| SC 13G/A | 2014-02-10 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 5,841,715 | 9.1% | EDGAR |
| SC 13G | 2014-02-04 | VANGUARD SPECIALIZED FUNDS | MEDICINES CO /DE | 4,599,069 | 7.2% | EDGAR |
| SC 13G | 2014-01-13 | ROYCE & ASSOCIATES LLC | MEDICINES CO /DE | 4,599,842 | 7.2% | EDGAR |
| SC 13G/A | 2014-01-10 | BlackRock Inc. | MEDICINES CO /DE | 6,968,624 | 10.9% | EDGAR |
| SC 13G/A | 2013-06-10 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 5,746,089 | 10.3% | EDGAR |
| SC 13G/A | 2013-06-07 | BlackRock Inc. | MEDICINES CO /DE | 5,995,747 | 10.7% | EDGAR |
| SC 13G/A | 2013-02-14 | SAC Capital Advisors LP | MEDICINES CO /DE | 3,484,356 | 6.5% | EDGAR |
| SC 13G/A | 2013-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 4,694,629 | 8.7% | EDGAR |
| SC 13G/A | 2013-02-14 | D. E. Shaw Valence Portfolios, L.L.C. | MEDICINES CO /DE | 2,071,622 | 3.9% | EDGAR |
| SC 13G/A | 2013-02-12 | VANGUARD GROUP INC | MEDICINES CO /DE | 3,579,733 | 6.6% | EDGAR |
| SC 13G/A | 2013-02-11 | PRICE T ROWE ASSOCIATES INC /MD/ | MEDICINES CO /DE | 5,789,845 | 10.7% | EDGAR |
| SC 13G/A | 2013-02-01 | BlackRock Inc. | MEDICINES CO /DE | 4,771,262 | 8.9% | EDGAR |
| SC 13G | 2012-11-19 | SAC Capital Advisors LP | MEDICINES CO /DE | 2,612,765 | 4.9% | EDGAR |
| SC 13G/A | 2012-11-09 | BlackRock Inc. | MEDICINES CO /DE | 5,630,522 | 10.5% | EDGAR |
| SC 13G/A | 2012-07-10 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 5,548,597 | 10.1% | EDGAR |
| SC 13G/A | 2012-02-14 | WELLINGTON MANAGEMENT CO LLP | MEDICINES CO /DE | 4,755,247 | 8.8% | EDGAR |
| SC 13G/A | 2012-02-14 | Ridgeback Capital Investments L.P. | MEDICINES CO /DE | 748,499 | 1.4% | EDGAR |
| SC 13G/A | 2012-02-14 | D. E. Shaw Valence Portfolios, L.L.C. | MEDICINES CO /DE | 4,663,090 | 8.6% | EDGAR |
| SC 13G/A | 2012-02-14 | Flynn James E | MEDICINES CO /DE | 879,533 | 1.6% | EDGAR |
| SC 13G/A | 2012-02-10 | BlackRock Inc. | MEDICINES CO /DE | 4,503,838 | 8.3% | EDGAR |