| GREAT POINT PARTNERS LLC | 677,426 | $31,249,661 | 6.12% |
|---|
| RTW INVESTMENTS, LP | 5,405,089 | $249,336,756 | 4.75% |
|---|
| First Light Asset Management, LLC | 589,963 | $27,214,993 | 2.13% |
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| Rock Springs Capital Management LP | 1,384,269 | $63,856,329 | 1.52% |
|---|
| Avidity Partners Management LP | 900,700 | $41,549,291 | 1.45% |
|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 541,480 | $24,978,472 | 1.34% |
|---|
| SPHERA FUNDS MANAGEMENT LTD. | 183,696 | $8,473,896 | 1.32% |
|---|
| CHI Advisors LLC | 85,000 | $3,921,050 | 1.19% |
|---|
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 80,052 | $3,691,198 | 1.12% |
|---|
| EMERALD ADVISERS, LLC | 552,136 | $25,470,034 | 1.11% |
|---|
| Privium Fund Management B.V. | 112,241 | $5,236,042 | 1.10% |
|---|
| EMERALD MUTUAL FUND ADVISERS TRUST | 440,141 | $20,303,704 | 1.10% |
|---|
| SECTOR GAMMA AS | 100,605 | $4,640,909 | 1.04% |
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| Ikarian Capital, LLC | 121,658 | $5,612,084 | 0.89% |
|---|
| AlphaCentric Advisors LLC | 28,500 | $1,314,705 | 0.73% |
|---|
| EFG Asset Management (North America) Corp. | 53,671 | $2,475,575 | 0.53% |
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| Avoro Capital Advisors LLC | 750,000 | $34,597,500 | 0.47% |
|---|
| Sands Capital Management | 2,673,638 | $123,334,921 | 0.38% |
|---|
| Motley Fool Asset Management LLC | 91,688 | $4,229,567 | 0.38% |
|---|
| Motley Fool Wealth Management, LLC | 110,120 | $5,080,068 | 0.30% |
|---|