| 2024-03-13 | McMinn Rachel | | Buy | Employee Stock Option (Right to buy) | 93282.0 | 93,282 | $0.0 | A |
| 2024-03-13 | Cobb Stuart | | Buy | Stock Option (Right to Buy) | 34450.0 | 34,450 | $0.0 | A |
| 2024-03-13 | Cobb Stuart | | Buy | Common Stock | 20391.0 | 20,391 | $0.0 | A |
| 2024-03-13 | Cvijic Christine Mikail | | Buy | Employee Stock Option (Right to buy) | 53900.0 | 53,900 | $0.0 | A |
| 2024-03-13 | Cvijic Christine Mikail | | Buy | Common Stock | 31903.0 | 52,844 | $0.0 | A |
| 2024-01-16 | Woods Robert Keith | | Buy | Stock Option (Right to Buy) | 15400.0 | 15,400 | $0.0 | A |
| 2024-01-16 | PALEKAR ROHAN | | Buy | Stock Option (Right to Buy) | 15400.0 | 15,400 | $0.0 | A |
| 2024-01-16 | Jordan Julie | | Buy | Stock Option (Right to Buy) | 75000.0 | 75,000 | $0.0 | A |
| 2024-01-16 | Freedland Cory S. | | Buy | Stock Option (Right to Buy) | 15400.0 | 15,400 | $0.0 | A |
| 2024-01-16 | Noonberg Sarah B. | | Buy | Stock Option (Right to Buy) | 15400.0 | 15,400 | $0.0 | A |
| 2024-01-16 | BAFFI ROBERT | | Buy | Stock Option (Right to Buy) | 15400.0 | 15,400 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 28782.0 | 107,107 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 310130.0 | 1,283,420 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 20562.0 | 127,669 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 221557.0 | 1,504,977 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 93480.0 | 221,149 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 1151124.0 | 2,656,101 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 78325.0 | 78,325 | $0.0 | A |
| 2023-12-18 | 667, L.P.BAKER FELIXBAKER JULIANBaker Bros. Advisors (GP) LLCBaker Brothers Life Sciences LPBAKER BROS. ADVISORS LP | | Buy | Prefunded Warrants | 973290.0 | 973,290 | $0.0 | A |
| 2023-10-05 | BAKER BROS. ADVISORS LPBaker Bros. Advisors (GP) LLCBAKER JULIANBAKER FELIXBaker Brothers Life Sciences LP667, L.P. | | Buy | Common Stock | 57049.0 | 155,874 | $0.0 | X |