.28%	–
ABUS	New	ARBUTUS BIOPHARMA CORP	$11,641,000	–	1,231,800	–	1.05%	–
	Sell	IRONWOOD PHARMACEUTICALS INCcall	$10,477,000	-5.1%	567,600	-1.7%	0.94%	-10.2%
SPRO	New	SPERO THERAPEUTICS INC	$9,383,000	–	892,741	–	0.84%	–
IMDZ	Sell	IMMUNE DESIGN CORP	$7,735,000	-61.7%	2,241,900	-49.5%	0.70%	-63.7%
ZLAB	New	ZAI LAB LTDsponsored adr	$6,818,000	–	350,000	–	0.61%	–
AQXP	Buy	AQUINOX PHARMACEUTICALS INC	$6,639,000	+117.8%	2,265,880	+97.0%	0.60%	+106.2%
ELAN	New	ELANCO ANIMAL HEALTH INC	$6,629,000	–	190,000	–	0.60%	–
SGMO	Sell	SANGAMO THERAPEUTICS INC	$5,818,000	-72.9%	343,231	-77.3%	0.52%	-74.3%
ACHN	Sell	ACHILLION PHARMACEUTICALS	$5,756,000	-47.7%	1,564,080	-59.8%	0.52%	-50.4%
MRSN	New	MERSANA THERAPEUTICS INC	$4,956,000	–	495,618	–	0.45%	–
KDMN	Sell	KADMON HOLDINGS INC	$4,946,000	-50.4%	1,480,870	-40.8%	0.45%	-53.1%
IONS	New	IONIS PHARMACEUTICALS INC	$3,731,000	–	72,326	–	0.34%	–
ONTX	New	ONCONOVA THERAPEUTICS INC	$3,670,000	–	500,000	–	0.33%	–
AVRO	New	AVROBIO INC	$3,561,000	–	68,646	–	0.32%	–
	New	JOUNCE THERAPEUTICS INCcall	$3,233,000	–	497,400	–	0.29%	–
CRVS	Sell	CORVUS PHARMACEUTICALS INC	$3,015,000	-39.0%	351,401	-22.0%	0.27%	-42.3%
WVE	Sell	WAVE LIFE SCIENCES LTD	$2,242,000	-85.8%	44,841	-89.1%	0.20%	-86.6%
CNST	New	CONSTELLATION PHARMACEUTICALS INC	$1,884,000	–	280,000	–	0.17%	–
FTSV	New	FORTY SEVEN INC	$1,477,000	–	99,000	–	0.13%	–
CHMA	New	CHIASMA INC	$1,367,000	–	379,753	–	0.12%	–
INFI	Buy	INFINITY PHARMACEUTICALS INC	$1,252,000	+59.1%	462,068	+12.2%	0.11%	+50.7%
ARVN	New	ARVINAS INC	$844,000	–	50,000	–	0.08%	–
ERYP	Sell	ERYTECH PHARMAsponsored adr	$590,000	-66.0%	69,569	-54.8%	0.05%	-67.9%
ONTX	Exit	ONCONOVA THERAPEUTICS INC	$0	–	-7,500,000	–	-0.29%	–
DBVT	Exit	DBV TECHNOLOGIES S Asponsored adr	$0	–	-298,100	–	-0.55%	–
MDGL	Exit	MADRIGAL PHARMACEUTICALS INC	$0	–	-199,500	–	-5.31%	–

