| SC 13G/A | 2005-02-11 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 3,739,210 | 7.7% | EDGAR |
| SC 13G/A | 2004-11-12 | BB BIOTECH AG | MEDICINES CO /DE | 4,727,854 | 9.9% | EDGAR |
| SC 13G/A | 2004-02-17 | BB BIOTECH AG | MEDICINES CO /DE | 4,700,000 | 9.9% | EDGAR |
| SC 13G/A | 2004-02-13 | QUINTILES TRANSNATIONAL CORP | MEDICINES CO /DE | 1,185,320 | 2.5% | EDGAR |
| SC 13G | 2004-02-13 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 3,247,055 | 6.9% | EDGAR |
| SC 13G/A | 2004-02-12 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 5,943,400 | 12.6% | EDGAR |
| SC 13G | 2004-02-10 | AXA FINANCIAL INC | MEDICINES CO /DE | 25,400 | 0.1% | EDGAR |
| SC 13G/A | 2004-02-06 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 2,370,910 | 5.0% | EDGAR |
| SC 13G/A | 2003-02-14 | BB BIOTECH AG | MEDICINES CO/ MA | 3,656,425 | 9.1% | EDGAR |
| SC 13G/A | 2003-02-14 | QUINTILES TRANSNATIONAL CORP | MEDICINES CO/ MA | 2,062,520 | 5.2% | EDGAR |
| SC 13G/A | 2003-02-12 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO/ MA | 5,357,240 | 13.6% | EDGAR |
| SC 13G/A | 2003-02-12 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO/ MA | 768,504 | 2.0% | EDGAR |
| SC 13G | 2003-02-12 | AXA FINANCIAL INC | MEDICINES CO/ MA | 2,096,430 | 5.3% | EDGAR |
| SC 13G | 2003-02-12 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO/ MA | 692,887 | 1.8% | EDGAR |
| SC 13G/A | 2003-02-04 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO/ MA | 2,996,810 | 7.6% | EDGAR |
| SC 13D/A | 2002-12-16 | WARBURG PINCUS VENTURES LP | MEDICINES CO/ MA | 1,641,601 | 4.0% | EDGAR |
| SC 13D/A | 2002-11-22 | WARBURG PINCUS VENTURES LP | MEDICINES CO/ MA | 4,151,258 | 10.2% | EDGAR |
| SC 13D/A | 2002-07-29 | WARBURG PINCUS VENTURES LP | MEDICINES CO/ MA | 9,138,757 | 22.7% | EDGAR |
| SC 13G | 2002-07-10 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO/ MA | 5,342,098 | 13.7% | EDGAR |
| SC 13G/A | 2002-07-01 | BB BIOTECH AG | MEDICINES CO/ MA | 4,780,762 | 13.4% | EDGAR |