INTERNATIONAL BIOTECHNOLOGY TRUST PLC Activity Q4 2016-Q3 2023

Q3 2023

			Value		Shares		↓ Weighting
AMGN	Sell	AMGEN INC COM	$21,297,363	-18.2%	79,246	-32.4%	7.18%	-9.4%
GILD	Buy	GILEAD SCIENCES INC COMMO	$17,507,121	+57.2%	233,584	+61.6%	5.90%	+74.0%
ITCI	Buy	INTRA-CELLULAR THERAPIES	$16,547,583	+48.0%	317,856	+79.7%	5.57%	+63.7%
BMRN	Buy	BIOMARIN PHARMACEUTICAL I	$13,595,483	+167.5%	153,656	+162.0%	4.58%	+196.1%
SUPN	Sell	SUPERNUS PHARMACEUTICALS	$11,754,340	-25.3%	426,500	-18.5%	3.96%	-17.3%
VERA	Sell	VERA THERAPEUTICScl a	$10,381,880	-33.6%	758,355	-22.2%	3.50%	-26.6%
BIIB	Buy	BIOGEN INC COMMON STOCK	$10,333,812	+229.9%	40,200	+265.5%	3.48%	+264.9%
HRMY	Sell	Harmony Biosciences Holdi	$10,306,165	-48.6%	314,500	-44.9%	3.47%	-43.2%
MRTX	Sell	MIRATI THERAPEUTICS INC C	$9,404,640	+0.1%	216,000	-16.9%	3.17%	+10.8%
RARE	Buy	ULTRAGENYX PHARMACEUTICAL	$8,914,354	+141.5%	250,052	+212.4%	3.00%	+167.2%
QURE	Buy	UNIQURE N.V. COM EUR0.05	$8,330,465	+4589.8%	1,241,500	+7909.7%	2.81%	+5096.3%
AUPH	Buy	AURINIA PHARMACEUTICALS I	$8,074,513	+45.4%	1,040,530	+81.4%	2.72%	+60.9%
UTHR	Sell	UNITED THERAPEUTICS CORP	$7,657,755	-34.3%	33,959	-35.6%	2.58%	-27.2%
REGN	Sell	REGENERON PHARMACEUTICALS	$7,278,338	-62.5%	8,847	-67.2%	2.45%	-58.5%
ALNY	Sell	ALNYLAM PHARMACEUTICALS I	$6,517,280	-58.0%	36,800	-54.9%	2.20%	-53.5%
	Buy	AMYLYX PHARMS.	$5,398,500	+902.5%	295,000	+1080.0%	1.82%	+1009.1%
KRYS	Buy	KRYSTAL BIOTECH INC COM	$5,344,828	-0.8%	46,092	+0.3%	1.80%	+9.8%
KRTX	Buy	KARUNA THERAPEUTICS INC C	$5,157,245	-7.4%	30,500	+18.7%	1.74%	+2.5%
	Buy	ERASCA INC COM	$3,794,220	-3.2%	1,926,000	+35.1%	1.28%	+7.0%
ACAD	Buy	ACADIA PHARMACEUTICALS IN	$3,739,599	+3.4%	179,702	+19.0%	1.26%	+14.4%
NBIX	Sell	NEUROCRINE BIOSCIENCES IN	$3,247,219	-50.0%	28,877	-58.1%	1.09%	-44.6%
SRPT	Buy	SAREPTA THERAPEUTICS INC	$3,234,972	+50.3%	26,700	+42.0%	1.09%	+66.4%
DNLI	Sell	DENALI THERAPEUTICS INC C	$3,172,400	-42.7%	154,000	-18.1%	1.07%	-36.6%
AZN	New	ASTRAZENECA PLC SPONSOREDsponsored adr	$3,148,515	–	46,500	–	1.06%	–
XENE	Buy	XENON PHARMACEUTICALS INC	$3,121,980	+218.0%	91,500	+258.8%	1.05%	+251.8%
CRSP	New	CRISPR THERAPEUTICS AG COnamen akt	$2,858,940	–	63,000	–	0.96%	–
HALO	Sell	HALOZYME THERAPEUTICS INC	$2,376,040	-31.0%	62,200	-34.9%	0.80%	-23.7%
	Buy	MARINUS PHARMACEUTICALS I	$2,337,400	+139.1%	290,000	+222.2%	0.79%	+164.1%
BGNE	Buy	BEIGENE LTD SPONSORED ADRsponsored adr	$2,281,555	+47.4%	12,700	+46.0%	0.77%	+63.3%
IOVA	Buy	IOVANCE BIOTHERAPEUTICS I	$2,024,750	+343.1%	445,000	+584.6%	0.68%	+390.6%
GMAB	New	GENMAB -SP ADRsponsored ads	$1,561,575	–	44,300	–	0.53%	–
COGT	New	COGENT BIOSCIENCES	$1,313,550	–	135,000	–	0.44%	–
DYN	Sell	DYNE THERAPEUTICS INC COM	$1,231,494	-63.6%	137,751	-54.2%	0.42%	-59.7%
NVCR	Buy	Novocure Ltd	$1,193,620	-10.1%	74,000	+131.2%	0.40%	-0.5%
FOLD	New	AMICUS THERAPEUTICS INC C	$1,092,600	–	90,000	–	0.37%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$1,002,200	–	20,000	–	0.34%	–
AKRO	Sell	AKERO THERAPEUTICS INC CO	$935,174	-74.5%	18,489	-76.4%	0.32%	-71.7%
KZR	New	KEZAR LIFE SCIENCES	$830,514	–	703,825	–	0.28%	–
PRTA	New	PROTHENA CORP PLC USD0.01	$722,850	–	15,000	–	0.24%	–
VIR	New	VIR BIOTECHNOLOGY INC COM	$439,920	–	47,000	–	0.15%	–
HCM	Exit	HUTCHMED CHINA LTDsponsored ads	$0	–	-68,000	–	-0.25%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-20,000	–	-0.29%	–
TVTX	Exit	TRAVERE THERAPEUTICS INC	$0	–	-441,019	–	-2.06%	–
HZNP	Exit	HORIZON THERAPEUTICS	$0	–	-67,000	–	-2.10%	–
APLS	Exit	APELLIS PHARMS.	$0	–	-129,700	–	-3.60%	–

Q2 2023

			Value		Shares		↓ Weighting
AMGN	New	AMGEN INC COM	$26,025,095	–	117,246	–	7.92%	–
INCY	New	INCYTE CORP	$22,303,008	–	358,454	–	6.79%	–
HRMY	New	HARMONY BIOSCIENCES HLDGS	$20,070,190	–	570,500	–	6.11%	–
REGN	New	REGENERON PHARMS.	$19,400,040	–	27,000	–	5.91%	–
SUPN	New	SUPERNUS PHARMS.	$15,736,410	–	523,500	–	4.79%	–
VERA	New	VERA THERAPEUTICScl a	$15,642,641	–	975,227	–	4.76%	–
ALNY	New	ALNYLAM PHARMS.	$15,499,104	–	81,600	–	4.72%	–
APLS	New	APELLIS PHARMS.	$11,810,482	–	129,700	–	3.60%	–
UTHR	New	UNITED THERAPEUTICS CORP DEL	$11,647,077	–	52,759	–	3.55%	–
ITCI	New	INTRA-CELLULAR THERAPIES	$11,182,605	–	176,856	–	3.40%	–
GILD	New	GILEAD SCIENCES	$11,137,306	–	144,584	–	3.39%	–
ILMN	New	ILLUMINA INC	$9,463,195	–	50,500	–	2.88%	–
MRTX	New	MIRATI THERAPEUTICS INC	$9,393,800	–	260,000	–	2.86%	–
VRTX	New	VERTEX PHARMACEUTICALS INC	$7,386,750	–	21,000	–	2.25%	–
RVNC	New	REVANCE THERAPEUTICS INC	$7,298,993	–	288,726	–	2.22%	–
HZNP	New	HORIZON THERAPEUTICS	$6,890,950	–	67,000	–	2.10%	–
TVTX	New	TRAVERE THERAPEUTICS INC	$6,769,642	–	441,019	–	2.06%	–
NBIX	New	NEUROCRINE BIOSCIENCES	$6,490,280	–	68,877	–	1.98%	–
KRTX	New	KARUNA THERAPEUTICS INC	$5,566,620	–	25,700	–	1.70%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$5,551,770	–	573,530	–	1.69%	–
DNLI	New	DENALI THERAPEUTICS	$5,538,480	–	188,000	–	1.69%	–
KRYS	New	KRYSTAL BIOTECH	$5,389,349	–	45,945	–	1.64%	–
BMRN	New	BIOMARIN PHARM.	$5,083,129	–	58,656	–	1.55%	–
MDGL	New	MADRIGAL PHARMS.	$4,227,300	–	18,300	–	1.29%	–
AXSM	New	AXSOME THERAPEUTICS	$4,185,940	–	58,300	–	1.27%	–
	New	ERASCA INC	$3,921,500	–	1,426,000	–	1.19%	–
RARE	New	ULTRAGENYX PHARM.	$3,691,198	–	80,052	–	1.12%	–
AKRO	New	AKERO THERAPEUTICS INC	$3,662,297	–	78,489	–	1.12%	–
ACAD	New	ACADIA PHARMACEUTICALS IN	$3,616,450	–	151,000	–	1.10%	–
HALO	New	HALOZYME THERAPEUTICS INC	$3,443,730	–	95,500	–	1.05%	–
DYN	New	DYNE THERAPEUTICS	$3,383,449	–	300,751	–	1.03%	–
BIIB	New	BIOGEN INC	$3,132,690	–	11,000	–	0.95%	–
RCKT	New	ROCKET PHARMS.	$3,093,480	–	156,000	–	0.94%	–
LEGN	New	LEGEND BIOTECHsponsored ads	$2,623,140	–	38,000	–	0.80%	–
ZLAB	New	Zai Lab Ltd ADR (V1 Ord)adr	$2,189,505	–	78,958	–	0.67%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$2,152,976	–	18,800	–	0.66%	–
JAZZ	New	JAZZ PHARMS.	$2,131,768	–	17,200	–	0.65%	–
IONS	New	IONIS PHARMS.	$1,763,860	–	43,000	–	0.54%	–
MIRM	New	MIRUM PHARMACEUTICALS INC	$1,742,850	–	67,500	–	0.53%	–
CLDX	New	CELLDEX THERAPEUTICS INC NEW	$1,630,075	–	48,099	–	0.50%	–
BGNE	New	BEIGENE ADRsponsored adr	$1,548,339	–	8,700	–	0.47%	–
NVCR	New	NOVOCURE LTD	$1,327,680	–	32,000	–	0.40%	–
GH	New	GUARDANT HEALTH	$1,305,605	–	36,500	–	0.40%	–
CYTK	New	CYTOKINETICS INC	$1,205,830	–	37,000	–	0.37%	–
XENE	New	XENON PHARMACEUTICALS INC	$981,750	–	25,500	–	0.30%	–
NTLA	New	INTELLIA THERAPEUTICS	$977,760	–	24,000	–	0.30%	–
	New	MARINUS PHARMACEUTICALS INC	$977,400	–	90,000	–	0.30%	–
SAGE	New	SAGE THERAPEUTICS INC	$939,400	–	20,000	–	0.29%	–
IMAB	New	I-MAB-SPONSORED ADRsponsored ads	$925,287	–	310,499	–	0.28%	–
INSM	New	INSMED INC	$845,308	–	40,100	–	0.26%	–
HCM	New	HUTCHMED CHINA LTDsponsored ads	$816,000	–	68,000	–	0.25%	–
BEAM	New	BEAM THERAPEUTICS INC	$750,355	–	23,500	–	0.23%	–
PTCT	New	PTC THERAPEUTICS	$691,730	–	17,000	–	0.21%	–
AGIO	New	AGIOS PHARMS.	$679,680	–	24,000	–	0.21%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$549,240	–	19,900	–	0.17%	–
	New	AMYLYX PHARMACEUTICALS INC	$538,500	–	25,000	–	0.16%	–
	New	VENTYX BIOSCIENCES INC	$491,400	–	15,000	–	0.15%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS	$456,950	–	65,000	–	0.14%	–
ARVN	New	ARVINAS INC	$421,090	–	17,000	–	0.13%	–
QURE	New	UNIQURE NV	$177,630	–	15,500	–	0.05%	–
RLMD	New	RELMADA THERAPEUTICS	$24,700	–	10,000	–	0.01%	–

