| Date | Person | Title | Type | Name | Shares | Shares (Total) | Price | Code |
|---|---|---|---|---|---|---|---|---|
| 2024-03-12 | THEUER CHARLES | Buy | Employee Stock Option (Right to Buy) | 518300.0 | 518,300 | $0.0 | A | |
| 2024-03-12 | Brown Scott B. | Buy | Employee Stock Option (Right to Buy) | 224800.0 | 224,800 | $0.0 | A | |
| 2023-11-10 | Opaleye Management Inc. | Sell | Common Stock, par value $0.001 per share | -4324008.0 | 0 | $0.3 | S | |
| 2023-11-10 | Opaleye Management Inc. | Sell | Common Stock, par value $0.001 per share | -440000.0 | 0 | $0.3 | S | |
| 2023-10-20 | THEUER CHARLES | Buy | Common Stock | 3500.0 | 406,417 | $0.1 | A | |
| 2023-04-27 | THEUER CHARLES | Buy | Common Stock | 47000.0 | 399,417 | $0.8 | P | |
| 2023-04-26 | THEUER CHARLES | Buy | Common Stock | 3999.0 | 352,417 | $0.7 | P | |
| 2023-04-20 | Brown Scott B. | Buy | Common Stock | 3500.0 | 25,128 | $0.1 | A | |
| 2023-04-20 | THEUER CHARLES | Buy | Common Stock | 3500.0 | 402,917 | $0.1 | A | |
| 2023-04-19 | WORLAND STEPHEN T | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-04-19 | MATTINGLY MARTIN A | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-04-19 | Twiford J Rainer | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-04-19 | Lam Carol C. | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-04-19 | PELLETIER SAUNDRA L | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-04-19 | Johnson-Pratt Lisa | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-04-19 | LARUE WILLIAM R | Buy | Director Stock Option (Right to Buy) | 18000.0 | 18,000 | $0.0 | A | |
| 2023-03-09 | Opaleye Management Inc. | Buy | Common Stock, par value $0.001 per share | 174508.0 | 4,324,508 | $1.4 | P | |
| 2023-03-01 | THEUER CHARLES | Buy | Common Stock | 4800.0 | 344,918 | $1.5 | P | |
| 2023-02-28 | THEUER CHARLES | Buy | Common Stock | 200.0 | 340,118 | $1.5 | P | |
| 2023-02-01 | THEUER CHARLES | Buy | Employee Stock Option (Right to Buy) | 332000.0 | 332,000 | $0.0 | A |