| Velan Capital Investment Management LP | 1,000,000 | $3,120,000 | 2.90% |
|---|
| Nan Fung Group Holdings Ltd | 613,223 | $1,913,256 | 1.22% |
|---|
| SECTORAL ASSET MANAGEMENT INC | 2,005,054 | $6,255,769 | 1.04% |
|---|
| Sofinnova Investments, Inc. | 3,083,712 | $9,621,181 | 0.63% |
|---|
| Novo Holdings A/S | 2,100,000 | $6,552,000 | 0.51% |
|---|
| Parkman Healthcare Partners LLC | 540,847 | $1,687,443 | 0.29% |
|---|
| Tekla Capital Management LLC | 898,374 | $2,802,927 | 0.11% |
|---|
| Global Assets Advisory, LLC | 24,500 | $72,721 | 0.07% |
|---|
| Alyeska Investment Group, L.P. | 2,500,000 | $7,800,000 | 0.06% |
|---|
| UBS OCONNOR LLC | 570,506 | $1,779,979 | 0.06% |
|---|
| Alyeska Investment Group, L.P. | 1,698,012 | $5,297,797 | 0.04% |
|---|
| XTX Topco Ltd | 53,492 | $166,895 | 0.03% |
|---|
| Blackstone Inc. | 1,678,984 | $5,238,430 | 0.02% |
|---|
| Pinnacle Wealth Management Advisory Group, LLC | 47,695 | $148,808 | 0.02% |
|---|
| FNY Investment Advisers, LLC | 2,500 | $7 | 0.01% |
|---|
| TUCKER ASSET MANAGEMENT LLC | 10,248 | $31,974 | 0.01% |
|---|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 112,000 | $349,440 | 0.01% |
|---|
| Jump Financial, LLC | 59,720 | $186,326 | 0.01% |
|---|
| Virtu Financial LLC | 24,030 | $75 | 0.01% |
|---|
| Schonfeld Strategic Advisors LLC | 147,300 | $459,576 | 0.00% |
|---|