| Pivotal bioVenture Partners Investment Advisor LLC | 3,661,518 | $20,394,655 | 6.72% |
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| CHI Advisors LLC | 1,195,027 | $6,656,301 | 2.02% |
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| Affinity Asset Advisors, LLC | 751,796 | $4,187,504 | 1.46% |
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| Sofinnova Investments, Inc. | 3,655,308 | $20,360,066 | 1.33% |
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| NEA Management Company, LLC | 2,437,689 | $13,577,928 | 1.04% |
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| SPHERA FUNDS MANAGEMENT LTD. | 1,131,967 | $6,305,056 | 0.98% |
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| Knott David M Jr | 220,000 | $1,225 | 0.49% |
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| Rock Springs Capital Management LP | 3,428,084 | $19,094,428 | 0.45% |
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| Deep Track Capital, LP | 1,644,021 | $9,157,197 | 0.42% |
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| MPM BioImpact LLC | 326,921 | $1,820,950 | 0.37% |
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| Overbrook Management Corp | 219,326 | $1,221,646 | 0.29% |
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| EAM Investors, LLC | 176,228 | $981,590 | 0.18% |
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| Parkman Healthcare Partners LLC | 168,790 | $940,160 | 0.16% |
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| Total Clarity Wealth Management, Inc. | 30,300 | $168,771 | 0.08% |
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| DENALI ADVISORS LLC | 26,700 | $148,719 | 0.05% |
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| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,250,000 | $23,672,500 | 0.05% |
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| Octagon Capital Advisors LP | 49,702 | $276,840 | 0.04% |
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| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 155,305 | $865,049 | 0.03% |
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| Woodline Partners LP | 288,827 | $1,608,766 | 0.02% |
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| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 116,600 | $649,462 | 0.02% |
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