SPHERA FUNDS MANAGEMENT LTD. - Q1 2017 holdings

Add to watchlist

$512 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 112 reported holdings in Q1 2017. The portfolio turnover from Q4 2016 to Q1 2017 was 61.5% .

All

			Value		Shares		↓ Weighting
	Sell	SPDR SERIES TRUSTput	$57,152,000	+75.6%	8,000	-98.5%	11.17%	+35.6%
CELG	Buy	CELGENE CORP	$31,108,000	+49.3%	250,000	+38.9%	6.08%	+15.3%
	New	SPDR S&P 500 ETF TRput	$23,808,000	–	1,000	+100.0%	4.65%	–
BIIB	New	BIOGEN INC	$20,507,000	–	75,000	+100.0%	4.01%	–
NVS	New	NOVARTIS A Gsponsored adr	$18,959,000	–	255,000	+100.0%	3.71%	–
MRK	Sell	MERCK & CO INC	$18,744,000	-29.2%	295,000	-34.4%	3.66%	-45.4%
SHPG	Buy	SHIRE PLCsponsored adr	$15,424,000	+178.6%	214,539	+560.1%	3.02%	+115.0%
	New	CELGENE CORPcall	$14,886,000	–	1,200	+100.0%	2.91%	–
SRPT	Buy	SAREPTA THERAPEUTICS INC	$14,298,000	+31.0%	483,047	+21.4%	2.80%	+1.1%
PFE	New	PFIZER INC	$13,342,000	–	390,000	+100.0%	2.61%	–
ITRN	Sell	ITURAN LOCATION AND CONTROL	$8,680,000	+6.8%	281,356	-8.2%	1.70%	-17.5%
BMY	New	BRISTOL MYERS SQUIBB CO	$8,157,000	–	150,000	+100.0%	1.60%	–
	New	NEUROCRINE BIOSCIENCES INCput	$8,010,000	–	1,500	+100.0%	1.57%	–
ASND	Sell	ASCENDIS PHARMA A Ssponsored adr	$7,153,000	+8.2%	255,455	-21.8%	1.40%	-16.4%
HZNP	Buy	HORIZON PHARMA PLC	$7,094,000	+46.1%	480,000	+60.0%	1.39%	+12.9%
	Sell	ISHARES TRput	$6,953,000	-48.4%	500	-99.5%	1.36%	-60.2%
NBIX	New	NEUROCRINE BIOSCIENCES INC	$6,495,000	–	150,000	+100.0%	1.27%	–
VSAR	Buy	VERSARTIS INC	$6,405,000	+71.9%	300,000	+20.0%	1.25%	+32.8%
ARRY	Sell	ARRAY BIOPHARMA INC	$6,258,000	-20.9%	700,000	-22.2%	1.22%	-38.9%
IMMU	Sell	IMMUNOMEDICS INC	$6,147,000	+59.5%	950,000	-9.5%	1.20%	+23.2%
CRVS	Sell	CORVUS PHARMACEUTICALS INC	$5,798,000	+26.6%	279,166	-12.8%	1.13%	-2.2%
TEVA	Sell	TEVA PHARMACEUTICAL INDS LTDsponsored adr	$5,519,000	-70.8%	172,000	-67.0%	1.08%	-77.5%
ORBK	Buy	ORBOTECH LTDord	$5,066,000	+235.3%	157,096	+247.4%	0.99%	+159.2%
AKAOQ	Sell	ACHAOGEN INC	$5,046,000	-24.7%	200,000	-61.1%	0.99%	-41.8%
	Sell	TEVA PHARMACEUTICAL INDS LTDcall	$4,737,000	-39.2%	1,500	-99.3%	0.93%	-53.1%
V	Buy	VISA INC	$4,706,000	+16.1%	52,951	+1.9%	0.92%	-10.3%
EIGR		EIGER BIOPHARMACEUTICALS INC	$4,412,000	-1.7%	385,301	0.0%	0.86%	-24.0%
ARDX	Buy	ARDELYX INC	$4,364,000	+102.4%	345,000	+127.3%	0.85%	+56.2%
NICE	Buy	NICE LTDsponsored adr	$4,318,000	+63.9%	63,520	+65.7%	0.84%	+26.5%
GLYC	Buy	GLYCOMIMETICS INC	$4,213,000	-7.4%	775,796	+4.0%	0.82%	-28.4%
TXMD	New	THERAPEUTICSMD INC	$4,176,000	–	580,000	+100.0%	0.82%	–
