| PERKINS CAPITAL MANAGEMENT INC | 1,391,093 | $7,164 | 7.10% |
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| Samjo Capital LLC | 2,912,300 | $14,998,345 | 5.90% |
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| Redmile Group, LLC | 15,630,327 | $80,496,184 | 3.83% |
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| Millrace Asset Group, Inc. | 338,832 | $1,745 | 2.16% |
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| G2 Investment Partners Management LLC | 920,525 | $4,740,704 | 1.16% |
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| Resolute Capital Asset Partners LLC | 301,045 | $1,550 | 1.09% |
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| AMERICAN FINANCIAL GROUP INC | 500,000 | $2,575 | 0.88% |
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| Divisadero Street Capital Management, LP | 474,870 | $2,445,581 | 0.77% |
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| EAM Investors, LLC | 369,979 | $1,905,392 | 0.37% |
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| ESSEX INVESTMENT MANAGEMENT CO LLC | 434,286 | $2,236,573 | 0.36% |
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| Parkman Healthcare Partners LLC | 376,082 | $1,936,822 | 0.36% |
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| Taylor Frigon Capital Management LLC | 85,000 | $437,750 | 0.24% |
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| Legato Capital Management LLC | 163,133 | $840,135 | 0.12% |
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| Spouting Rock Asset Management, LLC | 63,968 | $329,435 | 0.10% |
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| Portside Wealth Group, LLC | 53,350 | $276,000 | 0.05% |
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| Worth Venture Partners, LLC | 16,086 | $82,843 | 0.05% |
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| NORDEN GROUP LLC | 23,358 | $120,294 | 0.04% |
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| Lloyd Advisory Services, LLC. | 23,358 | $120,294 | 0.04% |
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| FirstPurpose Wealth LLC | 13,110 | $67,517 | 0.03% |
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| HighMark Wealth Management LLC | 6,000 | $30,900 | 0.03% |
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