Q3 2023
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| INSM | Sell | INSMED INC | $151,500,000 | +10.5% | 6,000,000 | -7.7% | 5.85% | -7.9% |
| JAZZ | Sell | JAZZ PHARMACEUTICALS PLC | $147,308,545 | -4.9% | 1,138,045 | -9.0% | 5.69% | -20.7% |
| ITCI | Buy | INTRA-CELLULAR THERAPIES INC | $135,434,000 | +38.1% | 2,600,000 | +67.9% | 5.23% | +15.2% |
| GH | Buy | GUARDANT HEALTH INC | $120,042,000 | +123.5% | 4,050,000 | +170.0% | 4.63% | +86.4% |
| IMVT | Sell | IMMUNOVANT INC | $107,413,492 | +4.4% | 2,797,955 | -48.4% | 4.15% | -12.9% |
| ALKS | Buy | ALKERMES PLC | $106,438,000 | +13.4% | 3,800,000 | +26.7% | 4.11% | -5.5% |
| DVAX | Buy | DYNAVAX TECHNOLOGIES CORP | $99,800,240 | +17.8% | 6,756,956 | +3.0% | 3.85% | -1.8% |
| Sell | STRUCTURE THERAPEUTICS INCsponsored ads | $96,554,300 | -12.2% | 1,915,000 | -27.6% | 3.73% | -26.8% | |
| PLRX | Buy | PLIANT THERAPEUTICS INC | $95,370,000 | +30.0% | 5,500,000 | +35.8% | 3.68% | +8.4% |
| AXSM | Buy | AXSOME THERAPEUTICS INC | $79,726,668 | +188.8% | 1,140,745 | +196.9% | 3.08% | +140.8% |
| BCYC | Buy | BICYCLE THERAPEUTICS PLCsponsored ads | $70,124,266 | -2.5% | 3,490,506 | +23.8% | 2.71% | -18.7% |
| NTLA | Buy | INTELLIA THERAPEUTICS INC | $63,240,000 | +85.6% | 2,000,000 | +139.4% | 2.44% | +54.8% |
| EDIT | Buy | EDITAS MEDICINE INC | $55,395,093 | +94.9% | 7,101,935 | +105.6% | 2.14% | +62.5% |
| GERN | Buy | GERON CORP | $54,484,000 | -29.8% | 25,700,000 | +6.3% | 2.10% | -41.5% |
| New | APOGEE THERAPEUTICS INC | $51,426,145 | – | 2,414,373 | – | 1.98% | – | |
| PACB | Buy | PACIFIC BIOSCIENCES CALIF IN | $50,100,000 | +159.6% | 6,000,000 | +313.5% | 1.93% | +116.6% |
| VRDN | Buy | VIRIDIAN THERAPEUTICS INC | $45,456,516 | +49.3% | 2,963,267 | +131.6% | 1.76% | +24.6% |
| NVCR | New | NOVOCURE LTD | $40,375,000 | – | 2,500,000 | – | 1.56% | – |
| New | HILLEVAX INC | $39,005,000 | – | 2,900,000 | – | 1.51% | – | |
| RPTX | Buy | REPARE THERAPEUTICS INC | $37,058,190 | +28.4% | 3,067,731 | +12.5% | 1.43% | +7.0% |
| AGEN | Buy | AGENUS INC | $35,818,219 | -25.4% | 31,697,539 | +5.7% | 1.38% | -37.8% |
| NBIX | New | NEUROCRINE BIOSCIENCES INC | $33,750,000 | – | 300,000 | – | 1.30% | – |
| TERN | Buy | TERNS PHARMACEUTICALS INC | $30,180,000 | +213.8% | 6,000,000 | +445.9% | 1.16% | +161.8% |
| RAPT | Buy | RAPT THERAPEUTICS INC | $24,930,000 | +32.7% | 1,500,000 | +49.3% | 0.96% | +10.6% |
| BEAM | Sell | BEAM THERAPEUTICS INC | $24,426,166 | -41.9% | 1,015,641 | -22.9% | 0.94% | -51.6% |
| ANAB | New | ANAPTYSBIO INC | $24,170,801 | – | 1,345,813 | – | 0.93% | – |
| OLMA | New | OLEMA PHARMACEUTICALS INC | $23,846,541 | – | 1,930,894 | – | 0.92% | – |
| ANIP | Sell | ANI PHARMACEUTICALS INC | $23,224,000 | -16.1% | 400,000 | -22.2% | 0.90% | -30.1% |
| New | AMYLYX PHARMACEUTICALS INC | $23,058,424 | – | 1,259,335 | – | 0.89% | – | |
| BNTX | New | BIONTECH SEsponsored ads | $21,728,000 | – | 200,000 | – | 0.84% | – |
| DYN | Sell | DYNE THERAPEUTICS INC | $21,536,901 | -23.4% | 2,403,672 | -3.8% | 0.83% | -36.2% |
| MRNA | New | MODERNA INC | $20,658,000 | – | 200,000 | – | 0.80% | – |
