| SC 13G/A | 2008-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 7,075,883 | 13.6% | EDGAR |
| SC 13G/A | 2008-02-14 | Flynn James E | MEDICINES CO /DE | 971,909 | 1.9% | EDGAR |
| SC 13G | 2008-02-14 | LORD ABBETT & CO LLC | MEDICINES CO /DE | 2,839,375 | 5.5% | EDGAR |
| SC 13G/A | 2008-02-13 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 2,426,990 | 4.6% | EDGAR |
| SC 13G/A | 2008-02-13 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 2,351,736 | 4.5% | EDGAR |
| SC 13G/A | 2008-02-13 | FEDERATED INVESTORS INC /PA/ | MEDICINES CO /DE | 3,004,850 | 5.8% | EDGAR |
| SC 13G/A | 2008-01-30 | FARALLON CAPITAL MANAGEMENT LLC | MEDICINES CO /DE | 465,400 | 0.9% | EDGAR |
| SC 13G/A | 2008-01-22 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO /DE | 1,177,170 | 2.3% | EDGAR |
| SC 13G/A | 2008-01-11 | D. E. Shaw Composite Portfolios, L.L.C. | MEDICINES CO /DE | 5,122,130 | 0.0% | EDGAR |
| SC 13G | 2007-08-24 | Flynn James E | MEDICINES CO /DE | 1,153,795 | 2.2% | EDGAR |
| SC 13G | 2007-07-13 | FARALLON CAPITAL MANAGEMENT LLC | MEDICINES CO /DE | 434,500 | 0.8% | EDGAR |
| SC 13G/A | 2007-05-10 | D. E. Shaw Meniscus Portfolios, L.L.C. | MEDICINES CO /DE | 4,983,087 | 0.0% | EDGAR |
| SC 13G | 2007-02-26 | D. E. Shaw Meniscus Portfolios, L.L.C. | MEDICINES CO /DE | 3,134,569 | 5.5% | EDGAR |
| SC 13G/A | 2007-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 6,203,710 | 12.2% | EDGAR |
| SC 13G/A | 2007-02-14 | D. E. SHAW & CO, L.P. | MEDICINES CO /DE | 2,241,491 | 4.4% | EDGAR |
| SC 13G/A | 2007-02-13 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 3,344,330 | 6.5% | EDGAR |
| SC 13G | 2007-02-13 | FEDERATED INVESTORS INC /PA/ | MEDICINES CO /DE | 2,870,174 | 5.6% | EDGAR |
| SC 13G/A | 2007-02-09 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 2,592,600 | 5.1% | EDGAR |
| SC 13G/A | 2007-02-05 | FRANKLIN RESOURCES INC | MEDICINES CO /DE | 2,249,873 | 4.4% | EDGAR |
| SC 13G/A | 2007-02-01 | FARALLON CAPITAL MANAGEMENT LLC | MEDICINES CO /DE | 9 | 11.0% | EDGAR |