Q2 2018

			Value		Shares		↓ Weighting
FGEN	New	FIBROGEN INC	$126,280,000	–	2,017,250	–	12.02%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$119,501,000	–	6,250,073	–	11.38%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$115,401,000	–	2,943,164	–	10.99%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$97,390,000	–	1,464,067	–	9.27%	–
KURA	New	KURA ONCOLOGY INC	$71,065,000	–	3,904,675	–	6.77%	–
MDGL	New	MADRIGAL PHARMACEUTICALS INC	$55,798,000	–	199,500	–	5.31%	–
	New	CELGENE CORPcall	$46,461,000	–	585,000	–	4.42%	–
SRRK	New	SCHOLAR ROCK HLDG CORP	$41,670,000	–	2,671,161	–	3.97%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$36,274,000	–	2,961,147	–	3.45%	–
MGNX	New	MACROGENICS INC	$29,955,000	–	1,450,606	–	2.85%	–
	New	ASCENDIS PHARMA A Scall	$29,735,000	–	447,000	–	2.83%	–
RCUS	New	ARCUS BIOSCIENCES INC	$27,373,000	–	2,236,387	–	2.61%	–
UBX	New	UNITY BIOTECHNOLOGY INC	$25,310,000	–	1,680,644	–	2.41%	–
KZR	New	KEZAR LIFE SCIENCES INC	$22,009,000	–	1,272,198	–	2.10%	–
	New	FIBROGEN INCcall	$21,910,000	–	350,000	–	2.09%	–
SGMO	New	SANGAMO THERAPEUTICS INC	$21,437,000	–	1,509,671	–	2.04%	–
MGTA	New	MAGENTA THERAPEUTICS INC	$20,764,000	–	1,538,088	–	1.98%	–
	New	GILEAD SCIENCES INCcall	$20,728,000	–	292,600	–	1.97%	–
IMDZ	New	IMMUNE DESIGN CORP	$20,191,000	–	4,437,600	–	1.92%	–
WVE	New	WAVE LIFE SCIENCES LTD	$15,792,000	–	412,871	–	1.50%	–
SURF	New	SURFACE ONCOLOGY INC	$14,529,000	–	890,808	–	1.38%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$12,682,000	–	1,039,500	–	1.21%	–
	New	IRONWOOD PHARMACEUTICALS INCcall	$11,044,000	–	577,600	–	1.05%	–
ACHN	New	ACHILLION PHARMACEUTICALS INC	$11,001,000	–	3,887,407	–	1.05%	–
KDMN	New	KADMON HLDGS INC	$9,975,000	–	2,500,000	–	0.95%	–
	New	ASSEMBLY BIOSCIENCES INCcall	$5,807,000	–	148,100	–	0.55%	–
DBVT	New	DBV TECHNOLOGIES S Asponsored adr	$5,750,000	–	298,100	–	0.55%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$4,945,000	–	450,400	–	0.47%	–
AQXP	New	AQUINOX PHARMACEUTICALS INC	$3,048,000	–	1,150,000	–	0.29%	–
ONTX	New	ONCONOVA THERAPEUTICS INC	$3,034,000	–	7,500,000	–	0.29%	–
ERYP	New	ERYTECH PHARMAsponsored adr	$1,734,000	–	153,964	–	0.16%	–
APTX	New	APTINYX INC	$992,000	–	41,037	–	0.09%	–
INFI	New	INFINITY PHARMACEUTICALS INC	$787,000	–	412,000	–	0.08%	–

Q4 2017

			Value		Shares		↓ Weighting
SBPH	Exit	SPRING BK PHARMACEUTICALS INC	$0	–	-16,000	–	-0.04%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS INC	$0	–	-45,000	–	-0.11%	–
BGNE	Exit	BEIGENE LTD SPONSORED ADRsponsored adr	$0	–	-9,800	–	-0.13%	–
BMY	Exit	BRISTOL MYERS SQUIBB CO	$0	–	-17,060	–	-0.14%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-104,000	–	-0.20%	–
ACRS	Exit	ACLARIS THERAPEUTICS INC	$0	–	-60,000	–	-0.21%	–
SGEN	Exit	SEATTLE GENETICS INC	$0	–	-30,000	–	-0.22%	–
XNCR	Exit	XENCOR INC	$0	–	-90,114	–	-0.28%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-25,765	–	-0.28%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-762,947	–	-0.37%	–
CMTA	Exit	CLEMENTIA PHARMACEUTICALS INC	$0	–	-194,166	–	-0.44%	–
SGMO	Exit	SANGAMO BIOSCIENCES INC	$0	–	-222,388	–	-0.44%	–
KIN	Exit	KINDRED BIOSCIENCES INC	$0	–	-544,880	–	-0.57%	–
ZLAB	Exit	ZAI LAB LIMITEDsponsored adr	$0	–	-159,535	–	-0.57%	–
OVAS	Exit	OVASCIENCE INC	$0	–	-3,512,332	–	-0.66%	–
DRNA	Exit	DICERNA PHARMACEUTICALS INC	$0	–	-957,992	–	-0.73%	–
RGLS	Exit	REGULUS THERAPEUTICS INC	$0	–	-5,239,225	–	-0.87%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-2,262,678	–	-1.19%	–
OMER	Exit	OMEROS CORP	$0	–	-450,000	–	-1.30%	–
	Exit	IRONWOOD PHARMACEUTICALS INCcall	$0	–	-620,000	–	-1.30%	–
	Exit	VERTEX PHARMACEUTICALS INCcall	$0	–	-67,600	–	-1.37%	–
CASC	Exit	CASCADIAN THERAPEUTICS INC	$0	–	-3,000,000	–	-1.64%	–
WVE	Exit	WAVE LIFE SCIENCES LTD	$0	–	-564,248	–	-1.64%	–
INSM	Exit	INSMED INC	$0	–	-405,400	–	-1.69%	–
	Exit	INTEC PHARMA LTD JERUSALEM	$0	–	-1,500,000	–	-1.79%	–
CRVS	Exit	CORVUS PHARMACEUTICALS INC	$0	–	-908,525	–	-1.93%	–
CTMX	Exit	CYTOMX THERAPEUTICS INC	$0	–	-829,771	–	-2.01%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-1,250,000	–	-2.05%	–
TOCA	Exit	TOCAGEN INC	$0	–	-1,502,373	–	-2.50%	–
LIFE	Exit	ATYR PHARMA INC	$0	–	-3,934,849	–	-2.65%	–
MRNS	Exit	MARINUS PHARMACEUTICALS INC	$0	–	-3,622,271	–	-2.83%	–
GLPG	Exit	GALAPAGOS NV SPON ADRsponsored adr	$0	–	-240,776	–	-3.26%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-689,986	–	-3.94%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-2,860,019	–	-5.33%	–
KURA	Exit	KURA ONCOLOGY INC COM	$0	–	-3,766,852	–	-7.50%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-2,107,600	–	-10.18%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-5,459,583	–	-11.48%	–
FGEN	Exit	FIBROGEN INC	$0	–	-1,735,677	–	-12.44%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-2,943,164	–	-13.70%	–