Q4 2022

			Value		Shares		↓ Weighting
	Exit	BLACK DIAMOND THERAPEUTIC	$0	–	-44,000	–	-0.02%	–
MIRM	Exit	MIRUM PHARMACEUTICALS INC	$0	–	-9,219	–	-0.06%	–
ALBO	Exit	ALBIREO PHARMA INC	$0	–	-16,093	–	-0.10%	–
MDGL	Exit	MADRIGAL PHARMS.	$0	–	-5,350	–	-0.11%	–
RLMD	Exit	RELMADA THERAPEUTICS	$0	–	-10,000	–	-0.12%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS	$0	–	-56,000	–	-0.17%	–
ALLO	Exit	ALLOGENE THERAPEUTICS	$0	–	-50,000	–	-0.17%	–
HCM	Exit	HUTCHMED CHINA LTDsponsored ads	$0	–	-68,000	–	-0.19%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-60,000	–	-0.20%	–
AXSM	Exit	AXSOME THERAPEUTICS	$0	–	-14,000	–	-0.20%	–
BCRX	Exit	BIOCRYST PHARMS.	$0	–	-57,000	–	-0.23%	–
ARVN	Exit	ARVINAS INC	$0	–	-17,000	–	-0.24%	–
INSM	Exit	INSMED INC	$0	–	-40,100	–	-0.28%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-25,500	–	-0.29%	–
RCKT	Exit	ROCKET PHARMS.	$0	–	-63,000	–	-0.32%	–
PTCT	Exit	PTC THERAPEUTICS	$0	–	-21,000	–	-0.34%	–
BEAM	Exit	BEAM THERAPEUTICS INC	$0	–	-23,500	–	-0.36%	–
DNLI	Exit	DENALI THERAPEUTICS	$0	–	-38,000	–	-0.37%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-200,800	–	-0.43%	–
NTLA	Exit	INTELLIA THERAPEUTICS	$0	–	-24,000	–	-0.43%	–
LEGN	Exit	LEGEND BIOTECHsponsored ads	$0	–	-38,000	–	-0.50%	–
FULC	Exit	FULCRUM THERAPEUTICS INC	$0	–	-193,741	–	-0.50%	–
IDYA	Exit	IDEAYA BIOSCIENCES	$0	–	-109,000	–	-0.52%	–
IMAB	Exit	I-MAB-SPONSORED ADRsponsored ads	$0	–	-507,239	–	-0.65%	–
BGNE	Exit	BEIGENE ADRsponsored adr	$0	–	-15,700	–	-0.68%	–
ACET	Exit	ADICET BIO INC	$0	–	-154,708	–	-0.70%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-34,200	–	-0.72%	–
JAZZ	Exit	JAZZ PHARMS.	$0	–	-17,200	–	-0.74%	–
NVAX	Exit	NOVAVAX INC	$0	–	-132,500	–	-0.77%	–
NVCR	Exit	NOVOCURE LTD	$0	–	-32,000	–	-0.78%	–
ZLAB	Exit	Zai Lab Ltd ADR (V1 Ord)adr	$0	–	-78,958	–	-0.86%	–
FATE	Exit	FATE THERAPEUTICS	$0	–	-121,000	–	-0.87%	–
	Exit	CARIBOU BIOSCIENCES INC	$0	–	-257,892	–	-0.87%	–
ASND	Exit	ASCENDIS PHARMA ADRsponsored adr	$0	–	-29,400	–	-0.97%	–
VTRS	Exit	UNITED THERAPEUTICS CORP DEL	$0	–	-364,000	–	-0.99%	–
KRYS	Exit	KRYSTAL BIOTECH	$0	–	-45,000	–	-1.00%	–
UTHR	Exit	UNITED THERAPEUTICS CORP DEL	$0	–	-15,000	–	-1.01%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES	$0	–	-30,000	–	-1.02%	–
RVNC	Exit	REVANCE THERAPEUTICS INC	$0	–	-120,000	–	-1.04%	–
AMGN	Exit	AMGEN INC COM	$0	–	-16,246	–	-1.17%	–
GH	Exit	GUARDANT HEALTH	$0	–	-74,500	–	-1.28%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-573,530	–	-1.38%	–
DYN	Exit	DYNE THERAPEUTICS	$0	–	-350,068	–	-1.42%	–
TVTX	Exit	TRAVERE THERAPEUTICS INC	$0	–	-186,019	–	-1.47%	–
KALV	Exit	KALVISTA PHARMS.	$0	–	-316,133	–	-1.47%	–
ILMN	Exit	ILLUMINA INC	$0	–	-25,000	–	-1.53%	–
BMRN	Exit	BIOMARIN PHARM.	$0	–	-58,656	–	-1.59%	–
GLPG	Exit	GALAPAGOS NVsponsored adr	$0	–	-123,300	–	-1.68%	–
SNY	Exit	SANOFIsponsored adr	$0	–	-143,500	–	-1.75%	–
VERA	Exit	VERA THERAPEUTICScl a	$0	–	-281,257	–	-1.92%	–
KDNY	Exit	CHINOOK THERAPEUTICS	$0	–	-340,389	–	-2.14%	–
RARE	Exit	ULTRAGENYX PHARM.	$0	–	-174,052	–	-2.31%	–
ALNY	Exit	ALNYLAM PHARMS.	$0	–	-38,000	–	-2.44%	–
REGN	Exit	REGENERON PHARMS.	$0	–	-11,200	–	-2.47%	–
EXEL	Exit	EXELIXIS INC	$0	–	-543,000	–	-2.73%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-136,000	–	-3.05%	–
SUPN	Exit	SUPERNUS PHARMS.	$0	–	-297,500	–	-3.23%	–
QURE	Exit	UNIQURE NV	$0	–	-544,500	–	-3.27%	–
ITCI	Exit	INTRA-CELLULAR THERAPIES	$0	–	-221,856	–	-3.30%	–
HRMY	Exit	HARMONY BIOSCIENCES HLDGS	$0	–	-264,500	–	-3.76%	–
BIIB	Exit	BIOGEN INC	$0	–	-45,500	–	-3.90%	–
GILD	Exit	GILEAD SCIENCES	$0	–	-208,784	–	-4.13%	–
ALKS	Exit	ALKERMES PLC	$0	–	-593,000	–	-4.25%	–
INCY	Exit	INCYTE CORP	$0	–	-289,000	–	-6.17%	–
SGEN	Exit	SEAGEN INC	$0	–	-166,200	–	-7.29%	–
HZNP	Exit	HORIZON THERAPEUTICS	$0	–	-454,973	–	-9.03%	–

Q3 2022

			Value		Shares		↓ Weighting
HZNP	Buy	HORIZON THERAPEUTICS	$28,158,000	-90.2%	454,973	+1885.5%	9.03%	+201.6%
SGEN	Buy	SEAGEN INC	$22,739,000	-65.3%	166,200	+1331.9%	7.29%	+965.9%
INCY	Buy	INCYTE CORP	$19,253,000	-91.9%	289,000	+1498.4%	6.17%	+148.7%
ALKS	Buy	ALKERMES PLC	$13,248,000	-74.0%	593,000	+38938.8%	4.25%	+698.5%
GILD	Buy	GILEAD SCIENCES	$12,880,000	-91.2%	208,784	+2216.7%	4.13%	+171.5%
BIIB	Buy	BIOGEN INC	$12,149,000	-76.6%	45,500	+329.0%	3.90%	+618.8%
HRMY	Buy	HARMONY BIOSCIENCES HLDGS	$11,715,000	-94.7%	264,500	+2350.4%	3.76%	+62.6%
ITCI	Buy	INTRA-CELLULAR THERAPIES	$10,303,000	-83.7%	221,856	+6057.5%	3.30%	+401.4%
QURE	Buy	UNIQURE NV	$10,209,000	-97.7%	544,500	+6446.0%	3.27%	-29.7%
SUPN	Buy	SUPERNUS PHARMS.	$10,070,000	-96.6%	297,500	+3357.7%	3.23%	+4.1%
MRTX	Buy	MIRATI THERAPEUTICS INC	$9,498,000	-93.0%	136,000	+1389.4%	3.05%	+114.7%
EXEL	Buy	EXELIXIS INC	$8,509,000	-97.6%	543,000	+7348.6%	2.73%	-25.3%
REGN	Sell	REGENERON PHARMS.	$7,715,000	-67.4%	11,200	-20.1%	2.47%	+901.6%
ALNY	Buy	ALNYLAM PHARMS.	$7,597,000	-80.0%	38,000	+585.7%	2.44%	+515.2%
RARE	Buy	ULTRAGENYX PHARM.	$7,197,000	-95.5%	174,052	+1711.2%	2.31%	+37.4%
KDNY	Buy	CHINOOK THERAPEUTICS	$6,685,000	-98.0%	340,389	+5623.7%	2.14%	-39.6%
VERA	Buy	VERA THERAPEUTICScl a	$5,994,000	-97.9%	281,257	+7253.1%	1.92%	-34.4%
SNY	Buy	SANOFIsponsored adr	$5,456,000	-82.7%	143,500	+9005.3%	1.75%	+431.9%
GLPG	Buy	GALAPAGOS NVsponsored adr	$5,251,000	-95.7%	123,300	+1693.2%	1.68%	+30.9%
BMRN	Buy	BIOMARIN PHARM.	$4,971,000	-93.8%	58,656	+788.6%	1.59%	+91.8%
ILMN	Buy	ILLUMINA INC	$4,766,000	-90.1%	25,000	+182.5%	1.53%	+205.0%
KALV	Buy	KALVISTA PHARMS.	$4,587,000	-98.8%	316,133	+8307.8%	1.47%	-63.2%
TVTX	Buy	TRAVERE THERAPEUTICS INC	$4,582,000	-98.8%	186,019	+1918.7%	1.47%	-62.9%
DYN	Buy	DYNE THERAPEUTICS	$4,439,000	-99.2%	350,068	+8957.4%	1.42%	-75.7%
AUPH	Buy	AURINIA PHARMACEUTICALS INC	$4,313,000	-99.2%	573,530	+9860.6%	1.38%	-76.9%
GH	Buy	GUARDANT HEALTH	$4,004,000	-94.6%	74,500	+2379.2%	1.28%	+65.3%
AMGN	Buy	AMGEN INC COM	$3,662,000	-91.0%	16,246	+63.9%	1.17%	+176.2%
RVNC	New	REVANCE THERAPEUTICS INC	$3,240,000	–	120,000	–	1.04%	–
NBIX	Buy	NEUROCRINE BIOSCIENCES	$3,185,000	-98.7%	30,000	+30.4%	1.02%	-58.5%
UTHR	Buy	UNITED THERAPEUTICS CORP DEL	$3,139,000	-84.3%	15,000	+218.3%	1.01%	+381.8%
KRYS	Buy	KRYSTAL BIOTECH	$3,132,000	-93.0%	45,000	+1422.8%	1.00%	+114.1%
VTRS	New	UNITED THERAPEUTICS CORP DEL	$3,101,000	–	364,000	–	0.99%	–
ASND	Buy	ASCENDIS PHARMA ADRsponsored adr	$3,036,000	-89.7%	29,400	+975.7%	0.97%	+217.3%
	Buy	CARIBOU BIOSCIENCES INC	$2,716,000	-98.9%	257,892	+18614.9%	0.87%	-67.2%
FATE	Buy	FATE THERAPEUTICS	$2,712,000	-98.3%	121,000	+2989.1%	0.87%	-47.2%
ZLAB	Buy	Zai Lab Ltd ADR (V1 Ord)adr	$2,692,000	-96.6%	78,958	+2785.9%	0.86%	+4.7%
NVCR	Buy	NOVOCURE LTD	$2,431,000	-92.4%	32,000	+1338.8%	0.78%	+133.5%
NVAX	Buy	NOVAVAX INC	$2,414,000	-98.2%	132,500	+1844.5%	0.77%	-44.0%
JAZZ	Buy	JAZZ PHARMS.	$2,291,000	-86.7%	17,200	+541.1%	0.74%	+310.6%
CRSP	Buy	CRISPR THERAPEUTICS AGnamen akt	$2,235,000	-93.5%	34,200	+1545.8%	0.72%	+100.8%
ACET	New	ADICET BIO INC	$2,195,000	–	154,708	–	0.70%	–
BGNE	Buy	BEIGENE ADRsponsored adr	$2,117,000	-86.5%	15,700	+517.6%	0.68%	+314.0%
IMAB	Buy	I-MAB-SPONSORED ADRsponsored ads	$2,024,000	-99.6%	507,239	+8039.3%	0.65%	-88.8%
IDYA	Buy	IDEAYA BIOSCIENCES	$1,625,000	-98.5%	109,000	+7161.8%	0.52%	-54.2%
FULC	Buy	FULCRUM THERAPEUTICS INC	$1,563,000	-99.2%	193,741	+20315.3%	0.50%	-75.2%
LEGN	Buy	LEGEND BIOTECHsponsored ads	$1,551,000	-65.5%	38,000	+15222.6%	0.50%	+957.4%
CNCE	Buy	CONCERT PHARMACEUTICALS INC	$1,345,000	-99.8%	200,800	+7593.5%	0.43%	-93.3%
NTLA	Buy	INTELLIA THERAPEUTICS	$1,343,000	-94.4%	24,000	+1832.4%	0.43%	+72.4%
DNLI	Buy	DENALI THERAPEUTICS	$1,166,000	-96.9%	38,000	+3298.9%	0.37%	-5.6%
BEAM	Buy	BEAM THERAPEUTICS INC	$1,119,000	-95.2%	23,500	+2482.4%	0.36%	+46.5%
PTCT	Buy	PTC THERAPEUTICS	$1,055,000	-95.0%	21,000	+2394.1%	0.34%	+54.3%
RCKT	Buy	ROCKET PHARMS.	$1,005,000	-98.4%	63,000	+7158.1%	0.32%	-51.0%
XENE	Buy	XENON PHARMACEUTICALS INC	$918,000	-96.4%	25,500	+3194.6%	0.29%	+10.5%
INSM	Buy	INSMED INC	$864,000	-97.8%	40,100	+4969.5%	0.28%	-33.7%
ARVN	New	ARVINAS INC	$756,000	–	17,000	–	0.24%	–
BCRX	Buy	BIOCRYST PHARMS.	$718,000	-98.7%	57,000	+9368.4%	0.23%	-61.3%
AXSM	Buy	AXSOME THERAPEUTICS	$625,000	-95.5%	14,000	+2516.8%	0.20%	+37.0%
IRWD	Buy	IRONWOOD PHARMACEUTICALS INC	$621,000	-99.0%	60,000	+8570.5%	0.20%	-68.2%
HCM	Buy	HUTCHMED CHINA LTDsponsored ads	$602,000	-99.1%	68,000	+7816.2%	0.19%	-72.8%
ALLO	Buy	ALLOGENE THERAPEUTICS	$539,000	-98.9%	50,000	+8671.9%	0.17%	-66.9%
IOVA	Buy	IOVANCE BIOTHERAPEUTICS	$536,000	-99.8%	56,000	+1759.8%	0.17%	-94.0%
RLMD	Buy	RELMADA THERAPEUTICS	$370,000	-96.3%	10,000	+5163.2%	0.12%	+14.4%
MDGL	Buy	MADRIGAL PHARMS.	$348,000	-93.5%	5,350	+1296.9%	0.11%	+100.0%
ALBO	New	ALBIREO PHARMA INC	$312,000	–	16,093	–	0.10%	–
MIRM	New	MIRUM PHARMACEUTICALS INC	$193,000	–	9,219	–	0.06%	–
	Buy	BLACK DIAMOND THERAPEUTIC	$75,000	-99.8%	44,000	+41021.5%	0.02%	-94.8%
	Exit	2SEVENTY BIO INC COM	$0	–	-48	–	-0.04%	–
ANAB	Exit	ANAPTYSBIO INC COM	$0	–	-203	–	-0.10%	–
KRTX	Exit	KARUNA THERAPEUTICS INC C	$0	–	-1,567	–	-0.13%	–
PRTA	Exit	PROTHENA CORP PLC USD0.01	$0	–	-407	–	-0.16%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS	$0	–	-128	–	-0.17%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS	$0	–	-401	–	-0.17%	–
BPMC	Exit	BLUEPRINT MEDICINES CORP	$0	–	-985	–	-0.20%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-476	–	-0.22%	–
BNTX	Exit	BIONTECH SE ADSsponsored ads	$0	–	-3,847	–	-0.27%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS	$0	–	-441	–	-0.33%	–
APLS	Exit	APELLIS PHARMACEUTICALS I	$0	–	-1,470	–	-0.34%	–
IONS	Exit	IONIS PHARMACEUTICALS INC	$0	–	-1,703	–	-0.48%	–
AVDL	Exit	AVADEL PHARMACEUTICALS PLsponsored adr	$0	–	-122	–	-0.52%	–
GMAB	Exit	GENMAB -SP ADRsponsored ads	$0	–	-1,857	–	-0.60%	–
IMVT	Exit	IMMUNOVANT INC COM	$0	–	-233	–	-0.63%	–
FOLD	Exit	AMICUS THERAPEUTICS INC C	$0	–	-1,017	–	-0.99%	–
GMDA	Exit	GAMIDA CELL	$0	–	-187	–	-1.12%	–
CCXI	Exit	CHEMOCENTRYX INC COM STK	$0	–	-3,000	–	-1.26%	–

