$461 Million is the total value of SPHERA FUNDS MANAGEMENT LTD.'s 91 reported holdings in Q1 2016. The portfolio turnover from Q4 2015 to Q1 2016 was 67.8% .
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| New | SELECT SECTOR SPDR TRput | $50,835,000 | – | 750,000 | +100.0% | 11.02% | – | |
| PFE | Buy | PFIZER INC | $42,285,000 | +11.3% | 1,426,612 | +21.2% | 9.16% | +64.8% |
| TEVA | Sell | TEVA PHARMACEUTICAL INDS LTDadr | $38,805,000 | -24.7% | 725,200 | -7.6% | 8.41% | +11.5% |
| BIIB | Sell | BIOGEN INC | $30,939,000 | -18.5% | 118,850 | -4.0% | 6.71% | +20.7% |
| New | ISHARES TRput | $27,658,000 | – | 250,000 | +100.0% | 6.00% | – | |
| AGN | ALLERGAN PLC | $26,803,000 | -14.2% | 100,000 | 0.0% | 5.81% | +27.0% | |
| SHPG | Buy | SHIRE PLCsponsored adr | $16,479,000 | +101.0% | 188,676 | +371.7% | 3.57% | +197.4% |
| GILD | Buy | GILEAD SCIENCES INC | $15,864,000 | +9.9% | 172,700 | +21.0% | 3.44% | +62.7% |
| MYL | New | MYLAN N V | $13,326,000 | – | 287,827 | +100.0% | 2.89% | – |
| ORA | Buy | ORMAT TECHNOLOGIES INC | $13,267,000 | -65.8% | 322,193 | +18.3% | 2.88% | -49.3% |
| CELG | Sell | CELGENE CORP | $10,009,000 | -43.2% | 100,000 | -32.1% | 2.17% | -16.0% |
| ITRN | New | ITURAN LOCATION AND CONTROL | $9,282,000 | – | 471,584 | +100.0% | 2.01% | – |
| ALXN | Sell | ALEXION PHARMACEUTICALS INC | $5,569,000 | -50.7% | 40,000 | -32.4% | 1.21% | -26.9% |
| V | Buy | VISA INC | $5,152,000 | +81.5% | 67,369 | +84.1% | 1.12% | +168.5% |
| New | SELECT SECTOR SPDR TRput | $4,500,000 | – | 200,000 | +100.0% | 0.98% | – | |
| ALNY | Buy | ALNYLAM PHARMACEUTICALS INC | $4,394,000 | +16.7% | 70,000 | +75.0% | 0.95% | +72.8% |
| GOOGL | New | ALPHABET INCcap stk cl a | $4,333,000 | – | 5,680 | +100.0% | 0.94% | – |
| VNDA | Buy | VANDA PHARMACEUTICALS INC | $4,281,000 | -0.5% | 512,051 | +10.8% | 0.93% | +47.3% |
| ACAD | Buy | ACADIA PHARMACEUTICALS INC | $4,194,000 | +17.6% | 150,000 | +50.0% | 0.91% | +74.1% |
| SAGE | Buy | SAGE THERAPEUTICS INC | $3,943,000 | -27.3% | 123,000 | +32.3% | 0.86% | +7.7% |
| ADMS | Buy | ADAMAS PHARMACEUTICALS INC | $3,904,000 | -8.1% | 270,000 | +80.0% | 0.85% | +36.0% |
| FPRX | Sell | FIVE PRIME THERAPEUTICS INC | $3,250,000 | -46.0% | 80,000 | -44.8% | 0.70% | -20.1% |
| ESLT | New | ELBIT SYS LTDord | $3,242,000 | – | 34,456 | +100.0% | 0.70% | – |
| AAP | Buy | ADVANCE AUTO PARTS INC | $3,229,000 | +37.9% | 20,136 | +29.5% | 0.70% | +104.1% |
| CHTR | Buy | CHARTER COMMUNICATIONS INC Dcl a new | $3,225,000 | +337.6% | 15,930 | +295.7% | 0.70% | +547.2% |
