| SC 13G | 2007-01-23 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO /DE | 1,516,435 | 3.0% | EDGAR |
| SC 13G/A | 2007-01-18 | ADAGE CAPITAL PARTNERS GP LLC | MEDICINES CO /DE | - | 0.0% | EDGAR |
| SC 13G/A | 2006-11-09 | BB BIOTECH AG | MEDICINES CO /DE | 2,371,602 | 4.7% | EDGAR |
| SC 13G | 2006-07-03 | SHAW D E & CO L P /NY/ | MEDICINES CO /DE | 2,528,405 | 5.0% | EDGAR |
| SC 13G/A | 2006-06-09 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 5,043,390 | 10.0% | EDGAR |
| SC 13G | 2006-03-23 | FARALLON CAPITAL MANAGEMENT LLC | MEDICINES CO /DE | 9 | 11.0% | EDGAR |
| SC 13G/A | 2006-02-14 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 3,806,140 | 7.6% | EDGAR |
| SC 13G/A | 2006-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 6,903,240 | 13.9% | EDGAR |
| SC 13G/A | 2006-02-14 | ADAGE CAPITAL PARTNERS GP LLC | MEDICINES CO /DE | 3,175,600 | 6.4% | EDGAR |
| SC 13G/A | 2006-02-14 | BB BIOTECH AG | MEDICINES CO /DE | 3,925,000 | 7.9% | EDGAR |
| SC 13G/A | 2006-02-14 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 4,303,315 | 8.7% | EDGAR |
| SC 13G | 2006-02-10 | BARCLAYS PLC | MEDICINES CO /DE | - | 0.0% | EDGAR |
| SC 13G/A | 2006-02-07 | FRANKLIN RESOURCES INC | MEDICINES CO /DE | 3,195,180 | 6.4% | EDGAR |
| SC 13G | 2006-01-26 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO /DE | 1,773,338 | 3.6% | EDGAR |
| SC 13G | 2005-10-14 | ADAGE CAPITAL PARTNERS GP LLC | MEDICINES CO /DE | 3,100,600 | 6.2% | EDGAR |
| SC 13G/A | 2005-03-22 | BB BIOTECH AG | MEDICINES CO /DE | 4,584,152 | 9.4% | EDGAR |
| SC 13G/A | 2005-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 6,687,270 | 13.9% | EDGAR |
| SC 13G/A | 2005-02-14 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 3,489,860 | 7.3% | EDGAR |
| SC 13G | 2005-02-14 | FRANKLIN RESOURCES INC | MEDICINES CO /DE | 2,974,800 | 6.2% | EDGAR |
| SC 13G | 2005-02-14 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO /DE | 1,491,412 | 3.1% | EDGAR |