| Opaleye Management Inc. | 3,795,000 | $54,534,150 | 17.74% |
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| Private Capital Management, LLC | 1,416,900 | $20,360,853 | 2.41% |
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| JACOB ASSET MANAGEMENT OF NEW YORK LLC | 91,779 | $1,318,864 | 1.86% |
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| Birchview Capital, LP | 150,000 | $2,155,500 | 1.84% |
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| Diametric Capital, LP | 286,127 | $4,111,644 | 1.72% |
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| Ophir Asset Management Pty Ltd | 492,179 | $7,072,612 | 1.67% |
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| BRAIDWELL LP | 1,808,684 | $25,990,789 | 0.82% |
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| Westside Investment Management, Inc. | 159,019 | $2,285,117 | 0.66% |
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| INVICTUS PRIVATE WEALTH, LLC | 400,066 | $5,748,948 | 0.63% |
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| Portolan Capital Management | 385,964 | $5,546,303 | 0.52% |
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| BARD ASSOCIATES INC | 65,450 | $940,517 | 0.39% |
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| STANSBERRY ASSET MANAGEMENT, LLC | 139,423 | $2,003,509 | 0.35% |
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| PARADIGM CAPITAL MANAGEMENT INC/NY | 393,500 | $5,654,595 | 0.32% |
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| Mendota Financial Group, LLC | 19,073 | $274,080 | 0.29% |
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| Intrinsic Edge Capital Management LLC | 169,820 | $2,440,313 | 0.28% |
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| Uniplan Investment Counsel, Inc. | 216,934 | $3,113 | 0.24% |
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| RICE HALL JAMES & ASSOCIATES, LLC | 250,380 | $3,597,961 | 0.23% |
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| DRIEHAUS CAPITAL MANAGEMENT LLC | 801,927 | $11,523,691 | 0.15% |
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| CORRADO ADVISORS, LLC | 14,417 | $207,173 | 0.14% |
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| Hillsdale Investment Management Inc. | 100,503 | $1,444,229 | 0.13% |
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