| Lion Point Capital, LP | 70,335 | $1,775,959 | 0.79% |
|---|
| ESSEX INVESTMENT MANAGEMENT CO LLC | 148,419 | $3,747,580 | 0.61% |
|---|
| TANG CAPITAL MANAGEMENT LLC | 166,203 | $4,196,626 | 0.59% |
|---|
| Parkman Healthcare Partners LLC | 125,000 | $3,156,250 | 0.58% |
|---|
| SAMLYN CAPITAL, LLC | 1,381,057 | $34,871,690 | 0.57% |
|---|
| Soleus Capital Management, L.P. | 218,000 | $5,504,500 | 0.51% |
|---|
| Ikarian Capital, LLC | 154,900 | $3,911,226 | 0.47% |
|---|
| Nebula Research & Development LLC | 27,867 | $703,642 | 0.37% |
|---|
| RICE HALL JAMES & ASSOCIATES, LLC | 224,465 | $5,667,741 | 0.36% |
|---|
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4,241,935 | $107,108,859 | 0.36% |
|---|
| GW&K Investment Management, LLC | 1,352,269 | $34,145 | 0.34% |
|---|
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 40,100 | $1,012,124 | 0.34% |
|---|
| Long Focus Capital Management, LLC | 371,649 | $9,384,137 | 0.34% |
|---|
| EFG Asset Management (North America) Corp. | 52,693 | $1,330,235 | 0.32% |
|---|
| EAM Investors, LLC | 64,558 | $1,630,090 | 0.32% |
|---|
| OAK RIDGE INVESTMENTS LLC | 95,523 | $2,411,956 | 0.31% |
|---|
| Eventide Asset Management | 635,185 | $16,038,421 | 0.29% |
|---|
| Hennion & Walsh Asset Management, Inc. | 171,006 | $4,317,902 | 0.28% |
|---|
| Knights of Columbus Asset Advisors LLC | 113,796 | $2,873,349 | 0.26% |
|---|
| PEREGRINE CAPITAL MANAGEMENT LLC | 340,125 | $8,588,156 | 0.26% |
|---|