| SC 13G/A | 2018-02-14 | Partner Fund Management, L.P. | MEDICINES CO /DE | - | 3.5% | EDGAR |
| SC 13G/A | 2018-02-14 | Boxer Capital, LLC | MEDICINES CO /DE | 750,000 | 1.0% | EDGAR |
| SC 13G/A | 2018-02-13 | FMR LLC | MEDICINES CO /DE | 10,934,594 | 15.0% | EDGAR |
| SC 13G/A | 2018-02-09 | VANGUARD GROUP INC | MEDICINES CO /DE | 6,244,562 | 8.6% | EDGAR |
| SC 13G/A | 2018-02-08 | BlackRock Inc. | MEDICINES CO /DE | 9,718,386 | 13.3% | EDGAR |
| SC 13G/A | 2018-02-08 | WELLINGTON MANAGEMENT GROUP LLP | MEDICINES CO /DE | 10,200,290 | 14.0% | EDGAR |
| SC 13G/A | 2018-02-02 | VANGUARD SPECIALIZED FUNDS | MEDICINES CO /DE | 5,564,220 | 7.6% | EDGAR |
| SC 13G | 2018-01-11 | MEDICINES CO /DE | MELINTA THERAPEUTICS, INC. /NEW/ | 3,313,702 | 10.6% | EDGAR |
| SC 13G | 2017-05-01 | Partner Fund Management, L.P. | MEDICINES CO /DE | - | 5.3% | EDGAR |
| SC 13G/A | 2017-03-23 | Boxer Capital, LLC | MEDICINES CO /DE | 1,898,700 | 2.7% | EDGAR |
| SC 13G | 2017-03-20 | Partner Fund Management, L.P. | MEDICINES CO /DE | - | 3.6% | EDGAR |
| SC 13G/A | 2017-02-14 | FMR LLC | MEDICINES CO /DE | 10,619,098 | 15.0% | EDGAR |
| SC 13G/A | 2017-02-13 | VANGUARD SPECIALIZED FUNDS | MEDICINES CO /DE | 5,564,220 | 7.8% | EDGAR |
| SC 13G/A | 2017-02-10 | VANGUARD GROUP INC | MEDICINES CO /DE | 5,776,854 | 8.2% | EDGAR |
| SC 13G/A | 2017-02-09 | WELLINGTON MANAGEMENT GROUP LLP | MEDICINES CO /DE | 9,908,409 | 14.0% | EDGAR |
| SC 13G/A | 2017-01-12 | BlackRock Inc. | MEDICINES CO /DE | 9,186,165 | 13.0% | EDGAR |
| SC 13G | 2016-11-22 | Boxer Capital, LLC | MEDICINES CO /DE | 1,455,598 | 2.1% | EDGAR |
| SC 13G/A | 2016-02-16 | PointState Capital LP | MEDICINES CO /DE | 809,747 | 1.2% | EDGAR |
| SC 13G/A | 2016-02-12 | FMR LLC | MEDICINES CO /DE | 10,457,984 | 15.0% | EDGAR |
| SC 13G/A | 2016-02-11 | WELLINGTON MANAGEMENT GROUP LLP | MEDICINES CO /DE | 9,722,732 | 14.0% | EDGAR |