| New | ORCHARD THERAPEUTICS PLCspon ads new | $15,782,109 | – | 2,041,670 | – | 0.61% | – | |
| NKTR | Buy | NEKTAR THERAPEUTICS | $10,959,040 | +6.0% | 18,400,000 | +2.4% | 0.42% | -11.7% |
| MORF | Buy | MORPHIC HLDG INC | $10,782,523 | -13.2% | 470,647 | +117.1% | 0.42% | -27.7% |
| AGIO | New | AGIOS PHARMACEUTICALS INC | $10,450,613 | – | 422,247 | – | 0.40% | – |
| ABOS | Sell | ACUMEN PHARMACEUTICALS INC | $10,429,133 | -44.6% | 2,513,044 | -35.8% | 0.40% | -53.8% |
| Sell | VIGIL NEUROSCIENCE INC | $9,524,836 | -42.9% | 1,767,131 | -0.4% | 0.37% | -52.3% | |
| Sell | ASTRIA THERAPEUTICS INC | $7,742,533 | -45.2% | 1,037,873 | -38.9% | 0.30% | -54.4% | |
| TXG | New | 10X GENOMICS INC | $7,536,004 | – | 182,691 | – | 0.29% | – |
| NVAX | New | NOVAVAX INC | $7,240,000 | – | 1,000,000 | – | 0.28% | – |
| New | ACELYRIN INC | $5,606,609 | – | 551,289 | – | 0.22% | – | |
| New | SYROS PHARMACEUTICALS INC | $3,272,516 | – | 828,485 | – | 0.13% | – | |
| SRRK | New | SCHOLAR ROCK HLDG CORP | $2,512,371 | – | 353,855 | – | 0.10% | – |
| CMPS | Sell | COMPASS PATHWAYS PLCsponsored ads | $2,430,338 | -56.7% | 328,424 | -51.6% | 0.09% | -63.8% |
| ETNB | Sell | 89BIO INC | $1,406,244 | -85.2% | 91,078 | -81.9% | 0.05% | -87.8% |
| IPSC | Sell | CENTURY THERAPEUTICS INC | $1,086,016 | -66.4% | 543,008 | -46.9% | 0.04% | -72.0% |
| Exit | MINK THERAPEUTICS INC | $0 | – | -324,867 | – | -0.03% | – | |
| IMUX | Exit | IMMUNIC INC | $0 | – | -308,314 | – | -0.04% | – |
| ALLK | Exit | ALLAKOS INC | $0 | – | -228,277 | – | -0.05% | – |
| FGEN | Exit | FIBROGEN INCcall | $0 | – | -764,700 | – | -0.10% | – |
| Exit | MOONLAKE IMMUNOTHERAPEUTICSclass a ord | $0 | – | -108,450 | – | -0.26% | – | |
| ZNTL | Exit | ZENTALIS PHARMACEUTICALS INC | $0 | – | -300,300 | – | -0.39% | – |
| INZY | Exit | INOZYME PHARMA INC | $0 | – | -1,644,021 | – | -0.42% | – |
| ORTX | Exit | ORCHARD THERAPEUTICS PLCspon ads new | $0 | – | -2,041,670 | – | -0.49% | – |
Q2 2023
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| JAZZ | New | JAZZ PHARMACEUTICALS PLC | $154,962,500 | – | 1,250,000 | – | 7.17% | – |
| INSM | New | INSMED INC | $137,150,000 | – | 6,500,000 | – | 6.35% | – |
| IONS | New | IONIS PHARMACEUTICALS INC | $116,281,851 | – | 2,834,069 | – | 5.38% | – |
| TVTX | New | TRAVERE THERAPEUTICS INC | $113,203,200 | – | 7,370,000 | – | 5.24% | – |
| New | STRUCTURE THERAPEUTICS INCsponsored ads | $110,026,714 | – | 2,646,782 | – | 5.09% | – | |
| IMVT | New | IMMUNOVANT INC | $102,842,630 | – | 5,421,330 | – | 4.76% | – |
| ITCI | New | INTRA-CELLULAR THERAPIES INC | $98,035,317 | – | 1,548,252 | – | 4.54% | – |
| ALKS | New | ALKERMES PLC | $93,900,000 | – | 3,000,000 | – | 4.35% | – |
| SWTX | New | SPRINGWORKS THERAPEUTICS INC | $92,987,526 | – | 3,546,435 | – | 4.30% | – |
| DVAX | New | DYNAVAX TECHNOLOGIES CORP | $84,726,983 | – | 6,557,816 | – | 3.92% | – |
| GERN | New | GERON CORP | $77,588,801 | – | 24,170,966 | – | 3.59% | – |
| PLRX | New | PLIANT THERAPEUTICS INC | $73,386,000 | – | 4,050,000 | – | 3.40% | – |
| BCYC | New | BICYCLE THERAPEUTICS PLCsponsored ads | $71,942,028 | – | 2,819,045 | – | 3.33% | – |
