| SC 13G/A | 2012-02-09 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 5,641,375 | 10.4% | EDGAR |
| SC 13G/A | 2012-02-09 | VANGUARD GROUP INC | MEDICINES CO /DE | 3,517,951 | 6.5% | EDGAR |
| SC 13G/A | 2011-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 6,157,365 | 11.5% | EDGAR |
| SC 13G/A | 2011-02-14 | Ridgeback Capital Investments L.P. | MEDICINES CO /DE | 4,829,900 | 9.0% | EDGAR |
| SC 13G/A | 2011-02-14 | D. E. Shaw Valence Portfolios, L.L.C. | MEDICINES CO /DE | 4,863,679 | 9.1% | EDGAR |
| SC 13G/A | 2011-02-11 | WESTFIELD CAPITAL MANAGEMENT CO LP | MEDICINES CO /DE | 0 | 0.0% | EDGAR |
| SC 13G/A | 2011-02-10 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 6,199,975 | 11.6% | EDGAR |
| SC 13G | 2011-02-10 | VANGUARD GROUP INC | MEDICINES CO /DE | 2,804,940 | 5.2% | EDGAR |
| SC 13G/A | 2011-02-09 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | - | 0.0% | EDGAR |
| SC 13G/A | 2011-02-07 | BlackRock Inc. | MEDICINES CO /DE | 3,641,596 | 6.8% | EDGAR |
| SC 13G/A | 2011-02-03 | Flynn James E | MEDICINES CO /DE | 2,610,532 | 4.9% | EDGAR |
| SC 13G/A | 2010-10-08 | PICTET & CIE EUROPE SA | MEDICINES CO /DE | 1 | 4.6% | EDGAR |
| SC 13G/A | 2010-08-09 | ORBIMED ADVISORS LLC | MEDICINES CO /DE | 311,300 | 0.6% | EDGAR |
| SC 13G/A | 2010-08-09 | Flynn James E | MEDICINES CO /DE | 2,577,371 | 4.8% | EDGAR |
| SC 13G | 2010-04-05 | Ridgeback Capital Investments L.P. | MEDICINES CO /DE | 3,442,896 | 6.5% | EDGAR |
| SC 13G/A | 2010-03-11 | PICTET & CIE EUROPE SA | MEDICINES CO /DE | 2,628,695 | 5.0% | EDGAR |
| SC 13G/A | 2010-02-16 | D. E. Shaw Valence Portfolios, L.L.C. | MEDICINES CO /DE | 5,084,121 | 9.6% | EDGAR |
| SC 13G/A | 2010-02-12 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 6,011,845 | 11.3% | EDGAR |
| SC 13G/A | 2010-02-12 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 6,630,268 | 12.5% | EDGAR |
| SC 13G/A | 2010-02-12 | SECTORAL ASSET MANAGEMENT INC | MEDICINES CO /DE | 4,123,674 | 7.8% | EDGAR |