| MRNS | MARINUS PHARMACEUTICALS INC | $3,071,000 | -29.6% | 570,908 | 0.0% | 0.67% | +4.2% | |
| PTNR | Buy | PARTNER COMMUNICATIONS CO LTadr | $2,909,000 | +7.7% | 624,230 | +1.0% | 0.63% | +59.7% |
| MGNX | MACROGENICS INC | $2,869,000 | -39.4% | 153,000 | 0.0% | 0.62% | -10.4% | |
| RDUS | Buy | RADIUS HEALTH INC | $2,830,000 | -34.3% | 90,000 | +28.6% | 0.61% | -2.9% |
| PANW | New | PALO ALTO NETWORKS INC | $2,802,000 | – | 17,175 | +100.0% | 0.61% | – |
| GNCA | Sell | GENOCEA BIOSCIENCES INC | $2,801,000 | -1.7% | 361,908 | -33.0% | 0.61% | +45.6% |
| NBIX | New | NEUROCRINE BIOSCIENCES INC | $2,769,000 | – | 70,000 | +100.0% | 0.60% | – |
| KMPH | KEMPHARM INC | $2,667,000 | -27.0% | 183,954 | 0.0% | 0.58% | +8.0% | |
| New | AMICUS THERAPEUTICS INCput | $2,535,000 | – | 300,000 | +100.0% | 0.55% | – | |
| FOLD | New | AMICUS THERAPEUTICS INC | $2,535,000 | – | 300,000 | +100.0% | 0.55% | – |
| DERM | New | DERMIRA INC | $2,482,000 | – | 120,000 | +100.0% | 0.54% | – |
| EIGR | New | EIGER BIOPHARMACEUTICALS INC | $2,474,000 | – | 147,514 | +100.0% | 0.54% | – |
| CYTK | New | CYTOKINETICS INC | $2,411,000 | – | 341,944 | +100.0% | 0.52% | – |
| New | NEURODERM LTD | $2,349,000 | – | 166,359 | +100.0% | 0.51% | – | |
| KITE | KITE PHARMA INC | $2,296,000 | -25.5% | 50,000 | 0.0% | 0.50% | +10.4% | |
| New | ACADIA PHARMACEUTICALS INCput | $2,237,000 | – | 80,000 | +100.0% | 0.48% | – | |
| FOMX | FOAMIX PHARMACEUTICALS LTD | $2,230,000 | -19.6% | 342,000 | 0.0% | 0.48% | +19.0% | |
| ADRO | Buy | ADURO BIOTECH INC | $2,178,000 | -35.5% | 170,000 | +41.7% | 0.47% | -4.5% |
| APD | New | AIR PRODS & CHEMS INC | $2,114,000 | – | 14,672 | +100.0% | 0.46% | – |
| CHMA | New | CHIASMA INC | $2,113,000 | – | 230,649 | +100.0% | 0.46% | – |
| FWP | FORWARD PHARMA A/Ssponsored adr | $2,066,000 | -10.5% | 121,500 | 0.0% | 0.45% | +32.5% | |
| AGIO | AGIOS PHARMACEUTICALS INC | $2,030,000 | -37.5% | 50,000 | 0.0% | 0.44% | -7.4% | |
| GLYC | New | GLYCOMIMETICS INC | $2,014,000 | – | 337,911 | +100.0% | 0.44% | – |
| EGLTQ | EGALET CORP | $2,007,000 | -37.7% | 292,500 | 0.0% | 0.44% | -7.8% | |
| MLNX | New | MELLANOX TECHNOLOGIES LTD | $1,997,000 | – | 36,760 | +100.0% | 0.43% | – |
| IMDZ | IMMUNE DESIGN CORP | $1,989,000 | -35.3% | 153,000 | 0.0% | 0.43% | -4.2% | |
| ACOR | Sell | ACORDA THERAPEUTICS INC | $1,931,000 | -68.4% | 73,000 | -49.0% | 0.42% | -53.2% |
| ICL | Buy | ISRAEL CHEMICALS LTD | $1,903,000 | +579.6% | 437,671 | +533.5% | 0.41% | +904.9% |