Q2 2022

			Value		Shares		↓ Weighting
CNCE	New	CONCERT PHARMACEUTICALS I	$620,000,000	–	2,610	–	6.47%	–
AUPH	New	AURINIA PHARMACEUTICALS I	$573,530,000	–	5,758	–	5.98%	–
DYN	New	DYNE THERAPEUTICS INC COM	$562,568,000	–	3,865	–	5.87%	–
IMAB	New	I-MAB SPONSORED ADSsponsored ads	$553,000,000	–	6,232	–	5.77%	–
QURE	New	UNIQURE N.V. COM EUR0.05	$446,500,000	–	8,318	–	4.66%	–
KALV	New	KALVISTA PHARMACEUTICALS	$383,233,000	–	3,760	–	4.00%	–
TVTX	New	TRAVERE THERAPEUTICS INC	$380,000,000	–	9,215	–	3.96%	–
EXEL	New	EXELIXIS INC COM	$350,000,000	–	7,290	–	3.65%	–
KDNY	New	CHINOOK THERAPEUTICS INC	$340,389,000	–	5,947	–	3.55%	–
SUPN	New	SUPERNUS PHARMACEUTICALS	$297,500,000	–	8,604	–	3.10%	–
HZNP	New	HORIZON THERAPEUTICS PLC	$286,973,000	–	22,915	–	2.99%	–
VERA	New	VERA THERAPEUTICScl a	$281,057,000	–	3,825	–	2.93%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS I	$273,000,000	–	3,011	–	2.85%	–
	New	CARIBOU BIOSCIENCES INC C	$254,692,000	–	1,378	–	2.66%	–
INCY	New	INCYTE CORP INC COM	$238,000,000	–	18,081	–	2.48%	–
NBIX	New	NEUROCRINE BIOSCIENCES IN	$236,000,000	–	23,008	–	2.46%	–
HRMY	New	Harmony Biosciences Holdi	$221,500,000	–	10,794	–	2.31%	–
FULC	New	FULCRUM THERAPEUTICS INC	$193,741,000	–	949	–	2.02%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL	$161,100,000	–	9,610	–	1.68%	–
FATE	New	FATE THERAPEUTICS INC COM	$158,000,000	–	3,917	–	1.65%	–
GILD	New	GILEAD SCIENCES INC COMMO	$145,784,000	–	9,012	–	1.52%	–
MRTX	New	MIRATI THERAPEUTICS INC C	$136,000,000	–	9,131	–	1.42%	–
NVAX	New	NOVAVAX INC	$132,500,000	–	6,814	–	1.38%	–
GLPG	New	GALAPAGOSsponsored adr	$123,300,000	–	6,876	–	1.29%	–
CCXI	New	CHEMOCENTRYX INC COM STK	$121,100,000	–	3,000	–	1.26%	–
IDYA	New	IDEAYA BIOSCIENCES INC CO	$109,000,000	–	1,501	–	1.14%	–
GMDA	New	GAMIDA CELL	$107,000,000	–	187	–	1.12%	–
FOLD	New	AMICUS THERAPEUTICS INC C	$94,600,000	–	1,017	–	0.99%	–
BMRN	New	BIOMARIN PHARMACEUTICAL I	$79,656,000	–	6,601	–	0.83%	–
ZLAB	New	ZAI LAB LTD ADRadr	$78,958,000	–	2,736	–	0.82%	–
GH	New	GUARDANT HEALTH INC COM	$74,500,000	–	3,005	–	0.78%	–
HCM	New	HUTCHMED CHINA LIMITED SPsponsored ads	$68,000,000	–	859	–	0.71%	–
SGEN	New	SEAGEN INC COM	$65,600,000	–	11,607	–	0.68%	–
ITCI	New	INTRA-CELLULAR THERAPIES	$63,156,000	–	3,603	–	0.66%	–
RCKT	New	ROCKET PHARMACEUTICALS IN	$63,000,000	–	868	–	0.66%	–
IRWD	New	IRONWOOD PHARMACEUTICALS	$60,000,000	–	692	–	0.63%	–
IMVT	New	IMMUNOVANT INC COM	$60,000,000	–	233	–	0.63%	–
GMAB	New	GENMAB -SP ADRsponsored ads	$57,189,000	–	1,857	–	0.60%	–
BCRX	New	BIOCRYST PHARMACEUTICALS	$57,000,000	–	602	–	0.60%	–
BIIB	New	BIOGEN INC COMMON STOCK	$52,000,000	–	10,606	–	0.54%	–
ALKS	New	ALKERMES PLC SHS	$51,000,000	–	1,519	–	0.53%	–
ALLO	New	ALLOGENE THERAPEUTICS INC	$50,000,000	–	570	–	0.52%	–
AVDL	New	AVADEL PHARMACEUTICALS PLsponsored adr	$50,000,000	–	122	–	0.52%	–
ILMN	New	ILLUMINA INC COM	$48,000,000	–	8,850	–	0.50%	–
IONS	New	IONIS PHARMACEUTICALS INC	$46,088,000	–	1,703	–	0.48%	–
KRYS	New	KRYSTAL BIOTECH INC COM	$45,000,000	–	2,955	–	0.47%	–
	New	BLACK DIAMOND THERAPEUTIC	$44,000,000	–	107	–	0.46%	–
AMGN	New	AMGEN INC COM	$40,746,000	–	9,915	–	0.42%	–
INSM	New	INSMED INC COM PAR $.01	$40,100,000	–	791	–	0.42%	–
ALNY	New	ALNYLAM PHARMACEUTICALS I	$38,000,000	–	5,542	–	0.40%	–
DNLI	New	DENALI THERAPEUTICS INC C	$38,000,000	–	1,118	–	0.40%	–
CRSP	New	CRISPR THERAPEUTICS AG COnamen akt	$34,200,000	–	2,078	–	0.36%	–
APLS	New	APELLIS PHARMACEUTICALS I	$32,500,000	–	1,470	–	0.34%	–
ICPT	New	INTERCEPT PHARMACEUTICALS	$32,000,000	–	441	–	0.33%	–
NVCR	New	Novocure Ltd	$32,000,000	–	2,224	–	0.33%	–
SNY	New	SANOFIsponsored adr	$31,500,000	–	1,576	–	0.33%	–
ASND	New	ASCENDIS PHARMA A/S SPONSsponsored adr	$29,400,000	–	2,733	–	0.31%	–
BNTX	New	BIONTECH SE ADSsponsored ads	$25,800,000	–	3,847	–	0.27%	–
XENE	New	XENON PHARMACEUTICALS INC	$25,500,000	–	774	–	0.27%	–
NTLA	New	INTELLIA THERAPEUTICS INC	$24,000,000	–	1,242	–	0.25%	–
REGN	New	REGENERON PHARMACEUTICALS	$23,700,000	–	14,010	–	0.25%	–
BEAM	New	BEAM THERAPEUTICS INC COM	$23,500,000	–	910	–	0.24%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$21,500,000	–	476	–	0.22%	–
PTCT	New	PTC THERAPEUTICS INC COM	$21,000,000	–	842	–	0.22%	–
UTHR	New	UNITED THERAPEUTICS CORP	$20,000,000	–	4,713	–	0.21%	–
BPMC	New	BLUEPRINT MEDICINES CORP	$19,500,000	–	985	–	0.20%	–
JAZZ	New	JAZZ PHARMACEUTICALS PLC	$17,200,000	–	2,683	–	0.18%	–
SWTX	New	SPRINGWORKS THERAPEUTICS	$16,300,000	–	401	–	0.17%	–
PTGX	New	PROTAGONIST THERAPEUTICS	$16,185,000	–	128	–	0.17%	–
BGNE	New	BEIGENE LTD SPONSORED ADRsponsored adr	$15,700,000	–	2,542	–	0.16%	–
PRTA	New	PROTHENA CORP PLC USD0.01	$15,000,000	–	407	–	0.16%	–
AXSM	New	AXSOME THERAPEUTICS INC.	$14,000,000	–	535	–	0.15%	–
KRTX	New	KARUNA THERAPEUTICS INC C	$12,400,000	–	1,567	–	0.13%	–
ANAB	New	ANAPTYSBIO INC COM	$10,000,000	–	203	–	0.10%	–
RLMD	New	RELMADA THERAPEUTICS INC	$10,000,000	–	190	–	0.10%	–
MDGL	New	MADRIGAL PHARMACEUTICALS	$5,350,000	–	383	–	0.06%	–
LEGN	New	Legend Biotech Corpsponsored ads	$4,500,000	–	248	–	0.05%	–
	New	2SEVENTY BIO INC COM	$3,666,000	–	48	–	0.04%	–

Q4 2021

			Value		Shares		↓ Weighting
ESPR	Exit	ESPERION THERAPEUTICS INC NE	$0	–	-9,500	–	-0.03%	–
FGEN	Exit	FibroGen Inc	$0	–	-19,700	–	-0.05%	–
BLUE	Exit	Bluebird Bio Inc	$0	–	-11,000	–	-0.05%	–
RLMD	Exit	RELMADA THERAPEUTICS INC	$0	–	-10,000	–	-0.06%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-10,000	–	-0.06%	–
BDTX	Exit	BLACK DIAMOND THERAPEUTICS I	$0	–	-44,000	–	-0.09%	–
XENE	Exit	XENON PHARMACEUTICALS INC	$0	–	-25,500	–	-0.09%	–
GMDA	Exit	GAMIDA CELL LTD	$0	–	-107,000	–	-0.10%	–
AXSM	Exit	AXSOME THERAPEUTICS INC	$0	–	-14,000	–	-0.11%	–
IMVT	Exit	IMMUNOVANT INC	$0	–	-60,000	–	-0.13%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS IN	$0	–	-21,800	–	-0.13%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS INC	$0	–	-16,600	–	-0.14%	–
FOLD	Exit	Amicus Therapeutics Inc	$0	–	-94,600	–	-0.22%	–
AGIO	Exit	Agios Pharmaceuticals Inc	$0	–	-21,500	–	-0.24%	–
EXAS	Exit	Exact Sciences Corp	$0	–	-10,700	–	-0.25%	–
ORIC	Exit	ORIC PHARMACEUTICALS INC	$0	–	-53,000	–	-0.27%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-67,000	–	-0.29%	–
ARNA	Exit	Arena Pharmaceuticals Inc	$0	–	-21,000	–	-0.30%	–
IMAB	Exit	I MABsponsored ads	$0	–	-18,000	–	-0.31%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-58,000	–	-0.34%	–
IONS	Exit	Ionis Pharmaceuticals Inc	$0	–	-44,781	–	-0.36%	–
KOD	Exit	KODIAK SCIENCES INC	$0	–	-16,200	–	-0.38%	–
NKTX	Exit	NKARTA INC	$0	–	-56,445	–	-0.38%	–
SWTX	Exit	SPRINGWORKS THERAPEUTICS INC	$0	–	-25,000	–	-0.38%	–
FATE	Exit	FATE THERAPEUTICS INC	$0	–	-28,000	–	-0.40%	–
ALLK	Exit	ALLAKOS INC	$0	–	-15,700	–	-0.40%	–
HARP	Exit	HARPOON THERAPEUTICS INC	$0	–	-215,000	–	-0.41%	–
RCKT	Exit	ROCKET PHARMACEUTICALS INC	$0	–	-63,000	–	-0.45%	–
BPMC	Exit	Blueprint Medicines Corp	$0	–	-19,500	–	-0.48%	–
ZGNX	Exit	ZOGENIX INC	$0	–	-135,000	–	-0.50%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-40,000	–	-0.55%	–
HCM	Exit	HUTCHMED CHINA LTDsponsored ads	$0	–	-68,000	–	-0.60%	–
LEGN	Exit	LEGEND BIOTECH CORPsponsored ads	$0	–	-49,500	–	-0.60%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-139,331	–	-0.63%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-123,500	–	-0.66%	–
IDYA	Exit	IDEAYA BIOSCIENCES INC	$0	–	-109,000	–	-0.67%	–
ITCI	Exit	INTRA CELLULAR THERAPIES INC	$0	–	-79,456	–	-0.71%	–
KDNY	Exit	CHINOOK THERAPEUTICS INC	$0	–	-235,000	–	-0.72%	–
DYN	Exit	DYNE THERAPEUTICS INC	$0	–	-250,000	–	-0.98%	–
ZLAB	Exit	ZAI LAB LTDadr	$0	–	-38,958	–	-0.99%	–
BMRN	Exit	Biomarin Pharmaceutical Inc	$0	–	-55,156	–	-1.03%	–
GH	Exit	GUARDANT HEALTH INC	$0	–	-36,500	–	-1.10%	–
REGN	Exit	Regeneron Pharmaceuticals	$0	–	-7,700	–	-1.12%	–
ASND	Exit	Ascendis Pharma ASsponsored adr	$0	–	-29,400	–	-1.13%	–
JAZZ	Exit	JAZZ PHARMACEUTICALS PLC	$0	–	-44,200	–	-1.39%	–
QURE	Exit	UNIQURE NV	$0	–	-182,194	–	-1.41%	–
INSM	Exit	INSMED INC	$0	–	-241,100	–	-1.60%	–
KALV	Exit	Kalvista Pharmaceuticals Inc	$0	–	-383,233	–	-1.61%	–
CCXI	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-94,300	–	-1.72%	–
BIIB	Exit	Biogen Inc	$0	–	-25,500	–	-1.74%	–
SUPN	Exit	SUPERNUS PHARMACEUTICALS INC	$0	–	-297,500	–	-1.91%	–
HRMY	Exit	HARMONY BIOSCIENCES HLDGS IN	$0	–	-236,000	–	-2.18%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-138,741	–	-2.22%	–
TVTX	Exit	TRAVERE THERAPEUTICS INC	$0	–	-380,000	–	-2.22%	–
RARE	Exit	ULTRAGENYX PHARMACEUTICAL IN	$0	–	-103,100	–	-2.24%	–
EXEL	Exit	Exelixis Inc	$0	–	-489,534	–	-2.50%	–
ILMN	Exit	ILLUMINA INC	$0	–	-27,000	–	-2.64%	–
VRTX	Exit	Vertex Pharmaceuticals Inc	$0	–	-77,222	–	-3.38%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-75,000	–	-3.42%	–
PTCT	Exit	PTC Therapuetics COM	$0	–	-449,000	–	-4.03%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-98,500	–	-4.20%	–
INCY	Exit	Incyte Corp	$0	–	-270,360	–	-4.48%	–
SGEN	Exit	SEAGEN INC	$0	–	-109,700	–	-4.49%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-176,400	–	-5.91%	–
AMGN	Exit	Amgen Inc	$0	–	-118,300	–	-6.06%	–
HZNP	Exit	HORIZON THERAPEUTICS PUB LTD	$0	–	-237,873	–	-6.28%	–
NBIX	Exit	Neurocrine Biosciences Inc	$0	–	-289,500	–	-6.69%	–
GILD	Exit	Gilead Sciences Inc	$0	–	-402,784	–	-6.78%	–

