| TCG Crossover Management, LLC | 1,750,387 | $32,119,601 | 4.73% |
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| Perceptive Advisors | 4,256,104 | $78,099,508 | 2.60% |
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| RA Capital Management | 4,724,207 | $86,689,198 | 1.71% |
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| Birchview Capital, LP | 70,448 | $1,292,721 | 1.10% |
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| Soleus Capital Management, L.P. | 549,183 | $10,077,508 | 0.93% |
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| Sofinnova Investments, Inc. | 743,294 | $13,639,445 | 0.86% |
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| SPHERA FUNDS MANAGEMENT LTD. | 256,371 | $4,704,408 | 0.86% |
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| Meridian Wealth Advisors, LLC | 122,315 | $2,244,481 | 0.56% |
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| VIKING GLOBAL INVESTORS LP | 7,150,826 | $131,217,657 | 0.53% |
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| Velan Capital Investment Management LP | 25,000 | $458,750 | 0.37% |
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| Woodline Partners LP | 1,524,915 | $27,982,190 | 0.33% |
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| PFM Health Sciences, LP | 288,617 | $5,296,122 | 0.25% |
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| ArrowMark Colorado Holdings LLC | 965,996 | $17,726,027 | 0.22% |
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| Ghost Tree Capital, LLC | 35,000 | $642,250 | 0.21% |
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| Alaethes Wealth LLC | 19,341 | $354,907 | 0.19% |
|---|
| PLATINUM INVESTMENT MANAGEMENT LTD | 229,036 | $4,202,811 | 0.16% |
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| Eventide Asset Management | 434,026 | $7,964,377 | 0.14% |
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| Laird Norton Wetherby Wealth Management, LLC | 136,328 | $2,501,619 | 0.14% |
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| RS CRUM INC. | 14,659 | $268,993 | 0.10% |
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| FOX RUN MANAGEMENT, L.L.C. | 12,621 | $231,595 | 0.07% |
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