| APIS CAPITAL ADVISORS, LLC | 148,000 | $1,638,360 | 2.12% |
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| Sio Capital Management, LLC | 595,002 | $6,586,672 | 2.04% |
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| 5AM Venture Management, LLC | 585,000 | $6,475,950 | 1.86% |
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| Artia Global Partners LP | 383,580 | $4,246,231 | 1.76% |
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| Integral Health Asset Management, LLC | 800,000 | $8,856,000 | 1.23% |
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| Boxer Capital, LLC | 2,000,000 | $22,140,000 | 1.18% |
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| DAFNA Capital Management LLC | 319,655 | $3,538,581 | 1.10% |
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| Affinity Asset Advisors, LLC | 332,600 | $3,681,882 | 1.04% |
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| MPM BioImpact LLC | 325,000 | $3,597,750 | 0.96% |
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| Affinity Asset Advisors, LLC | 300,000 | $3,321,000 | 0.93% |
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| Ghost Tree Capital, LLC | 225,000 | $2,490,750 | 0.82% |
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| Knott David M Jr | 185,555 | $2,054 | 0.78% |
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| Octagon Capital Advisors LP | 375,000 | $4,151,250 | 0.64% |
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| 683 Capital Management, LLC | 625,000 | $6,918,750 | 0.54% |
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| AlphaCentric Advisors LLC | 60,000 | $664,200 | 0.38% |
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| Quantum Private Wealth, LLC | 66,650 | $737,816 | 0.35% |
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| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 1,279,000 | $14,158,530 | 0.31% |
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| Rhenman & Partners Asset Management AB | 180,000 | $1,992,600 | 0.22% |
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| VIKING GLOBAL INVESTORS LP | 4,573,316 | $50,626,608 | 0.20% |
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| Eventide Asset Management | 750,000 | $8,302,500 | 0.15% |
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