Q3 2017

			Value		Shares		↓ Weighting
FGEN	Buy	FIBROGEN INC	$93,379,000	+82.3%	1,735,677	+9.5%	12.44%	+36.9%
IRWD	Buy	IRONWOOD PHARMACEUTICALS INC	$86,098,000	+21.5%	5,459,583	+45.4%	11.48%	-8.8%
ASND	Buy	ASCENDIS PHARMA A Ssponsored adr	$76,401,000	+85.6%	2,107,600	+42.2%	10.18%	+39.4%
KURA	Buy	KURA ONCOLOGY INC COM	$56,314,000	+197.8%	3,766,852	+85.2%	7.50%	+123.5%
IMMU	New	IMMUNOMEDICS INC	$39,983,000	–	2,860,019	–	5.33%	–
MYOK	New	MYOKARDIA INC	$29,566,000	–	689,986	–	3.94%	–
GLPG	Sell	GALAPAGOS NV SPON ADRsponsored adr	$24,499,000	-44.7%	240,776	-58.4%	3.26%	-58.5%
MRNS	New	MARINUS PHARMACEUTICALS INC	$21,263,000	–	3,622,271	–	2.83%	–
LIFE	Buy	ATYR PHARMA INC	$19,871,000	+154.9%	3,934,849	+71.6%	2.65%	+91.3%
ARRY	New	ARRAY BIOPHARMA INC	$15,375,000	–	1,250,000	–	2.05%	–
CTMX	Buy	CYTOMX THERAPEUTICS INC	$15,077,000	+22.4%	829,771	+4.4%	2.01%	-8.2%
CRVS	Buy	CORVUS PHARMACEUTICALS INC	$14,482,000	+48.7%	908,525	+12.9%	1.93%	+11.6%
	New	INTEC PHARMA LTD JERUSALEM	$13,425,000	–	1,500,000	–	1.79%	–
INSM	New	INSMED INC	$12,653,000	–	405,400	–	1.69%	–
WVE	New	WAVE LIFE SCIENCES LTD	$12,272,000	–	564,248	–	1.64%	–
	Buy	VERTEX PHARMACEUTICALS INCcall	$10,278,000	+12.8%	67,600	+12.7%	1.37%	-15.3%
	New	IRONWOOD PHARMACEUTICALS INCcall	$9,777,000	–	620,000	–	1.30%	–
OMER	New	OMEROS CORP	$9,729,000	–	450,000	–	1.30%	–
FATE	Sell	FATE THERAPEUTICS INC	$8,960,000	+9.0%	2,262,678	-10.8%	1.19%	-18.2%
RGLS	Buy	REGULUS THERAPEUTICS INC	$6,549,000	+79.1%	5,239,225	+41.3%	0.87%	+34.5%
DRNA	Buy	DICERNA PHARMACEUTICALS INC	$5,508,000	+126.2%	957,992	+24.7%	0.73%	+69.9%
ZLAB	New	ZAI LAB LIMITEDsponsored adr	$4,307,000	–	159,535	–	0.57%	–
SGMO	Sell	SANGAMO BIOSCIENCES INC	$3,336,000	-85.2%	222,388	-91.3%	0.44%	-88.9%
CMTA	New	CLEMENTIA PHARMACEUTICALS INC	$3,279,000	–	194,166	–	0.44%	–
ADVM	Sell	ADVERUM BIOTECHNOLOGIES INC	$2,785,000	+27.4%	762,947	-12.8%	0.37%	-4.4%
CLVS	Buy	CLOVIS ONCOLOGY INC	$2,123,000	+126.8%	25,765	+157.6%	0.28%	+70.5%
XNCR	New	XENCOR INC	$2,065,000	–	90,114	–	0.28%	–
SGEN	Buy	SEATTLE GENETICS INC	$1,632,000	+110.3%	30,000	+100.0%	0.22%	+58.0%
ACRS	Sell	ACLARIS THERAPEUTICS INC	$1,549,000	-69.2%	60,000	-67.7%	0.21%	-76.9%
SYRS	New	SYROS PHARMACEUTICALS INC	$1,531,000	–	104,000	–	0.20%	–
BGNE	New	BEIGENE LTD SPONSORED ADRsponsored adr	$1,009,000	–	9,800	–	0.13%	–
DCPH	New	DECIPHERA PHARMACEUTICALS INC	$855,000	–	45,000	–	0.11%	–
SBPH	New	SPRING BK PHARMACEUTICALS INC	$269,000	–	16,000	–	0.04%	–
PETX	Exit	ARATANA THERAPEUTICS INC	$0	–	-100,000	–	-0.13%	–
ALNY	Exit	ALNYLAM PHARMACEUTICALS INC	$0	–	-10,425	–	-0.15%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-118,000	–	-0.20%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-23,300	–	-0.21%	–
BHVN	Exit	BIOHAVEN PHARMACEUTICAL HLDG CO LTD	$0	–	-70,000	–	-0.31%	–
NERV	Exit	MINERVA NEUROSCIENCES INC	$0	–	-223,802	–	-0.35%	–
	Exit	NABRIVA THERAPEUTICS	$0	–	-264,773	–	-0.49%	–
ACHN	Exit	ACHILLION PHARMACEUTICALS INC	$0	–	-742,835	–	-0.60%	–
	Exit	EDITAS MEDICINE INC COMcall	$0	–	-255,000	–	-0.77%	–
TTPH	Exit	TETRAPHASE PHARMACEUTICALS INC	$0	–	-633,400	–	-0.80%	–
EDIT	Exit	EDITAS MEDICINE INC COM	$0	–	-717,107	–	-2.14%	–
	Exit	GILEAD SCIENCES INCcall	$0	–	-500,000	–	-6.76%	–
	Exit	ALEXION PHARMACEUTICALS, INCcall	$0	–	-569,500	–	-13.89%	–

