| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 426,500 | $11,754,340 | 3.96% |
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| ASHFORD CAPITAL MANAGEMENT INC | 916,747 | $25,274,715 | 3.72% |
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| ARMISTICE CAPITAL, LLC | 5,092,000 | $140,386,440 | 2.15% |
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| S&T BANK/PA | 215,578 | $5,943 | 1.15% |
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| Aristotle Capital Boston, LLC | 1,187,981 | $32,752,634 | 1.06% |
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| RICE HALL JAMES & ASSOCIATES, LLC | 544,468 | $15,010,983 | 0.95% |
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| Tributary Capital Management, LLC | 352,429 | $9,716,468 | 0.92% |
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| Bridge City Capital, LLC | 65,297 | $1,800,238 | 0.91% |
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| Integral Health Asset Management, LLC | 220,000 | $6,065,400 | 0.84% |
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| Retirement Planning Co of New England, Inc. | 51,608 | $1,422,833 | 0.79% |
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| Stephens Investment Management Group LLC | 1,704,698 | $46,998,524 | 0.77% |
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| Bruce & Co., Inc. | 82,105 | $2,263,634 | 0.77% |
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| Parkman Healthcare Partners LLC | 138,172 | $3,809,402 | 0.70% |
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| Seaport Global Advisors, LLC | 7,942 | $218,961 | 0.66% |
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| Phocas Financial Corp. | 157,066 | $4,330,000 | 0.63% |
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| THIRD AVENUE MANAGEMENT LLC | 116,549 | $3,272,696 | 0.55% |
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| Virtus Investment Advisers, Inc. | 29,148 | $803,610 | 0.55% |
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| HUSSMAN STRATEGIC ADVISORS, INC. | 93,600 | $2,580,552 | 0.49% |
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| Mitsubishi UFJ Asset Management (UK) Ltd. | 24,000 | $662 | 0.47% |
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| Mystic Asset Management, Inc. | 29,840 | $822,689 | 0.46% |
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