| HRTX | Sell | HERON THERAPEUTICS INC | $1,899,000 | -47.3% | 100,000 | -25.9% | 0.41% | -22.0% |
| ABUS | ARBUTUS BIOPHARMA CORP | $1,877,000 | -7.2% | 454,500 | 0.0% | 0.41% | +37.5% | |
| ITEK | Sell | INOTEK PHARMACEUTICALS CORP | $1,850,000 | -54.6% | 250,000 | -30.6% | 0.40% | -32.8% |
| RPTP | Sell | RAPTOR PHARMACEUTICAL CORP | $1,840,000 | -48.3% | 400,000 | -41.6% | 0.40% | -23.6% |
| CLVS | CLOVIS ONCOLOGY INC | $1,814,000 | -45.2% | 94,500 | 0.0% | 0.39% | -18.8% | |
| VRX | Buy | VALEANT PHARMACEUTICALS INTL | $1,802,000 | -47.5% | 68,500 | +103.0% | 0.39% | -22.1% |
| NICE | New | NICE SYS LTDsponsored adr | $1,769,000 | – | 27,300 | +100.0% | 0.38% | – |
| CLCD | Sell | COLUCID PHARMACEUTICALS INC | $1,726,000 | -27.8% | 278,337 | -2.5% | 0.37% | +6.9% |
| WAB | Buy | WABTEC CORP | $1,721,000 | +89.5% | 21,704 | +70.1% | 0.37% | +180.5% |
| New | PORTOLA PHARMACEUTICALS INCcall | $1,634,000 | – | 80,100 | +100.0% | 0.35% | – | |
| IONS | Sell | IONIS PHARMACEUTICALS INC | $1,620,000 | -67.8% | 40,000 | -50.7% | 0.35% | -52.3% |
| PTCT | Buy | PTC THERAPEUTICS INC | $1,610,000 | -24.7% | 250,000 | +278.7% | 0.35% | +11.5% |
| CRVS | New | CORVUS PHARMACEUTICALS INC | $1,608,000 | – | 110,921 | +100.0% | 0.35% | – |
| CYNA | CYNAPSUS THERAPEUTICS INC | $1,595,000 | -22.9% | 134,037 | 0.0% | 0.35% | +14.2% | |
| ORBK | Sell | ORBOTECH LTDord | $1,563,000 | -57.9% | 65,710 | -60.8% | 0.34% | -37.6% |
| PIRS | PIERIS PHARMACEUTICALS INC | $1,539,000 | -17.0% | 810,000 | 0.0% | 0.33% | +22.8% | |
| ALDR | Sell | ALDER BIOPHARMACEUTICALS INC | $1,531,000 | -58.8% | 62,500 | -44.4% | 0.33% | -39.0% |
| SMMT | Sell | SUMMIT THERAPEUTICS PLCspons ads | $1,392,000 | -40.0% | 198,863 | -1.7% | 0.30% | -11.2% |
| EDGE | Sell | EDGE THERAPEUTICS INC | $1,373,000 | -29.2% | 150,000 | -3.2% | 0.30% | +4.9% |
| BLUE | New | BLUEBIRD BIO INC | $1,275,000 | – | 30,000 | +100.0% | 0.28% | – |
| SCYX | SCYNEXIS INC | $1,228,000 | -35.1% | 304,600 | 0.0% | 0.27% | -4.0% | |
| TRILLIUM THERAPEUTICS INC | $1,224,000 | -26.6% | 132,300 | 0.0% | 0.26% | +8.6% | ||
| PTN | Sell | PALATIN TECHNOLOGIES INC | $1,223,000 | -41.2% | 2,264,426 | -27.7% | 0.26% | -13.1% |
| ABEO | Sell | ABEONA THERAPEUTICS INC | $1,198,000 | -40.6% | 468,050 | -22.0% | 0.26% | -11.9% |
| CATB | Buy | CATABASIS PHARMACEUTICALS IN | $1,159,000 | +81.1% | 230,041 | +184.9% | 0.25% | +167.0% |
| CPRX | Sell | CATALYST PHARMACEUTICALS INC | $1,059,000 | -70.3% | 905,000 | -37.8% | 0.23% | -55.9% |