FGEN	Buy	FIBROGEN INC	$4,085,000	+22.6%	165,700	+6.4%	0.80%	-5.2%
GNCA	Sell	GENOCEA BIOSCIENCES INC	$3,936,000	+37.2%	646,273	-7.2%	0.77%	+5.9%
CHTR	Sell	CHARTER COMMUNICATIONS INC Ncl a	$3,915,000	-15.9%	11,960	-26.0%	0.76%	-35.1%
RTRX	Buy	RETROPHIN INC	$3,861,000	+41.7%	209,131	+45.3%	0.76%	+9.4%
CLLS	New	CELLECTIS S Asponsored ads	$3,832,000	–	159,664	+100.0%	0.75%	–
		TEVA PHARMACEUTICAL FIN LLCdbcv 0.250% 2/0	$3,800,000	-10.5%	6,585	0.0%	0.74%	-30.9%
HRTX	New	HERON THERAPEUTICS INC	$3,750,000	–	250,000	+100.0%	0.73%	–
GOOGL	Sell	ALPHABET INCcap stk cl a	$3,685,000	-19.1%	4,346	-24.4%	0.72%	-37.6%
FOLD	Sell	AMICUS THERAPEUTICS INC	$3,565,000	-1.7%	500,000	-31.5%	0.70%	-24.1%
SAGE	Sell	SAGE THERAPEUTICS INC	$3,554,000	-22.7%	50,000	-44.4%	0.70%	-40.2%
ADMS	Sell	ADAMAS PHARMACEUTICALS INC	$3,421,000	-25.0%	195,500	-27.6%	0.67%	-42.1%
AVXS		AVEXIS INC	$3,421,000	+59.3%	45,000	0.0%	0.67%	+23.0%
ALDX	Buy	ALDEYRA THERAPEUTICS INC	$3,343,000	+69.6%	668,500	+81.4%	0.65%	+31.1%
LJPC	Buy	LA JOLLA PHARMACEUTICAL CO	$3,284,000	+269.8%	110,000	+117.1%	0.64%	+185.3%
SELB	Sell	SELECTA BIOSCIENCES INC	$3,273,000	-28.9%	228,534	-14.9%	0.64%	-45.1%
CSTE	New	CAESARSTONE LTD	$3,262,000	–	89,974	+100.0%	0.64%	–
DBVT	Buy	DBV TECHNOLOGIES S Asponsored adr	$3,176,000	+14.4%	90,167	+14.1%	0.62%	-11.7%
UNP	Sell	UNION PAC CORP	$3,037,000	-18.8%	28,670	-20.5%	0.59%	-37.3%
	New	ADVANCE AUTO PARTS INCcall	$2,843,000	–	200	+100.0%	0.56%	–
KITE	Sell	KITE PHARMA INC	$2,747,000	+22.5%	35,000	-30.0%	0.54%	-5.5%
SLB	Buy	SCHLUMBERGER LTD	$2,727,000	-5.5%	34,911	+1.6%	0.53%	-27.0%
SBUX	Buy	STARBUCKS CORP	$2,723,000	+7.5%	46,631	+2.2%	0.53%	-17.0%
PRTK		PARATEK PHARMACEUTICALS INC	$2,695,000	+25.0%	140,000	0.0%	0.53%	-3.5%
SNA	Buy	SNAP ON INC	$2,664,000	+41.8%	15,797	+44.0%	0.52%	+9.5%
XLRN		ACCELERON PHARMA INC	$2,647,000	+3.7%	100,000	0.0%	0.52%	-20.0%
PIRS	Buy	PIERIS PHARMACEUTICALS INC	$2,600,000	+129.3%	1,000,000	+23.5%	0.51%	+77.0%
CTMX	New	CYTOMX THERAPEUTICS INC	$2,591,000	–	150,000	+100.0%	0.51%	–
FB	Buy	FACEBOOK INCcl a	$2,570,000	+71.0%	18,092	+38.5%	0.50%	+32.1%
STML	New	STEMLINE THERAPEUTICS INC	$2,565,000	–	300,000	+100.0%	0.50%	–
BLCM	New	BELLICUM PHARMACEUTICALS INC	$2,468,000	–	200,000	+100.0%	0.48%	–
CASC	New	CASCADIAN THERAPEUTICS INC	$2,406,000	–	581,210	+100.0%	0.47%	–
CLSD		CLEARSIDE BIOMEDICAL INC	$2,382,000	-11.2%	300,000	0.0%	0.47%	-31.4%
MRNS	Sell	MARINUS PHARMACEUTICALS INC	$2,357,000	+74.1%	1,331,421	-0.7%	0.46%	+34.4%
FWP	Sell	FORWARD PHARMA A/Ssponsored adr	$2,328,000	+27.6%	108,023	-11.1%	0.46%	-1.5%