Q3 2021

			Value		Shares		↓ Weighting
NBIX	Buy	Neurocrine Biosciences Inc	$27,740,000	+37.8%	289,500	+39.9%	6.69%	+25.9%
AMGN	Buy	Amgen Inc	$25,146,000	+102.3%	118,300	+132.0%	6.06%	+84.8%
SGEN	Sell	SEAGEN INC	$18,618,000	-18.6%	109,700	-24.3%	4.49%	-25.6%
INCY	Buy	Incyte Corp	$18,590,000	+61.5%	270,360	+97.5%	4.48%	+47.6%
MRTX	Buy	MIRATI THERAPEUTICS INC	$17,419,000	+538.1%	98,500	+482.8%	4.20%	+482.7%
ALNY	Sell	Alnylam Pharmaceuticals Inc	$14,160,000	-43.9%	75,000	-49.7%	3.42%	-48.7%
VRTX	Buy	Vertex Pharmaceuticals Inc	$14,007,000	+7.2%	77,222	+19.1%	3.38%	-2.1%
ILMN	New	ILLUMINA INC	$10,944,000	–	27,000	–	2.64%	–
EXEL	Buy	Exelixis Inc	$10,344,000	+459.1%	489,534	+382.1%	2.50%	+411.3%
RARE	Buy	ULTRAGENYX PHARMACEUTICAL IN	$9,286,000	+62.0%	103,100	+71.5%	2.24%	+48.1%
TVTX	Buy	TRAVERE THERAPEUTICS INC	$9,215,000	+3055.8%	380,000	+1800.0%	2.22%	+2787.0%
TPTX	Buy	TURNING POINT THERAPEUTICS I	$9,217,000	-2.8%	138,741	+14.2%	2.22%	-11.2%
HRMY	Buy	HARMONY BIOSCIENCES HLDGS IN	$9,020,000	+92.5%	236,000	+42.2%	2.18%	+75.9%
SUPN	Buy	SUPERNUS PHARMACEUTICALS INC	$7,934,000	+27.3%	297,500	+47.0%	1.91%	+16.3%
BIIB	Sell	Biogen Inc	$7,212,000	-57.1%	25,500	-47.4%	1.74%	-60.8%
CCXI	Buy	CRISPR THERAPEUTICS AGnamen akt	$7,131,000	+76.4%	94,300	+62.3%	1.72%	+61.2%
KALV	Buy	Kalvista Pharmaceuticals Inc	$6,687,000	-1.5%	383,233	+35.3%	1.61%	-10.0%
INSM	Buy	INSMED INC	$6,637,000	+133.0%	241,100	+140.9%	1.60%	+112.9%
QURE	Sell	UNIQURE NV	$5,834,000	-39.9%	182,194	-42.3%	1.41%	-45.1%
JAZZ	Buy	JAZZ PHARMACEUTICALS PLC	$5,755,000	+62.0%	44,200	+121.0%	1.39%	+48.0%
ASND	Buy	Ascendis Pharma ASsponsored adr	$4,686,000	+158.2%	29,400	+113.0%	1.13%	+135.9%
REGN	Sell	Regeneron Pharmaceuticals	$4,656,000	-77.6%	7,700	-79.3%	1.12%	-79.5%
GH	Buy	GUARDANT HEALTH INC	$4,563,000	+116.1%	36,500	+114.7%	1.10%	+97.3%
ZLAB	Buy	ZAI LAB LTDadr	$4,098,000	+81.0%	38,958	+204.4%	0.99%	+65.2%
DYN	Buy	DYNE THERAPEUTICS INC	$4,060,000	+43.0%	250,000	+85.2%	0.98%	+30.5%
KDNY	Buy	CHINOOK THERAPEUTICS INC	$2,992,000	+24.0%	235,000	+37.6%	0.72%	+13.3%
IDYA	New	IDEAYA BIOSCIENCES INC	$2,778,000	–	109,000	–	0.67%	–
AUPH	Sell	AURINIA PHARMACEUTICALS INC	$2,724,000	-29.6%	123,500	-58.6%	0.66%	-35.7%
LEGN	New	LEGEND BIOTECH CORPsponsored ads	$2,497,000	–	49,500	–	0.60%	–
ENTA	Buy	ENANTA PHARMACEUTICALS INC	$2,263,000	+51.1%	40,000	+17.5%	0.55%	+38.2%
ZGNX	New	ZOGENIX INC	$2,051,000	–	135,000	–	0.50%	–
RCKT	New	ROCKET PHARMACEUTICALS INC	$1,883,000	–	63,000	–	0.45%	–
HARP	New	HARPOON THERAPEUTICS INC	$1,696,000	–	215,000	–	0.41%	–
FATE	New	FATE THERAPEUTICS INC	$1,660,000	–	28,000	–	0.40%	–
SWTX	New	SPRINGWORKS THERAPEUTICS INC	$1,582,000	–	25,000	–	0.38%	–
NKTX	Sell	NKARTA INC	$1,570,000	-29.1%	56,445	-19.4%	0.38%	-35.2%
KOD	New	KODIAK SCIENCES INC	$1,553,000	–	16,200	–	0.38%	–
IONS	Sell	Ionis Pharmaceuticals Inc	$1,502,000	-79.3%	44,781	-75.4%	0.36%	-81.1%
IMAB	Buy	I MABsponsored ads	$1,301,000	+158.6%	18,000	+200.0%	0.31%	+136.1%
DCPH	Sell	DECIPHERA PHARMACEUTICALS INC	$564,000	-84.6%	16,600	-83.4%	0.14%	-85.9%
RLMD	New	RELMADA THERAPEUTICS INC	$261,000	–	10,000	–	0.06%	–
ARDX	Exit	ARDELYX INC	$0	–	-78,000	–	-0.16%	–
ALKS	Exit	ALKERMES PLC	$0	–	-45,000	–	-0.29%	–
APLS	Exit	APELLIS PHARMACEUTICALS INCcm	$0	–	-23,400	–	-0.39%	–
SRPT	Exit	Sarepta Therapeutics Inc	$0	–	-31,500	–	-0.65%	–
HALO	Exit	Halozyme Therapeutics Inc	$0	–	-82,633	–	-0.99%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-152,000	–	-1.80%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-60,500	–	-2.00%	–
UTHR	Exit	UNITED THERAPEUTICS CORP DEL	$0	–	-43,300	–	-2.05%	–

Q2 2021

			Value		Shares		↓ Weighting
GILD	New	Gilead Sciences Inc	$27,724,000	–	402,784	–	7.32%	–
ALNY	New	Alnylam Pharmaceuticals Inc	$25,239,000	–	149,000	–	6.66%	–
SGEN	New	SEAGEN INC	$22,868,000	–	145,000	–	6.04%	–
HZNP	New	HORIZON THERAPEUTICS PUB LTD	$22,274,000	–	237,873	–	5.88%	–
REGN	New	Regeneron Pharmaceuticals	$20,778,000	–	37,200	–	5.49%	–
NBIX	New	Neurocrine Biosciences Inc	$20,127,000	–	207,000	–	5.31%	–
PTCT	New	PTC Therapuetics COM	$18,948,000	–	449,000	–	5.00%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$17,113,000	–	176,400	–	4.52%	–
BIIB	New	Biogen Inc	$16,794,000	–	48,500	–	4.43%	–
VRTX	New	Vertex Pharmaceuticals Inc	$13,069,000	–	64,822	–	3.45%	–
AMGN	New	Amgen Inc	$12,431,000	–	51,000	–	3.28%	–
INCY	New	Incyte Corp	$11,509,000	–	136,860	–	3.04%	–
QURE	New	UNIQURE NV	$9,705,000	–	315,500	–	2.56%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$9,481,000	–	121,541	–	2.50%	–
UTHR	New	UNITED THERAPEUTICS CORP DEL	$7,768,000	–	43,300	–	2.05%	–
XLRN	New	ACCELERON PHARMA INC	$7,592,000	–	60,500	–	2.00%	–
IONS	New	Ionis Pharmaceuticals Inc	$7,251,000	–	181,781	–	1.91%	–
PTGX	New	PROTAGONIST THERAPEUTICS INC	$6,813,000	–	152,000	–	1.80%	–
KALV	New	Kalvista Pharmaceuticals Inc	$6,786,000	–	283,233	–	1.79%	–
SUPN	New	SUPERNUS PHARMACEUTICALS INC	$6,233,000	–	202,436	–	1.65%	–
RARE	New	ULTRAGENYX PHARMACEUTICAL IN	$5,731,000	–	60,100	–	1.51%	–
HRMY	New	HARMONY BIOSCIENCES HLDGS IN	$4,686,000	–	166,000	–	1.24%	–
BMRN	New	Biomarin Pharmaceutical Inc	$4,602,000	–	55,156	–	1.22%	–
CCXI	New	CRISPR THERAPEUTICS AGnamen akt	$4,043,000	–	58,100	–	1.07%	–
AUPH	New	AURINIA PHARMACEUTICALS INC	$3,869,000	–	298,500	–	1.02%	–
HALO	New	Halozyme Therapeutics Inc	$3,752,000	–	82,633	–	0.99%	–
DCPH	New	DECIPHERA PHARMACEUTICALS INC	$3,661,000	–	100,000	–	0.97%	–
JAZZ	New	JAZZ PHARMACEUTICALS PLC	$3,553,000	–	20,000	–	0.94%	–
ITCI	New	INTRA CELLULAR THERAPIES INC	$3,243,000	–	79,456	–	0.86%	–
INSM	New	INSMED INC	$2,849,000	–	100,100	–	0.75%	–
DYN	New	DYNE THERAPEUTICS INC	$2,840,000	–	135,000	–	0.75%	–
MRTX	New	MIRATI THERAPEUTICS INC	$2,730,000	–	16,900	–	0.72%	–
HCM	New	HUTCHMED CHINA LTDsponsored ads	$2,671,000	–	68,000	–	0.70%	–
STRO	New	SUTRO BIOPHARMA INC	$2,590,000	–	139,331	–	0.68%	–
SRPT	New	Sarepta Therapeutics Inc	$2,450,000	–	31,500	–	0.65%	–
KDNY	New	CHINOOK THERAPEUTICS INC	$2,412,000	–	170,821	–	0.64%	–
ZLAB	New	ZAI LAB LTDadr	$2,264,000	–	12,800	–	0.60%	–
NKTX	New	NKARTA INC	$2,214,000	–	70,000	–	0.58%	–
GH	New	GUARDANT HEALTH INC	$2,112,000	–	17,000	–	0.56%	–
EXEL	New	Exelixis Inc	$1,850,000	–	101,534	–	0.49%	–
ASND	New	Ascendis Pharma ASsponsored adr	$1,815,000	–	13,800	–	0.48%	–
BPMC	New	Blueprint Medicines Corp	$1,715,000	–	19,500	–	0.45%	–
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$1,509,000	–	58,000	–	0.40%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$1,498,000	–	34,047	–	0.40%	–
APLS	New	APELLIS PHARMACEUTICALS INCcm	$1,476,000	–	23,400	–	0.39%	–
ARNA	New	Arena Pharmaceuticals Inc	$1,431,000	–	21,000	–	0.38%	–
ALLK	New	ALLAKOS INC	$1,338,000	–	15,700	–	0.35%	–
EXAS	New	Exact Sciences Corp	$1,328,000	–	10,700	–	0.35%	–
AGIO	New	Agios Pharmaceuticals Inc	$1,185,000	–	21,500	–	0.31%	–
NKTR	New	NEKTAR THERAPEUTICS	$1,149,000	–	67,000	–	0.30%	–
ALKS	New	ALKERMES PLC	$1,103,000	–	45,000	–	0.29%	–
AXSM	New	AXSOME THERAPEUTICS INC	$944,000	–	14,000	–	0.25%	–
ORIC	New	ORIC PHARMACEUTICALS INC	$938,000	–	53,000	–	0.25%	–
FOLD	New	Amicus Therapeutics Inc	$912,000	–	94,600	–	0.24%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS IN	$763,000	–	21,800	–	0.20%	–
GMDA	New	GAMIDA CELL LTD	$682,000	–	107,000	–	0.18%	–
IMVT	New	IMMUNOVANT INC	$634,000	–	60,000	–	0.17%	–
ARDX	New	ARDELYX INC	$591,000	–	78,000	–	0.16%	–
BDTX	New	BLACK DIAMOND THERAPEUTICS I	$535,000	–	44,000	–	0.14%	–
FGEN	New	FibroGen Inc	$525,000	–	19,700	–	0.14%	–
IMAB	New	I MABsponsored ads	$503,000	–	6,000	–	0.13%	–
XENE	New	XENON PHARMACEUTICALS INC	$474,000	–	25,500	–	0.12%	–
BLUE	New	Bluebird Bio Inc	$351,000	–	11,000	–	0.09%	–
TVTX	New	TRAVERE THERAPEUTICS INC	$292,000	–	20,000	–	0.08%	–
ANAB	New	ANAPTYSBIO INC	$259,000	–	10,000	–	0.07%	–
ESPR	New	ESPERION THERAPEUTICS INC NE	$201,000	–	9,500	–	0.05%	–

Q4 2020

			Value		Shares		↓ Weighting
ANAB	Exit	ANAPTYSBIO INC	$0	–	-10,000	–	-0.05%	–
ZEAL	Exit	ZEALAND PHARMA A Ssponsored adr	$0	–	-5,653	–	-0.07%	–
ESPR	Exit	ESPERION THERAPEUTICS INC NE	$0	–	-9,500	–	-0.11%	–
CYTK	Exit	CYTOKINETICS INC	$0	–	-25,000	–	-0.18%	–
BLUE	Exit	Bluebird Bio Inc	$0	–	-11,000	–	-0.19%	–
ITCI	Exit	INTRA CELLULAR THERAPIES INC	$0	–	-24,800	–	-0.21%	–
AGIO	Exit	Agios Pharmaceuticals Inc	$0	–	-21,500	–	-0.24%	–
FGEN	Exit	FibroGen Inc	$0	–	-19,700	–	-0.26%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS INC	$0	–	-17,000	–	-0.28%	–
GWPH	Exit	GW Pharmaceuticals Plcads	$0	–	-10,200	–	-0.32%	–
QURE	Exit	UNIQURE NV	$0	–	-27,500	–	-0.33%	–
INSM	Exit	INSMED INC	$0	–	-33,600	–	-0.35%	–
EXAS	Exit	Exact Sciences Corp	$0	–	-10,700	–	-0.35%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-67,000	–	-0.36%	–
GBT	Exit	Global Blood Therapeutics	$0	–	-21,800	–	-0.39%	–
ARNA	Exit	Arena Pharmaceuticals Inc	$0	–	-16,500	–	-0.40%	–
ALLK	Exit	ALLAKOS INC	$0	–	-15,700	–	-0.41%	–
CCXI	Exit	CHEMOCENTRYX INC	$0	–	-23,600	–	-0.42%	–
FOLD	Exit	Amicus Therapeutics Inc	$0	–	-94,600	–	-0.43%	–
MRSN	Exit	MERSANA THERAPEUTICS INC	$0	–	-72,000	–	-0.43%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-139,331	–	-0.45%	–
AUPH	Exit	AURINIA PHARMACEUTICALS INC	$0	–	-115,000	–	-0.55%	–
BPMC	Exit	Blueprint Medicines Corp	$0	–	-19,500	–	-0.58%	–
CRSP	Exit	CRISPR THERAPEUTICS AGnamen akt	$0	–	-22,000	–	-0.59%	–
IONS	Exit	Ionis Pharmaceuticals Inc	$0	–	-39,781	–	-0.61%	–
ASND	Exit	Ascendis Pharma ASsponsored adr	$0	–	-13,800	–	-0.69%	–
KALV	Exit	Kalvista Pharmaceuticals Inc	$0	–	-177,433	–	-0.72%	–
IMUX	Exit	IMMUNIC INC	$0	–	-123,000	–	-0.74%	–
PTGX	Exit	PROTAGONIST THERAPEUTICS INC	$0	–	-152,000	–	-0.96%	–
TPTX	Exit	TURNING POINT THERAPEUTICS I	$0	–	-35,000	–	-0.98%	–
IMMU	Exit	IMMUNOMEDICS INC	$0	–	-49,700	–	-1.36%	–
SRPT	Exit	Sarepta Therapeutics Inc	$0	–	-31,500	–	-1.43%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-26,900	–	-1.44%	–
IOVA	Exit	IOVANCE BIOTHERAPEUTICS INC	$0	–	-145,000	–	-1.54%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-36,300	–	-1.70%	–
REGN	Exit	Regeneron Pharmaceuticals	$0	–	-11,500	–	-2.08%	–
INCY	Exit	Incyte Corp	$0	–	-78,000	–	-2.26%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-71,000	–	-2.58%	–
HALO	Exit	Halozyme Therapeutics Inc	$0	–	-307,633	–	-2.61%	–
ALXN	Exit	Alexion Pharmaceuticals Inc	$0	–	-75,241	–	-2.78%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-137,400	–	-2.88%	–
MYOK	Exit	Myokardia INC	$0	–	-65,859	–	-2.90%	–
AMGN	Exit	Amgen Inc	$0	–	-44,000	–	-3.61%	–
BIIB	Exit	Biogen Inc	$0	–	-43,600	–	-3.99%	–
SGEN	Exit	SEATTLE GENETICS INC	$0	–	-65,500	–	-4.14%	–
EXEL	Exit	Exelixis Inc	$0	–	-526,534	–	-4.15%	–
PTCT	Exit	PTC Therapuetics COM	$0	–	-299,000	–	-4.50%	–
VRTX	Exit	Vertex Pharmaceuticals Inc	$0	–	-64,822	–	-5.69%	–
BMRN	Exit	Biomarin Pharmaceutical Inc	$0	–	-247,584	–	-6.07%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-486,000	–	-6.47%	–
GILD	Exit	Gilead Sciences Inc	$0	–	-321,284	–	-6.55%	–
NBIX	Exit	Neurocrine Biosciences Inc	$0	–	-221,800	–	-6.88%	–
HZNP	Exit	HORIZON THERAPEUTICS PUB LTD	$0	–	-389,000	–	-9.76%	–

