$887 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 100 reported holdings in Q4 2018. The portfolio turnover from Q3 2018 to Q4 2018 was 54.4% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| MRK | Sell | MERCK & CO INC | $36,066,000 | -34.8% | 472,000 | -39.5% | 4.06% | -36.0% |
| CSTE | Sell | CAESARSTONE LTD | $23,808,000 | +128.7% | 469,160 | -16.4% | 2.68% | +124.5% |
| VRNT | Sell | VERINT SYS INC | $23,573,000 | +213.4% | 149,100 | -0.7% | 2.66% | +207.9% |
| GILD | Sell | GILEAD SCIENCES INC | $21,893,000 | -32.5% | 350,000 | -16.7% | 2.47% | -33.7% |
| MSFT | Sell | MICROSOFT CORP | $17,838,000 | +123.9% | 46,998 | -32.5% | 2.01% | +119.8% |
| GSK | Sell | GLAXOSMITHKLINE PLCsponsored adr | $11,845,000 | -65.9% | 310,000 | -64.2% | 1.34% | -66.5% |
| MLNX | Sell | MELLANOX TECHNOLOGIES LTD | $9,787,000 | +166.0% | 28,351 | -43.4% | 1.10% | +161.4% |
| ARGX | Sell | ARGENX SEsponsored adr | $8,366,000 | -19.1% | 87,081 | -36.1% | 0.94% | -20.6% |
| AUTL | Sell | AUTOLUS THERAPEUTICS PLCspon ads | $6,666,000 | -25.4% | 202,994 | -31.5% | 0.75% | -26.8% |
| FSCT | Sell | FORESCOUT TECHNOLOGIES INC | $5,746,000 | +22.3% | 59,169 | -52.5% | 0.65% | +20.0% |
| VKTX | Sell | VIKING THERAPEUTICS INC | $5,705,000 | -61.9% | 745,727 | -13.3% | 0.64% | -62.6% |
| PRQR | Sell | PROQR THRAPEUTICS N V | $5,365,000 | -30.5% | 340,000 | -14.7% | 0.60% | -31.7% |
| NERV | Sell | MINERVA NEUROSCIENCES INC | $5,271,000 | -50.1% | 782,018 | -7.2% | 0.59% | -51.1% |
| BHVN | Sell | BIOHAVEN PHARMACTL HLDG CO L | $4,919,000 | -15.8% | 133,015 | -14.5% | 0.55% | -17.3% |
| AGLE | Sell | AEGLEA BIOTHERAPEUTICS INC | $4,494,000 | -28.1% | 600,000 | -8.1% | 0.51% | -29.4% |
| SBBP | Sell | STRONGBRIDGE BIOPHARMA PLC | $4,174,000 | -27.0% | 931,600 | -21.0% | 0.47% | -28.4% |
| SRRK | Sell | SCHOLAR ROCK HLDG CORP | $4,031,000 | -47.3% | 175,511 | -40.9% | 0.45% | -48.3% |
| ASND | Sell | ASCENDIS PHARMA A Ssponsored adr | $3,651,000 | -44.4% | 58,273 | -37.1% | 0.41% | -45.4% |
| FIXX | Sell | HOMOLOGY MEDICINES INC | $3,600,000 | -35.7% | 161,000 | -34.3% | 0.41% | -36.9% |
| ACIU | Sell | AC IMMUNE SA | $2,935,000 | -27.2% | 310,613 | -38.3% | 0.33% | -28.5% |
| VTGN | Sell | VISTAGEN THERAPEUTICS INC | $2,211,000 | -8.9% | 1,473,918 | -11.9% | 0.25% | -10.8% |
| ABEO | Sell | ABEONA THERAPEUTICS INC | $1,928,000 | -55.3% | 270,036 | -19.9% | 0.22% | -56.2% |
| ZFGN | Sell | ZAFGEN INC | $1,881,000 | -62.6% | 380,000 | -11.6% | 0.21% | -63.3% |
| PIRS | Sell | PIERIS PHARMACEUTICALS INC | $1,862,000 | -63.2% | 700,000 | -22.6% | 0.21% | -63.9% |
| ARRY | Sell | ARRAY BIOPHARMA INC | $1,781,000 | -70.3% | 125,000 | -68.4% | 0.20% | -70.8% |
| APLS | Sell | APELLIS PHARMACEUTICALS INC | $1,543,000 | -59.2% | 117,000 | -44.9% | 0.17% | -59.9% |
| SVRA | Sell | SAVARA INC | $833,000 | -64.4% | 110,000 | -47.5% | 0.09% | -65.1% |
| VRCA | Sell | VERRICA PHARMACEUTICALS INC | $791,000 | -58.4% | 97,000 | -17.1% | 0.09% | -59.2% |
| KZR | Sell | KEZAR LIFE SCIENCES INC | $472,000 | -89.6% | 20,000 | -90.6% | 0.05% | -89.8% |
| SRRA | Sell | SIERRA ONCOLOGY INC | $341,000 | -80.4% | 258,510 | -74.7% | 0.04% | -81.0% |
| ADVM | Sell | ADVERUM BIOTECHNOLOGIES INC | $200,000 | -55.9% | 63,355 | -15.5% | 0.02% | -55.8% |
