| Hennion & Walsh Asset Management, Inc. | 143,080 | $5,492,841 | 0.35% |
|---|
| Sofinnova Investments, Inc. | 139,885 | $5,370,185 | 0.34% |
|---|
| PLATINUM INVESTMENT MANAGEMENT LTD | 225,939 | $8,673,798 | 0.34% |
|---|
| BVF INC/IL | 300,000 | $11,517,000 | 0.31% |
|---|
| AWM Investment Company, Inc. | 50,000 | $1,919,500 | 0.28% |
|---|
| DAFNA Capital Management LLC | 22,500 | $863,775 | 0.27% |
|---|
| FRED ALGER MANAGEMENT, LLC | 1,186,031 | $45,531,730 | 0.26% |
|---|
| HAP Trading, LLC | 207,800 | $1,555,530 | 0.25% |
|---|
| SEVEN EIGHT CAPITAL, LP | 45,406 | $1,743,136 | 0.20% |
|---|
| Skandinaviska Enskilda Banken AB (publ) | 681,935 | $26,179 | 0.17% |
|---|
| Corton Capital Inc. | 7,505 | $288,117 | 0.14% |
|---|
| BOOTHBAY FUND MANAGEMENT, LLC | 146,800 | $5,635,652 | 0.13% |
|---|
| Polar Asset Management Partners Inc. | 155,500 | $5,969,645 | 0.13% |
|---|
| ALGERT GLOBAL LLC | 63,469 | $2,437 | 0.12% |
|---|
| Virtus ETF Advisers LLC | 4,647 | $178,398 | 0.11% |
|---|
| PROFUND ADVISORS LLC | 49,869 | $1,914,471 | 0.11% |
|---|
| BOOTHBAY FUND MANAGEMENT, LLC | 115,500 | $4,434,045 | 0.10% |
|---|
| FARALLON CAPITAL MANAGEMENT LLC | 504,000 | $19,348,560 | 0.10% |
|---|
| Baker Brothers Advisors | 425,009 | $16,316,096 | 0.09% |
|---|
| Y-Intercept (Hong Kong) Ltd | 22,060 | $846,883 | 0.08% |
|---|