SNDX		SYNDAX PHARMACEUTICALS INC	$2,282,000	+91.4%	166,310	0.0%	0.45%	+47.7%
SGEN	New	SEATTLE GENETICS INC	$2,263,000	–	36,000	+100.0%	0.44%	–
OBSV	New	OBSEVA SA	$2,197,000	–	211,086	+100.0%	0.43%	–
TBT	Buy	PROSHARES TR	$2,189,000	+187.6%	55,950	+200.0%	0.43%	+121.8%
ZYNE	New	ZYNERBA PHARMACEUTICALS INC	$2,010,000	–	100,000	+100.0%	0.39%	–
SMMT		SUMMIT THERAPEUTICS PLCspons ads	$1,967,000	+55.9%	147,450	0.0%	0.38%	+20.7%
VTVT	Buy	VTV THERAPEUTICS INCcl a	$1,965,000	+103.4%	300,000	+50.0%	0.38%	+56.7%
CYTK	New	CYTOKINETICS INC	$1,956,000	–	152,200	+100.0%	0.38%	–
SPNS	Buy	SAPIENS INTL CORP N V	$1,897,000	+21.0%	147,306	+34.7%	0.37%	-6.5%
TJX	New	TJX COS INC NEW	$1,795,000	–	22,700	+100.0%	0.35%	–
AVEO	New	AVEO PHARMACEUTICALS INC	$1,711,000	–	2,900,000	+100.0%	0.33%	–
ICPT	New	INTERCEPT PHARMACEUTICALS IN	$1,697,000	–	15,000	+100.0%	0.33%	–
AAP	Sell	ADVANCE AUTO PARTS INC	$1,666,000	-38.7%	11,237	-30.0%	0.33%	-52.6%
PRQR	Buy	PROQR THRAPEUTICS N V	$1,650,000	+68.4%	330,000	+65.0%	0.32%	+30.2%
AXSM	New	AXSOME THERAPEUTICS INC	$1,564,000	–	401,000	+100.0%	0.31%	–
EVOK	New	EVOKE PHARMA INC	$1,550,000	–	500,000	+100.0%	0.30%	–
TSEM	Sell	TOWER SEMICONDUCTOR LTD	$1,548,000	-3.1%	67,155	-20.0%	0.30%	-25.0%
MGNX		MACROGENICS INC	$1,510,000	-9.0%	81,200	0.0%	0.30%	-29.8%
FPRX		FIVE PRIME THERAPEUTICS INC	$1,446,000	-27.8%	40,000	0.0%	0.28%	-44.2%
	New	ISHARES TRcall	$1,391,000	–	100	+100.0%	0.27%	–
EDGE		EDGE THERAPEUTICS INC	$1,367,000	-27.1%	150,000	0.0%	0.27%	-43.8%
XENE		XENON PHARMACEUTICALS INC	$1,312,000	-48.1%	328,029	0.0%	0.26%	-59.9%
MA	Buy	MASTERCARD INCORPORATEDcl a	$1,296,000	+15.9%	11,525	+6.5%	0.25%	-10.6%
RARX		RA PHARMACEUTICALS INC	$1,277,000	+40.2%	60,000	0.0%	0.25%	+8.2%
FOMX	Sell	FOAMIX PHARMACEUTICALS LTD	$1,198,000	-68.4%	242,000	-29.2%	0.23%	-75.7%
ZGNX	New	ZOGENIX INC	$1,085,000	–	100,000	+100.0%	0.21%	–
VTGN		VISTAGEN THERAPEUTICS INC	$1,066,000	-47.5%	544,100	0.0%	0.21%	-59.5%
TMO	Buy	THERMO FISHER SCIENTIFIC INC	$1,062,000	+18.3%	6,913	+8.6%	0.21%	-8.4%
PTN		PALATIN TECHNOLOGIES INC	$952,000	-35.7%	2,906,037	0.0%	0.19%	-50.4%
RPRX	Sell	REPROS THERAPEUTICS INC	$935,000	-27.6%	778,800	-20.4%	0.18%	-44.0%
ITEK		INOTEK PHARMACEUTICALS CORP	$804,000	-67.2%	401,764	0.0%	0.16%	-74.7%
GNMX	Sell	AEVI GENOMIC MEDICINE INC	$753,000	-67.7%	405,000	-10.0%	0.15%	-75.1%
SEDG	Buy	SOLAREDGE TECHNOLOGIES INC	$729,000	+124.3%	46,750	+78.4%	0.14%	+74.4%
ANAB	New	ANAPTYSBIO INC	$708,000	–	25,500	+100.0%	0.14%	–
CATB	Buy	CATABASIS PHARMACEUTICALS IN	$621,000	-55.6%	388,030	+0.0%	0.12%	-65.8%
