| Essex Woodlands Management, Inc. | 3,490,921 | $27,892,459 | 24.59% |
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| ACUTA CAPITAL PARTNERS, LLC | 300,128 | $2,398,023 | 1.61% |
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| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,492,147 | $27,902,255 | 1.51% |
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| Cormorant Asset Management, LP | 3,200,000 | $25,568,000 | 1.49% |
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| Samsara BioCapital, LLC | 432,000 | $3,451,680 | 1.06% |
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| Ghost Tree Capital, LLC | 325,000 | $2,596,750 | 0.85% |
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| RA Capital Management | 3,370,506 | $26,930,343 | 0.53% |
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| Ikarian Capital, LLC | 4,487 | $3,585,113 | 0.43% |
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| Affinity Asset Advisors, LLC | 155,000 | $1,238,450 | 0.35% |
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| SECTORAL ASSET MANAGEMENT INC | 176,080 | $1,406,879 | 0.27% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 207,160 | $1,655,208 | 0.27% |
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| Corton Capital Inc. | 22,682 | $181,229 | 0.09% |
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| Legato Capital Management LLC | 77,401 | $618,434 | 0.09% |
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| Perceptive Advisors | 750,000 | $2,512,500 | 0.08% |
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| BARD ASSOCIATES INC | 19,100 | $152,609 | 0.06% |
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| INNOVIS ASSET MANAGEMENT LLC | 19,031 | $152,058 | 0.06% |
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| DENALI ADVISORS LLC | 13,900 | $111,061 | 0.04% |
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| SHERBROOKE PARK ADVISERS LLC | 12,620 | $100,834 | 0.03% |
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| Dynamic Technology Lab Private Ltd | 38,587 | $308 | 0.03% |
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| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,736,503 | $13,874,659 | 0.03% |
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