| SC 13G/A | 2020-02-14 | Boxer Capital, LLC | MEDICINES CO /DE | - | - | EDGAR |
| SC 13G/A | 2020-02-12 | VANGUARD SPECIALIZED FUNDS | MEDICINES CO /DE | 0 | 0.0% | EDGAR |
| SC 13G/A | 2020-02-12 | VANGUARD GROUP INC | MEDICINES CO /DE | 7,632,116 | 9.6% | EDGAR |
| SC 13G/A | 2020-02-10 | BlackRock Inc. | MEDICINES CO /DE | 12,125,788 | 15.2% | EDGAR |
| SC 13G/A | 2020-01-28 | IRIDIAN ASSET MANAGEMENT LLC/CT | MEDICINES CO /DE | - | - | EDGAR |
| SC 13D/A | 2020-01-07 | Sarissa Capital Management LP | MEDICINES CO /DE | 0 | 0.0% | EDGAR |
| SC 13G/A | 2020-01-07 | WESTFIELD CAPITAL MANAGEMENT CO LP | MEDICINES CO /DE | 1,368,720 | 1.7% | EDGAR |
| SC 13G/A | 2019-12-10 | FMR LLC | MEDICINES CO /DE | 3,913,932 | 4.9% | EDGAR |
| SC 13G/A | 2019-12-09 | WELLINGTON MANAGEMENT GROUP LLP | MEDICINES CO /DE | 365,895 | 0.5% | EDGAR |
| SC 13D | 2019-05-30 | Sarissa Capital Management LP | MEDICINES CO /DE | 4,152,000 | 5.6% | EDGAR |
| SC 13G/A | 2019-02-14 | Boxer Capital, LLC | MEDICINES CO /DE | 232,000 | 0.3% | EDGAR |
| SC 13G/A | 2019-02-14 | PointState Capital LP | MEDICINES CO /DE | 0 | 0.0% | EDGAR |
| SC 13G/A | 2019-02-13 | FMR LLC | MEDICINES CO /DE | 11,079,326 | 15.0% | EDGAR |
| SC 13G/A | 2019-02-12 | WELLINGTON MANAGEMENT GROUP LLP | MEDICINES CO /DE | 10,326,420 | 14.0% | EDGAR |
| SC 13G/A | 2019-02-11 | BlackRock Inc. | MEDICINES CO /DE | 11,407,224 | 15.4% | EDGAR |
| SC 13G/A | 2019-02-11 | VANGUARD GROUP INC | MEDICINES CO /DE | 6,859,838 | 9.3% | EDGAR |
| SC 13G | 2019-02-07 | WESTFIELD CAPITAL MANAGEMENT CO LP | MEDICINES CO /DE | 4,604,719 | 6.2% | EDGAR |
| SC 13G | 2019-02-06 | IRIDIAN ASSET MANAGEMENT LLC/CT | MEDICINES CO /DE | 3,743,851 | 5.1% | EDGAR |
| SC 13G/A | 2019-01-31 | VANGUARD SPECIALIZED FUNDS | MEDICINES CO /DE | 5,617,020 | 7.6% | EDGAR |
| SC 13G | 2018-06-11 | PointState Capital LP | MEDICINES CO /DE | 3,873,190 | 5.3% | EDGAR |