| Eagle Health Investments LP | 1,200,385 | $26,252,420 | 4.91% |
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| PURA VIDA INVESTMENTS, LLC | 543,069 | $11,876,919 | 1.57% |
|---|
| First Light Asset Management, LLC | 637,422 | $13,940,419 | 1.09% |
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| BRAIDWELL LP | 1,460,368 | $31,938,248 | 1.04% |
|---|
| NEXT CENTURY GROWTH INVESTORS LLC | 477,225 | $10,436,910 | 1.01% |
|---|
| Bellevue Group AG | 3,125,886 | $68,363,127 | 0.98% |
|---|
| AtonRa Partners | 22,945 | $501,807 | 0.78% |
|---|
| Rhenman & Partners Asset Management AB | 330,635 | $7,230,987 | 0.76% |
|---|
| Perceptive Advisors | 902,360 | $19,734,613 | 0.57% |
|---|
| Nebula Research & Development LLC | 24,398 | $533,584 | 0.40% |
|---|
| RTW INVESTMENTS, LP | 808,658 | $17,685,350 | 0.34% |
|---|
| 360 Financial, Inc. | 28,710 | $627,888 | 0.32% |
|---|
| C WorldWide Group Holding A/S | 1,000,000 | $21,870 | 0.28% |
|---|
| Champlain Investment Partners, LLC | 1,924,685 | $42,092,861 | 0.26% |
|---|
| OAK RIDGE INVESTMENTS LLC | 69,294 | $1,515,460 | 0.19% |
|---|
| GRIFFIN ASSET MANAGEMENT, INC. | 50,258 | $1,099,142 | 0.15% |
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| Polar Asset Management Partners Inc. | 354,100 | $7,744,167 | 0.14% |
|---|
| HARBOR CAPITAL ADVISORS, INC. | 18,559 | $405,885 | 0.08% |
|---|
| T. Rowe Price Investment Management, Inc. | 3,167,494 | $69,274 | 0.05% |
|---|
| GSA CAPITAL PARTNERS LLP | 18,640 | $408 | 0.04% |
|---|