| Essex Woodlands Management, Inc. | 1,551,521 | $13,498,233 | 4.40% |
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| Cormorant Asset Management, LP | 8,325,000 | $72,427,500 | 4.18% |
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| ORACLE INVESTMENT MANAGEMENT INC | 231,857 | $2,017,156 | 1.88% |
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| Finepoint Capital LP | 707,404 | $6,154,415 | 1.75% |
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| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,175,823 | $45,029,660 | 1.65% |
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| Octagon Capital Advisors LP | 1,093,503 | $9,513,476 | 1.50% |
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| TCG Crossover Management, LLC | 922,335 | $8,024,315 | 0.84% |
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| SUPERSTRING CAPITAL MANAGEMENT LP | 37,838 | $329,191 | 0.42% |
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| Corton Capital Inc. | 49,905 | $434,174 | 0.23% |
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| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | $870,000 | 0.20% |
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| MYDA Advisors LLC | 100,000 | $870,000 | 0.19% |
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| Artia Global Partners LP | 101,500 | $883,050 | 0.17% |
|---|
| Perceptive Advisors | 640,274 | $5,570,384 | 0.13% |
|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 877,790 | $7,636,773 | 0.13% |
|---|
| PFM Health Sciences, LP | 292,926 | $2,548,456 | 0.13% |
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| Laurion Capital Management LP | 1,072,577 | $9,331,420 | 0.11% |
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| Caption Management, LLC | 749,400 | $6,519,780 | 0.10% |
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| 5AM Venture Management, LLC | 50,000 | $435,000 | 0.10% |
|---|
| Granahan Investment Management | 201,332 | $1,751,588 | 0.07% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 42,538 | $370,081 | 0.07% |
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