Q3 2020

			Value		Shares		↓ Weighting
HZNP	Sell	HORIZON THERAPEUTICS PUB LTD	$30,218,000	+26.0%	389,000	-10.4%	9.76%	+22.3%
NBIX	Buy	Neurocrine Biosciences Inc	$21,328,000	+60.6%	221,800	+109.6%	6.88%	+56.0%
GILD	Buy	Gilead Sciences Inc	$20,286,000	-10.3%	321,284	+5.9%	6.55%	-12.9%
ACAD	Buy	ACADIA PHARMACEUTICALS INC	$20,048,000	+36.4%	486,000	+59.3%	6.47%	+32.5%
BMRN	Buy	Biomarin Pharmaceutical Inc	$18,806,000	-17.1%	247,584	+33.4%	6.07%	-19.5%
EXEL	Buy	Exelixis Inc	$12,853,000	+25.0%	526,534	+16.4%	4.15%	+21.4%
SGEN	Buy	SEATTLE GENETICS INC	$12,818,000	+40.5%	65,500	+18.0%	4.14%	+36.4%
BIIB	Sell	Biogen Inc	$12,349,000	-7.3%	43,600	-14.8%	3.99%	-10.0%
AMGN	Sell	Amgen Inc	$11,175,000	-7.2%	44,000	-15.4%	3.61%	-9.9%
BHVN	Buy	BIOHAVEN PHARMACTL HLDG CO L	$8,931,000	+186.3%	137,400	+205.3%	2.88%	+178.0%
ALXN	Sell	Alexion Pharmaceuticals Inc	$8,601,000	-12.4%	75,241	-14.7%	2.78%	-14.9%
XLRN	Buy	ACCELERON PHARMA INC	$7,978,000	+361.4%	71,000	+294.4%	2.58%	+347.8%
IOVA	New	IOVANCE BIOTHERAPEUTICS INC	$4,773,000	–	145,000	–	1.54%	–
MRTX	Sell	MIRATI THERAPEUTICS INC	$4,462,000	-11.3%	26,900	-38.7%	1.44%	-13.9%
SRPT	Buy	Sarepta Therapeutics Inc	$4,424,000	+26.4%	31,500	+46.5%	1.43%	+22.8%
IMMU	Sell	IMMUNOMEDICS INC	$4,224,000	-72.5%	49,700	-88.9%	1.36%	-73.2%
PTGX	New	PROTAGONIST THERAPEUTICS INC	$2,969,000	–	152,000	–	0.96%	–
BPMC	Buy	Blueprint Medicines Corp	$1,808,000	+96.9%	19,500	+62.5%	0.58%	+91.5%
AUPH	New	AURINIA PHARMACEUTICALS INC	$1,694,000	–	115,000	–	0.55%	–
MRSN	New	MERSANA THERAPEUTICS INC	$1,340,000	–	72,000	–	0.43%	–
CCXI	Sell	CHEMOCENTRYX INC	$1,292,000	-87.7%	23,600	-87.7%	0.42%	-88.0%
GBT	Buy	Global Blood Therapeutics	$1,202,000	+84.4%	21,800	+122.4%	0.39%	+78.8%
ITCI	Buy	INTRA CELLULAR THERAPIES INC	$637,000	+10.0%	24,800	+7.8%	0.21%	+7.3%
CYTK	New	CYTOKINETICS INC	$541,000	–	25,000	–	0.18%	–
MNTA	Exit	MOMENTA PHARMACEUTICALS INC	$0	–	-27,000	–	-0.32%	–
PRNB	Exit	PRINCIPIA BIOPHARMA INC	$0	–	-23,100	–	-0.43%	–
SAGE	Exit	Sage Therapeutics Inc	$0	–	-37,600	–	-0.52%	–
ENTA	Exit	ENANTA PHARMACEUTICALS INC	$0	–	-46,500	–	-0.76%	–
ZGNX	Exit	Zogenix Inc	$0	–	-236,832	–	-2.05%	–

Q2 2020

			Value		Shares		↓ Weighting
HZNP	New	HORIZON THERAPEUTICS PUB LTD	$23,992,000	–	434,000	–	7.98%	–
BMRN	New	Biomarin Pharmaceutical Inc	$22,675,000	–	185,584	–	7.54%	–
GILD	New	Gilead Sciences Inc	$22,616,000	–	303,284	–	7.52%	–
VRTX	New	Vertex Pharmaceuticals Inc	$18,486,000	–	64,822	–	6.14%	–
IMMU	New	IMMUNOMEDICS INC	$15,335,000	–	448,000	–	5.10%	–
PTCT	New	PTC Therapuetics COM	$15,135,000	–	299,000	–	5.03%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$14,698,000	–	305,000	–	4.89%	–
BIIB	New	Biogen Inc	$13,326,000	–	51,200	–	4.43%	–
NBIX	New	Neurocrine Biosciences Inc	$13,278,000	–	105,800	–	4.41%	–
AMGN	New	Amgen Inc	$12,042,000	–	52,000	–	4.00%	–
CCXI	New	CHEMOCENTRYX INC	$10,465,000	–	191,600	–	3.48%	–
EXEL	New	Exelixis Inc	$10,286,000	–	452,534	–	3.42%	–
ALXN	New	Alexion Pharmaceuticals Inc	$9,814,000	–	88,241	–	3.26%	–
SGEN	New	Seattle Genetics Inc	$9,123,000	–	55,500	–	3.03%	–
INCY	New	Incyte Corp	$7,993,000	–	78,000	–	2.66%	–
HALO	New	Halozyme Therapeutics Inc	$7,940,000	–	307,633	–	2.64%	–
REGN	New	Regeneron Pharmaceuticals	$7,020,000	–	11,500	–	2.33%	–
MYOK	New	Myokardia INC	$6,372,000	–	65,859	–	2.12%	–
ZGNX	New	Zogenix Inc	$6,172,000	–	236,832	–	2.05%	–
ALNY	New	Alnylam Pharmaceuticals Inc	$5,370,000	–	36,300	–	1.78%	–
MRTX	New	MIRATI THERAPEUTICS INC	$5,032,000	–	43,900	–	1.67%	–
SRPT	New	Sarepta Therapeutics Inc	$3,499,000	–	21,500	–	1.16%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$3,119,000	–	45,000	–	1.04%	–
IONS	New	Ionis Pharmaceuticals Inc	$2,363,000	–	39,781	–	0.78%	–
ENTA	New	ENANTA PHARMACEUTICALS INC	$2,280,000	–	46,500	–	0.76%	–
KALV	New	Kalvista Pharmaceuticals Inc	$2,246,000	–	177,433	–	0.75%	–
TPTX	New	TURNING POINT THERAPEUTICS I	$2,236,000	–	35,000	–	0.74%	–
ASND	New	Ascendis Pharma ASsponsored adr	$1,999,000	–	13,800	–	0.66%	–
XLRN	New	ACCELERON PHARMA INC	$1,729,000	–	18,000	–	0.58%	–
CRSP	New	CRISPR THERAPEUTICS AGnamen akt	$1,651,000	–	22,000	–	0.55%	–
SAGE	New	Sage Therapeutics Inc	$1,570,000	–	37,600	–	0.52%	–
IMUX	New	IMMUNIC INC	$1,531,000	–	123,000	–	0.51%	–
NKTR	New	NEKTAR THERAPEUTICS	$1,499,000	–	67,000	–	0.50%	–
FOLD	New	Amicus Therapeutics Inc	$1,470,000	–	94,600	–	0.49%	–
PRNB	New	PRINCIPIA BIOPHARMA INC	$1,298,000	–	23,100	–	0.43%	–
QURE	New	UNIQURE NV	$1,257,000	–	27,500	–	0.42%	–
GWPH	New	GW Pharmaceuticals Plcads	$1,244,000	–	10,200	–	0.41%	–
ALLK	New	ALLAKOS INC	$1,143,000	–	15,700	–	0.38%	–
AGIO	New	Agios Pharmaceuticals Inc	$1,139,000	–	21,500	–	0.38%	–
STRO	New	SUTRO BIOPHARMA INC	$1,097,000	–	139,331	–	0.36%	–
ARNA	New	Arena Pharmaceuticals Inc	$1,037,000	–	16,500	–	0.34%	–
DCPH	New	DECIPHERA PHARMACEUTICALS INC	$994,000	–	17,000	–	0.33%	–
MNTA	New	MOMENTA PHARMACEUTICALS INC	$970,000	–	27,000	–	0.32%	–
EXAS	New	Exact Sciences Corp	$920,000	–	10,700	–	0.31%	–
BPMC	New	Blueprint Medicines Corp	$918,000	–	12,000	–	0.30%	–
INSM	New	INSMED INC	$902,000	–	33,600	–	0.30%	–
FGEN	New	FibroGen Inc	$799,000	–	19,700	–	0.27%	–
BLUE	New	Bluebird Bio Inc	$660,000	–	11,000	–	0.22%	–
GBT	New	Global Blood Therapeutics	$652,000	–	9,800	–	0.22%	–
ITCI	New	INTRA CELLULAR THERAPIES INC	$579,000	–	23,000	–	0.19%	–
ESPR	New	ESPERION THERAPEUTICS INC NE	$452,000	–	9,500	–	0.15%	–
ANAB	New	ANAPTYSBIO INC	$227,000	–	10,000	–	0.08%	–
ZEAL	New	ZEALAND PHARMA A Ssponsored adr	$187,000	–	5,653	–	0.06%	–

Q4 2019

			Value		Shares		↓ Weighting
DERM	Exit	Dermira Inc	$0	–	-30,000	–	-0.09%	–
GTHX	Exit	G1 Therapeutics Inc	$0	–	-11,200	–	-0.12%	–
ARQL	Exit	Arqule INC	$0	–	-41,000	–	-0.14%	–
ANAB	Exit	ANAPTYSBIO INC	$0	–	-10,000	–	-0.16%	–
RDUS	Exit	Radius Health Inc	$0	–	-17,000	–	-0.20%	–
FOLD	Exit	Amicus Therapeutics Inc	$0	–	-58,600	–	-0.22%	–
AKCA	Exit	AKCEA THERAPEUTICS INC	$0	–	-31,723	–	-0.23%	–
SUPN	Exit	Supernus Pharmaceuticals Inc	$0	–	-19,953	–	-0.25%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS INC	$0	–	-17,000	–	-0.27%	–
ZGNX	Exit	Zogenix Inc	$0	–	-14,400	–	-0.27%	–
MYGN	Exit	Myriad Genetics inc	$0	–	-25,000	–	-0.33%	–
FGEN	Exit	FibroGen Inc	$0	–	-19,700	–	-0.34%	–
ARNA	Exit	Arena Pharmaceuticals Inc	$0	–	-16,500	–	-0.35%	–
HALO	Exit	Halozyme Therapeutics Inc	$0	–	-52,633	–	-0.38%	–
MRTX	Exit	MIRATI THERAPEUTICS INC	$0	–	-10,900	–	-0.39%	–
GBT	Exit	Global Blood Therapeutics	$0	–	-18,500	–	-0.42%	–
EXAS	Exit	Exact Sciences Corp	$0	–	-10,700	–	-0.45%	–
MNTA	Exit	MOMENTA PHARMACEUTICALS INC	$0	–	-80,000	–	-0.48%	–
QURE	Exit	UNIQURE NV	$0	–	-27,500	–	-0.50%	–
NKTR	Exit	NEKTAR THERAPEUTICS	$0	–	-60,000	–	-0.50%	–
TCDA	Exit	Tricida Inc	$0	–	-37,000	–	-0.53%	–
AGIO	Exit	Agios Pharmaceuticals Inc	$0	–	-36,500	–	-0.54%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-30,000	–	-0.55%	–
GMED	Exit	Globus Med Inc	$0	–	-24,200	–	-0.57%	–
BPMC	Exit	Blueprint Medicines Corp	$0	–	-17,000	–	-0.58%	–
MLND	Exit	Millendo Therapeutics Inc	$0	–	-177,825	–	-0.58%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-139,331	–	-0.58%	–
ASND	Exit	Ascendis Pharma ASsponsored adr	$0	–	-13,800	–	-0.61%	–
BLUE	Exit	Bluebird Bio Inc	$0	–	-17,000	–	-0.72%	–
MYOK	Exit	Myokardia INC	$0	–	-30,000	–	-0.72%	–
EXEL	Exit	Exelixis Inc	$0	–	-103,534	–	-0.85%	–
RGEN	Exit	REPLIGEN CORP	$0	–	-24,000	–	-0.85%	–
SRPT	Exit	Sarepta Therapeutics Inc	$0	–	-26,100	–	-0.91%	–
KALV	Exit	Kalvista Pharmaceuticals Inc	$0	–	-177,433	–	-0.95%	–
ABMD	Exit	Abiomed Inc	$0	–	-11,700	–	-0.96%	–
SAGE	Exit	Sage Therapeutics Inc	$0	–	-16,000	–	-1.04%	–
GWPH	Exit	GW Pharmaceuticals Plcads	$0	–	-19,800	–	-1.05%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-68,000	–	-1.13%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-33,800	–	-1.26%	–
IONS	Exit	Ionis Pharmaceuticals Inc	$0	–	-46,181	–	-1.28%	–
SGMO	Exit	Sangamo Therapeutics Inc	$0	–	-350,000	–	-1.46%	–
AMRN	Exit	Amarin Corp Plcspons adr new	$0	–	-259,000	–	-1.81%	–
SGEN	Exit	Seattle Genetics Inc	$0	–	-66,400	–	-2.62%	–
BMRN	Exit	Biomarin Pharmaceutical Inc	$0	–	-87,284	–	-2.72%	–
HZNP	Exit	HORIZON THERAPEUTICS PUB LTD	$0	–	-218,000	–	-2.74%	–
INSM	Exit	INSMED INC	$0	–	-356,600	–	-2.90%	–
INCY	Exit	Incyte Corp	$0	–	-96,500	–	-3.31%	–
BIIB	Exit	Biogen Inc	$0	–	-31,700	–	-3.41%	–
ILMN	Exit	ILLUMINA INC	$0	–	-25,100	–	-3.53%	–
PTCT	Exit	PTC Therapuetics COM	$0	–	-236,000	–	-3.69%	–
STML	Exit	Stemline Therapeutics Inc	$0	–	-835,245	–	-4.02%	–
ALXN	Exit	Alexion Pharmaceuticals Inc	$0	–	-102,141	–	-4.62%	–
REGN	Exit	Regeneron Pharmaceuticals	$0	–	-39,830	–	-5.11%	–
AMGN	Exit	Amgen Inc	$0	–	-66,000	–	-5.90%	–
NBIX	Exit	Neurocrine Biosciences Inc	$0	–	-147,300	–	-6.13%	–
VRTX	Exit	Vertex Pharmaceuticals Inc	$0	–	-84,022	–	-6.58%	–
CELG	Exit	Celgene Corp	$0	–	-171,022	–	-7.85%	–
GILD	Exit	Gilead Sciences Inc	$0	–	-316,284	–	-9.26%	–