| PTLA | Sell | PORTOLA PHARMACEUTICALS INC | $1,020,000 | -76.8% | 50,000 | -41.5% | 0.22% | -65.7% |
| ALDX | ALDEYRA THERAPEUTICS INC | $999,000 | -38.2% | 238,500 | 0.0% | 0.22% | -8.4% | |
| AXSM | Sell | AXSOME THERAPEUTICS INC | $938,000 | -53.3% | 109,069 | -50.4% | 0.20% | -31.0% |
| Sell | MANNKIND CORPcall | $746,000 | -32.3% | 463,600 | -39.0% | 0.16% | +0.6% | |
| IGLD | New | INTERNET GOLD-GOLDEN LINES Lord | $678,000 | – | 50,250 | +100.0% | 0.15% | – |
| OCRX | Sell | OCERA THERAPEUTICS INC | $549,000 | -68.0% | 186,800 | -66.0% | 0.12% | -52.6% |
| NVLS | Sell | NIVALIS THERAPEUTICS INC | $333,000 | -81.4% | 79,900 | -65.5% | 0.07% | -72.5% |
| SBBP | Sell | STRONGBRIDGE BIOPHARMA PLC | $277,000 | -80.0% | 60,718 | -66.6% | 0.06% | -70.3% |
| TBRA | Sell | TOBIRA THERAPEUTICS INC | $264,000 | -86.0% | 32,300 | -82.8% | 0.06% | -79.3% |
| ELLO | Sell | ELLOMAY CAPITAL LIMITED | $48,000 | -94.2% | 5,653 | -94.1% | 0.01% | -91.7% |
| TSEM | New | TOWER SEMICONDUCTOR LTD | $0 | – | 0 | +100.0% | 0.00% | – |
| AOS | Exit | SMITH A O | $0 | – | -2,700 | -100.0% | -0.03% | – |
| GNVC | Exit | GENVEC INC | $0 | – | -186,500 | -100.0% | -0.05% | – |
| LIFE | Exit | ATYR PHARMA INC | $0 | – | -36,450 | -100.0% | -0.05% | – |
| BMRN | Exit | BIOMARIN PHARMACEUTICAL INC | $0 | – | -3,700 | -100.0% | -0.06% | – |
| EZCH | Exit | EZCHIP SEMICONDUCTOR LIMITEDord | $0 | – | -20,447 | -100.0% | -0.07% | – |
| WIX | Exit | WIX COM LTD | $0 | – | -35,460 | -100.0% | -0.12% | – |
| 3106PS | Exit | DELPHI AUTOMOTIVE PLC | $0 | – | -10,065 | -100.0% | -0.13% | – |
| ARRY | Exit | ARRAY BIOPHARMA INC | $0 | – | -215,000 | -100.0% | -0.13% | – |
| LOXO | Exit | LOXO ONCOLOGY INC | $0 | – | -45,000 | -100.0% | -0.19% | – |
| CBYL | Exit | CARBYLAN THERAPEUTICS INC | $0 | – | -360,000 | -100.0% | -0.19% | – |
| PRQR | Exit | PROQR THRAPEUTICS N V | $0 | – | -150,000 | -100.0% | -0.19% | – |
| NXPI | Exit | NXP SEMICONDUCTORS N V | $0 | – | -16,920 | -100.0% | -0.21% | – |
| AXTA | Exit | AXALTA COATING SYS LTD | $0 | – | -56,173 | -100.0% | -0.22% | – |
| NBRV | Exit | NABRIVA THERAPEUTICS AGsponsored adr | $0 | – | -157,500 | -100.0% | -0.22% | – |
| NVS | Exit | NOVARTIS A Gsponsored adr | $0 | – | -18,000 | -100.0% | -0.23% | – |
| TSRO | Exit | TESARO INC | $0 | – | -30,686 | -100.0% | -0.24% | – |
| GWPH | Exit | GW PHARMACEUTICALS PLCads | $0 | – | -23,790 | -100.0% | -0.24% | – |
| VTAE | Exit | VITAE PHARMACEUTICALS INC | $0 | – | -120,000 | -100.0% | -0.32% | – |