Q2 2017

			Value		Shares		↓ Weighting
	New	ALEXION PHARMACEUTICALS, INCcall	$78,215,000	–	569,500	–	13.89%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$70,869,000	–	3,753,635	–	12.58%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$60,776,000	–	2,943,164	–	10.79%	–
FGEN	New	FIBROGEN INC	$51,210,000	–	1,585,457	–	9.09%	–
GLPG	New	GALAPAGOS NV SPON ADRsponsored adr	$44,267,000	–	578,505	–	7.86%	–
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$41,157,000	–	1,482,600	–	7.31%	–
	New	GILEAD SCIENCES INCcall	$38,045,000	–	500,000	–	6.76%	–
SGMO	New	SANGAMO BIOSCIENCES INC	$22,599,000	–	2,568,119	–	4.01%	–
KURA	New	KURA ONCOLOGY INC COM	$18,913,000	–	2,033,622	–	3.36%	–
TOCA	New	TOCAGEN INC	$18,074,000	–	1,502,373	–	3.21%	–
CTMX	New	CYTOMX THERAPEUTICS INC	$12,322,000	–	794,969	–	2.19%	–
EDIT	New	EDITAS MEDICINE INC COM	$12,033,000	–	717,107	–	2.14%	–
CASC	New	CASCADIAN THERAPEUTICS INC	$11,145,000	–	3,000,000	–	1.98%	–
CRVS	New	CORVUS PHARMACEUTICALS INC	$9,741,000	–	805,000	–	1.73%	–
	New	VERTEX PHARMACEUTICALS INCcall	$9,109,000	–	60,000	–	1.62%	–
FATE	New	FATE THERAPEUTICS INC	$8,220,000	–	2,537,026	–	1.46%	–
LIFE	New	ATYR PHARMA INC	$7,795,000	–	2,292,659	–	1.38%	–
OVAS	New	OVASCIENCE INC	$5,479,000	–	3,512,332	–	0.97%	–
ACRS	New	ACLARIS THERAPEUTICS INC	$5,030,000	–	185,472	–	0.89%	–
KIN	New	KINDRED BIOSCIENCES INC	$4,686,000	–	544,880	–	0.83%	–
TTPH	New	TETRAPHASE PHARMACEUTICALS INC	$4,516,000	–	633,400	–	0.80%	–
	New	EDITAS MEDICINE INC COMcall	$4,315,000	–	255,000	–	0.77%	–
RGLS	New	REGULUS THERAPEUTICS INC	$3,656,000	–	3,709,144	–	0.65%	–
ACHN	New	ACHILLION PHARMACEUTICALS INC	$3,410,000	–	742,835	–	0.60%	–
	New	NABRIVA THERAPEUTICS	$2,775,000	–	264,773	–	0.49%	–
DRNA	New	DICERNA PHARMACEUTICALS INC	$2,435,000	–	767,992	–	0.43%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$2,186,000	–	874,447	–	0.39%	–
NERV	New	MINERVA NEUROSCIENCES INC	$1,981,000	–	223,802	–	0.35%	–
BHVN	New	BIOHAVEN PHARMACEUTICAL HLDG CO LTD	$1,750,000	–	70,000	–	0.31%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,199,000	–	23,300	–	0.21%	–
CCXI	New	CHEMOCENTRYX INC	$1,104,000	–	118,000	–	0.20%	–
BMY	New	BRISTOL MYERS SQUIBB CO	$951,000	–	17,060	–	0.17%	–
CLVS	New	CLOVIS ONCOLOGY INC	$936,000	–	10,000	–	0.17%	–
ALNY	New	ALNYLAM PHARMACEUTICALS INC	$831,000	–	10,425	–	0.15%	–
SGEN	New	SEATTLE GENETICS INC	$776,000	–	15,000	–	0.14%	–
PETX	New	ARATANA THERAPEUTICS INC	$723,000	–	100,000	–	0.13%	–