Q3 2019

			Value		Shares		↓ Weighting
CELG	Buy	Celgene Corp	$16,981,000	+28.9%	171,022	+20.0%	7.85%	+60.7%
VRTX	Sell	Vertex Pharmaceuticals Inc	$14,232,000	-8.7%	84,022	-1.2%	6.58%	+13.8%
NBIX	Sell	Neurocrine Biosciences Inc	$13,266,000	+0.2%	147,300	-6.1%	6.13%	+24.9%
REGN	Buy	Regeneron Pharmaceuticals	$11,050,000	+51.4%	39,830	+70.7%	5.11%	+88.7%
ALXN	Buy	Alexion Pharmaceuticals Inc	$10,002,000	-22.6%	102,141	+3.5%	4.62%	-3.5%
STML	Buy	Stemline Therapeutics Inc	$8,695,000	-23.7%	835,245	+12.2%	4.02%	-5.0%
PTCT	Sell	PTC Therapuetics COM	$7,982,000	-31.4%	236,000	-8.9%	3.69%	-14.5%
BIIB	Sell	Biogen Inc	$7,381,000	-26.1%	31,700	-25.8%	3.41%	-7.9%
INCY	Buy	Incyte Corp	$7,161,000	+6.7%	96,500	+22.2%	3.31%	+33.0%
HZNP	Buy	HORIZON THERAPEUTICS PUB LTD	$5,938,000	+92.9%	218,000	+70.3%	2.74%	+140.5%
BMRN	Buy	Biomarin Pharmaceutical Inc	$5,883,000	+6.8%	87,284	+35.8%	2.72%	+33.2%
SGEN	Buy	Seattle Genetics Inc	$5,667,000	+34.4%	66,400	+9.0%	2.62%	+67.6%
AMRN	Buy	Amarin Corp Plcspons adr new	$3,926,000	+47.9%	259,000	+89.1%	1.81%	+84.3%
SGMO	Buy	Sangamo Therapeutics Inc	$3,168,000	+96.0%	350,000	+133.3%	1.46%	+144.4%
IONS	Sell	Ionis Pharmaceuticals Inc	$2,767,000	-48.0%	46,181	-44.2%	1.28%	-35.2%
ACAD	Buy	ACADIA PHARMACEUTICALS INC	$2,446,000	+72.9%	68,000	+28.3%	1.13%	+115.2%
GWPH	Buy	GW Pharmaceuticals Plcads	$2,276,000	+20.0%	19,800	+80.0%	1.05%	+49.6%
SAGE	Sell	Sage Therapeutics Inc	$2,245,000	-63.9%	16,000	-52.9%	1.04%	-55.1%
KALV	Sell	Kalvista Pharmaceuticals Inc	$2,058,000	-50.6%	177,433	-5.4%	0.95%	-38.4%
EXEL	Sell	Exelixis Inc	$1,830,000	-80.7%	103,534	-76.7%	0.85%	-75.9%
ASND	Sell	Ascendis Pharma ASsponsored adr	$1,329,000	-55.2%	13,800	-46.5%	0.61%	-44.2%
STRO	Sell	SUTRO BIOPHARMA INC	$1,264,000	-23.0%	139,331	-4.0%	0.58%	-4.1%
TCDA	Buy	Tricida Inc	$1,141,000	+44.8%	37,000	+85.0%	0.53%	+80.5%
GBT	Sell	Global Blood Therapeutics	$897,000	-39.1%	18,500	-33.9%	0.42%	-24.0%
HALO	Sell	Halozyme Therapeutics Inc	$816,000	-90.0%	52,633	-88.9%	0.38%	-87.5%
MYGN	Sell	Myriad Genetics inc	$716,000	-35.6%	25,000	-37.5%	0.33%	-19.7%
DCPH	New	DECIPHERA PHARMACEUTICALS INC	$577,000	–	17,000	–	0.27%	–
ANAB	New	ANAPTYSBIO INC	$350,000	–	10,000	–	0.16%	–
ARQL	Sell	Arqule INC	$294,000	-88.8%	41,000	-82.9%	0.14%	-86.1%
GTHX	Sell	G1 Therapeutics Inc	$255,000	-94.3%	11,200	-92.3%	0.12%	-92.9%
RTRX	Exit	Retrophin Inc	$0	–	-18,000	–	-0.13%	–
PRQR	Exit	PROQR therapeutics N V	$0	–	-56,000	–	-0.19%	–
LGND	Exit	Ligand Pharmaceuticals Inc	$0	–	-7,300	–	-0.31%	–
CNCE	Exit	CONCERT PHARMACEUTICALS INC	$0	–	-70,000	–	-0.31%	–
ALKS	Exit	ALKERMES PLC	$0	–	-70,000	–	-0.59%	–
XENT	Exit	Intersect Ent Inc	$0	–	-96,000	–	-0.81%	–
BHVN	Exit	BIOHAVEN PHARMACTL HLDG CO L	$0	–	-50,949	–	-0.83%	–
IOVA	Exit	Iovance Biotherapeutics INC	$0	–	-104,000	–	-0.94%	–

Q2 2019

			Value		Shares		↓ Weighting
GILD	New	Gilead Sciences Inc	$21,365,000	–	316,284	–	7.92%	–
VRTX	New	Vertex Pharmaceuticals Inc	$15,585,000	–	85,022	–	5.78%	–
NBIX	New	Neurocrine Biosciences Inc	$13,239,000	–	156,800	–	4.91%	–
CELG	New	Celgene Corp	$13,173,000	–	142,522	–	4.88%	–
ALXN	New	Alexion Pharmaceuticals Inc	$12,920,000	–	98,641	–	4.79%	–
AMGN	New	Amgen Inc	$12,159,000	–	66,000	–	4.51%	–
PTCT	New	PTC Therapuetics COM	$11,642,000	–	259,000	–	4.32%	–
STML	New	Stemline Therapeutics Inc	$11,402,000	–	744,245	–	4.23%	–
BIIB	New	Biogen Inc	$9,985,000	–	42,700	–	3.70%	–
EXEL	New	Exelixis Inc	$9,483,000	–	443,534	–	3.52%	–
ILMN	New	ILLUMINA INC	$9,241,000	–	25,100	–	3.43%	–
INSM	New	INSMED INC	$9,111,000	–	356,600	–	3.38%	–
HALO	New	Halozyme Therapeutics Inc	$8,162,000	–	475,633	–	3.03%	–
REGN	New	Regeneron Pharmaceuticals	$7,299,000	–	23,330	–	2.71%	–
INCY	New	Incyte Corp	$6,711,000	–	79,000	–	2.49%	–
SAGE	New	Sage Therapeutics Inc	$6,224,000	–	33,996	–	2.31%	–
BMRN	New	Biomarin Pharmaceutical Inc	$5,506,000	–	64,284	–	2.04%	–
IONS	New	Ionis Pharmaceuticals Inc	$5,320,000	–	82,781	–	1.97%	–
GTHX	New	G1 Therapeutics Inc	$4,472,000	–	146,000	–	1.66%	–
SGEN	New	Seattle Genetics Inc	$4,215,000	–	60,900	–	1.56%	–
KALV	New	Kalvista Pharmaceuticals Inc	$4,165,000	–	187,599	–	1.54%	–
SRPT	New	Sarepta Therapeutics Inc	$3,965,000	–	26,100	–	1.47%	–
HZNP	New	HORIZON THERAPEUTICS PUB LTD	$3,078,000	–	128,000	–	1.14%	–
ABMD	New	Abiomed Inc	$3,047,000	–	11,700	–	1.13%	–
ASND	New	Ascendis Pharma ASsponsored adr	$2,969,000	–	25,800	–	1.10%	–
AMRN	New	Amarin Corp Plcsponsored adr	$2,655,000	–	137,000	–	0.98%	–
ARQL	New	Arqule INC	$2,630,000	–	239,103	–	0.98%	–
IOVA	New	Iovance Biotherapeutics INC	$2,543,000	–	104,000	–	0.94%	–
ALNY	New	Alnylam Pharmaceuticals Inc	$2,453,000	–	33,800	–	0.91%	–
BHVN	New	BIOHAVEN PHARMACTL HLDG CO L	$2,231,000	–	50,949	–	0.83%	–
XENT	New	Intersect Ent Inc	$2,181,000	–	96,000	–	0.81%	–
BLUE	New	Bluebird Bio Inc	$2,163,000	–	17,000	–	0.80%	–
QURE	New	UNIQURE NV	$2,147,000	–	27,500	–	0.80%	–
NKTR	New	NEKTAR THERAPEUTICS	$2,135,000	–	60,000	–	0.79%	–
RGEN	New	REPLIGEN CORP	$2,061,000	–	24,000	–	0.76%	–
MLND	New	Millendo Therapeutics Inc	$2,056,000	–	177,825	–	0.76%	–
GWPH	New	GW Pharmaceuticals Plcads	$1,897,000	–	11,000	–	0.70%	–
AGIO	New	Agios Pharmaceuticals Inc	$1,821,000	–	36,500	–	0.68%	–
STRO	New	SUTRO BIOPHARMA INC	$1,642,000	–	145,154	–	0.61%	–
SGMO	New	Sangamo Therapeutics Inc	$1,616,000	–	150,000	–	0.60%	–
BPMC	New	Blueprint Medicines Corp	$1,604,000	–	17,000	–	0.60%	–
ALKS	New	ALKERMES PLC	$1,582,000	–	70,000	–	0.59%	–
MYOK	New	Myokardia INC	$1,505,000	–	30,000	–	0.56%	–
GBT	New	Global Blood Therapeutics	$1,472,000	–	28,000	–	0.55%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$1,415,000	–	53,000	–	0.52%	–
EXAS	New	Exact Sciences Corp	$1,263,000	–	10,700	–	0.47%	–
XLRN	New	ACCELERON PHARMA INC	$1,233,000	–	30,000	–	0.46%	–
MRTX	New	MIRATI THERAPEUTICS INC	$1,123,000	–	10,900	–	0.42%	–
MYGN	New	Myriad Genetics inc	$1,111,000	–	40,000	–	0.41%	–
GMED	New	Globus Med Inc	$1,024,000	–	24,200	–	0.38%	–
MNTA	New	MOMENTA PHARMACEUTICALS INC	$997,000	–	80,000	–	0.37%	–
ARNA	New	Arena Pharmaceuticals Inc	$967,000	–	16,500	–	0.36%	–
FGEN	New	FibroGen Inc	$889,000	–	19,700	–	0.33%	–
CNCE	New	CONCERT PHARMACEUTICALS INC	$839,000	–	70,000	–	0.31%	–
LGND	New	Ligand Pharmaceuticals Inc	$833,000	–	7,300	–	0.31%	–
TCDA	New	Tricida Inc	$788,000	–	20,000	–	0.29%	–
AKCA	New	AKCEA THERAPEUTICS INC	$743,000	–	31,723	–	0.28%	–
FOLD	New	Amicus Therapeutics Inc	$730,000	–	58,600	–	0.27%	–
ZGNX	New	Zogenix Inc	$687,000	–	14,400	–	0.26%	–
SUPN	New	Supernus Pharmaceuticals Inc	$659,000	–	19,953	–	0.24%	–
PRQR	New	PROQR therapeutics N V	$511,000	–	56,000	–	0.19%	–
RDUS	New	Radius Health Inc	$414,000	–	17,000	–	0.15%	–
RTRX	New	Retrophin Inc	$362,000	–	18,000	–	0.13%	–
DERM	New	Dermira Inc	$287,000	–	30,000	–	0.11%	–

Q4 2018

			Value		Shares		↓ Weighting
RSLS	Exit	ReShape Lifesciences Inc	$0	–	-52,546	–	-0.00%	–
RDUS	Exit	Radius Health Inc	$0	–	-18,799	–	-0.12%	–
ONCE	Exit	Spark Therapeutics Inc	$0	–	-12,000	–	-0.24%	–
FOLD	Exit	Amicus Therapeutics Inc	$0	–	-58,600	–	-0.26%	–
SBPH	Exit	Spring Bk Pharmaceuticals Inc	$0	–	-73,000	–	-0.32%	–
CRVS	Exit	Corvus Pharmaceuticals Inc	$0	–	-108,000	–	-0.34%	–
PRTK	Exit	Paratek Pharmaceuticals Inc	$0	–	-103,500	–	-0.36%	–
SUPN	Exit	Supernus Pharmaceuticals Inc	$0	–	-20,953	–	-0.38%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-65,000	–	-0.49%	–
HZNP	Exit	Horizon Pharma Plc	$0	–	-69,000	–	-0.49%	–
MRUS	Exit	Merus N V	$0	–	-75,060	–	-0.54%	–
CBAY	Exit	Cymabay Therapeutics Inc	$0	–	-145,000	–	-0.58%	–
GMED	Exit	Globus Med Inc	$0	–	-29,000	–	-0.60%	–
GWPH	Exit	GW Pharmaceuticals Plcads	$0	–	-9,600	–	-0.60%	–
SGMO	Exit	Sangamo Therapeutics Inc	$0	–	-113,000	–	-0.70%	–
FGEN	Exit	FibroGen Inc	$0	–	-31,400	–	-0.70%	–
MDGL	Exit	Madrigal Pharmaceuticals Inc	$0	–	-10,000	–	-0.78%	–
STRO	Exit	SUTRO BIOPHARMA INC	$0	–	-146,653	–	-0.80%	–
SAGE	Exit	Sage Therapeutics Inc	$0	–	-15,996	–	-0.82%	–
BLUE	Exit	Bluebird Bio Inc	$0	–	-17,000	–	-0.90%	–
IONS	Exit	Ionis Pharmaceuticals Inc	$0	–	-51,500	–	-0.97%	–
AGIO	Exit	Agios Pharmaceuticals Inc	$0	–	-36,500	–	-1.03%	–
DCPH	Exit	Deciphera Pharmaceuticals Inc	$0	–	-77,000	–	-1.09%	–
XENT	Exit	Intersect Ent Inc	$0	–	-112,000	–	-1.17%	–
SGEN	Exit	Seattle Genetics Inc	$0	–	-42,500	–	-1.19%	–
JAZZ	Exit	Jazz Pharmaceuticals PLC	$0	–	-21,600	–	-1.32%	–
GTHX	Exit	G1 Therapeutics Inc	$0	–	-72,000	–	-1.37%	–
SRPT	Exit	Sarepta Therapeutics Inc	$0	–	-27,000	–	-1.59%	–
NBIX	Exit	Neurocrine Biosciences Inc	$0	–	-35,500	–	-1.59%	–
SHPG	Exit	Shire plcsponsored adr	$0	–	-25,000	–	-1.65%	–
ALNY	Exit	Alnylam Pharmaceuticals Inc	$0	–	-52,800	–	-1.68%	–
SPPI	Exit	Spectrum Pharmaceuticals Inc	$0	–	-300,000	–	-1.84%	–
ZGNX	Exit	Zogenix Inc	$0	–	-110,000	–	-1.99%	–
ABMD	Exit	Abiomed Inc	$0	–	-13,200	–	-2.16%	–
PBYI	Exit	Puma Biotechnology Inc	$0	–	-144,300	–	-2.41%	–
GILD	Exit	Gilead Sciences Inc	$0	–	-90,284	–	-2.54%	–
KALV	Exit	Kalvista Pharmaceuticals Inc	$0	–	-322,436	–	-2.60%	–
ADMS	Exit	Adamas Pharmaceuticals Inc	$0	–	-370,000	–	-2.70%	–
AERI	Exit	Aerie Pharmaceuticals Inc	$0	–	-125,179	–	-2.81%	–
HALO	Exit	Halozyme Therapeutics Inc	$0	–	-428,633	–	-2.84%	–
BMRN	Exit	Biomarin Pharmaceutical Inc	$0	–	-97,284	–	-3.44%	–
LGND	Exit	Ligand Pharmaceuticals Inc	$0	–	-35,000	–	-3.50%	–
STML	Exit	Stemline Therapeutics Inc	$0	–	-585,930	–	-3.54%	–
ALXN	Exit	Alexion Pharmaceuticals Inc	$0	–	-81,641	–	-4.14%	–
EXEL	Exit	Exelixis Inc	$0	–	-704,534	–	-4.55%	–
REGN	Exit	Regeneron Pharmaceuticals	$0	–	-31,330	–	-4.61%	–
ARRY	Exit	Array Biopharma Inc	$0	–	-844,500	–	-4.68%	–
VRTX	Exit	Vertex Pharmaceuticals Inc	$0	–	-67,722	–	-4.76%	–
INCY	Exit	Incyte Corp	$0	–	-200,000	–	-5.04%	–
ILMN	Exit	ILLUMINA INC	$0	–	-51,600	–	-6.90%	–
CELG	Exit	Celgene Corp	$0	–	-253,522	–	-8.27%	–

