| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 23,500 | $1,119,000 | 0.36% |
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| HighVista Strategies LLC | 12,584 | $600,000 | 0.34% |
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| KRAEMATON INVESTMENT ADVISORS, INC | 5,515 | $263,000 | 0.34% |
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| Eagle Health Investments LP | 28,900 | $1,377,000 | 0.32% |
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| Yorktown Management & Research Co Inc | 5,005 | $238,000 | 0.31% |
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| Nikko Asset Management Americas, Inc. | 510,931 | $23,758,000 | 0.30% |
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| TANG CAPITAL MANAGEMENT LLC | 50,000 | $2,382,000 | 0.29% |
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| Reynders McVeigh Capital Management, LLC | 74,914 | $3,569,000 | 0.28% |
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| Eventide Asset Management | 267,025 | $12,721,000 | 0.25% |
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| Quantamental Technologies LLC | 13,354 | $636,000 | 0.25% |
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| JACOB ASSET MANAGEMENT OF NEW YORK LLC | 4,137 | $197,000 | 0.21% |
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| Granahan Investment Management | 110,435 | $5,261,000 | 0.17% |
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| CAPITAL ADVISORS INC/OK | 109,844 | $4,995,000 | 0.16% |
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| Rock Springs Capital Management LP | 111,430 | $5,309,000 | 0.14% |
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| Pearl River Capital, LLC | 15,455 | $736,000 | 0.14% |
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| Clarius Group, LLC | 28,111 | $1,339,000 | 0.13% |
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| K.J. Harrison & Partners Inc | 6,497 | $310,000 | 0.11% |
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| ClariVest Asset Management LLC | 43,656 | $2,080,000 | 0.10% |
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| GILDER GAGNON HOWE & CO LLC | 119,221 | $5,680,000 | 0.10% |
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| Family Management Corp | 5,690 | $271,000 | 0.07% |
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