| VRNA | New | VERONA PHARMA PLCsponsored ads | $67,381,953 | – | 3,187,415 | – | 3.12% | – |
| GH | New | GUARDANT HEALTH INC | $53,700,000 | – | 1,500,000 | – | 2.49% | – |
| FDMT | New | 4D MOLECULAR THERAPEUTICS IN | $50,200,393 | – | 2,778,107 | – | 2.32% | – |
| AGEN | New | AGENUS INC | $48,000,000 | – | 30,000,000 | – | 2.22% | – |
| BEAM | New | BEAM THERAPEUTICS INC | $42,061,900 | – | 1,317,316 | – | 1.95% | – |
| AUTL | New | AUTOLUS THERAPEUTICS PLCspon ads | $35,700,000 | – | 15,000,000 | – | 1.65% | – |
| NTLA | New | INTELLIA THERAPEUTICS INC | $34,069,488 | – | 835,446 | – | 1.58% | – |
| VRDN | New | VIRIDIAN THERAPEUTICS INC | $30,439,353 | – | 1,279,502 | – | 1.41% | – |
| NRIX | New | NURIX THERAPEUTICS INC | $29,948,322 | – | 2,997,830 | – | 1.39% | – |
| RPTX | New | REPARE THERAPEUTICS INC | $28,858,071 | – | 2,727,606 | – | 1.34% | – |
| EDIT | New | EDITAS MEDICINE INC | $28,424,313 | – | 3,453,744 | – | 1.32% | – |
| DYN | New | DYNE THERAPEUTICS INC | $28,124,010 | – | 2,499,912 | – | 1.30% | – |
| ANIP | New | ANI PHARMACEUTICALS INC | $27,669,750 | – | 514,021 | – | 1.28% | – |
| AXSM | New | AXSOME THERAPEUTICS INC | $27,608,612 | – | 384,200 | – | 1.28% | – |
| PNT | New | POINT BIOPHARMA GLOBAL INC | $25,200,979 | – | 2,781,565 | – | 1.17% | – |
| EWTX | New | EDGEWISE THERAPEUTICS INC | $21,312,500 | – | 2,750,000 | – | 0.99% | – |
| New | ZURA BIO LTD | $20,688,600 | – | 2,523,000 | – | 0.96% | – | |
| PACB | New | PACIFIC BIOSCIENCES CALIF IN | $19,300,973 | – | 1,451,201 | – | 0.89% | – |
| ABOS | New | ACUMEN PHARMACEUTICALS INC | $18,837,696 | – | 3,916,361 | – | 0.87% | – |
| RAPT | New | RAPT THERAPEUTICS INC | $18,785,291 | – | 1,004,561 | – | 0.87% | – |
| PRTA | New | PROTHENA CORP PLCput | $17,070,000 | – | 250,000 | – | 0.79% | – |
| New | VIGIL NEUROSCIENCE INC | $16,670,045 | – | 1,773,409 | – | 0.77% | – | |
| New | ASTRIA THERAPEUTICS INC | $14,139,467 | – | 1,697,415 | – | 0.66% | – | |
| NUVB | New | NUVATION BIO INC | $13,897,238 | – | 7,720,688 | – | 0.64% | – |
| MORF | New | MORPHIC HLDG INC | $12,426,392 | – | 216,752 | – | 0.58% | – |
| SLN | New | SILENCE THERAPEUTICS PLCads | $10,733,690 | – | 1,951,580 | – | 0.50% | – |
| ORTX | New | ORCHARD THERAPEUTICS PLCspon ads new | $10,637,101 | – | 2,041,670 | – | 0.49% | – |
| NKTR | New | NEKTAR THERAPEUTICS | $10,338,336 | – | 17,973,464 | – | 0.48% | – |
| TERN | New | TERNS PHARMACEUTICALS INC | $9,617,930 | – | 1,099,192 | – | 0.44% | – |
| ETNB | New | 89BIO INC | $9,533,745 | – | 503,100 | – | 0.44% | – |
| INZY | New | INOZYME PHARMA INC | $9,157,197 | – | 1,644,021 | – | 0.42% | – |
| ZNTL | New | ZENTALIS PHARMACEUTICALS INC | $8,471,463 | – | 300,300 | – | 0.39% | – |
| RLMD | New | RELMADA THERAPEUTICS INC | $6,981,032 | – | 2,837,818 | – | 0.32% | – |
| GHRS | New | GH RESEARCH PLCordinary shares | $5,925,381 | – | 499,400 | – | 0.27% | – |
| CMPS | New | COMPASS PATHWAYS PLCsponsored ads | $5,616,821 | – | 678,360 | – | 0.26% | – |
| New | MOONLAKE IMMUNOTHERAPEUTICSclass a ord | $5,530,950 | – | 108,450 | – | 0.26% | – | |