Q3 2018

			Value		Shares		↓ Weighting
CELG	Buy	Celgene Corp	$17,398,000	+15.6%	253,522	+33.8%	8.27%	+43.1%
ILMN	Buy	ILLUMINA INC	$14,522,000	+15.5%	51,600	+14.7%	6.90%	+43.0%
INCY	Buy	Incyte Corp	$10,593,000	+25.5%	200,000	+58.8%	5.04%	+55.3%
VRTX	Sell	Vertex Pharmaceuticals Inc	$10,009,000	-29.2%	67,722	-18.6%	4.76%	-12.4%
ARRY	Buy	Array Biopharma Inc	$9,844,000	-15.5%	844,500	+21.6%	4.68%	+4.6%
EXEL	Buy	Exelixis Inc	$9,574,000	+0.1%	704,534	+58.5%	4.55%	+23.9%
STML	Buy	Stemline Therapeutics Inc	$7,459,000	-5.1%	585,930	+18.9%	3.54%	+17.4%
AERI	Buy	Aerie Pharmaceuticals Inc	$5,908,000	+492.0%	125,179	+747.0%	2.81%	+633.2%
PBYI	Buy	Puma Biotechnology Inc	$5,074,000	+85.7%	144,300	+211.7%	2.41%	+129.9%
ZGNX	New	Zogenix Inc	$4,184,000	–	110,000	–	1.99%	–
ALNY	Buy	Alnylam Pharmaceuticals Inc	$3,543,000	-2.2%	52,800	+43.5%	1.68%	+21.0%
NBIX	Sell	Neurocrine Biosciences Inc	$3,348,000	-79.2%	35,500	-78.3%	1.59%	-74.2%
JAZZ	Buy	Jazz Pharmaceuticals PLC	$2,785,000	-0.2%	21,600	+33.3%	1.32%	+23.5%
IONS	Sell	Ionis Pharmaceuticals Inc	$2,037,000	-61.4%	51,500	-59.3%	0.97%	-52.2%
BLUE	Sell	Bluebird Bio Inc	$1,903,000	-39.3%	17,000	-15.0%	0.90%	-25.0%
SAGE	Sell	Sage Therapeutics Inc	$1,732,000	-74.2%	15,996	-62.8%	0.82%	-68.1%
STRO	New	SUTRO BIOPHARMA INC	$1,686,000	–	146,653	–	0.80%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$1,035,000	–	65,000	–	0.49%	–
CRVS	Buy	Corvus Pharmaceuticals Inc	$710,000	-20.4%	108,000	+32.8%	0.34%	-1.7%
VKTX	Exit	Viking Therapeutics Inc	$0	–	-70,000	–	-0.26%	–
PTLA	Exit	Portola Pharmaceuticals Inc	$0	–	-24,000	–	-0.35%	–
RIGL	Exit	Rigel Pharmaceuticals Inc	$0	–	-370,000	–	-0.40%	–
VSTM	Exit	Verastem Inc	$0	–	-500,000	–	-1.32%	–
TRXC	Exit	Transenterix Inc	$0	–	-889,082	–	-1.47%	–
BIIB	Exit	Biogen Inc	$0	–	-36,208	–	-4.04%	–

Q2 2018

			Value		Shares		↓ Weighting
NBIX	New	Neurocrine Biosciences Inc	$16,061,000	–	163,500	–	6.17%	–
CELG	New	Celgene Corp	$15,050,000	–	189,522	–	5.78%	–
VRTX	New	Vertex Pharmaceuticals Inc	$14,144,000	–	83,222	–	5.43%	–
ILMN	New	Illumina Inc	$12,568,000	–	45,000	–	4.83%	–
ARRY	New	Array Biopharma Inc	$11,647,000	–	694,500	–	4.47%	–
REGN	New	Regeneron Pharmaceuticals	$10,808,000	–	31,330	–	4.15%	–
BIIB	New	Biogen Inc	$10,510,000	–	36,208	–	4.04%	–
ALXN	New	Alexion Pharmaceuticals Inc	$10,136,000	–	81,641	–	3.89%	–
EXEL	New	Exelixis Inc	$9,566,000	–	444,534	–	3.67%	–
ADMS	New	Adamas Pharmaceuticals Inc	$9,550,000	–	370,000	–	3.67%	–
BMRN	New	Biomarin Pharmaceutical Inc	$9,164,000	–	97,284	–	3.52%	–
INCY	New	Incyte Corp	$8,442,000	–	125,975	–	3.24%	–
STML	New	Stemline Therapeutics Inc	$7,862,000	–	492,930	–	3.02%	–
LGND	New	Ligand Pharmaceuticals Inc	$7,250,000	–	35,000	–	2.78%	–
HALO	New	Halozyme Therapeutics Inc	$7,227,000	–	428,633	–	2.78%	–
SAGE	New	Sage Therapeutics Inc	$6,726,000	–	42,996	–	2.58%	–
GILD	New	Gilead Sciences Inc	$6,397,000	–	90,284	–	2.46%	–
SPPI	New	Spectrum Pharmaceuticals Inc	$6,285,000	–	300,000	–	2.41%	–
ABMD	New	Abiomed Inc	$5,400,000	–	13,200	–	2.07%	–
IONS	New	Ionis Pharmaceuticals Inc	$5,271,000	–	126,500	–	2.02%	–
SHPG	New	Shire plcsponsored adr	$4,220,000	–	25,000	–	1.62%	–
XENT	New	Intersect Ent Inc	$4,189,000	–	112,000	–	1.61%	–
TRXC	New	Transenterix Inc	$3,823,000	–	889,082	–	1.47%	–
ALNY	New	Alnylam Pharmaceuticals Inc	$3,624,000	–	36,800	–	1.39%	–
SRPT	New	Sarepta Therapeutics Inc	$3,568,000	–	27,000	–	1.37%	–
VSTM	New	Verastem Inc	$3,435,000	–	500,000	–	1.32%	–
BLUE	New	Bluebird Bio Inc	$3,137,000	–	20,000	–	1.20%	–
GTHX	New	G1 Therapeutics Inc	$3,121,000	–	72,000	–	1.20%	–
AGIO	New	Agios Pharmaceuticals Inc	$3,074,000	–	36,500	–	1.18%	–
DCPH	New	Deciphera Pharmaceuticals Inc	$3,028,000	–	77,000	–	1.16%	–
SGEN	New	Seattle Genetics Inc	$2,821,000	–	42,500	–	1.08%	–
JAZZ	New	Jazz Pharmaceuticals PLC	$2,791,000	–	16,200	–	1.07%	–
MDGL	New	Madrigal Pharmaceuticals Inc	$2,790,000	–	10,000	–	1.07%	–
PBYI	New	Puma Biotechnology Inc	$2,732,000	–	46,300	–	1.05%	–
KALV	New	Kalvista Pharmaceuticals Inc	$2,612,000	–	322,436	–	1.00%	–
FGEN	New	FibroGen Inc	$1,963,000	–	31,400	–	0.75%	–
CBAY	New	Cymabay Therapeutics Inc	$1,945,000	–	145,000	–	0.75%	–
MRUS	New	Merus N V	$1,692,000	–	75,060	–	0.65%	–
SGMO	New	Sangamo Therapeutics Inc	$1,605,000	–	113,000	–	0.62%	–
GMED	New	Globus Med Inc	$1,463,000	–	29,000	–	0.56%	–
GWPH	New	GW Pharmaceuticals Plcads	$1,339,000	–	9,600	–	0.51%	–
SUPN	New	Supernus Pharmaceuticals Inc	$1,253,000	–	20,953	–	0.48%	–
HZNP	New	Horizon Pharma Plc	$1,142,000	–	69,000	–	0.44%	–
PRTK	New	Paratek Pharmaceuticals Inc	$1,051,000	–	103,500	–	0.40%	–
RIGL	New	Rigel Pharmaceuticals Inc	$1,043,000	–	370,000	–	0.40%	–
AERI	New	Aerie Pharmaceuticals Inc	$998,000	–	14,779	–	0.38%	–
ONCE	New	Spark Therapeutics Inc	$992,000	–	12,000	–	0.38%	–
FOLD	New	Amicus Therapeutics Inc	$915,000	–	58,600	–	0.35%	–
PTLA	New	Portola Pharmaceuticals Inc	$906,000	–	24,000	–	0.35%	–
CRVS	New	Corvus Pharmaceuticals Inc	$892,000	–	81,341	–	0.34%	–
SBPH	New	Spring Bk Pharmaceuticals Inc	$860,000	–	73,000	–	0.33%	–
VKTX	New	Viking Therapeutics Inc	$664,000	–	70,000	–	0.26%	–
RDUS	New	Radius Health Inc	$554,000	–	18,799	–	0.21%	–
RSLS	New	ReShape Lifesciences Inc	$121,000	–	52,546	–	0.05%	–

Q4 2017

			Value		Shares		↓ Weighting
ASMB	Exit	ASSEMBLY BIOSCIENCES INC	$0	–	-5,104	–	-0.07%	–
MTEM	Exit	MOLECULAR TEMPLATES INC	$0	–	-48,141	–	-0.13%	–
XNCR	Exit	XENCOR INC	$0	–	-18,000	–	-0.16%	–
DCPH	Exit	DECIPHERA PHARMACEUTICALS IN	$0	–	-25,000	–	-0.19%	–
AERI	Exit	AERIE PHARMACEUTICALS INC	$0	–	-14,779	–	-0.28%	–
RDUS	Exit	RADIUS HEALTH INC	$0	–	-18,799	–	-0.28%	–
SUPN	Exit	SUPERNUS PHARMACEUTICALS INC	$0	–	-20,953	–	-0.33%	–
HZNP	Exit	HORIZON PHARMA PLC	$0	–	-69,000	–	-0.34%	–
FOLD	Exit	AMICUS THERAPEUTICS INC	$0	–	-58,600	–	-0.34%	–
IRWD	Exit	IRONWOOD PHARMACEUTICALS INC	$0	–	-59,000	–	-0.36%	–
GTHX	Exit	G1 THERAPEUTICS INC	$0	–	-39,000	–	-0.38%	–
SAGE	Exit	SAGE THERAPEUTICS INC	$0	–	-16,996	–	-0.41%	–
ONCE	Exit	SPARK THERAPEUTICS INC	$0	–	-12,000	–	-0.42%	–
AKAOQ	Exit	ACHAOGEN INC	$0	–	-74,538	–	-0.46%	–
TRXC	Exit	TRANSENTERIX INC	$0	–	-889,082	–	-0.50%	–
PTLA	Exit	PORTOLA PHARMACEUTICALS INC	$0	–	-24,000	–	-0.50%	–
OMER	Exit	OMEROS CORP	$0	–	-61,000	–	-0.51%	–
AGIO	Exit	AGIOS PHARMACEUTICALS INC	$0	–	-20,000	–	-0.52%	–
VCYT	Exit	VERACYTE INC	$0	–	-170,000	–	-0.58%	–
CORT	Exit	CORCEPT THERAPEUTICS INC	$0	–	-83,000	–	-0.62%	–
AVXS	Exit	AVEXIS INC	$0	–	-17,000	–	-0.64%	–
FGEN	Exit	FIBROGEN INC	$0	–	-31,400	–	-0.66%	–
STML	Exit	STEMLINE THERAPEUTICS INC	$0	–	-182,930	–	-0.79%	–
KALV	Exit	KALVISTA PHARMACEUTICALS INC	$0	–	-322,436	–	-0.84%	–
IONS	Exit	IONIS PHARMACEUTICAL INC	$0	–	-51,500	–	-1.02%	–
BLUE	Exit	BLUEBIRD BIO INC	$0	–	-20,000	–	-1.07%	–
SGYPQ	Exit	SYNERGY PHARMACEUTICALS DEL	$0	–	-971,922	–	-1.09%	–
JUNO	Exit	JUNO THERAPEUTICS INC	$0	–	-63,000	–	-1.10%	–
DERM	Exit	DERMIRA INC	$0	–	-108,000	–	-1.14%	–
CALA	Exit	CALITHERA BIOSCIENCES	$0	–	-188,000	–	-1.15%	–
ARRY	Exit	ARRAY BIOPHARMA INC	$0	–	-247,500	–	-1.18%	–
SGEN	Exit	SEATTLE GENETICS INC	$0	–	-57,500	–	-1.22%	–
FPRX	Exit	FIVE PRIME THERAPEUTICS INC	$0	–	-86,500	–	-1.38%	–
LGND	Exit	LIGAND PHARMACEUTICALS INC	$0	–	-29,000	–	-1.54%	–
NBIX	Exit	NEUROCRINE BIOSCIENCES INC	$0	–	-66,000	–	-1.57%	–
SGMO	Exit	SANGAMO THERAPEUTICS INC	$0	–	-273,000	–	-1.59%	–
TSRO	Exit	TESARO INC	$0	–	-35,000	–	-1.76%	–
CLVS	Exit	CLOVIS ONCOLOGY INC	$0	–	-56,000	–	-1.80%	–
ALNY	Exit	ALYNYLAM PHARMACEUTICALS INC	$0	–	-41,300	–	-1.89%	–
HALO	Exit	HALOZYME THERAPEUTICS INC	$0	–	-282,633	–	-1.91%	–
PRTK	Exit	PARATEK PHARMACEUTICALS INC	$0	–	-202,000	–	-1.97%	–
SRPT	Exit	SAREPTA THERAPEUTICS INC	$0	–	-121,000	–	-2.14%	–
XLRN	Exit	ACCELERON PHARMA INC	$0	–	-153,633	–	-2.24%	–
EXEL	Exit	EXELIXIS INC	$0	–	-254,334	–	-2.40%	–
ENTL	Exit	ENTELLUS MED INC	$0	–	-341,468	–	-2.45%	–
BMRN	Exit	BIOMARIN PHARMACEUTICAL INC	$0	–	-68,384	–	-2.48%	–
AMGN	Exit	AMGEN INC	$0	–	-36,104	–	-2.62%	–
ADMS	Exit	ADAMAS PHARMACEUTICALS INC	$0	–	-390,000	–	-3.21%	–
ACAD	Exit	ACADIA PHARMACEUTICALS INC	$0	–	-240,773	–	-3.53%	–
GILD	Exit	GILEAD SCIENCES INC	$0	–	-122,784	–	-3.87%	–
INCY	Exit	INCYTE CORP	$0	–	-88,975	–	-4.04%	–
ALXN	Exit	ALEXION PHARMACEUTICALS INC	$0	–	-92,141	–	-5.03%	–
VRTX	Exit	VERTEX PHARMACEUTICALS INC	$0	–	-88,722	–	-5.25%	–
REGN	Exit	REGENERON PHARMACEUTICALS	$0	–	-40,830	–	-7.10%	–
BIIB	Exit	BIOGEN INC	$0	–	-71,508	–	-8.71%	–
CELG	Exit	CELGENE CORP	$0	–	-180,522	–	-10.24%	–

