| Type | Filed | Filer | Subject | Shares Owned | Percent Owned | |
|---|---|---|---|---|---|---|
| SC 13G | 2019-02-15 | UBS Group AG | Shire plc | 84,229,093 | 9.2% | EDGAR |
| SC 13G/A | 2019-01-11 | BlackRock Inc. | Shire plc | 26,248,253 | 2.9% | EDGAR |
| SC 13G/A | 2019-01-10 | BlackRock Inc. | Shire plc | 26,248,253 | 2.9% | EDGAR |
| SC 13G/A | 2018-01-30 | BlackRock Inc. | Shire plc | 71,984,405 | 7.9% | EDGAR |
| SC 13G/A | 2017-01-27 | BlackRock Inc. | Shire plc | 74,361,939 | 8.2% | EDGAR |
| SC 13G/A | 2016-02-12 | FMR LLC | Shire plc | 15,930,680 | 2.7% | EDGAR |
| SC 13G/A | 2016-02-10 | BlackRock Inc. | Shire plc | 59,740,451 | 10.1% | EDGAR |
| SC 13G/A | 2016-01-27 | BlackRock Inc. | Shire plc | 49,495,974 | 8.4% | EDGAR |
| SC 13G | 2015-02-13 | FMR LLC | Shire plc | 33,861,812 | 5.7% | EDGAR |
| SC 13G/A | 2015-01-23 | BlackRock Inc. | Shire plc | 50,049,055 | 8.5% | EDGAR |
| SC 13G/A | 2014-02-03 | BlackRock Inc. | Shire plc | 54,030,642 | 9.2% | EDGAR |
| SC 13G/A | 2013-02-13 | JENNISON ASSOCIATES LLC | Shire plc | 25,744,041 | 4.6% | EDGAR |
| SC 13G/A | 2013-02-06 | PRUDENTIAL FINANCIAL INC | Shire plc | - | - | EDGAR |
| SC 13G/A | 2013-01-11 | BlackRock Inc. | Shire plc | 55,964,533 | 10.0% | EDGAR |
| SC 13G/A | 2012-06-11 | FMR LLC | Shire plc | 22,024,319 | 3.9% | EDGAR |
| SC 13G/A | 2012-02-14 | FMR LLC | Shire plc | 53,695,754 | 9.5% | EDGAR |
| SC 13G | 2012-02-14 | JENNISON ASSOCIATES LLC | Shire plc | 32,657,900 | 5.8% | EDGAR |
| SC 13G | 2012-02-14 | PRUDENTIAL FINANCIAL INC | Shire plc | 32,657,900 | 5.8% | EDGAR |
| SC 13G/A | 2012-02-13 | BlackRock Inc. | Shire plc | 38,390,805 | 6.8% | EDGAR |
| SC 13G/A | 2012-02-02 | CAPITAL GROUP INTERNATIONAL INC | Shire plc | 17,253,131 | 3.1% | EDGAR |