| IPSC | New | CENTURY THERAPEUTICS INC | $3,232,339 | – | 1,022,892 | – | 0.15% | – |
| HRTX | New | HERON THERAPEUTICS INC | $2,420,577 | – | 2,086,704 | – | 0.11% | – |
| FGEN | New | FIBROGEN INCcall | $2,064,690 | – | 764,700 | – | 0.10% | – |
| ALLK | New | ALLAKOS INC | $995,288 | – | 228,277 | – | 0.05% | – |
| IMUX | New | IMMUNIC INC | $773,868 | – | 308,314 | – | 0.04% | – |
| New | MINK THERAPEUTICS INC | $682,221 | – | 324,867 | – | 0.03% | – |
Q4 2022
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| GRTS | Exit | GRITSTONE BIO INC | $0 | – | -45,500 | – | -0.01% | – |
| PASG | Exit | PASSAGE BIO INC | $0 | – | -1,439,062 | – | -0.08% | – |
| SDGR | Exit | SCHRODINGER INC | $0 | – | -170,000 | – | -0.19% | – |
| RLMD | Exit | RELMADA THERAPEUTICS INCcall | $0 | – | -117,200 | – | -0.20% | – |
| ASMB | Exit | ASSEMBLY BIOSCIENCES INC | $0 | – | -3,000,000 | – | -0.22% | – |
| GHRS | Exit | GH RESEARCH PLCordinary shares | $0 | – | -499,400 | – | -0.27% | – |
| HOOK | Exit | HOOKIPA PHARMA INC | $0 | – | -5,035,998 | – | -0.31% | – |
| FULC | Exit | FULCRUM THERAPEUTICS INC | $0 | – | -900,711 | – | -0.33% | – |
| MGTA | Exit | MAGENTA THERAPEUTICS INC | $0 | – | -5,359,000 | – | -0.35% | – |
| RETA | Exit | REATA PHARMACEUTICALS INCput | $0 | – | -316,800 | – | -0.36% | – |
| TCDA | Exit | TRICIDA INCcall | $0 | – | -772,700 | – | -0.37% | – |
| INZY | Exit | INOZYME PHARMA INC | $0 | – | -3,250,000 | – | -0.40% | – |
| IPSC | Exit | CENTURY THERAPEUTICS INC | $0 | – | -924,641 | – | -0.42% | – |
| ANAB | Exit | ANAPTYSBIO INC | $0 | – | -360,000 | – | -0.42% | – |
| KROS | Exit | KEROS THERAPEUTICS INC | $0 | – | -248,500 | – | -0.43% | – |
| JNCE | Exit | JOUNCE THERAPEUTICS INC | $0 | – | -4,259,653 | – | -0.46% | – |
| ACET | Exit | ADICET BIO INC | $0 | – | -825,508 | – | -0.54% | – |
| TCDA | Exit | TRICIDA INC | $0 | – | -1,177,680 | – | -0.56% | – |
| ETNB | Exit | 89BIO INC | $0 | – | -2,636,000 | – | -0.70% | – |
| NTLA | Exit | INTELLIA THERAPEUTICS INC | $0 | – | -300,000 | – | -0.77% | – |
| RLMD | Exit | RELMADA THERAPEUTICS INC | $0 | – | -460,861 | – | -0.78% | – |
| ARDX | Exit | ARDELYX INC | $0 | – | -14,858,000 | – | -0.81% | – |
| FMTX | Exit | FORMA THERAPEUTICS HLDGS INC | $0 | – | -966,573 | – | -0.88% | – |
| SLN | Exit | SILENCE THERAPEUTICS PLCads | $0 | – | -1,951,580 | – | -0.90% | – |
| Exit | DICE THERAPEUTICS INC | $0 | – | -1,000,000 | – | -0.93% | – | |
| CRNX | Exit | CRINETICS PHARMACEUTICALS IN | $0 | – | -1,053,000 | – | -0.95% | – |
| NUVB | Exit | NUVATION BIO INC | $0 | – | -9,325,540 | – | -0.96% | – |
| ALBO | Exit | ALBIREO PHARMA INC | $0 | – | -1,110,624 | – | -0.98% | – |
| Exit | VIGIL NEUROSCIENCE INC | $0 | – | -2,363,188 | – | -0.98% | – | |
| GBT | Exit | GLOBAL BLOOD THERAPEUTICS IN | $0 | – | -326,600 | – | -1.02% | – |
| Exit | THIRD HARMONIC BIO INC | $0 | – | -1,268,220 | – | -1.10% | – | |
| FDMT | Exit | 4D MOLECULAR THERAPEUTICS IN | $0 | – | -3,196,642 | – | -1.18% | – |
| KALV | Exit | KALVISTA PHARMACEUTICALS INC | $0 | – | -1,824,000 | – | -1.21% | – |
| VERV | Exit | VERVE THERAPEUTICS INC | $0 | – | -775,000 | – | -1.22% | – |