Q4 2016

			Value		Shares		↓ Weighting
	Exit	CASCADIAN THERAPEUTICS INCcall	$0	–	-103,800	–	-0.05%	–
SYRS	Exit	SYROS PHARMACEUTICALS INC	$0	–	-63,596	–	-0.27%	–
	Exit	CHEMOCENTRYX INC	$0	–	-178,000	–	-0.33%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-590,527	–	-0.56%	–
OMED	Exit	ONCOMED PHARMACEUTICALS INC	$0	–	-265,784	–	-0.93%	–
CMRX	Exit	CHIMERIX INC	$0	–	-598,062	–	-1.02%	–
NTLA	Exit	INTELLIA THERAPEUTICS INC	$0	–	-200,858	–	-1.05%	–
NBRV	Exit	NABRIVA THERAPEUTICS AGsponsored adr	$0	–	-548,912	–	-1.19%	–
ADVM	Exit	ADVERUM BIOTECHNOLOGIES INC	$0	–	-946,263	–	-1.19%	–
ONCE	Exit	SPARK THERAPEUTICS INC	$0	–	-68,600	–	-1.26%	–
ASND	Exit	ASCENDIS PHARMA A Ssponsored adr	$0	–	-219,200	–	-1.35%	–
	Exit	IRONWOOD PHARMACEUTICALS INCcall	$0	–	-281,500	–	-1.37%	–
BGNE	Exit	BEIGENE LTDsponsored adr	$0	–	-163,470	–	-1.55%	–
SNDX	Exit	SYNDAX PHARMACEUTICALS INC	$0	–	-357,365	–	-1.66%	–
KIN	Exit	KINDRED BIOSCIENCES INC	$0	–	-1,432,765	–	-2.19%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-846,654	–	-2.38%	–
AKAOQ	Exit	ACHAOGEN INC	$0	–	-1,679,707	–	-2.47%	–
	Exit	EXACT SCIENCES CORPput	$0	–	-500,000	–	-2.85%	–
PTI	Exit	PROTEOSTASIS THERAPEUTICS INC	$0	–	-602,315	–	-2.88%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-200,000	–	-3.24%	–
	Exit	ALLERGAN PLCcall	$0	–	-50,000	–	-3.53%	–
	Exit	GILEAD SCIENCES INCcall	$0	–	-150,000	–	-3.64%	–
FGEN	Exit	FIBROGEN INC	$0	–	-686,184	–	-4.36%	–
FPRX	Exit	FIVE PRIME THERAPEUTICS INC	$0	–	-286,612	–	-4.62%	–
KURA	Exit	KURA ONCOLOGY INC	$0	–	-2,611,906	–	-5.01%	–
ARDX	Exit	ARDELYX INC	$0	–	-1,310,023	–	-5.20%	–
DERM	Exit	DERMIRA INC	$0	–	-522,000	–	-5.42%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-2,943,164	–	-6.51%	–
	Exit	BRISTOL MYERS SQUIBB COcall	$0	–	-500,000	–	-8.27%	–
GLPG	Exit	GALAPAGOS NVsponsored adr	$0	–	-500,576	–	-9.93%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-2,810,315	–	-13.69%	–

