| Zeal Asset Management Ltd | 73,253 | $13,116 | 33.29% |
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| HHLR ADVISORS, LTD. | 5,176,906 | $931,170,082 | 20.79% |
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| Baker Brothers Advisors | 11,668,897 | $2,098,884,503 | 12.10% |
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| Ovata Capital Management Ltd | 22,701 | $4,054,982 | 5.09% |
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| Boxer Capital, LLC | 500,000 | $89,935,000 | 4.79% |
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| Temasek Holdings (Private) Ltd | 3,014,171 | $542,158,938 | 3.23% |
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| Artal Group S.A. | 403,934 | $72,656 | 3.12% |
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| Old Well Partners, LLC | 19,165 | $3,447,209 | 2.99% |
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| Capital International, Inc./CA/ | 849,231 | $152,751,180 | 2.93% |
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| TANG CAPITAL MANAGEMENT LLC | 85,000 | $15,288,950 | 2.16% |
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| Nan Fung Group Holdings Ltd | 12,022 | $2,162,397 | 1.75% |
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| XY Capital Ltd | 15,416 | $2,772,876 | 1.59% |
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| Capital International Sarl | 165,545 | $29,776,579 | 1.36% |
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| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 60,890 | $10,952,284 | 1.32% |
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| Capricorn Fund Managers Ltd | 13,735 | $2,470,514 | 0.86% |
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| Pinpoint Asset Management Ltd | 7,534 | $3,612,149 | 0.85% |
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| Long Corridor Asset Management Ltd | 4,907 | $882,622 | 0.77% |
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| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 12,700 | $2,281,555 | 0.77% |
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| PRIMECAP MANAGEMENT CO/CA/ | 5,008,739 | $900,921,884 | 0.76% |
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| Seaport Global Advisors, LLC | 1,358 | $244,263 | 0.73% |
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