| NRIX | Exit | NURIX THERAPEUTICS INC | $0 | – | -2,053,621 | – | -1.22% | – |
| AKRO | Exit | AKERO THERAPEUTICS INC | $0 | – | -790,926 | – | -1.23% | – |
| ALLK | Exit | ALLAKOS INC | $0 | – | -4,518,575 | – | -1.27% | – |
| VRNA | Exit | VERONA PHARMA PLCsponsored ads | $0 | – | -2,829,094 | – | -1.32% | – |
| PLRX | Exit | PLIANT THERAPEUTICS INC | $0 | – | -1,399,744 | – | -1.34% | – |
| FATE | Exit | FATE THERAPEUTICS INC | $0 | – | -1,311,113 | – | -1.35% | – |
| EWTX | Exit | EDGEWISE THERAPEUTICS INC | $0 | – | -3,374,394 | – | -1.52% | – |
| ISEE | Exit | IVERIC BIO INCcall | $0 | – | -2,000,000 | – | -1.64% | – |
| HRTX | Exit | HERON THERAPEUTICS INC | $0 | – | -8,548,387 | – | -1.65% | – |
| NKTX | Exit | NKARTA INC | $0 | – | -2,814,844 | – | -1.70% | – |
| ESPR | Exit | ESPERION THERAPEUTICS INC NE | $0 | – | -5,636,587 | – | -1.73% | – |
| ABOS | Exit | ACUMEN PHARMACEUTICALS INC | $0 | – | -3,778,818 | – | -1.74% | – |
| RPTX | Exit | REPARE THERAPEUTICS INC | $0 | – | -3,127,667 | – | -1.74% | – |
| VRDN | Exit | VIRIDIAN THERAPEUTICS INC | $0 | – | -1,970,290 | – | -1.85% | – |
| DYN | Exit | DYNE THERAPEUTICS INC | $0 | – | -3,184,200 | – | -1.85% | – |
| AUPH | Exit | AURINIA PHARMACEUTICALS INC | $0 | – | -5,677,372 | – | -1.96% | – |
| KURA | Exit | KURA ONCOLOGY INC | $0 | – | -3,186,083 | – | -1.99% | – |
| BEAM | Exit | BEAM THERAPEUTICS INC | $0 | – | -1,000,000 | – | -2.18% | – |
| AGEN | Exit | AGENUS INC | $0 | – | -26,325,000 | – | -2.47% | – |
| IMVT | Exit | IMMUNOVANT INC | $0 | – | -9,860,246 | – | -2.52% | – |
| KDNY | Exit | CHINOOK THERAPEUTICS INC | $0 | – | -3,000,000 | – | -2.70% | – |
| BMRN | Exit | BIOMARIN PHARMACEUTICAL INC | $0 | – | -738,863 | – | -2.87% | – |
| BCYC | Exit | BICYCLE THERAPEUTICS PLCsponsored ads | $0 | – | -2,900,000 | – | -3.09% | – |
| SWTX | Exit | SPRINGWORKS THERAPEUTICS INC | $0 | – | -2,369,210 | – | -3.10% | – |
| ASND | Exit | ASCENDIS PHARMA A/Ssponsored adr | $0 | – | -800,000 | – | -3.78% | – |
| HZNP | Exit | HORIZON THERAPEUTICS PUB L | $0 | – | -1,462,800 | – | -4.15% | – |
| NVCR | Exit | NOVOCURE LTD | $0 | – | -1,293,761 | – | -4.50% | – |
| TVTX | Exit | TRAVERE THERAPEUTICS INC | $0 | – | -4,000,000 | – | -4.51% | – |
| ASND | Exit | ASCENDIS PHARMA A/Scall | $0 | – | -1,000,000 | – | -4.73% | – |
| JAZZ | Exit | JAZZ PHARMACEUTICALS PLC | $0 | – | -861,000 | – | -5.26% | – |
| ISEE | Exit | IVERIC BIO INC | $0 | – | -7,000,000 | – | -5.75% | – |
Q3 2022
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| ISEE | Buy | IVERIC BIO INC | $125,580,000 | +190.1% | 7,000,000 | +55.6% | 5.75% | +102.1% |
| JAZZ | Buy | JAZZ PHARMACEUTICALS PLC | $114,763,000 | +47.1% | 861,000 | +72.2% | 5.26% | +2.5% |
| ASND | New | ASCENDIS PHARMA A/Scall | $103,260,000 | – | 1,000,000 | – | 4.73% | – |
| TVTX | Buy | TRAVERE THERAPEUTICS INC | $98,560,000 | +13.6% | 4,000,000 | +11.7% | 4.51% | -20.8% |
| NVCR | Sell | NOVOCURE LTD | $98,300,000 | +5.4% | 1,293,761 | -3.5% | 4.50% | -26.5% |
| HZNP | New | HORIZON THERAPEUTICS PUB L | $90,533,000 | – | 1,462,800 | – | 4.15% | – |