Q3 2016

			Value		Shares		↓ Weighting
IRWD	Buy	IRONWOOD PHARMACEUTICALS INC	$44,628,000	+40.4%	2,810,315	+15.6%	13.69%	+9.3%
GLPG	Buy	GALAPAGOS NVsponsored adr	$32,367,000	+32.8%	500,576	+13.9%	9.93%	+3.4%
	New	BRISTOL MYERS SQUIBB COcall	$26,960,000	–	500,000	–	8.27%	–
DERM	Buy	DERMIRA INC	$17,654,000	+121.9%	522,000	+91.9%	5.42%	+72.7%
ARDX	New	ARDELYX INC	$16,952,000	–	1,310,023	–	5.20%	–
KURA	Buy	KURA ONCOLOGY INC	$16,324,000	+144.3%	2,611,906	+5.9%	5.01%	+90.2%
FPRX	New	FIVE PRIME THERAPEUTICS INC	$15,044,000	–	286,612	–	4.62%	–
FGEN	Sell	FIBROGEN INC	$14,204,000	+9.7%	686,184	-13.0%	4.36%	-14.6%
AGIO	New	AGIOS PHARMACEUTICALS INC	$10,564,000	–	200,000	–	3.24%	–
PTI	New	PROTEOSTASIS THERAPEUTICS INC	$9,390,000	–	602,315	–	2.88%	–
	New	EXACT SCIENCES CORPput	$9,285,000	–	500,000	–	2.85%	–
AKAOQ	Buy	ACHAOGEN INC	$8,046,000	+35.1%	1,679,707	+6.9%	2.47%	+5.1%
CYTK	Sell	CYTOKINETICS INC	$7,772,000	-61.7%	846,654	-60.4%	2.38%	-70.2%
BGNE	Sell	BEIGENE LTDsponsored adr	$5,037,000	-3.6%	163,470	-6.8%	1.55%	-25.0%
	Sell	IRONWOOD PHARMACEUTICALS INCcall	$4,470,000	-41.2%	281,500	-51.6%	1.37%	-54.3%
ASND	New	ASCENDIS PHARMA A Ssponsored adr	$4,406,000	–	219,200	–	1.35%	–
ONCE	New	SPARK THERAPEUTICS INC	$4,120,000	–	68,600	–	1.26%	–
ADVM	New	ADVERUM BIOTECHNOLOGIES INC	$3,889,000	–	946,263	–	1.19%	–
NBRV	Sell	NABRIVA THERAPEUTICS AGsponsored adr	$3,870,000	-8.3%	548,912	-2.5%	1.19%	-28.6%
NTLA	Sell	INTELLIA THERAPEUTICS INC	$3,419,000	-48.5%	200,858	-35.4%	1.05%	-59.9%
CMRX	New	CHIMERIX INC	$3,313,000	–	598,062	–	1.02%	–
OMED	New	ONCOMED PHARMACEUTICALS INC	$3,038,000	–	265,784	–	0.93%	–
FATE	New	FATE THERAPEUTICS INC	$1,842,000	–	590,527	–	0.56%	–
	New	CHEMOCENTRYX INC	$1,075,000	–	178,000	–	0.33%	–
SYRS	New	SYROS PHARMACEUTICALS INC	$882,000	–	63,596	–	0.27%	–
	New	CASCADIAN THERAPEUTICS INCcall	$170,000	–	103,800	–	0.05%	–
EIGR	Exit	EIGER BIOPHARMACEUTICALS INC	$0	–	-14,190	–	-0.11%	–
	Exit	TARGACEPT INCnote	$0	–	-669,166	–	-0.26%	–
ADXS	Exit	ADVAXIS INC	$0	–	-92,800	–	-0.30%	–
TSRO	Exit	TESARO INC	$0	–	-9,200	–	-0.30%	–
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-63,468	–	-0.34%	–
	Exit	IMMUNOGEN INCcall	$0	–	-299,500	–	-0.36%	–
FWP	Exit	FORWARD PHARMA A/Ssponsored adr	$0	–	-84,332	–	-0.60%	–
	Exit	ARRAY BIOPHARMA INCcall	$0	–	-520,000	–	-0.73%	–
EDIT	Exit	EDITAS MEDICINE INC	$0	–	-85,469	–	-0.82%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-136,882	–	-1.19%	–
XNCR	Exit	XENCOR INC	$0	–	-168,000	–	-1.26%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-281,776	–	-1.32%	–
EPZM	Exit	EPIZYME INC	$0	–	-755,046	–	-3.05%	–
ITCI	Exit	INTRA CELLULAR THERAPIES INC	$0	–	-244,950	–	-3.75%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-371,381	–	-4.98%	–
RTRX	Exit	RETROPHIN INC	$0	–	-1,225,084	–	-8.60%	–

Q2 2016

			Value		Shares		↓ Weighting
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$31,778,000	–	2,430,451	–	12.53%	–
GLPG	New	GALAPAGOS NVsponsored adr	$24,373,000	–	439,385	–	9.61%	–
RTRX	New	RETROPHIN INC	$21,819,000	–	1,225,084	–	8.60%	–
CYTK	New	CYTOKINETICS INC	$20,306,000	–	2,139,697	–	8.01%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$16,335,000	–	2,943,164	–	6.44%	–
FGEN	New	FIBROGEN INC	$12,943,000	–	788,745	–	5.10%	–
XLRN	New	ACCELERON PHARMA INC	$12,620,000	–	371,381	–	4.98%	–
	New	GILEAD SCIENCES INCcall	$12,513,000	–	150,000	–	4.93%	–
	New	ALLERGAN PLCcall	$11,555,000	–	50,000	–	4.56%	–
ITCI	New	INTRA CELLULAR THERAPIES INC	$9,509,000	–	244,950	–	3.75%	–
DERM	New	DERMIRA INC	$7,956,000	–	272,000	–	3.14%	–
EPZM	New	EPIZYME INC	$7,732,000	–	755,046	–	3.05%	–
	New	IRONWOOD PHARMACEUTICALS INCcall	$7,606,000	–	581,500	–	3.00%	–
KURA	New	KURA ONCOLOGY INC	$6,681,000	–	2,465,286	–	2.63%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$6,633,000	–	310,695	–	2.62%	–
AKAOQ	New	ACHAOGEN INC	$5,957,000	–	1,571,708	–	2.35%	–
BGNE	New	BEIGENE LTDsponsored adr	$5,226,000	–	175,380	–	2.06%	–
KIN	New	KINDRED BIOSCIENCES INC	$5,072,000	–	1,432,765	–	2.00%	–
NBRV	New	NABRIVA THERAPEUTICS AGsponsored adr	$4,221,000	–	562,741	–	1.66%	–
SNDX	New	SYNDAX PHARMACEUTICALS INC	$3,520,000	–	357,365	–	1.39%	–
COLL	New	COLLEGIUM PHARMACEUTICAL INC	$3,339,000	–	281,776	–	1.32%	–
XNCR	New	XENCOR INC	$3,190,000	–	168,000	–	1.26%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$3,018,000	–	136,882	–	1.19%	–
EDIT	New	EDITAS MEDICINE INC	$2,085,000	–	85,469	–	0.82%	–
	New	ARRAY BIOPHARMA INCcall	$1,851,000	–	520,000	–	0.73%	–
FWP	New	FORWARD PHARMA A/Ssponsored adr	$1,532,000	–	84,332	–	0.60%	–
	New	IMMUNOGEN INCcall	$922,000	–	299,500	–	0.36%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$856,000	–	63,468	–	0.34%	–
TSRO	New	TESARO INC	$773,000	–	9,200	–	0.30%	–
ADXS	New	ADVAXIS INC	$751,000	–	92,800	–	0.30%	–
	New	TARGACEPT INCnote	$669,000	–	669,166	–	0.26%	–
EIGR	New	EIGER BIOPHARMACEUTICALS INC	$281,000	–	14,190	–	0.11%	–

