| Decheng Capital Management III (Cayman), LLC | 2,099,583 | $42,117,635 | 14.06% |
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| Mayo Clinic | 187,143 | $3,754,089 | 7.23% |
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| Matrix Capital Management Company, LP | 13,959,973 | $280,037,058 | 3.36% |
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| 5AM Venture Management, LLC | 490,000 | $9,829,400 | 2.83% |
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| Eventide Asset Management | 7,814,039 | $156,749,622 | 2.82% |
|---|
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 961,486 | $19,287,410 | 2.70% |
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| Avidity Partners Management LP | 2,100,000 | $42,126,000 | 1.70% |
|---|
| First Light Asset Management, LLC | 848,477 | $17,020,449 | 1.62% |
|---|
| Sofinnova Investments, Inc. | 1,211,641 | $24,305,518 | 1.53% |
|---|
| SECTORAL ASSET MANAGEMENT INC | 386,525 | $7,753,692 | 1.51% |
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| Integral Health Asset Management, LLC | 450,000 | $9,027,000 | 1.25% |
|---|
| Cormorant Asset Management, LP | 700,000 | $14,042,000 | 0.82% |
|---|
| Ghost Tree Capital, LLC | 100,000 | $2,006,000 | 0.66% |
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| Values First Advisors, Inc. | 40,920 | $820,852 | 0.53% |
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| Boxer Capital, LLC | 450,000 | $9,027,000 | 0.48% |
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| Regency Capital Management Inc.\DE | 15,000 | $300,900 | 0.26% |
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| Woodline Partners LP | 1,000,000 | $20,060,000 | 0.24% |
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| Verition Fund Management LLC | 537,359 | $10,779,422 | 0.13% |
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| FEDERATED HERMES, INC. | 1,947,693 | $39,070,722 | 0.10% |
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| KENNEDY CAPITAL MANAGEMENT LLC | 156,475 | $3,138,889 | 0.08% |
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