| 2023-10-02 | Kirk Allan | | Buy | Stock Option (Right to Buy) | 150437.0 | 150,437 | $1.6 | A |
| 2023-10-02 | Robinson James A. Jr. | | Buy | Stock Option (Right to Buy) | 150437.0 | 150,437 | $1.6 | A |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Warrants to Purchase Common Stock | 2446209.0 | 2,446,209 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Common Stock, $0.001 par value | 1055445.0 | 2,330,418 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Common Stock, $0.001 par value | 837146.0 | 1,812,558 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Common Stock, $0.001 par value | 86341.0 | 145,029 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Pre-funded Warrants to Purchase Common Stock | 2028645.0 | 2,028,645 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Pre-funded Warrants to Purchase Common Stock | 1609063.0 | 1,609,063 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Pre-funded Warrants to Purchase Common Stock | 165950.0 | 165,950 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Warrants to Purchase Common Stock | 3084090.0 | 3,084,090 | $0.0 | P |
| 2023-05-05 | BVF INC/ILLAMPERT MARK NBVF PARTNERS L P/ILBIOTECHNOLOGY VALUE FUND L PBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS Ltd.BVF GP HOLDINGS LLC | | Buy | Warrants to Purchase Common Stock | 252291.0 | 252,291 | $0.0 | P |
| 2023-05-01 | Katkin Keith | | Buy | Stock Option (right to buy) | 752185.0 | 752,185 | $0.0 | A |
| 2023-05-01 | Hillson Jan | | Buy | Stock Option (right to buy) | 150437.0 | 150,437 | $0.0 | A |
| 2023-05-01 | Lee June | | Buy | Stock Option (right to buy) | 150437.0 | 150,437 | $0.0 | A |
| 2023-05-01 | McBride John S. | | Buy | Stock Option (right to buy) | 150437.0 | 150,437 | $0.0 | A |
| 2023-05-01 | Gros David-Alexandre C | | Buy | Common Stock (right to buy) | 383299.0 | 383,299 | $0.0 | A |
| 2023-05-01 | Perrin Steven | | Buy | Stock Option (right to buy) | 317147.0 | 317,147 | $0.0 | A |
| 2023-05-01 | Little Paul Sean | | Buy | Stock Option (right to buy) | 198126.0 | 198,126 | $0.0 | A |
| 2023-05-01 | LYONS GARY A | | Buy | Common Stock | 150437.0 | 150,437 | $0.0 | A |
| 2023-05-01 | Smith Bryan E. | | Buy | Stock Option (right to buy) | 179000.0 | 179,000 | $0.0 | A |