| SC 13G/A | 2010-02-12 | ORBIMED ADVISORS LLC | MEDICINES CO /DE | 1,779,900 | 3.4% | EDGAR |
| SC 13G/A | 2010-02-12 | Flynn James E | MEDICINES CO /DE | 1,813,083 | 3.4% | EDGAR |
| SC 13G/A | 2010-02-11 | WESTFIELD CAPITAL MANAGEMENT CO LP | MEDICINES CO /DE | 1,116,910 | 2.1% | EDGAR |
| SC 13G | 2010-01-29 | BlackRock Inc. | MEDICINES CO /DE | 3,525,528 | 6.7% | EDGAR |
| SC 13G | 2009-10-08 | ORBIMED ADVISORS LLC | MEDICINES CO /DE | 1,226,100 | 2.3% | EDGAR |
| SC 13G/A | 2009-09-10 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 5,404,245 | 10.2% | EDGAR |
| SC 13G/A | 2009-08-11 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 5,302,748 | 10.1% | EDGAR |
| SC 13G/A | 2009-06-10 | LORD ABBETT & CO LLC | MEDICINES CO /DE | 1,498,590 | 2.8% | EDGAR |
| SC 13G | 2009-05-27 | PICTET & CIE EUROPE SA | MEDICINES CO /DE | 3,191,833 | 6.0% | EDGAR |
| SC 13G/A | 2009-02-17 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 7,232,558 | 13.8% | EDGAR |
| SC 13G/A | 2009-02-17 | D. E. Shaw Valence Portfolios, L.L.C. | MEDICINES CO /DE | 5,087,030 | 9.7% | EDGAR |
| SC 13G/A | 2009-02-13 | LORD ABBETT & CO LLC | MEDICINES CO /DE | 4,391,419 | 8.4% | EDGAR |
| SC 13G/A | 2009-02-13 | Flynn James E | MEDICINES CO /DE | 1,149,831 | 2.2% | EDGAR |
| SC 13G | 2009-02-10 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 3,881,245 | 7.4% | EDGAR |
| SC 13G | 2009-02-05 | BARCLAYS GLOBAL INVESTORS NA /CA/ | MEDICINES CO /DE | 1,361,444 | 2.6% | EDGAR |
| SC 13G | 2009-02-04 | WESTFIELD CAPITAL MANAGEMENT CO LP | MEDICINES CO /DE | 2,782,100 | 5.3% | EDGAR |
| SC 13G/A | 2009-01-26 | FARALLON CAPITAL MANAGEMENT LLC | MEDICINES CO /DE | - | 0.0% | EDGAR |
| SC 13D | 2009-01-22 | MEDICINES CO /DE | Targanta Therapeutics Corp. | 7,622,942 | 36.3% | EDGAR |
| SC 13G/A | 2008-12-12 | PICTET & CIE EUROPE SA | MEDICINES CO /DE | 2,483,200 | 4.9% | EDGAR |
| SC 13G/A | 2008-05-12 | FEDERATED INVESTORS INC /PA/ | MEDICINES CO /DE | 1,930,750 | 3.7% | EDGAR |