| ASND | New | ASCENDIS PHARMA A/Ssponsored adr | $82,608,000 | – | 800,000 | – | 3.78% | – |
| SWTX | New | SPRINGWORKS THERAPEUTICS INC | $67,594,000 | – | 2,369,210 | – | 3.10% | – |
| BMRN | Buy | BIOMARIN PHARMACEUTICAL INC | $62,633,000 | +15.5% | 738,863 | +12.9% | 2.87% | -19.6% |
| KDNY | Sell | CHINOOK THERAPEUTICS INC | $58,980,000 | -1.7% | 3,000,000 | -12.5% | 2.70% | -31.5% |
| IMVT | Buy | IMMUNOVANT INC | $55,020,000 | +49.2% | 9,860,246 | +4.3% | 2.52% | +4.0% |
| AGEN | Buy | AGENUS INC | $53,966,000 | +25.1% | 26,325,000 | +18.4% | 2.47% | -12.9% |
| BEAM | Sell | BEAM THERAPEUTICS INC | $47,640,000 | -1.5% | 1,000,000 | -20.0% | 2.18% | -31.4% |
| KURA | Sell | KURA ONCOLOGY INC | $43,522,000 | -35.8% | 3,186,083 | -13.8% | 1.99% | -55.3% |
| AUPH | New | AURINIA PHARMACEUTICALS INC | $42,694,000 | – | 5,677,372 | – | 1.96% | – |
| DYN | Sell | DYNE THERAPEUTICS INC | $40,439,000 | +68.2% | 3,184,200 | -9.0% | 1.85% | +17.1% |
| VRDN | Buy | VIRIDIAN THERAPEUTICS INC | $40,411,000 | +198.5% | 1,970,290 | +68.4% | 1.85% | +108.0% |
| RPTX | Buy | REPARE THERAPEUTICS INC | $37,939,000 | +0.2% | 3,127,667 | +15.5% | 1.74% | -30.2% |
| ABOS | Buy | ACUMEN PHARMACEUTICALS INC | $37,902,000 | +160.1% | 3,778,818 | +21.9% | 1.74% | +81.2% |
| ESPR | Sell | ESPERION THERAPEUTICS INC NE | $37,765,000 | -1.0% | 5,636,587 | -6.1% | 1.73% | -31.0% |
| HRTX | New | HERON THERAPEUTICS INC | $36,074,000 | – | 8,548,387 | – | 1.65% | – |
| ISEE | New | IVERIC BIO INCcall | $35,880,000 | – | 2,000,000 | – | 1.64% | – |
| EWTX | New | EDGEWISE THERAPEUTICS INC | $33,204,000 | – | 3,374,394 | – | 1.52% | – |
| FATE | Sell | FATE THERAPEUTICS INC | $29,382,000 | -41.2% | 1,311,113 | -35.0% | 1.35% | -59.1% |
| PLRX | New | PLIANT THERAPEUTICS INC | $29,241,000 | – | 1,399,744 | – | 1.34% | – |
| VRNA | New | VERONA PHARMA PLCsponsored ads | $28,913,000 | – | 2,829,094 | – | 1.32% | – |
| ALLK | New | ALLAKOS INC | $27,654,000 | – | 4,518,575 | – | 1.27% | – |
| AKRO | New | AKERO THERAPEUTICS INC | $26,931,000 | – | 790,926 | – | 1.23% | – |
| NRIX | Sell | NURIX THERAPEUTICS INC | $26,759,000 | -13.3% | 2,053,621 | -15.7% | 1.22% | -39.6% |
| VERV | New | VERVE THERAPEUTICS INC | $26,621,000 | – | 775,000 | – | 1.22% | – |
| FDMT | Buy | 4D MOLECULAR THERAPEUTICS IN | $25,701,000 | +17.3% | 3,196,642 | +1.8% | 1.18% | -18.3% |
| New | THIRD HARMONIC BIO INC | $24,058,000 | – | 1,268,220 | – | 1.10% | – | |
| GBT | Sell | GLOBAL BLOOD THERAPEUTICS IN | $22,241,000 | -80.9% | 326,600 | -91.0% | 1.02% | -86.7% |
| ALBO | New | ALBIREO PHARMA INC | $21,502,000 | – | 1,110,624 | – | 0.98% | – |
| Buy | VIGIL NEUROSCIENCE INC | $21,505,000 | +2601.6% | 2,363,188 | +666.3% | 0.98% | +1794.2% | |
| NUVB | Sell | NUVATION BIO INC | $20,889,000 | -43.8% | 9,325,540 | -18.7% | 0.96% | -60.8% |
| Sell | DICE THERAPEUTICS INC | $20,280,000 | +25.3% | 1,000,000 | -4.1% | 0.93% | -12.7% | |
| SLN | Buy | SILENCE THERAPEUTICS PLCads | $19,584,000 | +73.7% | 1,951,580 | +105.1% | 0.90% | +21.1% |
| FMTX | Sell | FORMA THERAPEUTICS HLDGS INC | $19,283,000 | -30.9% | 966,573 | -76.1% | 0.88% | -51.9% |
