| Velan Capital Investment Management LP | 3,596,861 | $4,424,139 | 3.57% |
|---|
| GREAT POINT PARTNERS LLC | 8,839,939 | $10,873,125 | 1.98% |
|---|
| Bleichroeder LP | 4,045,132 | $4,975,512 | 1.23% |
|---|
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,699,237 | $4,550,062 | 0.52% |
|---|
| Nantahala Capital Management | 3,307,942 | $4,068,769 | 0.35% |
|---|
| EASTERLY INVESTMENT PARTNERS LLC | 1,257,235 | $1,546,399 | 0.17% |
|---|
| RICE HALL JAMES & ASSOCIATES, LLC | 1,050,074 | $1,291,591 | 0.08% |
|---|
| GMT CAPITAL CORP | 1,110,702 | $1,366,163 | 0.05% |
|---|
| PRELUDE CAPITAL MANAGEMENT, LLC | 180,000 | $221,400 | 0.01% |
|---|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 338,100 | $415,863 | 0.01% |
|---|
| Arete Wealth Advisors, LLC | 10,000 | $12,300 | 0.00% |
|---|
| Legato Capital Management LLC | 12,354 | $15,195 | 0.00% |
|---|
| FMR LLC | 14,848,870 | $18,264,110 | 0.00% |
|---|
| China Universal Asset Management Co., Ltd. | 2,876 | $4 | 0.00% |
|---|
| BROWN BROTHERS HARRIMAN & CO | 100,000 | $123,000 | 0.00% |
|---|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,851,080 | $3,506,828 | 0.00% |
|---|
| MORGAN STANLEY | 195,196 | $240,091 | 0.00% |
|---|
| Invesco Ltd. | 39,121 | $48,119 | 0.00% |
|---|
| AMALGAMATED BANK | 11,055 | $14 | 0.00% |
|---|
| ProShare Advisors LLC | 16,810 | $20,677 | 0.00% |
|---|