| Type | Filed | Filer | Subject | Shares Owned | Percent Owned | |
|---|---|---|---|---|---|---|
| SC 13G/A | 2020-11-10 | FMR LLC | AKCEA THERAPEUTICS, INC. | 0 | 0.0% | EDGAR |
| SC 13D/A | 2020-10-13 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 1,000 | 100.0% | EDGAR |
| SC 13G/A | 2020-10-13 | FMR LLC | AKCEA THERAPEUTICS, INC. | 5,716,836 | 5.6% | EDGAR |
| SC 13D/A | 2020-08-31 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 77,094,682 | 75.9% | EDGAR |
| SC 13G/A | 2020-02-07 | FMR LLC | AKCEA THERAPEUTICS, INC. | 10,796,139 | 11.5% | EDGAR |
| SC 13D/A | 2019-12-20 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 77,094,682 | 76.5% | EDGAR |
| SC 13D/A | 2019-04-02 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 70,221,338 | 75.8% | EDGAR |
| SC 13G/A | 2019-02-13 | FMR LLC | AKCEA THERAPEUTICS, INC. | 13,381,506 | 15.0% | EDGAR |
| SC 13D/A | 2018-10-22 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 67,383,965 | 75.5% | EDGAR |
| SC 13D/A | 2018-08-07 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 65,712,116 | 77.0% | EDGAR |
| SC 13D/A | 2018-04-26 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 64,114,545 | 75.0% | EDGAR |
| SC 13G/A | 2018-02-13 | FMR LLC | AKCEA THERAPEUTICS, INC. | 9,981,244 | 15.0% | EDGAR |
| SC 13G | 2017-08-10 | FMR LLC | AKCEA THERAPEUTICS, INC. | 6,485,757 | 10.1% | EDGAR |
| SC 13D | 2017-07-27 | IONIS PHARMACEUTICALS INC | AKCEA THERAPEUTICS, INC. | 45,447,879 | 68.3% | EDGAR |
| SC 13G | 2017-07-27 | NOVARTIS PHARMA AG | AKCEA THERAPEUTICS, INC. | 6,250,000 | 9.7% | EDGAR |