| ARDX | New | ARDELYX INC | $17,681,000 | – | 14,858,000 | – | 0.81% | – |
| RLMD | Sell | RELMADA THERAPEUTICS INC | $17,061,000 | +79.7% | 460,861 | -7.8% | 0.78% | +25.2% |
| NTLA | New | INTELLIA THERAPEUTICS INC | $16,788,000 | – | 300,000 | – | 0.77% | – |
| ETNB | New | 89BIO INC | $15,262,000 | – | 2,636,000 | – | 0.70% | – |
| TCDA | Sell | TRICIDA INC | $12,342,000 | -53.3% | 1,177,680 | -56.9% | 0.56% | -67.5% |
| ACET | Sell | ADICET BIO INC | $11,739,000 | -9.9% | 825,508 | -7.5% | 0.54% | -37.1% |
| KROS | Sell | KEROS THERAPEUTICS INC | $9,349,000 | -54.2% | 248,500 | -66.4% | 0.43% | -68.1% |
| ANAB | Sell | ANAPTYSBIO INC | $9,184,000 | -32.7% | 360,000 | -46.5% | 0.42% | -53.1% |
| TCDA | New | TRICIDA INCcall | $8,098,000 | – | 772,700 | – | 0.37% | – |
| RETA | New | REATA PHARMACEUTICALS INCput | $7,961,000 | – | 316,800 | – | 0.36% | – |
| FULC | Sell | FULCRUM THERAPEUTICS INC | $7,287,000 | +48.7% | 900,711 | -9.9% | 0.33% | +3.7% |
| RLMD | New | RELMADA THERAPEUTICS INCcall | $4,339,000 | – | 117,200 | – | 0.20% | – |
| SDGR | Sell | SCHRODINGER INC | $4,247,000 | -71.4% | 170,000 | -69.8% | 0.19% | -80.1% |
| PASG | Sell | PASSAGE BIO INC | $1,799,000 | -67.1% | 1,439,062 | -38.0% | 0.08% | -77.2% |
| GRTS | Sell | GRITSTONE BIO INC | $117,000 | -97.2% | 45,500 | -97.4% | 0.01% | -98.2% |
| LIFE | Exit | ATYR PHARMA INC | $0 | – | -290,844 | – | -0.05% | – |
| PTGX | Exit | PROTAGONIST THERAPEUTICS INCput | $0 | – | -260,500 | – | -0.14% | – |
| Exit | TENAYA THERAPEUTICS INC | $0 | – | -483,836 | – | -0.18% | – | |
| SAGE | Exit | SAGE THERAPEUTICS INC | $0 | – | -171,800 | – | -0.36% | – |
| ACAD | Exit | ACADIA PHARMACEUTICALS INC | $0 | – | -1,733,130 | – | -1.60% | – |
| MDGL | Exit | MADRIGAL PHARMACEUTICALS INC | $0 | – | -905,000 | – | -4.26% | – |
| ALNY | Exit | ALNYLAM PHARMACEUTICALS INCcall | $0 | – | -499,900 | – | -4.79% | – |
Q2 2022
| Value | Shares | ↓ Weighting | ||||||
|---|---|---|---|---|---|---|---|---|
| GBT | New | GLOBAL BLOOD THERAPEUTICS IN | $116,512,000 | – | 3,646,690 | – | 7.66% | – |
| NVCR | New | NOVOCURE LTD | $93,220,000 | – | 1,341,300 | – | 6.13% | – |
| TVTX | New | TRAVERE THERAPEUTICS INC | $86,760,000 | – | 3,580,700 | – | 5.70% | – |
| JAZZ | New | JAZZ PHARMACEUTICALS PLC | $78,005,000 | – | 500,000 | – | 5.13% | – |
| ALNY | New | ALNYLAM PHARMACEUTICALS INCcall | $72,910,000 | – | 499,900 | – | 4.79% | – |
| KURA | New | KURA ONCOLOGY INC | $67,784,000 | – | 3,697,969 | – | 4.46% | – |
| MDGL | New | MADRIGAL PHARMACEUTICALS INC | $64,780,000 | – | 905,000 | – | 4.26% | – |
| KDNY | New | CHINOOK THERAPEUTICS INC | $59,993,000 | – | 3,430,110 | – | 3.94% | – |
| BMRN | New | BIOMARIN PHARMACEUTICAL INC | $54,227,000 | – | 654,365 | – | 3.56% | – |
| FATE | New | FATE THERAPEUTICS INC | $50,006,000 | – | 2,018,005 | – | 3.29% | – |
| BCYC | New | BICYCLE THERAPEUTICS PLCsponsored ads | $48,662,000 | – | 2,900,000 | – | 3.20% | – |
| BEAM | New | BEAM THERAPEUTICS INC | $48,388,000 | – | 1,250,000 | – | 3.18% | – |
| ISEE | New | IVERIC BIO INC | $43,290,000 | – | 4,500,000 | – | 2.85% | – |
| AGEN | New | AGENUS INC | $43,148,000 | – | 22,241,417 | – | 2.84% | – |