| DVAX | Exit | DYNAVAX TECHNOLOGIES CORP | $0 | – | -90,000 | -100.0% | -0.32% | – |
| CTSH | Exit | COGNIZANT TECHNOLOGY SOLUTIOcl a | $0 | – | -36,600 | -100.0% | -0.32% | – |
| MDCO | Exit | MEDICINES CO | $0 | – | -60,000 | -100.0% | -0.33% | – |
| DMTX | Exit | DIMENSION THERAPEUTICS INC | $0 | – | -200,000 | -100.0% | -0.33% | – |
| HALO | Exit | HALOZYME THERAPEUTICS INC | $0 | – | -135,000 | -100.0% | -0.34% | – |
| QURE | Exit | UNIQURE NV | $0 | – | -153,500 | -100.0% | -0.37% | – |
| EXEL | Exit | EXELIXIS INC | $0 | – | -450,000 | -100.0% | -0.37% | – |
| ITCI | Exit | INTRA CELLULAR THERAPIES INC | $0 | – | -48,400 | -100.0% | -0.38% | – |
| RTRX | Exit | RETROPHIN INC | $0 | – | -135,000 | -100.0% | -0.38% | – |
| HON | Exit | HONEYWELL INTL INC | $0 | – | -25,595 | -100.0% | -0.39% | – |
| BITI | Exit | BIOTIE THERAPIES OYJsponsored adr | $0 | – | -193,646 | -100.0% | -0.40% | – |
| SBUX | Exit | STARBUCKS CORP | $0 | – | -46,828 | -100.0% | -0.41% | – |
| XLRN | Exit | ACCELERON PHARMA INC | $0 | – | -60,000 | -100.0% | -0.43% | – |
| MA | Exit | MASTERCARD INCcl a | $0 | – | -30,605 | -100.0% | -0.44% | – |
| ARWR | Exit | ARROWHEAD RESH CORP | $0 | – | -486,000 | -100.0% | -0.44% | – |
| MDLZ | Exit | MONDELEZ INTL INCcl a | $0 | – | -68,625 | -100.0% | -0.45% | – |
| SGEN | Exit | SEATTLE GENETICS INC | $0 | – | -70,000 | -100.0% | -0.46% | – |
| CARA | Exit | CARA THERAPEUTICS INC | $0 | – | -197,820 | -100.0% | -0.49% | – |
| NVAX | Exit | NOVAVAX INC | $0 | – | -400,000 | -100.0% | -0.49% | – |
| ANAC | Exit | ANACOR PHARMACEUTICALS INC | $0 | – | -30,000 | -100.0% | -0.50% | – |
| TJX | Exit | TJX COS INC NEW | $0 | – | -47,961 | -100.0% | -0.50% | – |
| CNCE | Exit | CONCERT PHARMACEUTICALS INC | $0 | – | -180,000 | -100.0% | -0.50% | – |
| Exit | GW PHARMACEUTICALS PLCcall | $0 | – | -50,000 | -100.0% | -0.51% | – | |
| Exit | GOOGLE INCcall | $0 | – | -4,600 | -100.0% | -0.52% | – | |
| CHKP | Exit | CHECK POINT SOFTWARE TECH LTord | $0 | – | -55,857 | -100.0% | -0.67% | – |
| BLCM | Exit | BELLICUM PHARMACEUTICALS INC | $0 | – | -231,515 | -100.0% | -0.69% | – |
| OPK | Exit | OPKO HEALTH INC | $0 | – | -500,000 | -100.0% | -0.74% | – |
| CELJF | Exit | CELLCOM ISRAEL LTD | $0 | – | -212,300 | -100.0% | -0.75% | – |
| INCY | Exit | INCYTE CORP | $0 | – | -51,621 | -100.0% | -0.82% | – |
| GOOGL | Exit | GOOGLE INCcl a | $0 | – | -7,409 | -100.0% | -0.84% | – |
| VRTX | Exit | VERTEX PHARMACEUTICALS INC | $0 | – | -48,400 | -100.0% | -0.89% | – |