Q4 2015

			Value		Shares		↓ Weighting
	Exit	REGULUS THERAPEUTICS INCcall	$0	–	-1,280	–	-0.02%	–
CBIO	Exit	CATALYST BIOSCIENCES INC	$0	–	-56,000	–	-0.12%	–
	Exit	VALEANT PHARMACEUTICALS INTLcall	$0	–	-1,265	–	-0.61%	–
QLTI	Exit	QLT INC	$0	–	-638,900	–	-0.77%	–
OREX	Exit	OREXIGEN THERAPEUTICS INC	$0	–	-937,958	–	-0.90%	–
	Exit	GILEAD SCIENCES INCcall	$0	–	-3,255	–	-0.98%	–
CALA	Exit	CALITHERA BIOSCIENCES INC	$0	–	-415,480	–	-1.03%	–
FPRX	Exit	FIVE PRIME THERAPEUTICS INC	$0	–	-149,000	–	-1.04%	–
FWP	Exit	FORWARD PHARMA A/Ssponsored adr	$0	–	-101,995	–	-1.09%	–
AKTX	Exit	AKARI THERAPEUTICS PLCsponsored adr	$0	–	-100,709	–	-1.10%	–
ONTY	Exit	ONCOTHYREON INC	$0	–	-943,500	–	-1.18%	–
CLDN	Exit	CELLADON CORP	$0	–	-2,843,170	–	-1.36%	–
GNVC	Exit	GENVEC INC	$0	–	-1,986,413	–	-2.09%	–
KIN	Exit	KINDRED BIOSCIENCES INC	$0	–	-1,323,431	–	-3.13%	–
NBRV	Exit	NABRIVA THERAPEUTICS AGsponsored adr	$0	–	-835,530	–	-3.61%	–
LIFE	Exit	ATYR PHARMA INC	$0	–	-840,462	–	-3.92%	–
COLL	Exit	COLLEGIUM PHARMACEUTICAL INC	$0	–	-465,118	–	-4.68%	–
FLKS	Exit	FLEX PHARMA INC	$0	–	-933,691	–	-5.10%	–
KITE	Exit	KITE PHARMA INC	$0	–	-281,400	–	-7.13%	–
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-1,887,069	–	-8.21%	–
EPZM	Exit	EPIZYME INC	$0	–	-1,492,700	–	-8.74%	–
RTRX	Exit	RETROPHIN INC	$0	–	-1,007,660	–	-9.29%	–
	Exit	ARRAY BIOPHARMA INCnote	$0	–	-22,534,000	–	-10.11%	–
ATRA	Exit	ATARA BIOTHERAPEUTICS INC	$0	–	-803,458	–	-11.50%	–
FGEN	Exit	FIBROGEN INC	$0	–	-1,230,391	–	-12.28%	–