| ESPR | New | ESPERION THERAPEUTICS INC NE | $38,160,000 | – | 6,000,000 | – | 2.51% | – |
| RPTX | New | REPARE THERAPEUTICS INC | $37,880,000 | – | 2,707,662 | – | 2.49% | – |
| NUVB | New | NUVATION BIO INC | $37,167,000 | – | 11,471,281 | – | 2.44% | – |
| IMVT | New | IMMUNOVANT INC | $36,875,000 | – | 9,455,000 | – | 2.42% | – |
| NKTX | New | NKARTA INC | $34,679,000 | – | 2,814,844 | – | 2.28% | – |
| NRIX | New | NURIX THERAPEUTICS INC | $30,866,000 | – | 2,436,164 | – | 2.03% | – |
| FMTX | New | FORMA THERAPEUTICS HLDGS INC | $27,905,000 | – | 4,050,000 | – | 1.83% | – |
| TCDA | New | TRICIDA INC | $26,447,000 | – | 2,732,117 | – | 1.74% | – |
| ACAD | New | ACADIA PHARMACEUTICALS INC | $24,420,000 | – | 1,733,130 | – | 1.60% | – |
| DYN | New | DYNE THERAPEUTICS INC | $24,045,000 | – | 3,500,000 | – | 1.58% | – |
| FDMT | New | 4D MOLECULAR THERAPEUTICS IN | $21,917,000 | – | 3,140,000 | – | 1.44% | – |
| KROS | New | KEROS THERAPEUTICS INC | $20,433,000 | – | 739,528 | – | 1.34% | – |
| CRNX | New | CRINETICS PHARMACEUTICALS IN | $19,638,000 | – | 1,053,000 | – | 1.29% | – |
| KALV | New | KALVISTA PHARMACEUTICALS INC | $17,948,000 | – | 1,824,000 | – | 1.18% | – |
| New | DICE THERAPEUTICS INC | $16,186,000 | – | 1,042,900 | – | 1.06% | – | |
| INZY | New | INOZYME PHARMA INC | $15,503,000 | – | 3,250,000 | – | 1.02% | – |
| SDGR | New | SCHRODINGER INC | $14,842,000 | – | 562,000 | – | 0.98% | – |
| ABOS | New | ACUMEN PHARMACEUTICALS INC | $14,570,000 | – | 3,100,000 | – | 0.96% | – |
| ANAB | New | ANAPTYSBIO INC | $13,653,000 | – | 672,569 | – | 0.90% | – |
| VRDN | New | VIRIDIAN THERAPEUTICS INC | $13,540,000 | – | 1,170,290 | – | 0.89% | – |
| ACET | New | ADICET BIO INC | $13,024,000 | – | 892,028 | – | 0.86% | – |
| JNCE | New | JOUNCE THERAPEUTICS INC | $12,907,000 | – | 4,259,653 | – | 0.85% | – |
| SLN | New | SILENCE THERAPEUTICS PLCads | $11,276,000 | – | 951,580 | – | 0.74% | – |
| RLMD | New | RELMADA THERAPEUTICS INC | $9,495,000 | – | 500,000 | – | 0.62% | – |
| HOOK | New | HOOKIPA PHARMA INC | $8,209,000 | – | 5,035,998 | – | 0.54% | – |
| IPSC | New | CENTURY THERAPEUTICS INC | $7,767,000 | – | 924,641 | – | 0.51% | – |
| MGTA | New | MAGENTA THERAPEUTICS INC | $6,431,000 | – | 5,359,000 | – | 0.42% | – |
| ASMB | New | ASSEMBLY BIOSCIENCES INC | $6,300,000 | – | 3,000,000 | – | 0.41% | – |
| SAGE | New | SAGE THERAPEUTICS INC | $5,549,000 | – | 171,800 | – | 0.36% | – |
| PASG | New | PASSAGE BIO INC | $5,475,000 | – | 2,320,000 | – | 0.36% | – |
| GHRS | New | GH RESEARCH PLCordinary shares | $4,984,000 | – | 499,400 | – | 0.33% | – |
| FULC | New | FULCRUM THERAPEUTICS INC | $4,900,000 | – | 1,000,000 | – | 0.32% | – |
| GRTS | New | GRITSTONE BIO INC | $4,162,000 | – | 1,720,000 | – | 0.27% | – |
| New | TENAYA THERAPEUTICS INC | $2,724,000 | – | 483,836 | – | 0.18% | – | |
| PTGX | New | PROTAGONIST THERAPEUTICS INCput | $2,061,000 | – | 260,500 | – | 0.14% | – |
| LIFE | New | ATYR PHARMA INC | $823,000 | – | 290,844 | – | 0.05% | – |
| New | VIGIL NEUROSCIENCE INC | $796,000 | – | 308,393 | – | 0.05% | – |