| 2020-10-10 | IONIS PHARMACEUTICALS INC | | Buy | Common Stock | 21237715.0 | 98,322,397 | $18.2 | P |
| 2020-08-31 | McDevitt Damien | | Buy | Common Stock | 1104.0 | 251,687 | $14.4 | A |
| 2020-07-09 | Andrews William T. | | Buy | Common Stock | 37500.0 | 37,500 | $0.0 | A |
| 2020-07-09 | Andrews William T. | | Buy | Stock Option (right to buy) | 250000.0 | 250,000 | $0.0 | A |
| 2020-05-18 | PRICE MICHAEL DENNIS | | Buy | Common Stock | 50000.0 | 50,000 | $0.0 | A |
| 2020-05-18 | PRICE MICHAEL DENNIS | | Buy | Stock Option (right to buy) | 300000.0 | 300,000 | $0.0 | A |
| 2020-04-15 | Patterson Joshua F. | | Buy | Common Stock | 12500.0 | 27,114 | $0.0 | A |
| 2020-04-13 | YANG MICHAEL J. | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-04-13 | KLEIN JOSEPH III | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-04-13 | PARSHALL B LYNNE | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-04-13 | Hochberg Elaine | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-04-13 | SMITH SANDFORD D | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-04-13 | Yanni Barbara | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-04-13 | Salzman Amber | | Buy | Stock Option (right to buy) | 26400.0 | 26,400 | $0.0 | A |
| 2020-03-19 | O'Dea Louis | | Buy | Common Stock | 16800.0 | 64,800 | $0.0 | A |
| 2020-03-19 | McDevitt Damien | | Buy | Stock Option (right to buy) | 200000.0 | 200,000 | $0.0 | A |
| 2020-03-19 | Howarth Alex G. | | Buy | Stock Option (right to buy) | 34200.0 | 34,200 | $0.0 | A |
| 2020-03-19 | McDevitt Damien | | Buy | Stock Option (right to buy) | 109800.0 | 109,800 | $0.0 | A |
| 2020-03-19 | McDevitt Damien | | Buy | Common Stock | 55200.0 | 255,200 | $0.0 | A |
| 2020-03-19 | Howarth Alex G. | | Buy | Common Stock | 16800.0 | 66,800 | $0.0 | A |