| Frazier Life Sciences Management, L.P. | 203,684 | $6,440,488 | 0.43% |
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| Contrarius Investment Management Ltd | 231,862 | $7,331 | 0.41% |
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| McGuire Investment Group, LLC | 65,984 | $2,086,414 | 0.40% |
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| Menard Financial Group LLC | 8,392 | $265,355 | 0.38% |
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| Artal Group S.A. | 276,077 | $8,730 | 0.37% |
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| Green Alpha Advisors, LLC | 14,777 | $467,249 | 0.36% |
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| Rokos Capital Management LLP | 1,389,296 | $44,311,596 | 0.32% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 24,000 | $757,920 | 0.26% |
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| Interchange Capital Partners, LLC | 9,634 | $304,630 | 0.24% |
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| Granahan Investment Management | 205,191 | $6,488,139 | 0.23% |
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| Value Star Asset Management (Hong Kong) Ltd | 20,700 | $654,534 | 0.23% |
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| Corton Capital Inc. | 14,088 | $445,463 | 0.22% |
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| Eventide Asset Management | 372,665 | $11,783,667 | 0.21% |
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| CAPITAL ADVISORS INC/OK | 211,359 | $6,683,172 | 0.18% |
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| Rhenman & Partners Asset Management AB | 50,000 | $1,581,000 | 0.17% |
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| FEDERATED HERMES, INC. | 1,771,578 | $56,017,296 | 0.15% |
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| PDT Partners, LLC | 37,077 | $1,172,375 | 0.15% |
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| Chevy Chase Trust Holdings, LLC | 1,002,955 | $31,713,437 | 0.12% |
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| HARBOR CAPITAL ADVISORS, INC. | 16,604 | $525,018 | 0.11% |
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| AIGEN INVESTMENT MANAGEMENT, LP | 17,569 | $555,532 | 0.10% |
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