| DAFNA Capital Management LLC | 13,680,554 | $21,615,275 | 6.72% |
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| Arbiter Partners Capital Management LLC | 2,678,807 | $4,232,515 | 5.41% |
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| Lagoda Investment Management, L.P. | 3,249,785 | $5,134,660 | 3.37% |
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| Archon Capital Management LLC | 2,678,275 | $4,231,675 | 1.11% |
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| AlphaCentric Advisors LLC | 600,000 | $948,000 | 0.54% |
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| Redmile Group, LLC | 5,765,792 | $9,109,951 | 0.43% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 1,309,108 | $2,068,391 | 0.34% |
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| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 722,720 | $1,142,000 | 0.25% |
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| Legato Capital Management LLC | 472,150 | $745,997 | 0.11% |
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| State of Wyoming | 190,265 | $300,619 | 0.06% |
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| WEALTH EFFECTS LLC | 69,060 | $109,115 | 0.05% |
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| Kovack Advisors, Inc. | 191,907 | $303,213 | 0.04% |
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| Coury Firm Asset Management LLC | 16,100 | $25,438 | 0.04% |
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| Cherry Creek Investment Advisors, Inc. | 37,149 | $58,695 | 0.04% |
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| Wellington Shields & Co., LLC | 35,393 | $55,921 | 0.01% |
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| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 249,700 | $394,526 | 0.01% |
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| Atom Investors LP | 22,686 | $35,844 | 0.01% |
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| GMT CAPITAL CORP | 126,581 | $199,998 | 0.01% |
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| Independent Advisor Alliance | 101,305 | $160,062 | 0.01% |
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| Summit Asset Management, LLC | 16,560 | $26,165 | 0.01% |
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