| 2023-08-01 | Lukowiak Andrew A | | Buy | Stock option (right to buy) | 30575.0 | 30,575 | $0.0 | A |
| 2023-07-17 | Markovich Rebecca | | Buy | Stock option (right to buy) | 13071.0 | 13,071 | $0.0 | A |
| 2023-06-09 | Popovits Kimberly J | | Buy | Stock option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2023-06-09 | Scott Randal W. | | Buy | Stock option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2023-06-09 | Ismagilov Rustem F. | | Buy | Stock option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2023-06-09 | Posard Matthew L. | | Buy | Stock option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2023-06-09 | BAKER BROS. ADVISORS LP667, L.P.BAKER JULIANBAKER FELIXBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LP | | Buy | Non- Qualified Stock Option (right to buy) | 23685.0 | 23,685 | $0.0 | A |
| 2023-06-09 | BAKER BROS. ADVISORS LP667, L.P.BAKER JULIANBAKER FELIXBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LP | | Buy | Non- Qualified Stock Option (right to buy) | 23685.0 | 23,685 | $0.0 | A |
| 2023-06-09 | Dreismann Heinrich | | Buy | Stock option (right to buy) | 5466.0 | 5,466 | $0.0 | A |
| 2023-06-09 | Gilliam Melissa | | Buy | Stock option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2023-05-19 | Dreismann Heinrich | | Buy | Stock option (right to buy) | 190000.0 | 190,000 | $0.0 | A |
| 2023-04-07 | Kelley Robert J. | | Buy | Stock option (right to buy) | 500000.0 | 500,000 | $0.0 | A |
| 2023-04-07 | Moody John Roger Jr | | Buy | Stock option (right to buy) | 300000.0 | 300,000 | $0.0 | A |
| 2022-06-10 | Baker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP667, L.P.BAKER JULIANBAKER FELIX | | Buy | Non- Qualified Stock Option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2022-06-10 | Gilliam Melissa | | Buy | Stock Option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2022-06-10 | Popovits Kimberly J | | Buy | Stock Option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2022-06-10 | Scott Randal W. | | Buy | Stock Option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2022-06-10 | Posard Matthew L. | | Buy | Stock Option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2022-06-10 | Ismagilov Rustem F. | | Buy | Stock Option (right to buy) | 95000.0 | 95,000 | $0.0 | A |
| 2022-06-01 | Kelley Robert J. | | Buy | Stock Option (right to buy) | 723560.0 | 723,560 | $0.0 | A |