| CMCSA | Exit | COMCAST CORP NEWcl a | $0 | – | -5,993 | -100.0% | -0.02% | – |
| SITE | Exit | SITEONE LANDSCAPE SUPPLY INC | $0 | – | -3,000 | -100.0% | -0.03% | – |
| CISN | Exit | CISION LTD | $0 | – | -15,000 | -100.0% | -0.03% | – |
| ULTI | Exit | ULTIMATE SOFTWARE GROUP INC | $0 | – | -800 | -100.0% | -0.03% | – |
| LOW | Exit | LOWES COS INC | $0 | – | -2,500 | -100.0% | -0.03% | – |
| EIDX | Exit | EIDOS THERAPEUTICS INC | $0 | – | -31,522 | -100.0% | -0.04% | – |
| ABUS | Exit | ARBUTUS BIOPHARMA CORP | $0 | – | -40,000 | -100.0% | -0.04% | – |
| SERV | Exit | SERVICEMASTER GLOBAL HLDGS I | $0 | – | -9,500 | -100.0% | -0.04% | – |
| VKTX | Exit | VIKING THERAPEUTICS INCcall | $0 | – | -23,900 | -100.0% | -0.05% | – |
| CHTR | Exit | CHARTER COMMUNICATIONS INC Ncl a | $0 | – | -1,419 | -100.0% | -0.05% | – |
| RDWR | Exit | RADWARE LTDord | $0 | – | -17,527 | -100.0% | -0.05% | – |
| UNH | Exit | UNITEDHEALTH GROUP INC | $0 | – | -2,000 | -100.0% | -0.06% | – |
| AUDC | Exit | AUDIOCODES LTDord | $0 | – | -59,226 | -100.0% | -0.07% | – |
| Exit | TEVA PHARMACEUTICAL FIN LLCdbcv 0.250% 2/0 | $0 | – | -2,135 | -100.0% | -0.10% | – | |
| AAP | Exit | ADVANCE AUTO PARTS INC | $0 | – | -5,336 | -100.0% | -0.10% | – |
| ZYME | Exit | ZYMEWORKS INC | $0 | – | -73,800 | -100.0% | -0.13% | – |
| SESN | Exit | SESEN BIO INC | $0 | – | -630,000 | -100.0% | -0.16% | – |
| AQST | Exit | AQUESTIVE THERAPEUTICS INC | $0 | – | -95,300 | -100.0% | -0.19% | – |
| FLEX | Exit | FLEX LTDord | $0 | – | -159,549 | -100.0% | -0.24% | – |
| LPTX | Exit | LEAP THERAPEUTICS INC | $0 | – | -332,525 | -100.0% | -0.30% | – |
| ALNY | Exit | ALNYLAM PHARMACEUTICALS INC | $0 | – | -40,000 | -100.0% | -0.40% | – |
| ASMB | Exit | ASSEMBLY BIOSCIENCES INC | $0 | – | -100,431 | -100.0% | -0.43% | – |
| ORLY | Exit | O REILLY AUTOMOTIVE INC NEW | $0 | – | -10,844 | -100.0% | -0.43% | – |
| GOOGL | Exit | ALPHABET INCcap stk cl a | $0 | – | -3,269 | -100.0% | -0.45% | – |
| IDRA | Exit | IDERA PHARMACEUTICALS INC | $0 | – | -445,558 | -100.0% | -0.46% | – |
| SNA | Exit | SNAP ON INC | $0 | – | -21,666 | -100.0% | -0.46% | – |
| OBSV | Exit | OBSEVA SA | $0 | – | -243,669 | -100.0% | -0.50% | – |
| BOLD | Exit | AUDENTES THERAPEUTICS INC | $0 | – | -120,000 | -100.0% | -0.54% | – |
| CSCO | Exit | CISCO SYS INC | $0 | – | -100,000 | -100.0% | -0.56% | – |
| MA | Exit | MASTERCARD INCORPORATEDcl a | $0 | – | -22,760 | -100.0% | -0.58% | – |
| IFF | Exit | INTERNATIONAL FLAVORS&FRAGRA | $0 | – | -36,450 | -100.0% | -0.58% | – |
| MRTX | Exit | MIRATI THERAPEUTICS INC | $0 | – | -112,908 | -100.0% | -0.61% | – |
| WAB | Exit | WABTEC CORP | $0 | – | -53,114 | -100.0% | -0.64% | – |
| SEDG | Exit | SOLAREDGE TECHNOLOGIES INC | $0 | – | -150,817 | -100.0% | -0.65% | – |
| V | Exit | VISA INC | $0 | – | -40,401 | -100.0% | -0.70% | – |
| BMRN | Exit | BIOMARIN PHARMACEUTICAL INC | $0 | – | -88,000 | -100.0% | -0.98% | – |
| JNJ | Exit | JOHNSON & JOHNSON | $0 | – | -325,000 | -100.0% | -5.16% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2019-02-14
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR | 2024-05-15 |
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.