| Pavadi Capital LLC | 85,594 | $5,947,071 | 7.75% |
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| Eagle Health Investments LP | 416,700 | $28,952,316 | 6.38% |
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| Velan Capital Investment Management LP | 75,000 | $5,211,000 | 4.20% |
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| Private Capital Management, LLC | 435,481 | $30,257,220 | 3.58% |
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| Decheng Capital Management III (Cayman), LLC | 142,196 | $9,879,778 | 3.30% |
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| REINHART PARTNERS, LLC. | 901,520 | $62,637,603 | 3.25% |
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| Taika Capital, LP | 96,910 | $6,733,307 | 3.19% |
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| Portolan Capital Management | 474,659 | $32,979,307 | 3.08% |
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| Hood River Capital Management LLC | 1,195,597 | $83,070,080 | 2.67% |
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| Telemark Asset Management, LLC | 185,000 | $12,853,800 | 1.95% |
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| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 629,445 | $43,733,839 | 1.91% |
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| S&T BANK/PA | 127,179 | $8,836 | 1.70% |
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| Atika Capital Management LLC | 178,000 | $12,367,440 | 1.62% |
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| Redwood Investments, LLC | 170,816 | $11,868,296 | 1.60% |
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| Avidity Partners Management LP | 558,400 | $38,797,632 | 1.56% |
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| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 510,700 | $35,483,436 | 1.55% |
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| Mesirow Institutional Investment Management, Inc. | 187,948 | $13,058,627 | 1.32% |
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| Nicholas Investment Partners, LP | 254,752 | $17,700,169 | 1.32% |
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| Rhenman & Partners Asset Management AB | 168,000 | $11,672,640 | 1.26% |
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| OBERWEIS ASSET MANAGEMENT INC/ | 169,340 | $11,765,743 | 1.25% |
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