SNSS		SUNESIS PHARMACEUTICALS INC	$513,000	+13.2%	125,000	0.0%	0.10%	-13.0%
TRVN	New	TREVENA INC	$429,000	–	116,800	+100.0%	0.08%	–
UNH	Buy	UNITEDHEALTH GROUP INC	$328,000	+20.6%	2,000	+17.6%	0.06%	-7.2%
MHK		MOHAWK INDS INC	$252,000	+14.5%	1,100	0.0%	0.05%	-12.5%
LOW		LOWES COS INC	$214,000	+15.7%	2,600	0.0%	0.04%	-10.6%
SERV	New	SERVICEMASTER GLOBAL HLDGS I	$209,000	–	5,000	+100.0%	0.04%	–
SEE	Buy	SEALED AIR CORP NEW	$196,000	+23.3%	4,500	+28.6%	0.04%	-5.0%
CMG	New	CHIPOTLE MEXICAN GRILL INC	$178,000	–	400	+100.0%	0.04%	–
TRIP	New	TRIPADVISOR INC	$173,000	–	4,000	+100.0%	0.03%	–
ULTI	New	ULTIMATE SOFTWARE GROUP INC	$156,000	–	800	+100.0%	0.03%	–
KRNT	New	KORNIT DIGITAL LTD	$17,000	–	900	+100.0%	0.00%	–
ATHX	New	ATHERSYS INC	$1,000	–	773	+100.0%	0.00%	–
ABUS	Exit	ARBUTUS BIOPHARMA CORP	$0	–	-22,000	-100.0%	-0.01%	–
RXDX	Exit	IGNYTA INC	$0	–	-22,065	-100.0%	-0.03%	–
	Exit	HORIZON PHARMA PLCcall	$0	–	-18,100	-100.0%	-0.07%	–
SITE	Exit	SITEONE LANDSCAPE SUPPLY INC	$0	–	-8,820	-100.0%	-0.08%	–
CABO	Exit	CABLE ONE INC	$0	–	-500	-100.0%	-0.08%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-80,528	-100.0%	-0.10%	–
ONS	Exit	ONCOBIOLOGICS INC	$0	–	-174,477	-100.0%	-0.13%	–
IMDZ	Exit	IMMUNE DESIGN CORP	$0	–	-103,000	-100.0%	-0.14%	–
PANW	Exit	PALO ALTO NETWORKS INC	$0	–	-7,052	-100.0%	-0.22%	–
MYOK	Exit	MYOKARDIA INC	$0	–	-83,240	-100.0%	-0.27%	–
AXGT	Exit	AXOVANT SCIENCES LTD	$0	–	-100,000	-100.0%	-0.31%	–
BA	Exit	BOEING CO	$0	–	-8,392	-100.0%	-0.33%	–
AZN	Exit	ASTRAZENECA PLCsponsored adr	$0	–	-50,000	-100.0%	-0.35%	–
CTSH	Exit	COGNIZANT TECHNOLOGY SOLUTIOcl a	$0	–	-27,875	-100.0%	-0.40%	–
PCRX	Exit	PACIRA PHARMACEUTICALS INC	$0	–	-50,000	-100.0%	-0.41%	–
PTCT	Exit	PTC THERAPEUTICS INC	$0	–	-150,000	-100.0%	-0.41%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-125,000	-100.0%	-0.46%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-100,000	-100.0%	-0.57%	–
	Exit	ISHARES TRput	$0	–	-12,000	-100.0%	-0.68%	–
TSRO	Exit	TESARO INC	$0	–	-20,000	-100.0%	-0.68%	–
APD	Exit	AIR PRODS & CHEMS INC	$0	–	-21,165	-100.0%	-0.77%	–
FIS	Exit	FIDELITY NATL INFORMATION SV	$0	–	-43,503	-100.0%	-0.83%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INC	$0	–	-45,000	-100.0%	-0.84%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-45,000	-100.0%	-0.94%	–
	Exit	NEURODERM LTD	$0	–	-175,951	-100.0%	-0.99%	–
CLCD	Exit	COLUCID PHARMACEUTICALS INC	$0	–	-358,000	-100.0%	-3.30%	–
	Exit	ISHARES TRcall	$0	–	-100,000	-100.0%	-3.41%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INC	$0	–	-113,000	-100.0%	-3.50%	–