Q3 2015

			Value		Shares		↓ Weighting
FGEN	Buy	FIBROGEN INC	$26,970,000	-4.8%	1,230,391	+2.1%	12.28%	+30.0%
ATRA	Sell	ATARA BIOTHERAPEUTICS INC	$25,261,000	-55.0%	803,458	-24.4%	11.50%	-38.5%
	Buy	ARRAY BIOPHARMA INCnote	$22,210,000	-8.4%	22,534,000	+17.4%	10.11%	+25.1%
RTRX	Buy	RETROPHIN INC	$20,415,000	+80.2%	1,007,660	+194.9%	9.29%	+146.1%
EPZM	Sell	EPIZYME INC	$19,196,000	-52.6%	1,492,700	-11.5%	8.74%	-35.2%
ASMB	Buy	ASSEMBLY BIOSCIENCES INC	$18,040,000	-40.5%	1,887,069	+19.9%	8.21%	-18.8%
FLKS	Buy	FLEX PHARMA INC	$11,214,000	-28.2%	933,691	+2.8%	5.10%	-2.1%
LIFE	Buy	ATYR PHARMA INC	$8,623,000	-44.4%	840,462	+0.4%	3.92%	-24.0%
NBRV	New	NABRIVA THERAPEUTICS AGsponsored adr	$7,938,000	–	835,530	–	3.61%	–
KIN	Buy	KINDRED BIOSCIENCES INC	$6,882,000	-22.0%	1,323,431	+2.2%	3.13%	+6.4%
ONTY	New	ONCOTHYREON INC	$2,585,000	–	943,500	–	1.18%	–
AKTX	New	AKARI THERAPEUTICS PLCsponsored adr	$2,417,000	–	100,709	–	1.10%	–
FWP	Sell	FORWARD PHARMA A/Ssponsored adr	$2,403,000	-60.3%	101,995	-35.8%	1.09%	-45.8%
FPRX	New	FIVE PRIME THERAPEUTICS INC	$2,293,000	–	149,000	–	1.04%	–
	New	GILEAD SCIENCES INCcall	$2,148,000	–	3,255	–	0.98%	–
OREX	New	OREXIGEN THERAPEUTICS INC	$1,979,000	–	937,958	–	0.90%	–
QLTI	Buy	QLT INC	$1,699,000	+2.8%	638,900	+59.7%	0.77%	+40.3%
	New	VALEANT PHARMACEUTICALS INTLcall	$1,347,000	–	1,265	–	0.61%	–
CBIO	New	CATALYST BIOSCIENCES INC	$261,000	–	56,000	–	0.12%	–
	Exit	EPIZYMEcall	$0	–	-150	–	-0.12%	–
XENE	Exit	XENON PHARMACEUTICALS	$0	–	-73,000	–	-0.28%	–
MCRB	Exit	SERES THERAPEUTICS	$0	–	-40,000	–	-0.55%	–
TRGT	Exit	TARGACEPT	$0	–	-619,699	–	-0.58%	–
BITI	Exit	BIOTIE THERAPIES OYJ SPONSORED ADRsponsored adr	$0	–	-100,000	–	-0.67%	–
ARRY	Exit	ARRAY BIOPHARMA	$0	–	-400,000	–	-0.96%	–
	Exit	OVASCIENCEcall	$0	–	-2,300	–	-2.22%	–
	Exit	ARRAY BIOPHARMAcall	$0	–	-11,000	–	-2.64%	–

Q2 2015

			Value		Shares		↓ Weighting
ATRA	New	ATARA BIOTHERAPEUTICS	$56,094,000	–	1,063,189	–	18.70%	–
EPZM	New	EPIZYME	$40,459,000	–	1,685,800	–	13.49%	–
ASMB	New	ASSEMBLY BIOSCIENCES	$30,317,000	–	1,574,107	–	10.11%	–
FGEN	New	FIBROGEN	$28,327,000	–	1,205,391	–	9.44%	–
	New	ARRAY BIOPHARMA SR CONV NT 3.000% Due 06/01/2020note	$24,240,000	–	19,200,000	–	8.08%	–
KITE	New	KITE PHARMA	$17,157,000	–	281,400	–	5.72%	–
FLKS	New	FLEX PHARMA	$15,629,000	–	908,691	–	5.21%	–
LIFE	New	ATYR PHARMA	$15,499,000	–	836,860	–	5.17%	–
RTRX	New	RETROPHIN	$11,326,000	–	341,650	–	3.78%	–
KIN	New	KINDRED BIOSCIENCES	$8,828,000	–	1,294,431	–	2.94%	–
COLL	New	COLLEGIUM PHARMACEUTICAL	$8,298,000	–	465,118	–	2.77%	–
	New	ARRAY BIOPHARMAcall	$7,931,000	–	11,000	–	2.64%	–
	New	OVASCIENCEcall	$6,654,000	–	2,300	–	2.22%	–
FWP	New	FORWARD PHARMA A/S SPONSORED ADRsponsored adr	$6,049,000	–	158,985	–	2.02%	–
GNVC	New	GENVEC	$4,052,000	–	1,986,413	–	1.35%	–
CLDN	New	CELLADON	$3,582,000	–	2,843,170	–	1.19%	–
CALA	New	CALITHERA BIOSCIENCES	$2,967,000	–	415,480	–	0.99%	–
ARRY	New	ARRAY BIOPHARMA	$2,884,000	–	400,000	–	0.96%	–
BITI	New	BIOTIE THERAPIES OYJ SPONSORED ADRsponsored adr	$1,997,000	–	100,000	–	0.67%	–
TRGT	New	TARGACEPT	$1,729,000	–	619,699	–	0.58%	–
MCRB	New	SERES THERAPEUTICS	$1,660,000	–	40,000	–	0.55%	–
QLTI	New	QLT	$1,652,000	–	400,000	–	0.55%	–
	New	REGULUS THERAPEUTICScall	$1,403,000	–	1,280	–	0.47%	–
XENE	New	XENON PHARMACEUTICALS	$842,000	–	73,000	–	0.28%	–
	New	EPIZYMEcall	$360,000	–	150	–	0.12%	–

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