Q3 2017

			Value		Shares		↓ Weighting
CELG	Buy	CELGENE CORP	$26,318,000	+14.2%	180,522	+1.7%	10.24%	+17.0%
BIIB	Buy	BIOGEN INC	$22,377,000	+35.0%	71,508	+17.0%	8.71%	+38.3%
REGN	Sell	REGENERON PHARMACEUTICALS	$18,253,000	-22.8%	40,830	-15.2%	7.10%	-20.9%
VRTX	Sell	VERTEX PHARMACEUTICALS INC	$13,488,000	-22.8%	88,722	-34.5%	5.25%	-20.9%
ALXN	Sell	ALEXION PHARMACEUTICALS INC	$12,926,000	+9.9%	92,141	-4.7%	5.03%	+12.6%
INCY	Buy	INCYTE CORP	$10,386,000	+6.5%	88,975	+14.8%	4.04%	+9.1%
GILD	Buy	GILEAD SCIENCES INC	$9,946,000	+15.4%	122,784	+0.8%	3.87%	+18.2%
ACAD	Buy	ACADIA PHARMACEUTICALS INC	$9,068,000	+136.0%	240,773	+74.8%	3.53%	+141.8%
ADMS	Buy	ADAMAS PHARMACEUTICALS INC	$8,252,000	+155.0%	390,000	+110.5%	3.21%	+161.1%
AMGN	Sell	AMGEN INC	$6,727,000	-22.0%	36,104	-27.9%	2.62%	-20.1%
BMRN	Sell	BIOMARIN PHARMACEUTICAL INC	$6,362,000	-40.7%	68,384	-42.1%	2.48%	-39.3%
EXEL	Buy	EXELIXIS INC	$6,163,000	+20.9%	254,334	+22.9%	2.40%	+23.9%
XLRN	Sell	ACCELERON PHARMA INC	$5,749,000	+6.5%	153,633	-13.5%	2.24%	+9.1%
SRPT	Buy	SAREPTA THERAPEUTICS INC	$5,489,000	+167.0%	121,000	+98.4%	2.14%	+173.6%
PRTK	Buy	PARATEK PHARMACEUTICALS INC	$5,070,000	+263.4%	202,000	+248.3%	1.97%	+272.5%
HALO	Buy	HALOZYME THERAPEUTICS INC	$4,907,000	+87.2%	282,633	+38.1%	1.91%	+91.8%
ALNY	New	ALYNYLAM PHARMACEUTICALS INC	$4,850,000	–	41,300	–	1.89%	–
CLVS	Buy	CLOVIS ONCOLOGY INC	$4,614,000	+40.8%	56,000	+60.0%	1.80%	+44.3%
TSRO	Buy	TESARO INC	$4,518,000	-3.6%	35,000	+4.5%	1.76%	-1.2%
SGMO	New	SANGAMO THERAPEUTICS INC	$4,095,000	–	273,000	–	1.59%	–
NBIX	New	NEUROCRINE BIOSCIENCES INC	$4,044,000	–	66,000	–	1.57%	–
LGND	Buy	LIGAND PHARMACEUTICALS INC	$3,946,000	+261.0%	29,000	+222.2%	1.54%	+270.1%
FPRX	Buy	FIVE PRIME THERAPEUTICS INC	$3,535,000	+186.2%	86,500	+111.0%	1.38%	+193.4%
SGEN	Sell	SEATTLE GENETICS INC	$3,129,000	-7.0%	57,500	-11.5%	1.22%	-4.7%
ARRY	Sell	ARRAY BIOPHARMA INC	$3,044,000	+13.5%	247,500	-22.8%	1.18%	+16.3%
CALA	Sell	CALITHERA BIOSCIENCES	$2,952,000	-18.5%	188,000	-23.0%	1.15%	-16.6%
DERM	Sell	DERMIRA INC	$2,916,000	-22.4%	108,000	-16.3%	1.14%	-20.5%
JUNO	New	JUNO THERAPEUTICS INC	$2,824,000	–	63,000	–	1.10%	–
SGYPQ	Buy	SYNERGY PHARMACEUTICALS DEL	$2,799,000	-18.3%	971,922	+25.9%	1.09%	-16.3%
BLUE	New	BLUEBIRD BIO INC	$2,746,000	–	20,000	–	1.07%	–
STML	Sell	STEMLINE THERAPEUTICS INC	$2,031,000	-51.3%	182,930	-59.6%	0.79%	-50.1%
FGEN	New	FIBROGEN INC	$1,688,000	–	31,400	–	0.66%	–
AVXS	New	AVEXIS INC	$1,644,000	–	17,000	–	0.64%	–
CORT	New	CORCEPT THERAPEUTICS INC	$1,601,000	–	83,000	–	0.62%	–
AGIO	Sell	AGIOS PHARMACEUTICALS INC	$1,334,000	-29.9%	20,000	-45.9%	0.52%	-28.3%
OMER	Buy	OMEROS CORP	$1,319,000	+119.1%	61,000	+101.7%	0.51%	+124.0%
PTLA	Sell	PORTOLA PHARMACEUTICALS INC	$1,297,000	-69.6%	24,000	-68.4%	0.50%	-68.9%
AKAOQ	Sell	ACHAOGEN INC	$1,189,000	-64.6%	74,538	-51.8%	0.46%	-63.7%
ONCE	New	SPARK THERAPEUTICS INC	$1,069,000	–	12,000	–	0.42%	–
GTHX	New	G1 THERAPEUTICS INC	$971,000	–	39,000	–	0.38%	–
FOLD	New	AMICUS THERAPEUTICS INC	$883,000	–	58,600	–	0.34%	–
HZNP	Sell	HORIZON PHARMA PLC	$876,000	-56.3%	69,000	-59.2%	0.34%	-55.2%
RDUS	Sell	RADIUS HEALTH INC	$725,000	-86.0%	18,799	-83.6%	0.28%	-85.7%
AERI	Sell	AERIE PHARMACEUTICALS INC	$718,000	-85.4%	14,779	-84.2%	0.28%	-85.1%
DCPH	New	DECIPHERA PHARMACEUTICALS IN	$478,000	–	25,000	–	0.19%	–
MTEM	New	MOLECULAR TEMPLATES INC	$334,000	–	48,141	–	0.13%	–
ASMB	New	ASSEMBLY BIOSCIENCES INC	$178,000	–	5,104	–	0.07%	–
GBT	Exit	GLOBAL BLOOD THERAPEUTICS INC	$0	–	-20,500	–	-0.21%	–
	Exit	TRILLIUM THERAPEUTICS INC	$0	–	-161,069	–	-0.26%	–
PIRS	Exit	PIERIS PHARMACEUTICALS INC	$0	–	-141,061	–	-0.27%	–
PCRX	Exit	PACIRA PHARMACEUTICALS INC	$0	–	-16,000	–	-0.29%	–
GWPH	Exit	GW PHARMACEUTICALS PLCads	$0	–	-9,200	–	-0.35%	–
MGNX	Exit	MACROGENICS INC	$0	–	-54,000	–	-0.36%	–
MRUS	Exit	MERUS NV	$0	–	-60,946	–	-0.37%	–
VNDA	Exit	VANDA PHARMACEUTICALS INC	$0	–	-62,905	–	-0.39%	–
ICPT	Exit	INTERCEPT PHARMACEUTICALS IN	$0	–	-11,155	–	-0.51%	–
FOMX	Exit	FOAMIX PHARMACEUTICALS LTD	$0	–	-358,975	–	-0.63%	–
PRTA	Exit	PROTHENA CORP PLC	$0	–	-42,000	–	-0.86%	–
KITE	Exit	KITE PHARMA INC	$0	–	-22,100	–	-0.87%	–
ILMN	Exit	ILLUMINA INC	$0	–	-13,641	–	-0.90%	–
	Exit	UNITED THERAPEUTICS CORP DEL	$0	–	-21,700	–	-1.07%	–
JAZZ	Exit	JAZZ PHARMACEUTICALS PLC	$0	–	-27,000	–	-1.60%	–
	Exit	NEURODERM LTD	$0	–	-168,025	–	-1.90%	–
SHPG	Exit	SHIRE PLCsponsored adr	$0	–	-32,700	–	-2.05%	–
MYL	Exit	MYLAN NV	$0	–	-140,000	–	-2.06%	–

Q2 2017

			Value		Shares		↓ Weighting
REGN	New	REGENERON PHARMACEUTICALS	$23,639,000	–	48,130	–	8.98%	–
CELG	New	CELGENE CORP	$23,053,000	–	177,522	–	8.76%	–
VRTX	New	VERTEX PHARMACEUTICALS INC	$17,465,000	–	135,522	–	6.64%	–
BIIB	New	BIOGEN INC	$16,577,000	–	61,108	–	6.30%	–
ALXN	New	ALEXION PHARMACEUTICALS INC	$11,758,000	–	96,641	–	4.47%	–
BMRN	New	BIOMARIN PHARMACEUTICALS INC	$10,732,000	–	118,166	–	4.08%	–
INCY	New	INCYTE CORP	$9,755,000	–	77,475	–	3.71%	–
AMGN	New	AMGEN INC	$8,629,000	–	50,104	–	3.28%	–
GILD	New	GILEAD SCIENCES INC	$8,619,000	–	121,784	–	3.28%	–
ENTL	New	ENTELLUS MED INC	$5,655,000	–	341,468	–	2.15%	–
MYL	New	MYLAN NV	$5,433,000	–	140,000	–	2.06%	–
SHPG	New	SHIRE PLCsponsored adr	$5,404,000	–	32,700	–	2.05%	–
XLRN	New	ACCELERON PHARMA INC	$5,397,000	–	177,643	–	2.05%	–
RDUS	New	RADIUS HEALTH INC	$5,194,000	–	114,799	–	1.97%	–
EXEL	New	EXELIXIS INC	$5,096,000	–	207,000	–	1.94%	–
	New	NEURODERM LTD	$5,007,000	–	168,025	–	1.90%	–
AERI	New	AERIE PHARMACEUTICALS INC	$4,926,000	–	93,822	–	1.87%	–
TSRO	New	TESARO INC	$4,685,000	–	33,500	–	1.78%	–
PTLA	New	PORTOLA PHARMACEUTICALS INC	$4,269,000	–	76,000	–	1.62%	–
JAZZ	New	JAZZ PHARMACEUTICALS PLC	$4,199,000	–	27,000	–	1.60%	–
STML	New	STEMLINE THERAPEUTICS INC	$4,168,000	–	453,000	–	1.58%	–
ACAD	New	ACADIA PHARMACEUTICALS INC	$3,842,000	–	137,773	–	1.46%	–
DERM	New	DERMIRA INC	$3,756,000	–	129,000	–	1.43%	–
CALA	New	CALITHERA BIOSCIENCES INC	$3,623,000	–	244,000	–	1.38%	–
SGYPQ	New	SYNERGY PHARMACEUTICALS DEL	$3,428,000	–	772,000	–	1.30%	–
SGEN	New	SEATTLE GENETICS INC	$3,363,000	–	65,000	–	1.28%	–
AKAOQ	New	ACHAOGEN INC	$3,358,000	–	154,538	–	1.28%	–
CLVS	New	CLOVIS ONCOLOGY INC	$3,276,000	–	35,000	–	1.24%	–
ADMS	New	ADAMAS PHARMACEUTICALS INC	$3,236,000	–	185,234	–	1.23%	–
	New	UNITED THERAPEUTICS CORP DEL	$2,815,000	–	21,700	–	1.07%	–
ARRY	New	ARRAY BIOPHARMA INC	$2,681,000	–	320,744	–	1.02%	–
IONS	New	IONIS PHARMACEUTICALS INC	$2,620,000	–	51,500	–	1.00%	–
HALO	New	HALOZYME THERAPEUTICS INC	$2,621,000	–	204,633	–	1.00%	–
ILMN	New	ILLUMINA INC	$2,367,000	–	13,641	–	0.90%	–
KITE	New	KITE PHARMA INC	$2,291,000	–	22,100	–	0.87%	–
KALV	New	KALVISTA PHARMACEUTICALS INC	$2,276,000	–	322,436	–	0.86%	–
PRTA	New	PROTHENA CORP PLC	$2,274,000	–	42,000	–	0.86%	–
SRPT	New	SAREPTA THERAPEUTICS INC	$2,056,000	–	61,000	–	0.78%	–
HZNP	New	HORIZON PHARMA PLC	$2,004,000	–	169,000	–	0.76%	–
AGIO	New	AGIOS PHARMACEUTICALS INC	$1,904,000	–	37,000	–	0.72%	–
FOMX	New	FOAMIX PHARMACEUTICALS LTD	$1,666,000	–	358,975	–	0.63%	–
VCYT	New	VERACYTE INC	$1,414,000	–	170,000	–	0.54%	–
PRTK	New	PARATEK PHARMACEUTICALS INC	$1,395,000	–	58,000	–	0.53%	–
SAGE	New	SAGE THERAPEUTICS INC	$1,353,000	–	16,996	–	0.51%	–
ICPT	New	INTERCEPT PHARMACEUTICALS IN	$1,351,000	–	11,155	–	0.51%	–
FPRX	New	FIVE PRIME THERAPEUTICS INC	$1,235,000	–	41,000	–	0.47%	–
IRWD	New	IRONWOOD PHARMACEUTICALS INC	$1,113,000	–	59,000	–	0.42%	–
LGND	New	LIGAND PHARMACEUTICALS INC	$1,093,000	–	9,000	–	0.42%	–
VNDA	New	VANDA PHARMACEUTICALS INC	$1,022,000	–	62,905	–	0.39%	–
MRUS	New	MERUS NV	$966,000	–	60,946	–	0.37%	–
MGNX	New	MACROGENICS INC	$945,000	–	54,000	–	0.36%	–
GWPH	New	GW PHARMACEUTICALS PLCads	$922,000	–	9,200	–	0.35%	–
SUPN	New	SUPERNUS PHARMACEUTICALS INC	$902,000	–	20,953	–	0.34%	–
PCRX	New	PACIRA PHARMACEUTICALS INC	$762,000	–	16,000	–	0.29%	–
PIRS	New	PIERIS PHARMACEUTICALS INC	$712,000	–	141,061	–	0.27%	–
	New	TRILLIUM THERAPEUTICS INC	$693,000	–	161,069	–	0.26%	–
TRXC	New	TRANSENTERIX INC	$625,000	–	889,082	–	0.24%	–
OMER	New	OMEROS CORP	$602,000	–	30,239	–	0.23%	–
GBT	New	GLOBAL BLOOD THERAPEUTICS INC	$561,000	–	20,500	–	0.21%	–
XNCR	New	XENCOR INC	$380,000	–	18,000	–	0.14%	–

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