Other managers

Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):

Original filings

The following EDGAR filing(s) were analyzed to create this report:

View 13F-HR filed 2017-05-11

Signatures

The EDGAR filing(s) were signed by:

Israel Mor — Partner

Top long-term holdings

Name	Quarters owned	Latest quarter owned	Max weighting
TEVA PHARMACEUTICAL-SP ADR	36	Q3 2023	8.4%
MERCK & CO INC NEW	35	Q3 2023	8.4%
NICE Systems Ltd	27	Q3 2023	4.4%
BIOGEN INC	26	Q3 2023	6.7%
AMICUS THERAPEUTICS INC	26	Q2 2022	4.3%
PFIZER INC	25	Q3 2023	9.2%
SAREPTA THERAPEUTICS INC	25	Q3 2023	3.2%
JOHNSON & JOHNSON	24	Q3 2023	8.0%
UNIQURE NV	23	Q3 2023	1.2%
SYNDAX PHARMACEUTICALS INC	22	Q3 2023	3.9%

View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.

Latest significant ownerships (13-D/G)

SPHERA FUNDS MANAGEMENT LTD. Q1 2017 significant holdings filed using form 13D/G when ownership exceeds 5% of a company's total stock issue.
	Filed	Shares	Percentage
Cyclacel Pharmaceuticals, Inc.	February 06, 2023	250,000	2.0%
Altimmune, Inc.	February 14, 2022	1,244,241	3.1%
Allot Ltd.	February 16, 2021	1,129,054	3.2%
Larimar Therapeutics, Inc.	February 16, 2021	?	?
Neos Therapeutics, Inc.	February 16, 2021	?	?
Orgenesis Inc.	February 16, 2021	525,216	0.0%
Sio Gene Therapies Inc.	February 16, 2021	?	?
X4 Pharmaceuticals, Inc	February 16, 2021	250,000	0.0%
Axovant Gene Therapies Ltd.	February 25, 2020	2,931,017	8.0%
Axovant Gene Therapies Ltd.	February 11, 2020	398,540	1.8%

View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.

Latest filings

Type	Filed
13F-HR/A	2024-02-15
13F-HR	2024-02-14
SC 13G	2024-02-08
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
SC 13G/A	2024-02-05
13F-HR	2023-11-14
SC 13G	2023-10-10
SC 13G	2023-08-30

View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.

All filings

View complete filings history.

Compare quarters

Issues

The following issues were detected while analyzing the report:

The reported total value is incorrect (511525000.0 != 511533000.0)

Export SPHERA FUNDS MANAGEMENT LTD.'s holdings