| BMY | Exit | BRISTOL MYERS SQUIBB CO | $0 | – | -121,500 | -100.0% | -1.22% | – |
| Exit | MYLAN N Vcall | $0 | – | -300,000 | -100.0% | -2.38% | – | |
| ABBV | Exit | ABBVIE INC | $0 | – | -362,000 | -100.0% | -3.14% | – |
| Exit | SPDR SERIES TRUSTput | $0 | – | -329,800 | -100.0% | -3.39% | – | |
| Exit | SPDR S&P 500 ETF TRput | $0 | – | -400,000 | -100.0% | -11.94% | – |
Other managers
Other managers that, in addition to the filing manager(s), that filed the EDGAR filing(s):
Original filings
The following EDGAR filing(s) were analyzed to create this report:
- View 13F-HR filed 2016-05-16
Top long-term holdings
| Name | Quarters owned | Latest quarter owned | Max weighting |
|---|---|---|---|
| TEVA PHARMACEUTICAL-SP ADR | 36 | Q3 2023 | 8.4% |
| MERCK & CO INC NEW | 35 | Q3 2023 | 8.4% |
| NICE Systems Ltd | 27 | Q3 2023 | 4.4% |
| BIOGEN INC | 26 | Q3 2023 | 6.7% |
| AMICUS THERAPEUTICS INC | 26 | Q2 2022 | 4.3% |
| PFIZER INC | 25 | Q3 2023 | 9.2% |
| SAREPTA THERAPEUTICS INC | 25 | Q3 2023 | 3.2% |
| JOHNSON & JOHNSON | 24 | Q3 2023 | 8.0% |
| UNIQURE NV | 23 | Q3 2023 | 1.2% |
| SYNDAX PHARMACEUTICALS INC | 22 | Q3 2023 | 3.9% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete holdings history.
Latest significant ownerships (13-D/G)
| Filed | Shares | Percentage | |
|---|---|---|---|
| Cyclacel Pharmaceuticals, Inc. | February 06, 2023 | 250,000 | 2.0% |
| Altimmune, Inc. | February 14, 2022 | 1,244,241 | 3.1% |
| Allot Ltd. | February 16, 2021 | 1,129,054 | 3.2% |
| Larimar Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Neos Therapeutics, Inc. | February 16, 2021 | ? | ? |
| Orgenesis Inc. | February 16, 2021 | 525,216 | 0.0% |
| Sio Gene Therapies Inc. | February 16, 2021 | ? | ? |
| X4 Pharmaceuticals, Inc | February 16, 2021 | 250,000 | 0.0% |
| Axovant Gene Therapies Ltd. | February 25, 2020 | 2,931,017 | 8.0% |
| Axovant Gene Therapies Ltd. | February 11, 2020 | 398,540 | 1.8% |
View SPHERA FUNDS MANAGEMENT LTD.'s complete significant-ownership history.
Latest filings
| Type | Filed |
|---|---|
| 13F-HR/A | 2024-02-15 |
| 13F-HR | 2024-02-14 |
| SC 13G | 2024-02-08 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| SC 13G/A | 2024-02-05 |
| 13F-HR | 2023-11-14 |
| SC 13G | 2023-10-10 |
| SC 13G | 2023-08-30 |
View SPHERA FUNDS MANAGEMENT LTD.'s complete filings history.
All filings
- Holdings (13F-HR)
- Significant ownership (13-D/G)
- Insider transactions (4, 5, 6)
- Events (8-K)
- Shareholder votes (proxy)
View complete filings history.