| ALETHEA CAPITAL MANAGEMENT, LLC | 1,627,670 | $1,533,591 | 1.88% |
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| 5AM Venture Management, LLC | 1,134,511 | $1,068,936 | 0.31% |
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| Nantahala Capital Management | 2,538,406 | $2,391,686 | 0.20% |
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| BVF INC/IL | 6,861,127 | $6,464,554 | 0.17% |
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| Monashee Investment Management LLC | 369,099 | $347,765 | 0.14% |
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| West Family Investments, Inc. | 368,910 | $347,587 | 0.12% |
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| JEPPSON WEALTH MANAGEMENT, LLC | 137,560 | $129,609 | 0.06% |
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| XTX Topco Ltd | 202,758 | $191,039 | 0.03% |
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| GSA CAPITAL PARTNERS LLP | 136,974 | $129 | 0.01% |
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| Callan Capital, LLC | 103,462 | $97,482 | 0.01% |
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| Legacy Wealth Asset Management, LLC | 30,000 | $28,266 | 0.01% |
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| Aveo Capital Partners, LLC | 42,502 | $40,045 | 0.01% |
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| Pale Fire Capital SE | 54,356 | $51,214 | 0.01% |
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| Schonfeld Strategic Advisors LLC | 611,100 | $575,778 | 0.00% |
|---|
| Pacifica Partners Inc. | 8,000 | $7,784 | 0.00% |
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| Point72 Asset Management, L.P. | 1,250,000 | $1,177,750 | 0.00% |
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| Renaissance Technologies | 1,599,673 | $1,507 | 0.00% |
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| LIBERTY WEALTH MANAGEMENT LLC | 12,000 | $11 | 0.00% |
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| Virtu Financial LLC | 19,064 | $18 | 0.00% |
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| Connor, Clark & Lunn Investment Management Ltd. | 329,200 | $310,172 | 0.00% |
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